79 completed, 8 unknown, 7 recruiting, 5 not yet recruiting. 108 Phase 1, 28 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 108 | Completed 79, Unknown 8, Recruiting 7, Not yet recruiting 5, Active not recruiting 3, Terminated 3, Withdrawn 3 |
| Phase 2 | 28 | Completed 21, Recruiting 4, Unknown 2, Withdrawn 1 |
Follow Chronic Pain: new trials by email Literature Review of Chronic Pain trials Research Report on Chronic Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care Coaching - Chronic Pain, Musculoskeletal Pain | Phase 1 | Not yet recruiting | VA Office of Research and Development | 30 | 2029-01-01 | 2026-03-06 |
| Noninvasive Neuromodulation Of The Subjective Value Network In Chronic Pain Transcranial magnetic stimulation, Sham - Chronic Neurogenic Pain | Phase 1 | Not yet recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 9 | 2026-12-01 | 2026-09-28 |
| A Study to Evaluate the Drug-Drug Interaction Between KL0011034 Injection and Alfentanil Hydrochloride Injection in Participants With Moderate-to-Severe Non-Cancer Chronic Pain KL0011034 injection, Alfentanil Hydrochloride Injection - Chronic Pain | Phase 1 | Not yet recruiting | The Third Xiangya Hospital of Central South University | 27 | 2026-07-30 | 2026-08-07 |
| A Study Evaluating the Drug-Drug Interaction Between KL0011034 Injection and Alfentanil Hydrochloride Injection KL0011034 injection, Alfentanil Hydrochloride Injection - Chronic Pain | Phase 1 | Completed | Hunan Kelun Pharmaceutical Co., Ltd. | 27 | 2026-07-15 | 2026-09-17 |
| Safety and Preliminary Efficacy of Endoscopic Submucosal Injection of Hyaluronic Acid Into the Bladder Wall in Patients With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) Hyaluronic Acid (HA) - Cystitis, Interstitial, Chronic Pain | Phase 1 | Not yet recruiting | Sverdlovsk Regional Clinical Hospital No.1 | 15 | 2026-07-01 | 2026-06-25 |
| Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSD Ketamine Infusion, Mindfulness-based cognitive therapy - Chronic Pain, Posttraumatic Stress Disorder (PTSD) | Phase 1 / Phase 2 | Recruiting | Dr. Yuliya Knyahnytska | 30 | 2026-03-31 | 2026-09-15 |
| Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling MagVenture X100 Pro transcranial magnetic stimulation system - Chronic Pain | Phase 1 | Recruiting | University of Minnesota | 30 | 2026-03-01 | 2026-03-27 |
| Safety, Tolerability, and Pharmacokinetics of Multiple-Dose RFUS-949 in Healthy Chinese Participants RFUS-949, Placebo - Acute and Chronic Pain | Phase 1 | Active not recruiting | The Affiliated Hospital of Qingdao University | 28 | 2026-01-22 | 2026-06-30 |
| Psilocybin With Intracranial Neural Sensing Psilocybin - Chronic Pain | Phase 1 | Withdrawn | Joshua Woolley, MD, PhD | 2025-06-01 | 2026-11-12 | |
| Cannabidiol in Sickle Cell Disease Cannabidiol, Placebo - Sickle Cell Disease | Phase 1 / Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 52 | 2025-04-03 | 2025-06-25 |
| Study of PIPE-791 for Subjects With Chronic Osteoarthritis Pain or Chronic Low Back Pain PIPE-791, Placebo - Chronic Osteoarthritis Pain, Chronic Low Back Pain | Phase 1 | Completed | Contineum Therapeutics | 43 | 2025-02-04 | 2026-03-18 |
| Integrative Breathwork Intervention for Chronic Pain Integrative Breathwork Intervention - Chronic Low-back Pain | Phase 1 / Phase 2 | Completed | University of Florida | 19 | 2024-10-24 | 2026-04-14 |
| PETMRI for Chronic Pain from Spinal or Peripheral Nerve Origin [18F]FTC-146 - Nerve Pain, Neuropathic Pain | Phase 1 | Not yet recruiting | Stanford University | 200 | 2024-10-01 | 2024-09-19 |
| (2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain Ketamine, (2R,6R)-hydroxynorketamine, Saline - Pain, Neuropathic | Phase 1 / Phase 2 | Recruiting | Rush University Medical Center | 25 | 2024-09-19 | 2026-08-03 |
| ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain Buprenorphine Patch, Placebo, Transcranial Magnetic Stimulation (TMS) - Opioid Withdrawal, Chronic Pain | Phase 1 / Phase 2 | Recruiting | Medical University of South Carolina | 240 | 2024-08-12 | 2026-11-05 |
