176 completed, 96 recruiting, 65 unknown, 27 active not recruiting. 198 Not applicable, 93 Phase 2, 46 Phase 3, 34 Phase 1, 34 Phase 4.
Follow Depressive Disorder, Treatment-Resistant: new trials by email Literature Review of Depressive Disorder, Treatment-Resistant trials Research Report on Depressive Disorder, Treatment-Resistant
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder Psilocybin - Treatment Resistant Depression, Substance Use Disorders | Phase 1 / Phase 2 | Not yet recruiting | Indiana University | 50 | 2027-02-01 | 2026-10-23 |
| Effect of Neurofeedback and TMS Repetitive Transcranial Magnetic Stimulation, Alpha-down EEG Neurofeedback - Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Massachusetts General Hospital | 20 | 2027-01-01 | 2026-10-23 |
| Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression Ketamine hydrochloride injection - Treatment Resistant Depression (TRD), Chronic Pain | Phase 2 | Not yet recruiting | University of Rochester | 25 | 2026-12-01 | 2026-09-24 |
| A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial Neuronavigated robotic-enabled TMS, NRX-101, Sham TMS - Treatment Resistant Depression, Treatment Resistant Depression (TRD) | Phase 2 / Phase 3 | Recruiting | NeuroRx, Inc. | 240 | 2026-12-01 | 2026-10-21 |
| EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression MagVenture TMS Therapy System with Localite Navigation System and actiCHamp EEG - Major Depressive Disorder (MDD), Treatment Resistant Depression | Not applicable | Not yet recruiting | Mayo Clinic | 60 | 2026-11-01 | 2026-10-16 |
| Home-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression Spaced Transcranial Direct Current Stimulation (tDCS), Sham Spaced tDCS - Treatment Resistant Depression (TRD), Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | University of California, San Diego | 74 | 2026-10-15 | 2026-09-22 |
| Ketogenic Diet and Neuromodulation in Treatment Resistant Depression Accelerated Intermittent Theta Burst Stimulation (iTBS), Ketogenic Diet, Canadian Food Guide-Aligned Diet - Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD) | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 60 | 2026-10-01 | 2026-09-25 |
| The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression. Aripiprazole Augmentation, Bupropion Augmentation - Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder | Phase 2 | Not yet recruiting | Washington University School of Medicine | 300 | 2026-10-01 | 2026-10-16 |
| Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan Trial Transcranial Magnetic Stimulation - Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 160 | 2026-10-01 | 2026-09-18 |
| SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®) with the Magnus Neuromodulation System - Depressive Disorder, Treatment-Resistant, Memory Deficits | Not applicable | Recruiting | BrainHealth Solutions, Inc. | 20 | 2026-10-01 | 2026-10-23 |
| One-Day cTBS Over the Precuneus Precuneus-targeted continuous theta-burst stimulation, Left dorsolateral prefrontal cortex intermittent theta-burst stimulation, Sham transcranial magnetic stimulation - Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Mclean Hospital | 69 | 2026-09-08 | 2026-09-11 |
| Ketamine Treatment for Treatment-Resistant Depression - the Role of Framing Psychedelic framing, Biomedical framing - Treatment Resistant Depression (TRD) | Not applicable | Not yet recruiting | Valdemar Landgren | 120 | 2026-09-01 | 2026-09-17 |
| Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression Intermittent Theta Burst Stimulation (iTBS) - Treatment-resistant Depression (TRD), Major Depression | Not applicable | Recruiting | Gulhane Training and Research Hospital | 100 | 2026-09-01 | 2026-09-14 |
| Maintenance Individualized Neuromodulation and Depression-detection Via Sensors for Early Treatment Individualized resting-state functional connectivity-guided iTBS, Symptom-titrated algorithm-based longitudinal ECT (STABLE) algorithm - Depression Disorder | Not applicable | Not yet recruiting | National University Hospital, Singapore | 24 | 2026-09-01 | 2026-09-02 |
| Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression Ketamine (0.5 mg/kg), Behavioural Activation Therapy - Treatment Resistant Depression, Major Depressive Disorder (MDD) | Phase 2 / Phase 3 | Not yet recruiting | The Royal's Institute of Mental Health Research | 60 | 2026-09-01 | 2026-09-03 |
