13 completed, 8 unknown, 3 recruiting, 2 not yet recruiting. 26 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 26 | Completed 13, Unknown 8, Recruiting 3, Not yet recruiting 2 |
Follow Ketamine: new trials by email Literature Review of Ketamine trials Research Report on Ketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Two Intravenous Doses of Ketamine in Reducing the Oculocardiac Reflex in Adult Patients Undergoing Ophthalmic Surgery 0.5 mg/kg intravenous ketamine, 0.75 mg/kg intravenous ketamine - Ketamine, Oculocardiac Reflex | Not applicable | Recruiting | Cairo University | 40 | 2026-07-01 | 2026-07-16 |
| Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery Ketamine group, Control Group - Cardiac Anaesthesia, Chronic Pain | Not applicable | Not yet recruiting | Bursa City Hospital | 100 | 2026-04-15 | 2026-03-24 |
| Role of Opioid Free Anaesthesia in Elderly Patients Undergoing Elective Coronary Artery Bypass Graft Surgeries With Cardiopulmonary Bypass in Enhanced Recovery After Surgeries Opioid free anesthesia, Opioid based Anesthesia - CABG, Dexmedetomidine | Not applicable | Not yet recruiting | Ain Shams University | 60 | 2026-01-01 | 2026-01-22 |
| Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass Fentanyl (IV), lidocaine - Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction | Not applicable | Completed | Cairo University | 48 | 2025-12-01 | 2026-08-07 |
| Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil - Magnesium Sulfate, Remifentanil | Not applicable | Recruiting | University General Hospital of Patras | 150 | 2025-09-11 | 2025-09-18 |
| Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain Ketamine, 29 ml bupivacaine 0.25% + 1 ml saline - Ketamine, Adjuvant | Not applicable | Completed | Tanta University | 50 | 2025-08-23 | 2026-02-27 |
| Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty Ketamine, Standard Analgesia - Knee Arthroplasty, Postoperative Pain | Not applicable | Completed | State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia | 100 | 2025-07-01 | 2026-03-02 |
| Erector Spinae Block Vs Ketamine-based Multimodal Analgesia Protocol in Lumber Decompressive Surgery ketamine, Erector Spinae Plane Block, Wound infiltration - Spinal Decompression, Analgesia | Not applicable | Completed | Kasr El Aini Hospital | 62 | 2025-06-20 | 2026-03-24 |
| Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty Ketamine and Magnesium Sulfate, Saline 0.9% - Intraoperative, Ketamine | Not applicable | Recruiting | Ain Shams University | 50 | 2025-05-12 | 2025-05-13 |
| Intraoperative Ketamine Versus Lidocaine Infusion on Postoperative Cognitive Dysfunction in Patients Undergoing Hip Surgery Group Ketamine, Group Lidocaine, Group Placebo - Ketamine, Cognitive | Not applicable | Completed | Tanta University | 120 | 2025-03-30 | 2026-09-24 |
| General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients General Anesthesia, Local anesthesia - General Anesthesia, Dexmedetomidine | Not applicable | Completed | Tanta University | 60 | 2024-05-01 | 2026-02-17 |
| Propofol-ketamine or Propofol-fentanyl for Procedural Sedation in the Short-term Gynecological Case Ketamine, Fentanyl - Ketamine, Sedation | Not applicable | Completed | Ondokuz Mayıs University | 60 | 2024-04-20 | 2024-08-20 |
| Dexmedetomidine and Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain Ketamine, Dexmedetomidine, Bupivacaine - Dexmedetomidine, Ketamine | Not applicable | Completed | Tanta University | 40 | 2024-03-26 | 2025-01-07 |
| Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock Ketamine, Fentanyl - Ketamine, Fentanyl | Not applicable | Completed | Cairo University | 86 | 2023-08-01 | 2023-12-22 |
| Opioid Sparing Anesthesia in Cervical Spine Surgery ketamine-lidocaine, Remifentanil - Pain, Postoperative, Pain, Acute | Not applicable | Unknown | Evangelismos Hospital | 60 | 2022-11-01 | 2023-02-08 |
| Opioid Sparing Anesthesia in Lumbar Spine Surgery dexmedetomidine-ketamine-lidocaine, Remifentanil - Pain, Postoperative, Pain, Acute | Not applicable | Unknown | Aretaieion University Hospital | 60 | 2022-08-01 | 2022-10-31 |
| Opioid-free Anesthesia in Thyroidectomies dexmedetomidine-ketamine-lidocaine (DKL), remifentanil infusion - Pain, Post Operative, Pain, Acute | Not applicable | Unknown | Aretaieion University Hospital | 60 | 2022-03-07 | 2023-04-26 |
| The Application of Ketamine for Sedation in Patients With Cardiac Arrest - - KetCat (KETamine in Cardiac ArresT) Study Ketamine Hydrochloride - Cardiac Arrest, Out-Of-Hospital, Ketamine | Not applicable | Unknown | Fraser Health | 24 | 2022-02-28 | 2023-01-10 |
| Effects of Bolus Versus Infusion Ketamine During Laparoscopic Cholecystectomy ketamine bolus, ketamin infusion, Normal Saline - Laparoscopic Cholecystectomy, Optic Nerve Sheath Diameter Measurement | Not applicable | Completed | Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital | 102 | 2021-12-01 | 2026-10-30 |
| Opioid-free Anesthesia in Laparoscopic Cholecystectomies ketamine-lidocaine-dexmedetomidine, fentanyl - Pain, Postoperative, Pain, Acute | Not applicable | Unknown | Aretaieion University Hospital | 70 | 2021-10-11 | 2023-02-24 |
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Pain, Postoperative (10) · Agnosia (8) · Chronic Pain (8) · Acute Pain (7) · Neuralgia (4) · Nociceptive Pain (4) · Depression, Postpartum (2) · Pain (2) · Brain Ischemia (1) · Cognitive Dysfunction (1) · Coronary Artery Disease (1) · Genital Diseases, Female (1) · Heart Septal Defects, Atrial (1) · Nausea (1) · Neurologic Manifestations (1)
Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (13) · Neurologic Manifestations (12) · Nervous System Diseases (11) · Pathologic Processes (11) · Postoperative Complications (10) · Pain (9) · Neurobehavioral Manifestations (8) · Perceptual Disorders (8) · Cardiovascular Diseases (4) · Neuromuscular Diseases (4) · Peripheral Nervous System Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (3) · Heart Diseases (3) · Mental Disorders (3)
Ketamine (11) · Fentanyl (5) · Saline Solution (4) · Control Groups (3) · Remifentanil (3) · Bupivacaine (2) · Esketamine (2) · Magnesium Sulfate (2) · Sodium Chloride (2) · Anesthesia, General (1) · Anesthesia, Local (1) · Anesthetics, Local (1) · Dexmedetomidine (1) · Drug Combinations (1) · Lidocaine (1)
Aretaieion University Hospital (6) · Tanta University (4) · Cairo University (3) · Ain Shams University (2) · Peking University First Hospital (2) · Bursa City Hospital (1) · Evangelismos Hospital (1) · Fraser Health (1) · Instituto Mexicano del Seguro Social (1) · Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital (1) · Kasr El Aini Hospital (1) · Ondokuz Mayıs University (1) · State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia (1) · University General Hospital of Patras (1)
Egypt (9) · Greece (8) · Turkey (Türkiye) (3) · China (2) · Canada (1) · Mexico (1) · Russia (1)
Kassiani Theodoraki (3) · Dong-Xin Wang, MD, PhD (2) · Kassiani Theodoraki, PhD, DESA (2) · Boris Teplykh, MD (1) · Ivan Shcheparev, MD, PhD (1) · Kassiani Theodoraki, phD, DESA (1) · Mohammed S Elsharkawy, MD (1)