1787 completed, 327 recruiting, 326 unknown, 187 terminated. 1147 Not applicable, 504 Phase 2, 437 Phase 3, 333 Phase 4, 211 Phase 1.
Follow this condition Literature Review of Depressive Disorder, Major trials Research Report on Depressive Disorder, Major
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module - Severe Mental Illness, Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ludwig-Maximilians - University of Munich | 140 | 2028-10-01 | 2026-05-14 |
| iMORE+ Study: A Multi-Omics Cohort Study of Major Depressive Disorder Major Depressive Disorder (MDD) | Not yet recruiting | Shanghai Mental Health Center | 150 | 2027-09-01 | 2026-08-03 | |
| Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder bupropion hydrobromide, Placebo - Major Depressive Disorder | Phase 4 | Not yet recruiting | Bausch Health Americas, Inc. | 246 | 2027-07-01 | 2026-09-29 |
| Evaluation of the Acceptability, Feasibility and Exploration of the Efficacy of an Integrated Care Pathway CARIBOU CARIBOU Integrated Care Pathway, Treatment as Usual (TAU) - Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | Universidad de los Andes, Chile | 72 | 2027-07-01 | 2026-10-20 |
| Stony Brook Medicine Anti-Inflammatory Trial Celecoxib, Minocycline - Major Depressive Disorder | Phase 4 | Not yet recruiting | Stony Brook University | 42 | 2027-06-01 | 2026-04-23 |
| A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression Symptoms Self-Guided STAIR Coach with Real-Time Assessment, Real-Time Assessment - Psychosocial Functioning, Stress Disorders, Post-Traumatic | Not applicable | Not yet recruiting | VA Office of Research and Development | 40 | 2027-04-01 | 2026-10-06 |
| Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation. Major Depressive Disorder (MDD) | Not yet recruiting | Sohag University | 90 | 2027-03-14 | 2026-08-20 | |
| A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients PDC-1421 Capsule - Major Depressive Disorder | Phase 1 / Phase 2 | Not yet recruiting | BioLite, Inc. | 12 | 2027-01-15 | 2026-04-20 |
| Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder | Not applicable | Not yet recruiting | Central South University | 400 | 2027-01-01 | 2026-03-04 |
| Augmented Depression Therapy (ADepT) Case Series Augmented Depression Therapy (ADepT) - Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ohio State University | 40 | 2027-01-01 | 2026-10-15 |
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder | Phase 2 | Suspended | Massachusetts General Hospital | 35 | 2026-12-01 | 2025-11-13 |
| Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized Trial CAMS Brief Intervention, Stanley-Brown Safety Planning Intervention - Suicidal Ideation, Suicide Attempt | Not applicable | Not yet recruiting | The Cleveland Clinic | 118 | 2026-12-01 | 2026-10-07 |
| Accelerated iTBS for Depression and Suicidality Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT) - Major Depressive Disorder, Suicide | Not applicable | Not yet recruiting | University of Iowa | 50 | 2026-12-01 | 2025-05-20 |
| Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia - Major Depressive Disorder | Not applicable | Not yet recruiting | University of California, San Francisco | 60 | 2026-12-01 | 2026-10-13 |
| EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression MagVenture TMS Therapy System with Localite Navigation System and actiCHamp EEG - Major Depressive Disorder (MDD), Treatment Resistant Depression | Not applicable | Not yet recruiting | Mayo Clinic | 60 | 2026-11-01 | 2026-10-16 |
| Brief Psychoanalytic Therapy Versus Cognitive Behavioral Therapy for Major Depressive Disorder Brief Psychoanalytic Therapy, Cognitive Behavioral Therapy - Major Depressive Disorder (MDD | Not applicable | Not yet recruiting | Istanbul Nisantasi University | 90 | 2026-11-01 | 2026-10-05 |
