97 completed, 19 unknown, 15 terminated, 9 recruiting. 156 Phase 3, 20 Phase 2.
Follow Chronic Pain: new trials by email Literature Review of Chronic Pain trials Research Report on Chronic Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| "Evaluation of the Efficacy of Intravenous Lidocaine on Chronic Post-operative Pain in Patients Requiring Emergency Abdominal Surgery. A Multicentre, Randomised, Controlled, Double-blind Study." Lidocain, Placebo - Chronic Pain | Phase 3 | Not yet recruiting | Nantes University Hospital | 266 | 2027-01-15 | 2026-10-09 |
| Clinical Trial to Evaluate the Efficacy and Safety of Platelet-rich Plasma Infiltration in Chronic Omalgia Platelet-rich Plasma Local injection, betamethasone and Ropivacaine - Chronic Pain | Phase 3 | Recruiting | Biobizkaia Health Research Institute | 86 | 2026-02-24 | 2026-03-04 |
| The Beat Pain Better Trial Text Messaging, Motivational Messaging, Physical Activity Counseling and Self-Directed Walk with Ease - Osteoarthritis, Chronic Pain Management | Phase 3 | Recruiting | University of Utah | 346 | 2025-05-28 | 2026-01-29 |
| Clinical Analgesic Management in Dementia Tylex - Alzheimer Disease | Phase 3 | Recruiting | Xuanwu Hospital, Beijing | 10 | 2025-03-01 | 2026-01-07 |
| Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits Mindfulness Oriented Recovery Enhancement, Patient-Centered Chronic Pain Management Visits - Chronic Pain, Prescription Opioid Misuse | Phase 3 | Recruiting | University of Utah | 300 | 2025-02-25 | 2026-02-03 |
| CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial Tizanidine, MI-Opioid Taper, Placebo - Chronic Pain, Back Pain | Phase 3 | Recruiting | Stanford University | 375 | 2024-12-05 | 2026-05-06 |
| Tele-Collaborative Outreach to Rural Patients With Chronic Pain CORPs Intervention, Minimally Enhanced Usual Care (MEUC) - Chronic Pain | Phase 3 | Active not recruiting | Oregon Health and Science University | 608 | 2024-07-11 | 2026-05-28 |
| Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty Vitamin C, Placebo - Chronic Pain, Knee Pain Chronic | Phase 3 | Recruiting | University Health Network, Toronto | 3216 | 2024-04-16 | 2026-11-13 |
| Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain Celecoxib+Pregabalin+Vitamin B fixed dose, Celecoxib + Vitamin B fixed dose, Pregabalin + Vitamin B fixed dose - Chronic Low-back Pain | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 192 | 2024-04-11 | 2025-04-04 |
| Analgesic Effectiveness of Capsaicin 8% Cutaneous Patch in Children Capsaicin 8% patch, Hydrocolloid dressing - Neuropathic Pain, Chronic Pain | Phase 3 | Recruiting | University Hospital, Brest | 46 | 2024-03-05 | 2026-06-15 |
| Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Diabetic Polyneuropathy Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Diabetic Polyneuropathy Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis Adezunap, Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Mobile & Online-Based Interventions to Lessen Pain Empowered Relief On-Demand, Health Education - Chronic Pain, Opioid Misuse | Phase 3 | Completed | Stanford University | 234 | 2023-08-23 | 2025-12-18 |
| Divided or Single Exposure (DOSE) Study Methadone (100% dose), Methadone (50% dose) - Opioid Use Disorder, Chronic Pain | Phase 2 / Phase 3 | Recruiting | University of Maryland, Baltimore | 150 | 2023-02-21 | 2026-02-03 |
Showing 20 of 156. Sign in to see all of them.
Pain (41) · Low Back Pain (26) · Osteoarthritis (18) · Back Pain (13) · Neuralgia (12) · Agnosia (11) · Pain, Postoperative (11) · Marijuana Abuse (9) · Fibromyalgia (8) · Somatoform Disorders (8) · Neoplasms (7) · Opioid-Related Disorders (6) · Acute Pain (5) · Osteoarthritis, Knee (5)
Pathological Conditions, Signs and Symptoms (156) · Signs and Symptoms (156) · Neurologic Manifestations (154) · Pain (115) · Musculoskeletal Diseases (37) · Nervous System Diseases (37) · Rheumatic Diseases (33) · Joint Diseases (27) · Neuromuscular Diseases (27) · Arthritis (25) · Mental Disorders (20) · Back Pain (19) · Pathologic Processes (18) · Postoperative Complications (15) · Chemically-Induced Disorders (14)
Fentanyl (9) · Buprenorphine (8) · Tapentadol (8) · Ketamine (7) · Oxycodone (6) · Morphine (5) · Pregabalin (5) · Ropivacaine (5) · Sodium Chloride (5) · Tramadol (5) · Celecoxib (4) · Gabapentin (3) · Saline Solution (3) · tanezumab (3) · 6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenylspiro(cyclohexane-1,1'(3'H)-pyrano(3,4-b)indol)-4-amine (2)
Purdue Pharma LP (11) · Apurano Pharmaceuticals GmbH (8) · Endo USA Inc., a Keenova Therapeutics Company (7) · Grünenthal GmbH (7) · Pfizer (6) · Bausch Health Americas, Inc. (5) · Janssen Pharmaceutical K.K. (5) · BioDelivery Sciences International (4) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (4) · Cephalon (3) · Mallinckrodt (3) · University Health Network, Toronto (3) · University of Utah (3) · University of Washington (3) · Assiut University (2)
United States (72) · Germany (17) · Canada (15) · France (13) · Denmark (9) · Spain (9) · United Kingdom (9) · Japan (8) · Poland (8) · Belgium (5) · Bulgaria (5) · Hungary (5) · Austria (4) · Brazil (4) · Italy (4)
Richard Rauck, MD (4) · Andrew Finn, PharmD (2) · Dennis C. Turk, PhD (2) · James B. Jones, MD, PharmD (2) · James Khan, MD (2) · Adelfia Urenda-Quezada (1) · Alejandro Gugliucci, MD, PhD (1)
PMID 39428602, PMID 20521870, PMID 22437221, PMID 23340531, PMID 23709304, PMID 24353047, PMID 24916058, PMID 24985410, PMID 26695349, PMID 11020770, PMID 11591092, PMID 15556826, PMID 15943960, PMID 16284992, PMID 16698416, PMID 17257473, PMID 17327338, PMID 19507806, PMID 19903919, PMID 20429852, PMID 21075272, PMID 21083513, PMID 21904098, PMID 21945130, PMID 21957829, PMID 22108765, PMID 22231424, PMID 22336956, PMID 22443293, PMID 22792000, PMID 23318127, PMID 23340346, PMID 23340351, PMID 23475406, PMID 23686969, PMID 23855816, PMID 23875181, PMID 25350473, PMID 25495134, PMID 25993547, PMID 26262828, PMID 26359327, PMID 27199314, PMID 27209166, PMID 27713336, PMID 28025837, PMID 28416501, PMID 28600725, PMID 28860855, PMID 29041942
2009 (6), 2014 (2), 1UG3AT012257-01 (1), 2017 (1), 2019 (1), 4UH3AT012257-02 (1), K23NS050485 (1), K24DA053564 (1), R01AR044724 (1), R01AR047298 (1), R01AR050028 (1), R01CA271220 (1), R01DA056045 (1), U48DP006833 (1)