292 completed, 87 unknown, 33 terminated, 17 recruiting. 198 Not applicable, 167 Phase 4, 27 Phase 3, 26 Phase 2, 11 Phase 1.
Follow this drug Literature Review of Remifentanil trials Research Report on Remifentanil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| REmifentanil And Dexmedetomidine for EarlY Intensive Blood Pressure Lowering in ICH. Remifentanil and Dexmedetomidine, Guideline standard care - Intracerebral Hemorrhage | Not applicable | Not yet recruiting | The Third Affiliated Hospital of Southern Medical University | 1116 | 2026-12-01 | 2026-10-07 |
| Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After Thyroidectomy remifentanil, Lidocaine %2 ampoule - Tracheal Extubation, Cough | Phase 4 | Recruiting | Pamukkale University | 60 | 2026-10-01 | 2026-10-08 |
| Demedetomidine and Remifentanil in Electroconvulsive Therapy (ECT) Saline (0.9% NaCl), Dexmedetomidine, Remifentanil - Hemodynamic Response | Phase 4 | Recruiting | Inonu University | 24 | 2026-09-21 | 2026-09-29 |
| Remifentanil vs Fentanyl in Children 7-12 After Urologic Surgery: Emergence Delirium and Recovery Quality Opioids - Emergence Delirium, Emergence Agitation | Phase 4 | Not yet recruiting | Konya City Hospital | 88 | 2026-09-05 | 2026-10-06 |
| REMIfentanil (2 vs. 4 mcg/kg) Facilitated Intubation Without Neuromuscular Blockade Versus Succinylcholine and Rocuronium With Sugammadex for Endotracheal Intubation in Spine Surgery Requiring Motor Evoked Potential Monitoring Low-Dose Remifentanil, High-Dose Remifentanil, Succinylcholine - Airway Management, Endotracheal Intubation | Phase 4 | Not yet recruiting | Mayo Clinic | 316 | 2026-09-01 | 2026-09-22 |
| Afentanil and Remifentanil for Anesthesia Quality and Recovery alfentanil, Remifentanil - Anesthesia Recovery Period ； Postoperative Pain； Hemodynamic Stability During Surgery | Phase 4 | Not yet recruiting | Qianfoshan Hospital | 990 | 2026-09-01 | 2026-08-12 |
| Opioid-Free Anesthesia in FESS: A Prospective ERAS Study Dexmedetomidine, Remifentanil - Chronic Sinusitis, Postoperative Pain | Recruiting | Filiz Kaya | 104 | 2026-08-15 | 2026-09-10 | |
| Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants. Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine - Knee Osteoarthritis, Replacement, Knee | Not applicable | Not yet recruiting | China-Japan Friendship Hospital | 100 | 2026-08-01 | 2026-07-30 |
| Subcostal TAP Block and EEG Dynamics in Laparoscopic Cholecystectomy Remifentanil, Ultrasound-Guided Subcostal Transversus Abdominis Plane Block - Laparoscopic Cholecystectomy, Postoperative Pain | Recruiting | Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital | 60 | 2026-07-15 | 2026-09-14 | |
| The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline Anesthesia Midazolam, Dexmedetomidine, Esketamine - Depth of Anesthesia Monitoring, BIS-EEG | Not applicable | Not yet recruiting | China-Japan Friendship Hospital | 120 | 2026-06-30 | 2026-07-13 |
| Remifentanil Monotherapy vs. Remifentanil-Nicardipine for Controlled Hypotension in Otolaryngological Surgery Remifentanil / Nicardipine, Remifentanil - Otolaryngological Surgery, Anesthesia | Not applicable | Not yet recruiting | Dicle University | 60 | 2026-06-30 | 2026-06-22 |
| Remifentanil vs. Nicardipine for Controlled Hypotension in Elective Nasal Surgery Nicardipine, Remifentanil - Nasal Surgery, Anesthesia | Not applicable | Not yet recruiting | Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital | 44 | 2026-06-25 | 2026-06-22 |
| Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization Remifentanil, Esmolol - Cerebral Aneurysm Unruptured, Intracranial Pressure | Not applicable | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 84 | 2026-06-22 | 2026-06-22 |
| Opioid-Free Versus Opioid-Based Sedation for Endoscopic Procedures Dexmedetomidine, Remifentanil - Sedation, Endoscopy | Not applicable | Not yet recruiting | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 80 | 2026-06-01 | 2026-06-16 |
