4938 completed, 1117 unknown, 855 recruiting, 370 not yet recruiting. 5193 Not applicable, 664 Phase 2, 460 Phase 3, 437 Phase 4, 311 Phase 1.
Follow this condition Literature Review of Depression trials Research Report on Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module - Severe Mental Illness, Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ludwig-Maximilians - University of Munich | 140 | 2028-10-01 | 2026-05-14 |
| INNOV5-MH-MAROC: Integrated Mental Health Care for Adolescents and Adults in Primary Care Centers and Schools in Morocco INNOV5 Integrated Mental Health Program, Enhanced Treatment as Usual (TAU+) - Depression in Adolescence, Depression in Adults | Not applicable | Not yet recruiting | Swiss Medical Academy Maroc | 146 | 2028-03-01 | 2025-12-02 |
| Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE Stepped collaborative care intervention, Enhanced Usual Care - Cancer, Depression | Not applicable | Not yet recruiting | University of Pittsburgh | 40 | 2028-01-14 | 2026-04-09 |
| Pilot Randomized Trial of BA-GSH in VA PC-MHI Behavioral Activation-Guided Self-Help - Depression | Not applicable | Not yet recruiting | VA Office of Research and Development | 30 | 2027-10-15 | 2026-04-21 |
| AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN YOUTH Peer-mentoring behavioral intervention, Health Education - Anxiety Depression | Not applicable | Not yet recruiting | University of Patras | 1680 | 2027-09-01 | 2026-04-14 |
| Prevalence of Depression Among Patients With Alopecia Areata Observation only - Alopecia Areata Depression, Depression | Not yet recruiting | Sohag University | 100 | 2027-09-01 | 2026-07-17 | |
| Whole Selves User Testing and Feasibility Study Whole Selves - Alcohol Use, Unspecified, Relationship, Social | Not applicable | Not yet recruiting | Boston University | 107 | 2027-09-01 | 2026-07-28 |
| Mental Health INtervention With Digital APPlications (MIND-APP): Randomized Controlled Researcher Blinded Trial Evaluating the Effectiveness of the Tankevirus and Grubl Mental Health Apps Tankevirus, Grubl, Placebo Application - Anxiety, Depression | Not applicable | Not yet recruiting | University Hospital, Akershus | 1000 | 2027-08-15 | 2026-06-04 |
| Virtual Intervention for Behavioral Health in Emerging Adults; "VIBE in the Parks" "VIBE in the Parks", Digital Control - Anxiety, Depression | Not applicable | Not yet recruiting | University of Illinois at Chicago | 268 | 2027-07-01 | 2026-04-23 |
| The Effect of the Safe and Sound Protocol on Depression and Anxiety Symptoms Safe and Sound Protocol, Control - Anxiety, Depression | Not applicable | Not yet recruiting | HealthPartners Institute | 120 | 2027-06-01 | 2026-10-20 |
| Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Randomized Controlled Trial UJI Online Transdiagnostic Protocol, UJI On Line Transdiagnostic Hibrid Protocol - Emotional Disorders, Anxiety | Not applicable | Not yet recruiting | Universitat Jaume I | 366 | 2027-05-01 | 2026-05-27 |
| Virtual Communication in the Hospital: Impact on Patients and Surrogates VCHIPS - Communication, Anxiety | Not applicable | Withdrawn | Indiana University | 2027-03-31 | 2026-04-22 | |
| Technology dRiven Enhancement to Engage & Connect TREE-Connect, Clinician-delivered psychotherapy - Depression | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 60 | 2027-03-01 | 2026-03-24 |
| The Effects of Chiropractic on Adults With Depression Chiropractic Care - Depression Disorder | Not applicable | Suspended | Life University | 20 | 2027-03-01 | 2026-05-07 |
| Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain | Phase 2 | Not yet recruiting | VA Office of Research and Development | 102 | 2027-03-01 | 2026-06-16 |
| Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms Resilience Training for Veterans (REST-V), Usual resources - Depression, Stress Disorders, Post-Traumatic | Not applicable | Not yet recruiting | VA Office of Research and Development | 200 | 2027-03-01 | 2026-09-01 |
| Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress TEAM-LEADS - Lupus, Dermatomyositis, Juvenile | Not applicable | Not yet recruiting | Duke University | 25 | 2027-02-01 | 2026-05-27 |
