1269 completed, 140 recruiting, 98 terminated, 57 withdrawn. 991 Not applicable, 155 Phase 2, 124 Phase 1, 83 Phase 4, 40 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| UNC Cashew Sublingual Immunotherapy Cashew sublingual immunotherapy, Placebo sublingual immunotherapy - Cashew Nut Allergy, Tree Nut Allergies | Phase 2 | Not yet recruiting | University of North Carolina, Chapel Hill | 45 | 2027-03-01 | 2026-10-20 |
| Preventing Childhood Asthma Using Prophylactic House Dust Mite Allergen Immunotherapy HDM sublingual Immunotherapy, Placebo - Asthma, Allergy | Phase 2 | Withdrawn | Boston Children's Hospital | 2027-02-01 | 2024-11-26 | |
| Insecticide-Treated Baby Wraps for the Prevention of Malaria Permethrin-treated lesu, Etofenprox-treated lesu, Untreated lesu - Malaria (Plasmodium Falciparum), Malaria Incidence | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 1296 | 2027-01-01 | 2026-08-19 |
| Obesity and Oral Diseases in Adult Patients Lifestyle course., Bariatric surgery. - Obesity, Oral Diseases | Not yet recruiting | University of Bergen | 400 | 2026-11-01 | 2026-05-08 | |
| Anakinra Rescue Treatment for Moderate Asthma Attacks (ARTMA) Anakinra 100 Mg/0.67 Ml Inj Syringe, Saline Placebo/0.67 Ml Inj Syringe - Asthma (Diagnosis), Persistent Asthma | Phase 1 | Not yet recruiting | University of North Carolina, Chapel Hill | 60 | 2026-11-01 | 2026-07-15 |
| Pilot HIV Self-Testing And Self-collected STI Testing Strategy for Sex Worker Empowerment Study Venue-based, peer-enhanced strategy for integrated HIV self-testing (and self-collected STI testing - HIV, Syphilis | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 232 | 2026-10-01 | 2026-09-18 |
| SCIPI Implementation and Evaluation: A Multi-site Proof-of-Concept Pilot Trial SCIPI - Prostate Cancer | Not applicable | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 200 | 2026-10-01 | 2025-12-19 |
| Teen Vulnerability to Irritability: Brain and Estrogen Changes Kurvelo, Placebo COC - Depression - Major Depressive Disorder, Irritability | Phase 4 | Not yet recruiting | University of North Carolina, Chapel Hill | 50 | 2026-10-01 | 2026-08-24 |
| E.N.D.E.A.V.O.R.: An Exemestane Needed Dose Efficacy and Verification as an Ovulation Induction Regimen Study Exemestane 25 MG, Placebo, Exemestane 50 MG - Poly Cystic Ovary Syndrome | Phase 1 | Recruiting | University of North Carolina, Chapel Hill | 40 | 2026-10-01 | 2026-09-23 |
| Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities Care coordination, Electronic massage, support gift #1 - Preterm Birth Complication, Preterm Birth | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 1228 | 2026-10-01 | 2026-09-29 |
| Study to Evaluate the Effects of Oral Glyceryl Guiacolate (Guaifenesin, GGE) on Sputum Rheology in Subjects With Mucus Hypersecretion Glycerol Guiacolate, SOC (Standard of care) - Bronchitis, Bronchitis, Chronic | Phase 4 | Not yet recruiting | University of North Carolina, Chapel Hill | 40 | 2026-10-01 | 2026-10-14 |
| A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis Upadacitinib 30mg Dose, Upadacitinib Matching Placebo - EoE, Eosinophilic Esophagitis | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 52 | 2026-09-30 | 2026-10-06 |
| Mechanistic Evaluation of Atrasentan in Patients With IgA Nephropathy (IgAN) atrasentan - IgA Nephropathy (IgAN), Immunoglobulin A Nephropathy (IgAN) | Phase 4 | Not yet recruiting | University of Illinois at Chicago | 20 | 2026-09-29 | 2026-09-21 |
| Post-traumatic Estradiol Administration and Care Evaluation (PEACE) 17β-estradiol, Placebo - Chronic Musculoskeletal Pain, Sexual Assault | Phase 2 | Not yet recruiting | University of North Carolina, Chapel Hill | 30 | 2026-09-28 | 2026-10-09 |