| Respiratory and Haemodynamic Effects of Conscious Sedation With Dexmedetomidine for a TAVI Procedure Sedation with dexmedetomidine, sedation propofol and remifentanil - TAVI(Transcatheter Aortic Valve Implantation) | Not applicable | Recruiting | Erasme University Hospital | 80 | 2026-04-22 | 2026-04-30 |
| Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio Light anesthesia, Deep anesthesia - Elderly, Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 200 | 2026-04-01 | 2026-03-18 |
| A Trial of Tegileridine Fumarate Lnjection for Prolonged Mechanical Ventilation Abirritation in the Intensive Care Unit (ICU) Tegileridine Fumarate lnjection, Remifentanil Hydrochloride for Injection - Abirritation in the ICU | Phase 2 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 121 | 2026-02-24 | 2026-08-28 |
| Osellidine is Used for Analgesia During Daytime Hysteroscopic Surgery Oxelidine, Sufentanil or Remifentanil - Gynecological Day Surgery | Not yet recruiting | Tongji Hospital | 310 | 2026-02-10 | 2026-02-23 | |
| Propofol vs Remifentanil for Sedation in Gastroscopy Propofol (Astra-Zeneca), Remifentanil - Conscious Sedation, Procedural Sedation | Not applicable | Completed | Fatih Sultan Mehmet Training and Research Hospital | 80 | 2026-02-02 | 2026-04-21 |
| Sedation Methods in Percutaneous Transhepatic Biliary Drainage: Procedure Quality and Recovery Remifentanil, Ketamine - Fragility, Biliary Obstruction | Not applicable | Recruiting | Ankara City Hospital Bilkent | 98 | 2026-02-01 | 2026-06-10 |
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Pain (48) · Pain, Postoperative (32) · Agnosia (28) · Hyperalgesia (16) · Postoperative Nausea and Vomiting (10) · Cough (9) · Chronic Pain (7) · Emergence Delirium (7) · Respiratory Insufficiency (7) · Acute Pain (6) · Obesity (6) · Brain Neoplasms (5) · Nociceptive Pain (5) · Postoperative Complications (5) · Delirium (4)
Yonsei University (15) · Seoul National University Hospital (12) · Ajou University School of Medicine (11) · Hopital Foch (6) · Changhai Hospital (5) · GlaxoSmithKline (5) · Medical University of Vienna (5) · Severance Hospital (5) · University Medical Center Groningen (5) · Region Örebro County (4) · Ankara City Hospital Bilkent (3) · Beth Israel Deaconess Medical Center (3) · Capital Medical University (3) · Centre hospitalier de l'Université de Montréal (CHUM) (3) · Chosun University Hospital (3)
South Korea (72) · China (58) · Turkey (Türkiye) (48) · United States (37) · France (31) · Canada (16) · Italy (13) · Greece (11) · Norway (11) · Germany (10) · Netherlands (9) · Spain (8) · Sweden (8) · Switzerland (8) · Austria (7)
Marc Fischler, MD (6) · Burkhard Gustorff, MD (3) · Jong Yeop Kim (3) · Jong Yeop Kim, MD (3) · Ki Tae Jung, M.D. (3) · Andrew J Davidson, MD (2) · Chang-Hoon Koo (2) · Dong Woo Han, MD,PhD (2) · Guolin Wang, MD (2) · Jason Hayes, MD (2) · Jian-Xin Zhou, MD (2) · Kassiani Theodoraki (2) · Maxim Mazanikov, MD (2)
PMID 21786531, PMID 22185726, PMID 23193905, PMID 24282774, PMID 26030032, PMID 35857365, PMID 15711683, PMID 15785115, PMID 17376252, PMID 17959973, PMID 21040558, PMID 21233500, PMID 23843351, PMID 24052249, PMID 26934941, PMID 27275059, PMID 31027480, PMID 8214320, PMID 10525595, PMID 10910490, PMID 10927999, PMID 11159231, PMID 11573581, PMID 11698314, PMID 11867379, PMID 12623040, PMID 14595310, PMID 14633533, PMID 15312228, PMID 15377583, PMID 15681957, PMID 15690283, PMID 15721724, PMID 15905753, PMID 15983467, PMID 16037145, PMID 16517337, PMID 16526829, PMID 1683182, PMID 17056949, PMID 17668184, PMID 17959952, PMID 17991265, PMID 18038077, PMID 18289455, PMID 18495056, PMID 18786243, PMID 18813039, PMID 19142813, PMID 19228415
2019 (6), 2008 (2), 2009 (2), 2014 (2), 2015 (1), 2016 (1), 2017 (1), 2025 (1), R01DA047368 (1)