1048 completed, 194 unknown, 163 recruiting, 115 terminated. 634 Not applicable, 232 Phase 4, 229 Phase 3, 176 Phase 2, 75 Phase 1.
Follow Bipolar Disorder: new trials by email Literature Review of Bipolar Disorder trials Research Report on Bipolar Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module - Severe Mental Illness, Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ludwig-Maximilians - University of Munich | 140 | 2028-10-01 | 2026-05-14 |
| Targeted Alternating Current and Cognitive Training Intervention for Cognitive Control in Bipolar Disorders Soterix 1x1 tES mini-CT - Bipolar Disorder, Bipolar and Related Disorders | Not applicable | Not yet recruiting | VA Office of Research and Development | 138 | 2027-06-01 | 2026-09-28 |
| Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation. Major Depressive Disorder (MDD) | Not yet recruiting | Sohag University | 90 | 2027-03-14 | 2026-08-20 | |
| Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder | Not applicable | Not yet recruiting | Central South University | 400 | 2027-01-01 | 2026-03-04 |
| Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase in Bipolar Disorder Lurasidone (Latuda) - Bipolar Disorder Depression | Phase 4 | Not yet recruiting | Martin Lan | 60 | 2026-11-01 | 2026-09-08 |
| BAROMETRE : Study on the Prognosis and Course of Individuals With Bipolar Spectrum Disorder Structured clinical follow-up and psychometric assessment - Bipolar Disorder (BD) | Not yet recruiting | University Hospital, Angers | 60 | 2026-11-01 | 2026-10-14 | |
| Evaluating the Impact of Ketogenic Therapy on Symptom Severity and Metabolic Side Effect Profile Among Individuals Living With Bipolar Disorder in A Rural Southern Catchment Area Ketogenic foodstuffs, Standard of Care Oral antipsychotics, Standard of care long acting injectable medication for bipolar disorder - Bipolar Disorder | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 100 | 2026-11-01 | 2026-10-07 |
| A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness MoodSync, Standard care - Severe Mental Illness, Bipolar Disorder | Not applicable | Not yet recruiting | Alexandria University | 60 | 2026-11-01 | 2026-10-16 |
| Evaluating the PolarUs App in People With Bipolar Disorder PolarUs Mobile App - Bipolar Disorder (BD), Quality of Life (QOL) | Not applicable | Not yet recruiting | University of British Columbia | 504 | 2026-11-01 | 2026-10-22 |
| Testing a New Gold Nanoparticle-Based Lithium Delivery Method for Bipolar Disorder in Laboratory Models Peripheral blood sampling for PBMC isolation - Bipolar Disorder (BD), Bipolar Disorder (BPD) | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 20 | 2026-10-01 | 2026-07-29 |
| Cognition and Affective Research in China Neurodegenerative Disease, Dementia | Not yet recruiting | Xuanwu Hospital, Beijing | 3000 | 2026-10-01 | 2026-09-22 | |
| Effect of Occupational Therapy on Psychosocial Parameters and Functioning in Individuals With Severe Mental Illness Occupational Therapy Group Intervention - Schizophenia Disorder, Severe Mental Illness | Not applicable | Not yet recruiting | Biruni University | 50 | 2026-10-01 | 2026-10-16 |
| Pramipexole vs Placebo Treatment in Bipolar Disorder With Anhedonic Depression Pramipexole, Placebo - Bipolar Disorder (BD) | Phase 3 | Recruiting | Daniel Lindqvist | 126 | 2026-10-01 | 2026-10-22 |
| Safety and Feasibility of DBS for Bipolar Depression Medtronic Percept PC DBS system - Bipolar I Disorder, Bipolar Depression | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 5 | 2026-09-21 | 2026-09-22 |
| Senyo Health App - Comorbid Alcohol Use Disorder Treatment in Individuals With Bipolar Disorder Using a Telehealth Collaborative Care Platform Senyo Health App - Bipolar Disorder | Not applicable | Not yet recruiting | Mayo Clinic | 40 | 2026-09-16 | 2026-07-31 |
| The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression Lumateperone 42 mg - Bipolar Depression Depressed Phase, Obesity & Overweight | Phase 4 | Recruiting | Massachusetts General Hospital | 25 | 2026-09-09 | 2026-09-11 |
