Mood Disorders: Clinical Trials

3676 completed, 743 unknown, 685 recruiting, 356 terminated. 2645 Not applicable, 818 Phase 2, 753 Phase 3, 648 Phase 4, 391 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	2645	Completed 1419, Unknown 397, Recruiting 389, Not yet recruiting 141, Terminated 109, Active not recruiting 91, Withdrawn 58, Enrolling by invitation 26, Suspended 15
Phase 2	818	Completed 528, Recruiting 82, Terminated 76, Unknown 56, Withdrawn 33, Not yet recruiting 20, Active not recruiting 19, Enrolling by invitation 2, Suspended 2
Phase 3	753	Completed 558, Terminated 65, Recruiting 48, Unknown 28, Withdrawn 25, Active not recruiting 15, Not yet recruiting 11, Suspended 2, Enrolling by invitation 1
Phase 4	648	Completed 436, Unknown 74, Terminated 55, Recruiting 32, Withdrawn 30, Not yet recruiting 15, Active not recruiting 4, Enrolling by invitation 1, Suspended 1
Phase 1	391	Completed 279, Terminated 26, Recruiting 25, Unknown 24, Withdrawn 18, Active not recruiting 8, Not yet recruiting 8, Enrolling by invitation 2, Suspended 1
Early Phase 1	51	Completed 20, Unknown 13, Recruiting 6, Terminated 4, Withdrawn 3, Active not recruiting 2, Not yet recruiting 2, Enrolling by invitation 1

Follow Mood Disorders: new trials by email Literature Review of Mood Disorders trials Research Report on Mood Disorders

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module - Severe Mental Illness, Depression / Major Depressive Disorder	Not applicable	Not yet recruiting	Ludwig-Maximilians - University of Munich	140	2028-10-01	2026-05-14
Whole-Body Hyperthermia for Mood and Anxiety Disorders Whole-Body Hyperthermia, fMRI - Postpartum Depression, Mood Disorders	Not applicable	Not yet recruiting	Weill Medical College of Cornell University	240	2028-06-01	2026-06-23
ACT for Veterans With IBD and Mental Health Challenges Acceptance and Commitment Therapy - Inflammatory Bowel Diseases, Crohn's Disease	Not applicable	Not yet recruiting	VA Office of Research and Development	50	2028-01-01	2026-02-09
iMORE+ Study: A Multi-Omics Cohort Study of Major Depressive Disorder Major Depressive Disorder (MDD)		Not yet recruiting	Shanghai Mental Health Center	150	2027-09-01	2026-08-03
Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder bupropion hydrobromide, Placebo - Major Depressive Disorder	Phase 4	Not yet recruiting	Bausch Health Americas, Inc.	246	2027-07-01	2026-09-29
Evaluation of the Acceptability, Feasibility and Exploration of the Efficacy of an Integrated Care Pathway CARIBOU CARIBOU Integrated Care Pathway, Treatment as Usual (TAU) - Major Depressive Disorder (MDD)	Not applicable	Not yet recruiting	Universidad de los Andes, Chile	72	2027-07-01	2026-10-20
Targeted Alternating Current and Cognitive Training Intervention for Cognitive Control in Bipolar Disorders Soterix 1x1 tES mini-CT - Bipolar Disorder, Bipolar and Related Disorders	Not applicable	Not yet recruiting	VA Office of Research and Development	138	2027-06-01	2026-09-28
Stony Brook Medicine Anti-Inflammatory Trial Celecoxib, Minocycline - Major Depressive Disorder	Phase 4	Not yet recruiting	Stony Brook University	42	2027-06-01	2026-04-23
Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Randomized Controlled Trial UJI Online Transdiagnostic Protocol, UJI On Line Transdiagnostic Hibrid Protocol - Emotional Disorders, Anxiety	Not applicable	Not yet recruiting	Universitat Jaume I	366	2027-05-01	2026-05-27
A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression Symptoms Self-Guided STAIR Coach with Real-Time Assessment, Real-Time Assessment - Psychosocial Functioning, Stress Disorders, Post-Traumatic	Not applicable	Not yet recruiting	VA Office of Research and Development	40	2027-04-01	2026-10-06
Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation. Major Depressive Disorder (MDD)		Not yet recruiting	Sohag University	90	2027-03-14	2026-08-20
Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder Psilocybin - Treatment Resistant Depression, Substance Use Disorders	Phase 1 / Phase 2	Not yet recruiting	Indiana University	50	2027-02-01	2026-10-23
A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients PDC-1421 Capsule - Major Depressive Disorder	Phase 1 / Phase 2	Not yet recruiting	BioLite, Inc.	12	2027-01-15	2026-04-20
Qualitative Study of Student Financial Insecurity and Psychiatry Semi-structured interviews - Depressive Disorder, Generalized Anxiety Disorder		Not yet recruiting	Assistance Publique - Hôpitaux de Paris	30	2027-01-01	2026-08-05
Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder	Not applicable	Not yet recruiting	Central South University	400	2027-01-01	2026-03-04
The SPARK-PMDD Study Premenstrual Dysphoric Disorder, PMDD		Not yet recruiting	King's College London	120	2027-01-01	2026-08-18
Postpartum Care in the NICU Multi-Site Postpartum Doula Support in the NICU - Postpartum, Postpartum Depression (PPD)	Not applicable	Not yet recruiting	Children's Hospital of Philadelphia	756	2027-01-01	2026-10-14
Augmented Depression Therapy (ADepT) Case Series Augmented Depression Therapy (ADepT) - Depression / Major Depressive Disorder	Not applicable	Not yet recruiting	Ohio State University	40	2027-01-01	2026-10-15
Effect of Neurofeedback and TMS Repetitive Transcranial Magnetic Stimulation, Alpha-down EEG Neurofeedback - Depression - Major Depressive Disorder	Not applicable	Not yet recruiting	Massachusetts General Hospital	20	2027-01-01	2026-10-23
Psilocybin for Depression in Veterans Psilocybin, modafinil, zolpidem - Major Depression	Phase 2	Not yet recruiting	VA Office of Research and Development	150	2027-01-01	2026-10-26

