4774 completed, 805 recruiting, 657 unknown, 347 terminated. 3467 Not applicable, 1461 Phase 2, 778 Phase 1, 536 Phase 3, 461 Phase 4.
Follow Substance-Related Disorders: new trials by email Literature Review of Substance-Related Disorders trials Research Report on Substance-Related Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis Cannabidiol (CBD), Placebo - Schizophrenia Spectrum Disorders, Cannabis Use | Phase 2 | Withdrawn | University of Maryland, Baltimore | 2050-01-01 | 2021-04-19 | |
| A Hybrid Type 1 Randomized Controlled Trial of an Online and Text-Messaging Intervention to Prevent Alcohol and Cannabis Initiation, Escalation, and Consequences Among First-Year College Students Online and Text Message Intervention - Alcohol, Cannabis | Not applicable | Not yet recruiting | The University of Texas at Arlington | 800 | 2028-09-01 | 2026-10-30 |
| RISE for PTSD and Substance Use Disorder in Veterans Written Exposure Therapy, Cognitive Behavioral Therapy for Substance Use Disorders (skill components), Cognitive Behavioral Therapy for Substance Use Disorders - Stress Disorders, Post-Traumatic, Substance-Related Disorders | Not applicable | Not yet recruiting | VA Office of Research and Development | 30 | 2028-08-01 | 2026-10-29 |
| The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veterans Acceptance and Commitment Therapy for Social Health, Achievement, and Relationship Effectiveness (ACT-SHARE) - Alcohol Problems, Post-Traumatic Stress Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 29 | 2028-07-03 | 2026-11-02 |
| Dynamic Treatment Regimes for Opioid Use Disorder Medication for opioid use disorder, psychotherapy - Opioid Use Disorder | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 75 | 2028-07-01 | 2025-11-04 |
| Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans Integrated care - Opioid Use Disorder, HIV | Not applicable | Not yet recruiting | VA Office of Research and Development | 60 | 2028-04-03 | 2026-04-24 |
| A Digital Pill System to Measure and Support Acamprosate Adherence in Individuals With Alcohol Associated Liver Disease AcamproSync - Alcohol Use Disorder, Alcohol Associated Liver Disease | Not applicable | Not yet recruiting | Yale University | 50 | 2027-10-01 | 2026-04-28 |
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Self-administered Neurostimulation Intervention for Firefighter Traumatic Stress to Reduce Alcohol Use: Pilot Study Transcutaneous auricular neurostimulation (tAN), Active Sham - Posttraumatic Stress Symptoms, Heavy Alcoholic Consumption | Not applicable | Not yet recruiting | University of Cincinnati | 20 | 2027-09-01 | 2026-10-09 |
| Family-Focused Study to Support Medication for Opioid Use Disorder FamilyCHESS, Standard of Care - Opioid Use Disorder, Opioid Use Disorder, Moderate | Not applicable | Not yet recruiting | University of Wisconsin, Madison | 338 | 2027-08-31 | 2026-07-07 |
| Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania IDEAS-AUD - Alcohol Use Disorder, Suicide Prevention | Not applicable | Not yet recruiting | Duke University | 30 | 2027-08-01 | 2026-03-17 |
| MedSMA℞T Mobile ED MedSMA℞T Mobile - Opiate-Related Disorders, Opiate Use Disorder | Not applicable | Not yet recruiting | Olufunmilola Abraham | 244 | 2027-08-01 | 2026-10-09 |
| Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder Ibogaine Hydrochloride, Extended-release naltrexone injection, 380 mg, Matching Oral Placebo - Opioid Use Disorder, Opioid Withdrawal | Phase 1 / Phase 2 | Not yet recruiting | Clive Michelsen | 60 | 2027-07-01 | 2026-10-13 |
| Permanent Supportive Housing Overdose Prevention+ Study TA Intervention - Overdose, Substance Use | Not applicable | Not yet recruiting | NYU Langone Health | 2940 | 2027-07-01 | 2026-05-06 |
| Efficacy and Safety of NTI164 in Children and Young Adults With Rett Syndrome NTI164, Placebo - RETT Syndrome With Proven MECP2 Mutation, Rett Syndrome | Phase 2 / Phase 3 | Not yet recruiting | Fenix Innovation Group | 40 | 2027-07-01 | 2026-09-09 |
| Development of a Mobile Health Intervention to Support Functioning of Veterans With Substance Use Disorders METS4Vets - Substance Use | Not applicable | Not yet recruiting | VA Office of Research and Development | 30 | 2027-06-01 | 2026-10-05 |
| Real-World Evaluation of Compl-AI for Predicting Early Medication Dropout in Opioid Use Disorder Treatment Opioid Use Disorder | Not yet recruiting | Tools4Patient | 295 | 2027-06-01 | 2026-10-01 | |
| A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults Large language model-based chatbot brief alcohol intervention session - Alcohol Use Disorder | Not applicable | Not yet recruiting | Massachusetts General Hospital | 20 | 2027-06-01 | 2025-10-22 |
| TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD) TMS Low-Dose, TMS High-Dose - Alcohol Use Disorder, Opioid Use Disorder | Not applicable | Recruiting | Washington State University | 60 | 2027-06-01 | 2026-05-29 |
| eTSF for Latinx Young Adults With Alcohol Use Disorder eTSF, Educational materials - Alcohol Use Disorder (AUD) | Not applicable | Not yet recruiting | University of Texas at Austin | 40 | 2027-05-01 | 2026-11-04 |
Showing 20 of 7454. Sign in to see all of them.