| Medication Adherence in Severe Mental Illness: a Promotion Program Telehealth Psychoeducational Adherence Program - Treatment Adherence and Compliance, Severe Mental Disorders | Not applicable | Not yet recruiting | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 1640 | 2026-09-01 | 2026-03-03 |
| Time Restricted Eating (TRE) in Bipolar Disorder Time Restricted Eating - Bipolar Disorder (BD), Bipolar Disorder Depression | Not applicable | Recruiting | Massachusetts General Hospital | 40 | 2026-09-01 | 2026-10-07 |
| A Study to Assess Adverse Events and How Oral ABBV-932 Moves Through the Body When Given With Oral Itraconazole in Adult Participants With Bipolar Disorder ABBV-932, Itraconazole - Bipolar Disorder | Phase 1 | Recruiting | AbbVie | 20 | 2026-08-20 | 2026-09-16 |
| Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to Treatment Blood sampling, lumbar puncture, stool sampling, skin microbiopsy and psychometrics scales - Schizophrenia, Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Centre Hospitalier St Anne | 700 | 2026-08-20 | 2026-09-21 |
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Schizophrenia (342) · Depression (292) · Depressive Disorder, Major (248) · Psychotic Disorders (218) · Mania (114) · Mood Disorders (108) · Mental Disorders (104) · Depressive Disorder (81) · Anxiety Disorders (60) · Stress Disorders, Post-Traumatic (36) · Depressive Disorder, Treatment-Resistant (33) · Substance-Related Disorders (32) · Alcoholism (31) · Cognitive Dysfunction (30)
Bipolar and Related Disorders (1653) · Mental Disorders (1558) · Mood Disorders (1554) · Behavior (452) · Schizophrenia Spectrum and Other Psychotic Disorders (398) · Behavioral Symptoms (338) · Depressive Disorder (248) · Pathological Conditions, Signs and Symptoms (232) · Nervous System Diseases (208) · Signs and Symptoms (207) · Neurologic Manifestations (164) · Neurobehavioral Manifestations (145) · Chemically-Induced Disorders (81) · Nutritional and Metabolic Diseases (61) · Neurodevelopmental Disorders (50)
Quetiapine Fumarate (77) · Lithium (64) · Valproic Acid (56) · Lamotrigine (49) · Olanzapine (47) · Aripiprazole (44) · Risperidone (40) · Lithium Carbonate (37) · Therapeutics (35) · ziprasidone (35) · Ketamine (32) · Lurasidone Hydrochloride (26) · Transcranial Magnetic Stimulation (22) · Cognitive Behavioral Therapy (16) · Sugars (16)
Massachusetts General Hospital (63) · AstraZeneca (47) · National Institute of Mental Health (NIMH) (41) · Mclean Hospital (33) · Stanford University (23) · University of Pittsburgh (22) · University of Texas Southwestern Medical Center (22) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (21) · University Hospitals Cleveland Medical Center (21) · VA Office of Research and Development (21) · Eli Lilly and Company (19) · New York State Psychiatric Institute (19) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (18) · Centre for Addiction and Mental Health (17) · Dartmouth-Hitchcock Medical Center (17)
United States (832) · Canada (134) · France (98) · China (74) · Spain (50) · Denmark (48) · United Kingdom (44) · Turkey (Türkiye) (43) · Germany (40) · Brazil (34) · Russia (33) · South Korea (28) · Taiwan (28) · Ukraine (25) · Bulgaria (23)
Martha Sajatovic, MD (12) · Joseph Biederman, MD (8) · Keming Gao, MD, PhD (7) · Amit Anand, MD (6) · Benjamin I Goldstein, MD, PhD (6) · Janet Wozniak, MD (6)
PMID 34523118, PMID 41401709, PMID 31969269, PMID 32476658, PMID 34689733, PMID 41130742, PMID 42393474, PMID 32336984, PMID 32792252, PMID 32942346, PMID 33677183, PMID 33915374, PMID 39520655, PMID 41017591, PMID 14702256, PMID 18588360, PMID 19210948, PMID 19956459, PMID 20854181, PMID 21095016, PMID 22198448, PMID 23473546, PMID 23511717, PMID 23609405, PMID 23761037, PMID 23945460, PMID 24111980, PMID 24329543, PMID 25083802, PMID 25978742, PMID 26462799, PMID 26598478, PMID 26730454, PMID 27215976, PMID 27529375, PMID 27780336, PMID 28446253, PMID 28832750, PMID 29017067, PMID 29105003, PMID 29931798, PMID 31279534, PMID 31344528, PMID 31957686, PMID 32046986, PMID 34131914, PMID 34510411, PMID 34623633, PMID 34817851, PMID 35377567
2016 (7), 2023 (4), 2004 (2), 2019 (2), 2025 (2), K01MH112876 (2), K23DA050808 (2), K23MH065599 (2), KL2TR000440 (2), R01MH060353 (2), R01MH064662 (2), R01MH077210 (2), R34MH078967 (2), R34MH117198 (2), 1IK2RX003069-01A2 (1)