Showing 20 of 6112. Sign in to see all of them.

Narrower conditions

Depressive Disorder, Major (2965)  ·  Depression (1780)  ·  Bipolar Disorder (1664)  ·  Depressive Disorder (854)  ·  Depression, Postpartum (561)  ·  Anxiety Disorders (514)  ·  Depressive Disorder, Treatment-Resistant (447)  ·  Schizophrenia (422)  ·  Psychotic Disorders (277)  ·  Mental Disorders (234)  ·  Stress Disorders, Post-Traumatic (158)  ·  Psychological Well-Being (123)  ·  Mania (118)  ·  Suicidal Ideation (102)

Broader conditions

Mental Disorders (5878)  ·  Depressive Disorder (3629)  ·  Behavior (2182)  ·  Behavioral Symptoms (1877)  ·  Bipolar and Related Disorders (1655)  ·  Pathological Conditions, Signs and Symptoms (666)  ·  Urogenital Diseases (608)  ·  Female Urogenital Diseases and Pregnancy Complications (592)  ·  Pregnancy Complications (556)  ·  Puerperal Disorders (549)  ·  Nervous System Diseases (518)  ·  Schizophrenia Spectrum and Other Psychotic Disorders (514)  ·  Signs and Symptoms (457)  ·  Neurologic Manifestations (343)

Interventions

Escitalopram (201)  ·  Ketamine (164)  ·  Transcranial Magnetic Stimulation (163)  ·  Therapeutics (133)  ·  Cognitive Behavioral Therapy (121)  ·  Sertraline (115)  ·  Quetiapine Fumarate (104)  ·  Duloxetine Hydrochloride (102)  ·  Fluoxetine (88)  ·  Transcranial Direct Current Stimulation (81)  ·  Aripiprazole (80)  ·  Lithium (80)  ·  Vortioxetine (71)  ·  Bupropion (67)  ·  Venlafaxine Hydrochloride (63)

Sponsors

Massachusetts General Hospital (159)  ·  National Institute of Mental Health (NIMH) (121)  ·  GlaxoSmithKline (86)  ·  New York State Psychiatric Institute (83)  ·  Stanford University (83)  ·  Eli Lilly and Company (79)  ·  AstraZeneca (77)  ·  Centre for Addiction and Mental Health (77)  ·  Mclean Hospital (67)  ·  Shanghai Mental Health Center (59)  ·  University of Pittsburgh (59)  ·  VA Office of Research and Development (57)  ·  Janssen Research & Development, LLC (54)  ·  Otsuka Pharmaceutical Development & Commercialization, Inc. (50)  ·  University of Texas Southwestern Medical Center (50)

Countries

United States (2825)  ·  Canada (546)  ·  China (340)  ·  France (303)  ·  Germany (278)  ·  United Kingdom (197)  ·  Spain (190)  ·  Turkey (Türkiye) (146)  ·  Poland (125)  ·  Taiwan (114)  ·  Denmark (113)  ·  Australia (106)  ·  Brazil (105)  ·  South Korea (104)  ·  Sweden (101)

Top investigators

Carlos A Zarate, M.D. (15)  ·  Maurizio Fava, MD (15)  ·  Martha Sajatovic, MD (12)  ·  Hesheng Liu, Ph.D. (11)

Results publications

PMID 34817851, PMID 34510411, PMID 25758058, PMID 39428602, PMID 26644956, PMID 26709542, PMID 34183490, PMID 42383885, PMID 24816198, PMID 29140227, PMID 34131914, PMID 24067192, PMID 24175720, PMID 24571916, PMID 26474010, PMID 29912955, PMID 30508090, PMID 22700038, PMID 27685842, PMID 27780334, PMID 31577867, PMID 31818787, PMID 32792252, PMID 33128208, PMID 34523118, PMID 36708956, PMID 41401709, PMID 17074942, PMID 23485955, PMID 23497790, PMID 26644957, PMID 27488181, PMID 29608461, PMID 31969269, PMID 32242018, PMID 32476658, PMID 32860422, PMID 34235612, PMID 34286512, PMID 34689733, PMID 34874888, PMID 37656180, PMID 38819882, PMID 41130742, PMID 42393474, PMID 11556941, PMID 16390886, PMID 21095016, PMID 21731833, PMID 22106941

NIH funding

2023 (18), 2008 (15), 2025 (15), 2016 (14), 2018 (12), 2019 (12), 2014 (11), 2015 (9), 2017 (8), 2004 (3), 2009 (3), R25DA020537 (3), 2005 (2), 271201100006I-0-27100007-1 (2), 5UH3NS103550 (2)