756 completed, 255 unknown, 75 recruiting, 71 terminated. 497 Not applicable, 440 Phase 4, 115 Phase 3, 88 Phase 2, 55 Phase 1.
Follow Propofol: new trials by email Literature Review of Propofol trials Research Report on Propofol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Neuromuscular Blocking Agent Use on Video Laryngeal Mask Airway Insertion Rocuronium, Standard Anesthesia Induction (Propofol and Remifentanil) - Airway Management, Supraglottic Airway Device Insertion | Phase 4 | Not yet recruiting | Hacettepe University | 128 | 2027-02-01 | 2026-10-26 |
| Prospective Study of Induction Medications Used in the Trauma RSI Ketamine, Etomidate, Propofol - Trauma, Rapid Sequence Intubation | Withdrawn | University of Southern California | 2027-01-01 | 2026-05-04 | ||
| Remimazolam vs Propofol for Motor and Somatosensory Evoked Potentials in Spinal Tumor Surgery Remimazolam, Propofol - Spinal Cord Neoplasms, Spinal Neoplasms | Phase 4 | Not yet recruiting | Beijing Tsinghua Chang Gung Hospital | 190 | 2027-01-01 | 2026-10-28 |
| Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus Surgery Ketamine and Propofol, Sevoflurane - Postoperative Vomiting, Postoperative Nausea and Vomiting | Phase 4 | Not yet recruiting | Assiut University | 50 | 2026-11-01 | 2026-10-13 |
| Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery Remimazolam Besylate, propofol - Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch | Phase 4 | Not yet recruiting | Seoul National University Hospital | 80 | 2026-11-01 | 2026-10-29 |
| Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department. Ketamine (1 mg/kg), propofol, Dexmedetomidine - Procedural Sedation | Phase 4 | Not yet recruiting | Sultan Qaboos University | 100 | 2026-10-10 | 2026-10-15 |
| Effect of Remimazolam on Hypoxemia and/or Hypotension in Prostate Biopsy Using remimazolam for sedation during prostate biopsy, Administer 1.5mg/kg of propofol for sedation - Prostate Biopsy, Sedation Complication | Not applicable | Not yet recruiting | RenJi Hospital | 1146 | 2026-10-08 | 2026-10-08 |
| Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam - Coronary Artery Disease, Postoperative Complications | Not applicable | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 416 | 2026-10-08 | 2026-08-26 |
| Propofol or Esketamine: Tracheal Intubation Comparison Esketamine, Propofol - Critically Ill Adults Requiring Emergency Tracheal Intubation in the Intensive Care Unit | Phase 4 | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 130 | 2026-10-08 | 2026-09-29 |
| Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial Fibrillation Ablation Sevoflurane, propofol - Persistent Atrial Fibrillation | Phase 4 | Not yet recruiting | Hüseyin Ulaş Pinar | 124 | 2026-10-01 | 2026-10-16 |
| Impact of Dexmedetomidine Versus Propofol on Intracranial Pressure in Adult Traumatic Brain Injury Patients: Randomized Controlled Double-Blind Trial Propofol, Dexmedetomidine - Traumatic Brain Injuries | Phase 4 | Not yet recruiting | Assiut University | 80 | 2026-10-01 | 2026-09-10 |
| Dexametedomidine Ketamine Infusion Versus Dexametedomidine Propofol Infusion in Non-compliant Agitated Patients on Continuous Positive Airway Pressure (CPAP) Mask Ventilation in the Intensive Care Unit Group DK will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and ketamine (0.5 mg/kg/hr)., Group KP will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and propofol (2-4 mg/kg/hr).( - CPAP Ventilation, Sedation | Not applicable | Not yet recruiting | Ain Shams University | 100 | 2026-10-01 | 2026-10-22 |
| Effect of Remimazolam Versus Propofol Total Intravenous Anesthesia on Intraoperative Hemodynamic Stability in Patients Undergoing Thoracic or Abdominal Endovascular Aortic Repair Remimazolam Besylate, propofol - Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal | Phase 4 | Recruiting | Seoul National University Hospital | 44 | 2026-10-01 | 2026-10-29 |
| Ciprofol, Propofol and Sevoflurane for Postoperative Delirium in Elderly Brain Tumor Patients Ciprofol, Propofol, Sevoflurane - Brain Neoplasms, Delirium - Postoperative | Not applicable | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 381 | 2026-09-30 | 2026-09-02 |