| Combination of Equisetum Arvense and Palmitoylethanolamide (PEA) for the Management of Patients With Chronic Pain in a Before-after Study Supplement - Chronic Pain, Chronic Pain (Back / Neck) | Phase 1 / Phase 2 | Completed | noiVita Srls | 50 | 2024-07-29 | 2025-08-07 |
| Managing Chronic Tendon Pain by Metformin Metformin, Placebo - Tendinopathy, Chronic Pain | Phase 1 | Terminated | James Wang | 21 | 2024-05-24 | 2026-08-27 |
| A Study to Test the Effects of Kindolor at Different Doses in Healthy Adults Kindolor Tosylate, Placebo - Chronic Pain | Phase 1 | Terminated | Lohocla Research Corporation | 16 | 2024-04-21 | 2026-05-27 |
| Noninvasive Modulation of Chronic Neuropathic Pain Active stimulation using low-frequency ultrasonic transducer, Sham stimulation using low-frequency ultrasonic transducer - Neuropathic Pain, Chronic Pain | Phase 1 / Phase 2 | Withdrawn | University of Utah | 2024-02-10 | 2025-05-22 | |
| A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral ABP-745 Administration in Healthy Volunteers ABP-745, Placebo - Gout, Acute Gout Flare | Phase 1 | Completed | Atom Therapeutics Co., Ltd | 90 | 2024-01-23 | 2025-08-17 |
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Pain (21) · Neuralgia (14) · Opioid-Related Disorders (14) · Acute Pain (7) · Low Back Pain (6) · Nociceptive Pain (6) · Agnosia (4) · Fibromyalgia (4) · Osteoarthritis (4) · Pain, Postoperative (4) · Back Pain (2) · Drug Misuse (2) · Narcotic-Related Disorders (2) · Neuralgia, Postherpetic (2)
Neurologic Manifestations (108) · Pathological Conditions, Signs and Symptoms (108) · Signs and Symptoms (108) · Pain (87) · Nervous System Diseases (29) · Mental Disorders (20) · Neuromuscular Diseases (18) · Chemically-Induced Disorders (15) · Substance-Related Disorders (15) · Peripheral Nervous System Diseases (14) · Musculoskeletal Diseases (13) · Narcotic-Related Disorders (12) · Pathologic Processes (10) · Rheumatic Diseases (10) · Joint Diseases (7)
Oxycodone (5) · Cognitive Behavioral Therapy (4) · Ketamine (4) · 6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo(d)thiazol-2(3H)-one (3) · Buprenorphine (3) · Lidocaine (3) · Receptors, Oxytocin (3) · Tablets (3) · Transcranial Magnetic Stimulation (3) · AZD1386 (2) · Alfentanil (2) · Mindfulness-Based Cognitive Therapy (2) · Naltrexone (2) · Psilocybin (2) · Saline Solution (2)
Pfizer (9) · AstraZeneca (6) · Mundipharma (China) Pharmaceutical Co. Ltd (5) · Stanford University (4) · Yale University (4) · VA Office of Research and Development (3) · Assiut University (2) · Centrexion Therapeutics (2) · Grünenthal GmbH (2) · Johns Hopkins University (2) · Joshua Woolley, MD, PhD (2) · Kessler Foundation (2) · National Center for Complementary and Integrative Health (NCCIH) (2) · University of Florida (2) · University of Utah (2)
United States (57) · China (8) · Canada (6) · United Kingdom (6) · Australia (5) · Germany (4) · Belgium (3) · Egypt (2) · Sweden (2) · Brazil (1) · Denmark (1) · France (1) · Italy (1) · Japan (1) · Norway (1)
Declan T Barry, Ph.D. (2) · Jeanne M Zanca, PhD, MPT (2) · Rolf Karlsten (2) · Aleksandra Zgierska, MD PhD (1) · Alexander B Herman, MD, PhD (1) · Allan V Danielsen, MD (1) · Amol Soin, MD, MBA (1) · Anand Veeravagu (1) · Anand Veeravagu, MD (1) · Asokumar Buvanendran, MD (1) · Aynur Unalp-Arida, MD, PhD (1) · Biljana Lilja (1)
PMID 35295458, PMID 10870744, PMID 11165371, PMID 11786502, PMID 14621285, PMID 15647484, PMID 15800228, PMID 16508405, PMID 17123731, PMID 17237664, PMID 17433624, PMID 17635557, PMID 17853395, PMID 18294378, PMID 18362258, PMID 18378801, PMID 18419722, PMID 18619874, PMID 18774343, PMID 19409861, PMID 19789074, PMID 20031953, PMID 20086062, PMID 21029787, PMID 21148579, PMID 21249671, PMID 21412914, PMID 21765969, PMID 21812908, PMID 22336864, PMID 22494121, PMID 22717418, PMID 22898544, PMID 23403253, PMID 23936895, PMID 24604566, PMID 24661411, PMID 24867013, PMID 25221944, PMID 25418676, PMID 25872113, PMID 25957198, PMID 26011742, PMID 26029937, PMID 26449617, PMID 26968850, PMID 26987082, PMID 27407096, PMID 27574837, PMID 28074005
2017 (1), 2019 (1), I01CX002516 (1), IK2CX002286 (1), K01AT012066 (1), K23DA024050 (1), K23DA029609 (1), P01NS119159 (1), R01AR053732 (1), R01DA024695 (1), R01DA058620 (1), R01DK132709 (1), R03DA032517 (1), R21AR055716 (1), R21DA020831 (1)