328 completed, 87 unknown, 30 terminated, 27 withdrawn. 195 Not applicable, 122 Phase 2, 66 Phase 4, 54 Phase 1, 49 Phase 3.
Follow Oxytocin: new trials by email Literature Review of Oxytocin trials Research Report on Oxytocin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Intravenous Oxytocin to Speed Recovery After THA intravenous administration of oxytocin, Placebo - Total Hip Arthroplasty | Phase 2 | Enrolling by invitation | Wake Forest University Health Sciences | 80 | 2026-10-01 | 2026-09-24 |
| Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery Oxytocin (Low dose), Oxytocin (High dose), Placebo (saline) - Pain, Pituitary Surgery | Phase 2 | Not yet recruiting | Yale University | 75 | 2026-10-01 | 2026-10-21 |
| Oromucosal Oxytocin and Vasopressin Modulation of Emotional Face Attention Oxytocin (OT), Arginine Vasopressin (AVP), Placebo (PLC) - Healhty | Not applicable | Recruiting | University of Electronic Science and Technology of China | 120 | 2026-09-18 | 2026-09-24 |
| Effect of Intravenous Oxytocin on Post Dural Puncture Headache After Caesarean Sections oxytocin, Normal Saline - Post Dural Puncture Headache | Phase 4 | Not yet recruiting | Assiut University | 100 | 2026-09-01 | 2026-10-02 |
| Effect of Oxytocin Bolus Versus Slow Infusion on Haemodynamic Stability During Caesarean Section Under Spinal Anaesthesia Oxytocin - Cesarean Section, Hypotension | Not applicable | Not yet recruiting | Khyber Girls Medical College | 60 | 2026-09-01 | 2026-08-25 |
| Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial Carbetocin, Oxytocin, Placebo Saline Infusion - Postpartum Hemorrhage, Uterine Atony | Phase 4 | Recruiting | Mansoura University | 332 | 2026-08-08 | 2026-10-09 |
| Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia Placebo, Oxytocin Intranasal Spray 12 International Unit (12IU), Oxytocin Intranasal Spray 24 International Unit (24IU) - Stress | Phase 2 | Recruiting | University of Nebraska | 32 | 2026-06-20 | 2026-05-05 |
| Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage Carbetocin, Oxytocin - Postpartum Hemorrhage, Twin Pregnancy | Phase 4 | Recruiting | Sheba Medical Center | 120 | 2026-05-05 | 2026-05-08 |
| PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM) Sequential Induction: Dinoprostone Followed by Oxytocin, Immediate Oxytocin Induction - Premature Rupture of Fetal Membranes, Labor, Induced | Not applicable | Recruiting | National Hospital of Obstetrics and Gynecology | 450 | 2026-02-10 | 2026-02-20 |
| Oxytocin's Effects on Emotional Processing and Its Acting Routes placebo (compared to vasoconstrictor), vasoconstrictor (Otrivin), placebo (compared to oxytocin) - Healthy Adult Male | Not applicable | Recruiting | University of Electronic Science and Technology of China | 120 | 2026-01-24 | 2026-02-23 |
| Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain Intravenous oxytocin, Intravenous placebo, Intranasal oxytocin - Pain, Acute | Phase 2 | Completed | Wake Forest University Health Sciences | 24 | 2025-11-05 | 2026-06-30 |
| Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section Oxytocin - Postpartum Hemorrhage | Not applicable | Not yet recruiting | Assiut University | 282 | 2025-10-01 | 2025-09-23 |
| Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium Oxytocin, Carbetocin, Calcium - Postpartum Hemorrhage (Primary) | Not applicable | Recruiting | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | 40 | 2025-09-15 | 2025-09-24 |
| Oxytocin-Augmented Group Psychotherapy for Patients With Schizophrenia - an Oxytocin-dose Comparison Oxytocin, Placebo - Schizophrenia Spectrum Disorders (SSD) | Not applicable | Recruiting | Charite University, Berlin, Germany | 120 | 2025-09-08 | 2026-08-21 |
| Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM Oxytocin plus Foley Catheter, Oxytocin - Preterm PROM (Pregnancy) | Phase 4 | Recruiting | Eastern Virginia Medical School | 80 | 2025-07-14 | 2025-08-13 |