| Individual Narratives of Stimulation (ECT and TMS) There is no intervention in this observation study (qualitative interviews about past treatment experiences) - Major Depression | Not yet recruiting | University of Nottingham | 12 | 2026-11-01 | 2026-09-30 | |
| Acupuncture and Escitalopram for Treating Major Depression Clinical Study acupuncture, escitalopram, sham-acupuncure - Depressive Disorder, Major | Not applicable | Not yet recruiting | Shanghai 7th People's Hospital | 216 | 2026-11-01 | 2026-03-11 |
| Cortical rTMS as a Treatment for Depression Repetitive Transcranial Magnetic Stimulation - Major Depressive Disorder, Opioid Use Disorder | Not applicable | Recruiting | Baylor College of Medicine | 50 | 2026-11-01 | 2026-10-13 |
| A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness MoodSync, Standard care - Severe Mental Illness, Bipolar Disorder | Not applicable | Not yet recruiting | Alexandria University | 60 | 2026-11-01 | 2026-10-16 |
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Depression (1057) · Bipolar Disorder (248) · Depressive Disorder (212) · Depressive Disorder, Treatment-Resistant (171) · Anxiety Disorders (136) · Mood Disorders (124) · Schizophrenia (118) · Stress Disorders, Post-Traumatic (85) · Mental Disorders (78) · Psychotic Disorders (71) · Generalized Anxiety Disorder (66) · Suicidal Ideation (56) · Dysthymic Disorder (51) · Recurrence (43)
Mental Disorders (2880) · Mood Disorders (2834) · Depressive Disorder (2746) · Behavior (1163) · Behavioral Symptoms (1098) · Bipolar and Related Disorders (246) · Pathological Conditions, Signs and Symptoms (226) · Nervous System Diseases (195) · Schizophrenia Spectrum and Other Psychotic Disorders (139) · Signs and Symptoms (130) · Pathologic Processes (110) · Neurologic Manifestations (100) · Trauma and Stressor Related Disorders (92) · Stress Disorders, Traumatic (83) · Self-Injurious Behavior (74)
Escitalopram (166) · Transcranial Magnetic Stimulation (109) · Ketamine (108) · Duloxetine Hydrochloride (80) · Sertraline (77) · Cognitive Behavioral Therapy (67) · Vortioxetine (64) · Fluoxetine (62) · Therapeutics (62) · Transcranial Direct Current Stimulation (54) · Bupropion (50) · Venlafaxine Hydrochloride (46) · Selective Serotonin Reuptake Inhibitors (44) · Paroxetine (41) · Citalopram (37)
Massachusetts General Hospital (85) · National Institute of Mental Health (NIMH) (65) · Eli Lilly and Company (57) · New York State Psychiatric Institute (50) · Centre for Addiction and Mental Health (48) · Janssen Research & Development, LLC (38) · Shanghai Mental Health Center (38) · Stanford University (38) · University of California, Los Angeles (37) · Otsuka Pharmaceutical Development & Commercialization, Inc. (36) · H. Lundbeck A/S (34) · AstraZeneca (33) · Mclean Hospital (32) · GlaxoSmithKline (29) · Forest Laboratories (27)
United States (1468) · Canada (307) · China (189) · Germany (159) · France (125) · United Kingdom (90) · Spain (87) · Poland (81) · Taiwan (67) · Australia (66) · South Korea (66) · Bulgaria (59) · Israel (58) · Russia (56) · Sweden (56)
Maurizio Fava, MD (14) · Carlos A Zarate, M.D. (13) · Jenna Hoogerheyde (11) · Hesheng Liu, Ph.D. (9) · Carl Gommoll, MS (8)
PMID 25758058, PMID 34817851, PMID 26644956, PMID 26709542, PMID 34183490, PMID 34510411, PMID 24816198, PMID 29140227, PMID 24067192, PMID 24175720, PMID 24571916, PMID 26474010, PMID 30508090, PMID 27685842, PMID 27780334, PMID 31577867, PMID 31818787, PMID 36708956, PMID 23485955, PMID 23497790, PMID 26644957, PMID 29608461, PMID 32242018, PMID 37656180, PMID 21731833, PMID 22106941, PMID 23106023, PMID 23216998, PMID 23585997, PMID 23585999, PMID 23673347, PMID 24127687, PMID 24766999, PMID 25271445, PMID 27035159, PMID 27488181, PMID 29523415, PMID 30439678, PMID 31087825, PMID 34131914, PMID 34874888, PMID 34894307, PMID 36999619, PMID 37099968, PMID 37585253, PMID 38421922, PMID 38819882, PMID 40607746, PMID 40852147, PMID 41055581
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