| Focal Mass Drug Administration for the Prevention of Malaria in Pregnancy Dihydroartemisinin Piperaquine - Malaria Prevention | Early Phase 1 | Recruiting | University of North Carolina, Chapel Hill | 300 | 2026-09-27 | 2026-08-17 |
| Marine Lipids Ease Painful TMD SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement - Temporomandibular Disorder (TMD) | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 100 | 2026-09-25 | 2026-08-31 |
| Light Bulb Stimuli to Reduce Chronic Pain S-Cone Stimulating Chromatic Light, Equal-Energy White Light - Fibromyalgia, Musculoskeletal Pain | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 40 | 2026-09-21 | 2026-09-17 |
| Creatine for Recovery and Thinking in Mothers Creatine Monohdyrate - Post-partum, Women | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 40 | 2026-09-08 | 2026-08-31 |
| Reducing Stigma and Building Employability Skills for Young People With HIV in Zambia Stigma Reduction Support Group (SRSG), Financial Literacy, Technical and Vocational Education and Training (TVET) - HIV, Mental Health | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 100 | 2026-09-03 | 2026-08-12 |
| ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their Caregivers ICU-SUCCEED, Augmented Usual Care - Acute Respiratory Failure, Critical Illness | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 144 | 2026-09-01 | 2026-08-21 |
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HIV Infections (85) · Obesity (85) · Depression (60) · Acquired Immunodeficiency Syndrome (57) · Motor Activity (42) · Overweight (37) · Asthma (30) · Cardiovascular Diseases (30) · Psychotic Disorders (28) · Schizophrenia (26) · Cystic Fibrosis (25) · Diabetes Mellitus (25) · Weight Loss (24) · Anxiety Disorders (23) · Substance-Related Disorders (23)
Sugars (25) · Standard of Care (22) · Exercise (14) · Therapeutics (14) · Tenofovir (13) · Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (12) · Saline Solution (11) · Cognitive Behavioral Therapy (10) · Progesterone (10) · Estradiol (9) · Ethanol (9) · Methods (9) · Sodium Chloride (9) · Bupivacaine (8) · Educational Status (8)
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Flavio Frohlich, PhD (22) · Michelle Hernandez, MD (18) · Abbie Smith-Ryan, PhD (16) · Angela DM Kashuba, PharmD (12) · Linmarie Sikich, MD (11) · Wesley Burks, MD (11) · Terry Noah, MD (9) · Evan S Dellon, MD, MPH (8) · Nicholas Shaheen, MD, MPH (8) · David B Peden, MD, MS (7) · Jonathan Ellen, MD (7) · Kelli D Allen, PhD (7) · Noel T Brewer, PhD (7) · Cynthia Bulik, PhD (6) · Deborah F Tate, PhD (6)
PMID 40354181, PMID 29523147, PMID 15778652, PMID 15844722, PMID 17079539, PMID 17292958, PMID 17299117, PMID 17401691, PMID 17673281, PMID 22420675, PMID 2318652, PMID 23477994, PMID 24476355, PMID 24568613, PMID 25410132, PMID 25470436, PMID 25693422, PMID 26053349, PMID 26652312, PMID 27454250, PMID 28953905, PMID 30111326, PMID 30260797, PMID 30354190, PMID 30554396, PMID 30714689, PMID 31179503, PMID 33622517, PMID 33900099, PMID 3397865, PMID 34929010, PMID 35085056, PMID 35700276, PMID 36383760, PMID 36656594, PMID 36907457, PMID 37148652, PMID 37929831, PMID 38072392, PMID 38815760, PMID 39213738, PMID 39996757, PMID 41232107, PMID 41873211, PMID 42370263, PMID 7998630, PMID 8712272, PMID 11213143, PMID 11346045, PMID 11442730
R01HL135235 (6), P30AI050410 (5), R01MH101547 (5), U19HD089881 (5), U54HL096458 (5), K01HL147713 (4), R01AI114310 (4), UL1TR001111 (4), P01AT002620 (3), P01DK058335 (3), P01HD112215 (3), P30DK056350 (3), P50HL084934 (3), P50HL105184 (3), R01AI122319 (3)