| Induction of Labor After Cesarean Using Foley Alone vs. Concurrent Foley and Oxytocin Foley balloon, Oxytocin - Labor Induction, Cesarean Delivery | Not applicable | Active not recruiting | University of Pennsylvania | 100 | 2025-07-10 | 2026-09-03 |
| Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Controls Oxytocin nasal spray, Placebo - Arginine Vasopressin Deficiency, Central Diabetes Insipidus | Phase 2 | Recruiting | University Hospital, Basel, Switzerland | 42 | 2025-07-01 | 2025-10-03 |
| The Effect of Oral Oxytocin and Atosiban on Social Attention Oxytocin lower dose (24IU), Oxytocin higher dose (48IU), Atosiban - Healhty | Early Phase 1 | Recruiting | University of Electronic Science and Technology of China | 250 | 2025-06-09 | 2025-07-30 |
| Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy Oxytocin, Placebo - Postoperative Pain | Phase 2 | Recruiting | Brigham and Women's Hospital | 152 | 2025-06-01 | 2026-08-13 |
| The Effect of Oxytocin on the Alpha Cell Response to Hypoglycaemia in Patients With Type 1 Diabetes Placebo, Oxytocin - Type 1 Diabetes | Not applicable | Completed | University Hospital, Gentofte, Copenhagen | 16 | 2025-03-25 | 2025-09-09 |
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Postpartum Hemorrhage (102) · Schizophrenia (24) · Autism Spectrum Disorder (18) · Hemorrhage (17) · Alcoholism (14) · Stress Disorders, Post-Traumatic (14) · Autistic Disorder (13) · Fetal Membranes, Premature Rupture (13) · Prader-Willi Syndrome (11) · Anxiety Disorders (10) · Obesity (10) · Diabetes Insipidus (9) · Substance-Related Disorders (9) · Blood Loss, Surgical (8) · Chronic Pain (8)
University of Electronic Science and Technology of China (29) · Samuel Lunenfeld Research Institute, Mount Sinai Hospital (25) · Wake Forest University Health Sciences (19) · Cairo University (18) · Assiut University (15) · Medical University of South Carolina (12) · University of California, San Francisco (12) · Massachusetts General Hospital (11) · University Hospital, Bonn (9) · University of North Carolina, Chapel Hill (8) · KU Leuven (7) · University Hospital, Toulouse (7) · University of Maryland, Baltimore (7) · Ain Shams Maternity Hospital (6) · Aswan University Hospital (6)
United States (173) · Egypt (55) · Canada (42) · China (34) · Israel (20) · Germany (18) · Turkey (Türkiye) (14) · France (12) · Belgium (9) · Sweden (9) · Norway (8) · India (7) · Denmark (5) · Australia (4) · Brazil (4)
Mrinalini Balki, MD (21) · James C Eisenach, MD (16) · Josh D Woolley, MD/PhD (6) · Keith Kendrick, PhD (6) · Kaat Alaerts, PhD (5) · Keith Kendrick, Dr. (5) · Beverly Winikoff, MD, MPH (4) · David Feifel, MD, PhD (3) · Eric Hahn, PD (3) · Evdokia Anagnostou, M.D. (3) · Jill Durocher (3) · Keith M Kendrick, PhD (3) · Rene Hurlemann, MSc MD PhD (3) · Aimee L McRae-Clark, PharmD (2) · Aimee McRae-Clark, Pharm.D. (2)
PMID 36996264, PMID 33169839, PMID 33232518, PMID 37811711, PMID 18515515, PMID 26879587, PMID 29215519, PMID 33232306, PMID 35141873, PMID 38767196, PMID 40121179, PMID 8598837, PMID 9704771, PMID 10472877, PMID 10811917, PMID 10863541, PMID 10960643, PMID 11146149, PMID 11194687, PMID 11284645, PMID 11303205, PMID 11336776, PMID 11687101, PMID 11704164, PMID 12013166, PMID 12648175, PMID 14749647, PMID 15121558, PMID 1554660, PMID 15802392, PMID 15931222, PMID 16125041, PMID 1623693, PMID 16305563, PMID 16398771, PMID 16437525, PMID 1656970, PMID 16753768, PMID 17138963, PMID 17567419, PMID 17961568, PMID 18333937, PMID 19370687, PMID 19384121, PMID 19587265, PMID 19858734, PMID 20012748, PMID 20060161, PMID 20060162, PMID 20129334
P01NS119159 (5), 2014 (4), 2016 (3), P50MH082999 (3), 2015 (2), 1IK2CX001495-01 (1), 2004 (1), 2019 (1), I01CX001761 (1), K12HD001258 (1), K12HD055885 (1), P20GM130414 (1), P50DA016511 (1), P50MH100023 (1), R01AA025942 (1)