40 completed, 14 unknown, 10 recruiting, 4 not yet recruiting. 26 Not applicable, 21 Phase 4, 7 Phase 2, 6 Phase 3, 3 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Propofol-Ketamine Versus Sevoflurane for Laryngeal Mask Anesthesia in Pediatric Cardiac Catheterization Ketamine-Propofol, Sevoflurane - Propofol, Ketamine | Phase 4 | Recruiting | Rawalpindi Institute of Cardiology | 68 | 2026-10-24 | 2026-10-30 |
| Outcomes Registry After Ketamine Infusions for Chronic Pain: A Longitudinal Evaluation Ketamine (Ketalar) - Chronic Pain, Ketamine | Not yet recruiting | Stanford University | 800 | 2026-10-01 | 2026-09-15 | |
| Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial Esketamine combined with dexmedetomidine, Dexmedetomidine - Dexmedetomidine, Ketamine | Phase 4 | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 356 | 2026-09-28 | 2026-09-03 |
| Biomarker-Guided Antidepressant Selection TMS, Ketamine - Depression - Major Depressive Disorder, Treatment-resistant Depression (TRD) | Phase 4 | Recruiting | Weill Medical College of Cornell University | 27 | 2026-08-10 | 2026-09-23 |
| Two Intravenous Doses of Ketamine in Reducing the Oculocardiac Reflex in Adult Patients Undergoing Ophthalmic Surgery 0.5 mg/kg intravenous ketamine, 0.75 mg/kg intravenous ketamine - Ketamine, Oculocardiac Reflex | Not applicable | Recruiting | Cairo University | 40 | 2026-07-01 | 2026-07-16 |
| Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE) Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU) - Suicide Prevention, Ketamine | Phase 4 | Recruiting | University of Sao Paulo | 478 | 2026-06-01 | 2026-09-16 |
| Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients induction type for intubation in ICU - Critically Ill, Intubation Complication | Completed | Zeliha Alicikus | 806 | 2026-04-18 | 2026-10-08 | |
| Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery Ketamine group, Control Group - Cardiac Anaesthesia, Chronic Pain | Not applicable | Not yet recruiting | Bursa City Hospital | 100 | 2026-04-15 | 2026-03-24 |
| Role of Opioid Free Anaesthesia in Elderly Patients Undergoing Elective Coronary Artery Bypass Graft Surgeries With Cardiopulmonary Bypass in Enhanced Recovery After Surgeries Opioid free anesthesia, Opioid based Anesthesia - CABG, Dexmedetomidine | Not applicable | Not yet recruiting | Ain Shams University | 60 | 2026-01-01 | 2026-01-22 |
| Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass Fentanyl (IV), lidocaine - Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction | Not applicable | Completed | Cairo University | 48 | 2025-12-01 | 2026-08-07 |
| Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil - Magnesium Sulfate, Remifentanil | Not applicable | Recruiting | University General Hospital of Patras | 150 | 2025-09-11 | 2025-09-18 |
| Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain Ketamine, 29 ml bupivacaine 0.25% + 1 ml saline - Ketamine, Adjuvant | Not applicable | Completed | Tanta University | 50 | 2025-08-23 | 2026-02-27 |
| Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty Ketamine, Standard Analgesia - Knee Arthroplasty, Postoperative Pain | Not applicable | Completed | State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia | 100 | 2025-07-01 | 2026-03-02 |
| Erector Spinae Block Vs Ketamine-based Multimodal Analgesia Protocol in Lumber Decompressive Surgery ketamine, Erector Spinae Plane Block, Wound infiltration - Spinal Decompression, Analgesia | Not applicable | Completed | Kasr El Aini Hospital | 62 | 2025-06-20 | 2026-03-24 |
| Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty Ketamine and Magnesium Sulfate, Saline 0.9% - Intraoperative, Ketamine | Not applicable | Recruiting | Ain Shams University | 50 | 2025-05-12 | 2025-05-13 |
| Intraoperative Ketamine Versus Lidocaine Infusion on Postoperative Cognitive Dysfunction in Patients Undergoing Hip Surgery Group Ketamine, Group Lidocaine, Group Placebo - Ketamine, Cognitive | Not applicable | Completed | Tanta University | 120 | 2025-03-30 | 2026-09-24 |
| Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression (2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg), Placebo - Suicide, Depressive Disorder, Treatment-Resistant | Phase 2 | Recruiting | National Institute of Mental Health (NIMH) | 50 | 2024-11-06 | 2026-10-05 |
| Nebulized Ketamine for the Treatment of Major Depressive Disorder nebulized ketamine, nebulized midazolam - Severe Depression, Moderate Depression | Phase 3 | Recruiting | Theresa Jacob, PhD, MPH | 40 | 2024-10-16 | 2026-04-24 |
| Natural History of Depression, Bipolar Disorder and Suicide Risk Behavioral Symptoms, Suicide | Recruiting | National Institute of Mental Health (NIMH) | 500 | 2024-09-09 | 2026-10-01 | |
| Postoperative Opioid Consumption in Gastric Sleeve Surgery Obesity &Amp; Overweight, General Anesthetic | Completed | Balikesir University | 96 | 2024-06-03 | 2026-04-14 |
Showing 20 of 73. Sign in to see all of them.