| Effects of Low-Dose Ketamine Added to Propofol Sedation During Colonoscopy Propofol group, Propofol + Ketamine - Colonoscopy Procedures, Sedation | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 100 | 2026-09-14 | 2026-09-09 |
| The Effect of Ciprofol Versus Propofol Anesthesia on Postoperative Neurological Complications Ciprofo, Propofol - Intracranial Tumors | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 434 | 2026-09-07 | 2026-09-09 |
| The Effect of Remimazolam Tosylate on the Incidence of Postoperative Delirium in Older Patients Undergoing Cardiac Surgery: A Prospective Randomized Controlled Trial Remimazolam Tosylate, Propofol - Delirium - Postoperative | Not applicable | Recruiting | Nanjing First Hospital, Nanjing Medical University | 600 | 2026-09-05 | 2026-10-30 |
| Effect of Dexmedetomidine on Hemodynamic Stability in Carotid Endarterectomy: Reduced Norepinephrine Use and Propofol Dosing Via Central Sympatholytic Action dexmedetomidine to the standard treatment, Standard anaesthesia with propofol with co-administration of Dexmedetomidine and Propofol with Dexmedetomidine (bolus 0.4 mcg/kg over 10 minutes followed by an continuous infusion with 0.4 mcg/kg/h un - Steno-occlusive Disease | Phase 4 | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 44 | 2026-09-01 | 2026-05-19 |
| Propofol-Dexmedetomine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery :Effect on Anesthetic Consumption ,Perioperative Outcomes,and Early Recovery Propofol (Astra-Zeneca), propofol and dexmetomidine - Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery | Phase 1 / Phase 2 | Not yet recruiting | Kafrelsheikh University | 60 | 2026-09-01 | 2026-09-01 |
| Dexmedetomidine vs Propofol Sedation in Endovascular Aortic Repair Dexmedetomidine, propofol - Abdominal Aortic Aneurysm, Acute Kidney Injury | Completed | Bursa City Hospital | 282 | 2026-09-01 | 2026-10-05 |
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Emergence Delirium (51) · Pain (37) · Pain, Postoperative (35) · Delirium (33) · Agnosia (26) · Obesity (21) · Neoplasms (16) · Respiratory Insufficiency (16) · Coronary Artery Disease (15) · Respiratory Aspiration (15) · Cognitive Dysfunction (14) · Postoperative Cognitive Complications (14) · Hypotension (13) · Postoperative Nausea and Vomiting (13) · Hypoxia (12)
Yonsei University (29) · Seoul National University Hospital (21) · Ain Shams University (16) · Assiut University (16) · Cairo University (12) · RenJi Hospital (12) · Tongji Hospital (11) · Beijing Tiantan Hospital (10) · Sichuan Haisco Pharmaceutical Group Co., Ltd (10) · Konkuk University Medical Center (9) · Mansoura University (9) · Tanta University (9) · Ajou University School of Medicine (8) · Haisco Pharmaceutical Group Co., Ltd. (8) · Jiangsu HengRui Medicine Co., Ltd. (8)
China (235) · United States (206) · South Korea (114) · Egypt (91) · Turkey (Türkiye) (62) · France (42) · Canada (33) · Switzerland (26) · Taiwan (26) · Germany (23) · Italy (22) · India (20) · Belgium (18) · Brazil (17) · United Kingdom (14)
Goverdhan D Puri, MD, PhD (6) · Nitin Sethi, DNB (5) · Stanley SC Wong, MBBS (5) · Yunseok Jeon, MD, PhD (5) · Alibek Kh Mustafin, Professor (4) · Dong-Xin Wang, MD, PhD (4) · Marc Fischler, MD (4) · Amitabh Dutta, MD (3) · Amitabh Dutta, MD, PGDHR (3) · Eberhard Kochs, MD (3) · James R Miner, MD (3) · Sameh Abdelkhalek Ahmed, MD (3) · Seong-Hyop Kim, M.D,Ph.D (3) · Sherief Abd-Elsalam, MD (3)
PMID 19443532, PMID 22045879, PMID 12127688, PMID 14570648, PMID 18540930, PMID 19617584, PMID 20841416, PMID 20930611, PMID 21233500, PMID 21935924, PMID 22192060, PMID 22436955, PMID 29187413, PMID 29723512, PMID 30292760, PMID 31521119, PMID 32417976, PMID 38954871, PMID 39428602, PMID 8404160, PMID 10320158, PMID 10360845, PMID 10366002, PMID 10400452, PMID 10464905, PMID 10485753, PMID 10485781, PMID 10517999, PMID 10536559, PMID 10616858, PMID 10735670, PMID 10758459, PMID 10793585, PMID 10927999, PMID 10960408, PMID 10981581, PMID 11056756, PMID 11065205, PMID 11189177, PMID 11193758, PMID 11256129, PMID 11307125, PMID 11323159, PMID 11465585, PMID 11475180, PMID 11506101, PMID 11698314, PMID 11779730, PMID 12225610, PMID 12358867
2019 (4), R01GM103894 (4), 2009 (3), 2018 (2), 2025 (2), K08GM083213 (2), R35GM146822 (2), U01MH128483 (2), 2005 (1), 2008 (1), 2016 (1), 2017 (1), 2023 (1), 5DP1OD003646 (1), 5KL2RR025006 (1)