82 completed, 30 unknown, 14 recruiting, 9 not yet recruiting. 77 Not applicable, 13 Phase 4, 9 Phase 1, 6 Phase 2, 5 Phase 3.
Follow Nociceptive Pain: new trials by email Literature Review of Nociceptive Pain trials Research Report on Nociceptive Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TAP vs. ESP Blocks for Post-Cesarean Analgesia Ropivacaine, Ultrasound-guided Nerve Block, Ketoprofen and Paracetamol - Postoperative Pain After Cesarean Section | Not applicable | Not yet recruiting | Maternity Hospital - State Budgetary Institution of the Rostov Region, Taganrog | 162 | 2026-10-15 | 2026-10-06 |
| Evaluation of Consciousness Depth (qCON) and Analgesia Depth (qNOX) Indices in General Anesthesia Cesarean Section (MeSH: D002585), Anesthesia | Not yet recruiting | Kudret Dogru | 140 | 2026-10-15 | 2026-10-22 | |
| Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline - Pain, Acute Post-Operative, Dexmedetomidine | Not applicable | Recruiting | Vasiliki Samartzi | 90 | 2026-07-15 | 2026-09-29 |
| Gastric Electrical Stimulation for Abdominal Pain in Patients With Gastroparesis Enterra™ neurostimulator - Gastroparesis, Chronic Abdominal Pain | Not applicable | Not yet recruiting | University of Louisville | 150 | 2026-07-01 | 2026-05-04 |
| Functional Brain MRI to Understand Pain Phenotypes in Knee Osteoarthritis blood sampling, Resting-state functional MRI - Gonarthrosis, Neuropathic Pain, Nociceptive Pain | Phase 2 | Not yet recruiting | University Hospital, Clermont-Ferrand | 60 | 2026-07-01 | 2026-06-25 |
| Catheter Redosing of Autonomic Neural Blockade After Sleeve Gastrectomy Bupivacaine 0.5% and Dexamethasone via Temporary Catheter - Pain, Acute Post-Operative, Nausea and Vomiting, Postoperative | Not applicable | Not yet recruiting | Universidad Simón Bolívar | 30 | 2026-06-15 | 2026-06-18 |
| Preventive Analgesia With Anrikefon in Laparoscopic Cholecystectomy Anrikefon for Preventive Analgesia, Anrikefon for bridging analgesia - Postoperative Pain | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 274 | 2026-06-02 | 2026-07-01 |
| Pleasant Touch Perception in Persistent Pain. Chronic Pain, Persistent Pain | Not yet recruiting | Göteborg University | 100 | 2026-04-26 | 2026-04-27 | |
| Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon - Laparoscopic Surgery, Visceral Pain, Postoperative | Phase 4 | Recruiting | Peking University First Hospital | 140 | 2026-04-14 | 2026-04-24 |
| EFficacy and safEty of cRisugabalin on nocipLastic paIn in Patients With Parkinson's Disease (RELIEF-PD): a Multicentre, Double-blind, Randomised Controlled Trial Crisugabalin, Placebo - PARKINSON DISEASE (Disorder) | Phase 4 | Active not recruiting | Guangdong Provincial People's Hospital | 166 | 2026-03-13 | 2026-09-14 |
| Frailty and Chronic Pain Profiles in Patients Aged ≥65 Years Geriatric Pain | Completed | Ankara City Hospital Bilkent | 393 | 2026-01-01 | 2026-05-13 | |
| Anrikefon-based Patient-controlled Intravenous Analgesia After Laparoscopic Surgery High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon - Laparoscopic Surgery, Visceral Pain, Postoperative | Phase 4 | Terminated | Peking University First Hospital | 13 | 2025-12-25 | 2026-04-09 |
| Central Sensitisation in Nociceptive and Neuropathic Pain Neuropsychological assessment, Laser evoked potentials - Chronic Pain, Nociceptive Pain | Active not recruiting | IRCCS Centro Neurolesi Bonino Pulejo | 185 | 2025-12-15 | 2026-04-20 | |
| Accelerated Intermittent Theta Burst Stimulation (AiTBS)on Neuropathic Pain Repetitive transcranial magnetic stimulation - Neuropathic Pain, Nociceptive Pain | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 120 | 2025-09-12 | 2026-01-26 |
| Objective Integrated Multimodal Electrophysiological Index for the Quantification of Visceral Pain IBS-PPSM intervention - Abdominal Pain | Not applicable | Recruiting | University of Connecticut | 120 | 2025-09-08 | 2025-09-15 |
| A Research Study Exploring How Musculoskeletal Function and the Autonomic Nervous System Relate to Visceral Pain in Women With and Without Dysmenorrhea (Painful Periods). Visceral Pain Stimulus - Dysmenorrhea, Dysmenorrhea Primary | Not applicable | Recruiting | Azusa Pacific University | 60 | 2025-08-01 | 2025-10-07 |
| Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy Levobupivacaine, Dexamethasone contained in the solution for thoracic paravertebral block, Adrenaline - Obese Patients, Bariatric Surgical Pain | Not applicable | Not yet recruiting | IVO JURISIC | 36 | 2025-07-30 | 2025-07-24 |
| Comparison of the Surgical Pleth Index and the Nociception Level Index in the Pediatric Population Connecting all patients to the nociception level index(NOL) and the surgical pleth index (SPI), All patient will receive a tetanic stimuli (60mA, 100hz) of 5 seconds before start of incision - Nociceptive Pain, Anesthesia | Completed | Radboud University Medical Center | 40 | 2025-07-04 | 2026-09-08 | |
| Neurolytic Block Techniques In Abdominal Visceral Cancer Pain Splanchnic nerve neurolysis - 5 ml of absolute alcohol (100%), Celiac Plexus Neurolysis - 5 ml of absolute alcohol (100%) - Cancer, Malignant Tumors, Abdominal Cancer | Not applicable | Not yet recruiting | Instituto do Cancer do Estado de São Paulo | 64 | 2025-05-30 | 2025-06-03 |
| Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia NOL (Nociception Level Index), Control (Standard treatment) - Nociceptive Pain, Pain, Postoperative | Not applicable | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 240 | 2025-05-12 | 2025-06-08 |
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Visceral Pain (53) · Neuralgia (31) · Pain (30) · Pain, Postoperative (29) · Agnosia (25) · Chronic Pain (25) · Acute Pain (12) · Abdominal Pain (8) · Irritable Bowel Syndrome (6) · Postoperative Nausea and Vomiting (5) · Anxiety Disorders (4) · Neoplasms (4) · Dysmenorrhea (3) · Low Back Pain (3)
Neurologic Manifestations (147) · Pathological Conditions, Signs and Symptoms (147) · Signs and Symptoms (147) · Pain (117) · Nervous System Diseases (59) · Pathologic Processes (44) · Neuromuscular Diseases (32) · Peripheral Nervous System Diseases (31) · Postoperative Complications (30) · Neurobehavioral Manifestations (25) · Perceptual Disorders (25) · Digestive System Diseases (16) · Signs and Symptoms, Digestive (13) · Musculoskeletal Diseases (10)
Remifentanil (5) · Sodium Chloride (5) · Saline Solution (4) · 6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo(d)thiazol-2(3H)-one (3) · Dexmedetomidine (3) · Lidocaine (3) · Morphine (3) · Oxycodone (3) · Propofol (3) · esmolol (3) · Butorphanol (2) · Control Groups (2) · Dexamethasone (2) · Dronabinol (2) · Fentanyl (2)
Aretaieion University Hospital (5) · Ciusss de L'Est de l'Île de Montréal (4) · Radboud University Medical Center (4) · Stanford University (4) · Universidad Simón Bolívar (4) · University Hospital, Lille (4) · Universitätsklinikum Hamburg-Eppendorf (4) · Erasme University Hospital (3) · Aalborg University (2) · Beth Israel Deaconess Medical Center (2) · Cara Therapeutics, Inc. (2) · Centrexion Therapeutics (2) · China International Neuroscience Institution (2) · Endeavor Health (2) · Grünenthal GmbH (2)
United States (32) · China (11) · France (10) · Netherlands (8) · Belgium (7) · Germany (7) · Greece (7) · Turkey (Türkiye) (7) · Canada (6) · Denmark (6) · South Korea (5) · Spain (5) · Chile (3) · Egypt (3) · Israel (3)
Rainer Nitzschke, MD (4) · Dong-Xin Wang, MD, PhD (2) · Emily K. Pauli, PharmD (2) · Frank Tu, MD, MPH (2) · Kassiani Theodoraki (2) · Sandra Funcke, MD (2) · A Masclee, Prof, PhD, MD (1) · Ajibole Abatunde, MD (1) · Akram Z Abu Mahfouz, MS, RPh (1) · Aleksandr A. Bezverkhiy, PhD (1) · Ali Ekemen (1) · Anand Veeravagu (1) · Anand Veeravagu, MD (1)
PMID 27720917, PMID 33228979, PMID 35295458, PMID 19402781, PMID 21620344, PMID 22647429, PMID 23475406, PMID 23835792, PMID 23945010, PMID 25963754, PMID 26154185, PMID 26247858, PMID 26741741, PMID 26817405, PMID 27171828, PMID 28344100, PMID 30025944, PMID 30284674, PMID 30440445, PMID 30829658, PMID 30997633, PMID 31603076, PMID 32950246, PMID 33259449, PMID 33428347, PMID 33635894, PMID 33709262, PMID 33783846, PMID 34597955, PMID 34718774, PMID 34793406, PMID 34799534, PMID 35069809, PMID 35472586, PMID 35579382, PMID 35925157, PMID 36050617, PMID 36091708, PMID 36977981, PMID 37226937, PMID 37545692, PMID 38091501, PMID 38661677, PMID 39382864, PMID 39891061, PMID 40032662, PMID 40053798, PMID 40663304, PMID 40765391, PMID 41042488
2025 (2), 1UG3NS140971-01 (1), 2009 (1), 2014 (1), 2023 (1), R01AR077706 (1), R01CA252211 (1), R01DK048351 (1), R01DK100368 (1), R01MH076136 (1), R03DK071851 (1), U24AT011969 (1)