Agnosia (15) · Pain, Postoperative (11) · Chronic Pain (10) · Acute Pain (8) · Depression (7) · Depressive Disorder, Treatment-Resistant (7) · Depression, Postpartum (5) · Depressive Disorder, Major (5) · Neuralgia (5) · Nociceptive Pain (4) · Depressive Disorder (3) · Pain (3) · Behavioral Symptoms (2) · Bipolar Disorder (2) · Emergencies (2)
Pathological Conditions, Signs and Symptoms (31) · Signs and Symptoms (26) · Neurologic Manifestations (23) · Nervous System Diseases (20) · Neurobehavioral Manifestations (15) · Pathologic Processes (15) · Perceptual Disorders (15) · Pain (13) · Behavior (12) · Mental Disorders (12) · Mood Disorders (11) · Postoperative Complications (11) · Depressive Disorder (9) · Behavioral Symptoms (8) · Female Urogenital Diseases and Pregnancy Complications (7)
Ketamine (41) · Fentanyl (10) · Sodium Chloride (7) · Dexmedetomidine (6) · Saline Solution (6) · Esketamine (5) · Midazolam (5) · Control Groups (4) · Magnesium Sulfate (4) · Propofol (4) · Remifentanil (4) · Sevoflurane (4) · Lidocaine (3) · Acetaminophen (2) · Bupivacaine (2)
Aretaieion University Hospital (6) · Tanta University (5) · Cairo University (4) · Peking University First Hospital (4) · University of Saskatchewan (4) · Ain Shams University (2) · National Institute of Mental Health (NIMH) (2) · The First Affiliated Hospital with Nanjing Medical University (2) · Theresa Jacob, PhD, MPH (2) · University of Padova (2) · Abigail Nixon (1) · Assistance Publique - Hôpitaux de Paris (1) · Balikesir University (1) · Bo Hu (1) · Brooke Army Medical Center (1)
United States (17) · Egypt (13) · Greece (8) · China (7) · Turkey (Türkiye) (6) · Canada (5) · Italy (2) · Malaysia (2) · Austria (1) · Brazil (1) · Chile (1) · France (1) · Mexico (1) · Pakistan (1) · Poland (1)
Dong-Xin Wang, MD, PhD (3) · Kassiani Theodoraki (3) · Jonathan Gamble, MD (2) · Kassiani Theodoraki, PhD, DESA (2) · Theresa Jacob, PhD, MPH (2) · Amit Anand, MD (1) · Andrew W Gorlin, M.D. (1) · Boris Teplykh, MD (1) · Britany L Raymond, MD (1) · Carlos A Zarate, M.D. (1) · Chian Yong Liu, MMed (Anaes) (1) · Chien-Kun Ting, MD, PhD (1) · Conor Liston, MD, PhD (1) · David Barbic, MD MSc FRCPC, (1)
PMID 11027905, PMID 11576800, PMID 1349061, PMID 17355955, PMID 22965960, PMID 28657160, PMID 29045739, PMID 29850262, PMID 30477544, PMID 30572160, PMID 34046159, PMID 34398056, PMID 36570810, PMID 36993617, PMID 37224232, PMID 37391729, PMID 38752431, PMID 38808490, PMID 38956664, PMID 39154316, PMID 39428602, PMID 39485729, PMID 39546215, PMID 40739637, PMID 40879542, PMID 40900112, PMID 40903379, PMID 41299290, PMID 42159864, PMID 42372120, PMID 42548425, PMID 8577492
2014 (1), 2019 (1), UG3MH137656 (1)