| Lumateperone for Late-Life Depression Lumateperone, Placebo - Treatment Resistant Depression (TRD), Late Life Depression (LLD) | Phase 3 | Recruiting | Eric Lenze | 100 | 2026-09-01 | 2026-09-16 |
| Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium Motif XCS System - Major Depressive Disorder | Not applicable | Recruiting | Motif Neurotech, Inc. | 20 | 2026-09-01 | 2026-10-21 |
| Study of rTMS in Maintenance in Treatment Resistant Depression Transcranial Magnetic Stimulation, quetiapine - Treatment Resistant Depression (TRD) | Phase 3 | Not yet recruiting | All India Institute of Medical Sciences, Bhubaneswar | 68 | 2026-08-30 | 2026-08-12 |
| Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to Treatment Blood sampling, lumbar puncture, stool sampling, skin microbiopsy and psychometrics scales - Schizophrenia, Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Centre Hospitalier St Anne | 700 | 2026-08-20 | 2026-09-21 |
| Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium - Maintenance Motif XCS System - Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | Motif Neurotech, Inc. | 10 | 2026-08-10 | 2026-07-06 |
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Depressive Disorder, Major (171) · Depression (138) · Depressive Disorder (41) · Bipolar Disorder (33) · Mood Disorders (16) · Mental Disorders (13) · Suicidal Ideation (7) · Anxiety Disorders (6) · Behavioral Symptoms (6) · Inflammation (6) · Anhedonia (5) · Suicide (5) · Motor Activity (4) · Schizophrenia (4)
Mental Disorders (434) · Mood Disorders (431) · Depressive Disorder (406) · Behavior (151) · Behavioral Symptoms (140) · Bipolar and Related Disorders (32) · Pathological Conditions, Signs and Symptoms (26) · Nervous System Diseases (23) · Signs and Symptoms (15) · Neurologic Manifestations (13) · Pathologic Processes (12) · Neurobehavioral Manifestations (11) · Self-Injurious Behavior (11) · Suicide (7) · Central Nervous System Diseases (6)
Ketamine (53) · Transcranial Magnetic Stimulation (32) · Psilocybin (26) · Esketamine (21) · Midazolam (13) · Escitalopram (11) · Sertraline (11) · Deep Brain Stimulation (10) · Duloxetine Hydrochloride (9) · Transcranial Direct Current Stimulation (9) · Antidepressive Agents (8) · Aripiprazole (7) · Bupropion (7) · Nitrous Oxide (6) · Therapeutics (6)
Janssen Research & Development, LLC (16) · Centre for Addiction and Mental Health (15) · Stanford University (13) · Washington University School of Medicine (12) · Massachusetts General Hospital (11) · Changping Laboratory (8) · Sunnybrook Health Sciences Centre (8) · Unity Health Toronto (7) · University of California, San Diego (7) · Taipei Veterans General Hospital, Taiwan (6) · University of Oxford (6) · Axsome Therapeutics, Inc. (5) · COMPASS Pathways (5) · Charite University, Berlin, Germany (5) · National Institute of Mental Health (NIMH) (5)
United States (203) · Canada (76) · China (29) · Germany (28) · United Kingdom (26) · France (23) · Spain (18) · Belgium (15) · Poland (14) · Taiwan (13) · Australia (11) · Brazil (11) · Turkey (Türkiye) (11) · Czechia (10) · Denmark (10)
Hesheng Liu, Ph.D. (7) · Charles Conway, MD (4) · David Spiegel, MD (4) · Eric Lenze, MD (4) · Maurizio Fava, MD (4) · Nolan Williams, MD (4) · Scott Aaronson, MD (4) · Helen Mayberg, MD (3) · Ishrat Husain, MBBS, MD (3) · Abhishek Datta, PhD (2) · Amit Anand, MD (2) · Carlos A Zarate, M.D. (2) · Claus Normann, MD (2)
PMID 39428602, PMID 32860422, PMID 33128208, PMID 34235612, PMID 17074942, PMID 23982301, PMID 29282469, PMID 35022754, PMID 38557430, PMID 10686270, PMID 16390886, PMID 22840761, PMID 23380715, PMID 24268616, PMID 25010396, PMID 27056608, PMID 27733282, PMID 28086004, PMID 31270774, PMID 32367114, PMID 34131914, PMID 34288609, PMID 34510411, PMID 34711062, PMID 34973081, PMID 36149841, PMID 36273682, PMID 37019044, PMID 37558912, PMID 37585253, PMID 37730990, PMID 38025416, PMID 38025433, PMID 39435126, PMID 10082232, PMID 12813115, PMID 1308374, PMID 15644873, PMID 15677610, PMID 15748841, PMID 15800181, PMID 16426099, PMID 16457894, PMID 16551710, PMID 16554525, PMID 16554526, PMID 16566612, PMID 16566901, PMID 16636629, PMID 16642436
2014 (5), 2017 (2), 2018 (2), 271201100006I-0-27100007-1 (2), 5UH3NS103550 (2), 1UG3MH137353-01 (1), 2005 (1), 2015 (1), 2019 (1), 2023 (1), 2025 (1), 5KL2TR002379 (1), 5KL2TR002379-08 (1), K01MH128663 (1), K12TR004415 (1)