| Identification of Depressive and Anxiety Symptoms Among a Sample of Emergency Department Patients Using Artificial Intelligence (AI) Technology Biometrics (or AI Biomaker) - Artificial Intelligence (AI) | Not applicable | Not yet recruiting | University Hospitals Cleveland Medical Center | 30 | 2027-02-01 | 2026-09-15 |
| Community Health Worker Implementation of Transdiagnostic Evidence-based Mental Health Intervention for Spanish-speaking Latine Parents Common Elements Treatment Approach (CETA) - Depression, Anxiety | Not applicable | Not yet recruiting | University of Illinois at Chicago | 52 | 2027-02-01 | 2026-02-05 |
| Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health. Gardasil 9 vaccine, Hepatitis B Virus Vaccine(HBV), Cognitive Behavioral Therapy - Hepatitis B, Human Papilloma Virus | Phase 4 | Not yet recruiting | Eunice Dube | 2140 | 2027-01-30 | 2026-07-30 |
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Anxiety Disorders (2888) · Depressive Disorder, Major (1057) · Stress Disorders, Post-Traumatic (462) · Psychological Well-Being (453) · Depressive Disorder (418) · Bipolar Disorder (292) · Sleep Initiation and Maintenance Disorders (271) · Pain (257) · Mood Disorders (230) · Motor Activity (228) · Fatigue (223) · Mental Disorders (202) · Neoplasms (179) · Cognitive Dysfunction (173)
Behavioral Symptoms (8163) · Behavior (8159) · Mental Disorders (5067) · Pathological Conditions, Signs and Symptoms (1551) · Mood Disorders (1545) · Nervous System Diseases (1329) · Signs and Symptoms (1151) · Depressive Disorder (1087) · Neurologic Manifestations (792) · Pathologic Processes (575) · Central Nervous System Diseases (573) · Brain Diseases (529) · Trauma and Stressor Related Disorders (513) · Stress Disorders, Traumatic (478) · Personal Satisfaction (445)
Cognitive Behavioral Therapy (238) · Therapeutics (228) · Escitalopram (159) · Ketamine (126) · Sertraline (119) · Exercise (111) · Transcranial Magnetic Stimulation (109) · Fluoxetine (74) · Transcranial Direct Current Stimulation (66) · Duloxetine Hydrochloride (64) · Citalopram (61) · Venlafaxine Hydrochloride (58) · Methods (56) · Surveys and Questionnaires (53) · Paroxetine (51)
Massachusetts General Hospital (155) · University of Pittsburgh (102) · VA Office of Research and Development (98) · National Institute of Mental Health (NIMH) (96) · University of California, Los Angeles (80) · Stanford University (74) · University of Michigan (71) · New York State Psychiatric Institute (70) · University of Washington (68) · University of California, San Francisco (61) · Duke University (60) · University of Pennsylvania (60) · Northwestern University (59) · Yale University (57) · Weill Medical College of Cornell University (55)
United States (3609) · Canada (511) · Turkey (Türkiye) (323) · China (308) · United Kingdom (269) · Germany (259) · France (251) · Spain (218) · Sweden (173) · Taiwan (153) · Hong Kong (134) · Denmark (122) · Norway (105) · Netherlands (104) · Italy (96)
Maurizio Fava, MD (15) · Asle Hoffart, PhD (14) · Carlos A Zarate, M.D. (13) · Gerhard Andersson, PhD (13) · Heather Hadjistavropoulos, PhD (11) · Sverre Urnes Johnson, PhD (11) · Amit Anand, MD (10) · Peter J Schmidt, M.D. (9) · Areum Han, PhD (8)
PMID 33884617, PMID 34817851, PMID 40243391, PMID 34510411, PMID 2748771, PMID 16717171, PMID 25080392, PMID 31577867, PMID 34131914, PMID 39428602, PMID 11556941, PMID 17074942, PMID 24067192, PMID 24816198, PMID 26474010, PMID 26644957, PMID 30508090, PMID 31969269, PMID 32368793, PMID 32476658, PMID 32608505, PMID 33677832, PMID 34689733, PMID 36708956, PMID 37656180, PMID 41130742, PMID 42393474, PMID 16390886, PMID 21348556, PMID 23485955, PMID 23497790, PMID 24175720, PMID 24571916, PMID 24960439, PMID 25758058, PMID 26644956, PMID 26709542, PMID 29140227, PMID 29523415, PMID 31599736, PMID 32336984, PMID 32402261, PMID 32942346, PMID 33355633, PMID 33677183, PMID 33915374, PMID 34183490, PMID 34231203, PMID 34910821, PMID 36602886
2023 (19), 2025 (11), P50MH115838 (11), 2008 (10), 2016 (10), P50MH115837 (9), 2018 (8), P30MH085943 (7), 2009 (6), 2019 (6), P50MH113838 (6), 2015 (5), P30CA012197 (5), P50MH122351 (5), U10CA081851 (5)