Alcoholism (1674) · Opioid-Related Disorders (1473) · Tobacco Use Disorder (1026) · Marijuana Abuse (562) · Cocaine-Related Disorders (416) · Smoking Cessation (341) · Behavior, Addictive (305) · Smoking (288) · Depression (275) · Alcohol Drinking (263) · Stress Disorders, Post-Traumatic (240) · Anxiety Disorders (225) · Chronic Pain (159) · Alcohol-Related Disorders (156)
Chemically-Induced Disorders (7418) · Mental Disorders (7060) · Behavior (2078) · Alcohol-Related Disorders (1972) · Narcotic-Related Disorders (1604) · Pathological Conditions, Signs and Symptoms (916) · Signs and Symptoms (550) · Health Behavior (491) · Pathologic Processes (440) · Neurologic Manifestations (408) · Urogenital Diseases (406) · Infections (398) · Communicable Diseases (358) · Behavioral Symptoms (353)
Ethanol (234) · Buprenorphine (191) · Therapeutics (173) · Naltrexone (162) · Tobacco Use Cessation Devices (137) · Varenicline (123) · Buprenorphine, Naloxone Drug Combination (122) · nabiximols (119) · Nicotine (115) · Cognitive Behavioral Therapy (114) · Dronabinol (101) · Motivational Interviewing (101) · Sugars (95) · Bupropion (77) · vivitrol (64)
Yale University (357) · National Institute on Drug Abuse (NIDA) (331) · Medical University of South Carolina (155) · Johns Hopkins University (144) · New York State Psychiatric Institute (142) · VA Office of Research and Development (140) · University of Pennsylvania (137) · University of California, Los Angeles (106) · University of California, San Francisco (92) · Centre for Addiction and Mental Health (79) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (79) · Brown University (73) · University of Washington (71) · Massachusetts General Hospital (67) · University of Wisconsin, Madison (67)
United States (5199) · Canada (277) · France (253) · Germany (136) · United Kingdom (119) · Spain (102) · China (97) · Sweden (88) · Denmark (75) · Norway (71) · Switzerland (55) · Australia (49) · Turkey (Türkiye) (49) · Belgium (46) · Netherlands (40)
Walter Ling, M.D. (35) · Warren Bickel, Ph.D. (22) · Dorothy Hatsukami, Ph.D. (19) · James Zacny, Ph.D. (17) · Elisabeth Kruse, PhD (16) · Elliot Stein, Ph.D. (14) · Mark Greenwald, PhD (13) · Thomas R Kosten, M.D. (12) · Lorenzo Leggio, M.D. (11) · Herbert Kleber, M.D. (10) · Kenneth Silverman, Ph.D. (10) · Eric C. Strain, MD (9) · Eugene Somoza, M.D., Ph.D. (9) · Frances R Levin, M.D. (9)
PMID 37142273, PMID 37230961, PMID 40342086, PMID 37335995, PMID 39868569, PMID 34611902, PMID 25630964, PMID 29912955, PMID 34231914, PMID 37795783, PMID 33348423, PMID 41085955, PMID 42560883, PMID 22700038, PMID 33605440, PMID 35287034, PMID 36063082, PMID 39101506, PMID 25911999, PMID 25938124, PMID 35420700, PMID 37393415, PMID 40833692, PMID 20707781, PMID 22339949, PMID 24896818, PMID 25227627, PMID 26582720, PMID 27342744, PMID 30865232, PMID 32086791, PMID 32280263, PMID 32608505, PMID 32628945, PMID 33079196, PMID 33788162, PMID 33884617, PMID 34242666, PMID 34255068, PMID 34295186, PMID 34532852, PMID 36208817, PMID 37011138, PMID 37023858, PMID 37657559, PMID 38236223, PMID 39240566, PMID 42423707, PMID 10776874, PMID 10964347
R01DA008391 (17), P50DA009236 (16), 2025 (14), P50DA009262 (13), P50DA009241 (12), P50DA018197 (12), 2023 (10), P50DA027840 (10), 2008 (8), 2014 (8), 2015 (8), 2009 (7), P50DA009250 (7), P50DA012756 (7), P60DA005186 (7)