329 completed, 75 recruiting, 70 unknown, 30 not yet recruiting. 385 Not applicable, 33 Phase 2, 21 Phase 3, 14 Phase 4, 10 Phase 1.
Follow Depression, Postpartum: new trials by email Literature Review of Depression, Postpartum trials Research Report on Depression, Postpartum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Whole-Body Hyperthermia for Mood and Anxiety Disorders Whole-Body Hyperthermia, fMRI - Postpartum Depression, Mood Disorders | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 240 | 2028-06-01 | 2026-06-23 |
| Postpartum Care in the NICU Multi-Site Postpartum Doula Support in the NICU - Postpartum, Postpartum Depression (PPD) | Not applicable | Not yet recruiting | Children's Hospital of Philadelphia | 756 | 2027-01-01 | 2026-10-14 |
| AI-Enabled Wearable Monitoring for Detection of Postpartum Depression and Anxiety Postpartum Depression (PPD), Postpartum Anxiety | Not yet recruiting | University of Hawaii | 100 | 2026-12-01 | 2026-10-21 | |
| Evaluation of the EPDS and PC-PTSD-5 Scales for Screening Postpartum Mental Health Disorders Among Migrant Women. psychiatric interview - Post Partum Depression | Not applicable | Not yet recruiting | Fondation Hôpital Saint-Joseph | 80 | 2026-12-01 | 2026-11-10 |
| Routine vs. Early Postpartum Depression Screening: A Pragmatic Clinical Trial Early PPD Screening - Postpartum Depression (PPD) | Not applicable | Enrolling by invitation | Massachusetts General Hospital | 428 | 2026-11-01 | 2026-11-12 |
| Treatment With Repetitive Transcranial Magnetic Stimulation in Peripartal Depression Repetitive transcranial magnetic stimulation, Sham repetitive transcranial magnetic stimulation - Depression During Pregnancy, Postpartum Depression (PPD) | Not applicable | Recruiting | Psychiatric University Hospital, Zurich | 60 | 2026-10-27 | 2026-11-03 |
| A Web-based Intervention Program for Postpartum Depression Web-based program for postpartum depression - Postpartum Depression (PPD), Web-based Intervention | Early Phase 1 | Recruiting | Babes-Bolyai University | 30 | 2026-10-27 | 2026-10-28 |
| The Goal is to Examine the Impact of Doula-delivered, Nurse-coordinated Postpartum Care Among Individuals With Preterm Births <34 Weeks' Gestation Requiring NICU Admission. Doula-delivered, Nurse-coordinated postpartum support - Doula Support, Postpartum | Not applicable | Recruiting | University of South Carolina | 350 | 2026-10-21 | 2026-10-23 |
| Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms Contingency Management & Problem Solving Therapy, Usual Care - Postpartum Depression (PPD), Alcohol Use | Not applicable | Recruiting | University of Illinois at Chicago | 30 | 2026-10-01 | 2026-10-13 |
| Effect of Peripartum 40 Hz Audiovisual Stimulation on Postpartum Depression in Women Undergoing Elective Cesarean Section: A Randomized Clinical Trial 40 Hz Audiovisual Stimulation, Placebo Audiovisual Stimulation - Depression, Postpartum | Not applicable | Not yet recruiting | The First People's Hospital of Lianyungang | 204 | 2026-10-01 | 2026-09-08 |
| LLM-Generated Medical Summaries During Hospitalization to Improve Patient Activation in High-Risk Pregnancies LLM-Generated Medical Summaries - High-risk Pregnancy, Hospitalization | Not applicable | Not yet recruiting | Sheba Medical Center | 200 | 2026-10-01 | 2026-09-16 |
| Transcranial Magnetic Therapy (TMS) for Treatment of Perinatal Depression Transcranial Magnetic Stimulation (TMS) - Perinatal Depression | Not applicable | Active not recruiting | Rana Jawish | 100 | 2026-09-23 | 2026-11-10 |
| Deconstructing Maternal Burdens: Doulas and the Community Unite for Health Doula, Standard (non-enhanced) Medicaid doula support - Pregnancy, Post Partum | Not applicable | Recruiting | University of Florida | 516 | 2026-09-15 | 2026-09-28 |
| The Effects of a Caregiver-initiated Reading Intervention to Their Infant in the Neonatal Intensive Care Unit Reading Intervention - Infant Admitted to Neonatal Intensive Care Unit (NICU) | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 120 | 2026-09-14 | 2026-08-27 |
| Smartphone-Assisted Single-Session Psychotherapy Intervention for Postpartum Depression Smartphone-Assisted Single-Session Psychotherapy Intervention - Postpartum Depression, Depression | Not applicable | Recruiting | University of Sao Paulo | 104 | 2026-09-09 | 2026-11-09 |
| Early Detection of Perinatal Depression With Wearable Technology Oura Ring (Photoplethysmography-based wearable ring), EmbracePlus Watch (Electrodermal activity wristband sensor) - Perinatal Depression | Not applicable | Not yet recruiting | Women's College Hospital | 10 | 2026-09-01 | 2026-08-25 |
| Multimodal Biomarkers and Precision TMS for Postpartum Depression Repetitive Transcranial Magnetic Stimulation (rTMS) - Depression, Postpartum | Not applicable | Not yet recruiting | University of Macau | 290 | 2026-09-01 | 2026-08-11 |
| Mental and Reproductive Health Integration and Access MARIA Integrated Maternal Mental Health and Family Planning Package - Family Planning Services, Post Partum Depression | Not applicable | Not yet recruiting | Eastern Mediterranean Public Health Network | 920 | 2026-09-01 | 2026-06-22 |
| POSH-Ex: Physiotherapist-Led Telerehabilitation Exercise Programme for Postpartum Sexual Health POSH-Ex (Postpartum Sexual Health Exercise) - Postpartum Sexual Dysfunction, Postpartum Depression | Not applicable | Not yet recruiting | University Medical Centre Ljubljana | 84 | 2026-09-01 | 2026-08-05 |
| Brexanolone Lifting Outcomes Of Moms LPCN 1154A, Placebo - Depression, Postpartum, Postpartum Depression (PPD) | Phase 3 | Recruiting | Lipocine Inc. | 120 | 2026-09-01 | 2026-09-16 |
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Depression (102) · Anxiety Disorders (53) · Breast Feeding (37) · Psychological Well-Being (27) · Premature Birth (24) · Depressive Disorder, Major (20) · Stress Disorders, Post-Traumatic (14) · Motor Activity (13) · Mood Disorders (12) · Puerperal Disorders (12) · Depressive Disorder (10) · Mental Disorders (10) · COVID-19 (8) · Pregnancy Complications (8)
Female Urogenital Diseases and Pregnancy Complications (564) · Urogenital Diseases (564) · Pregnancy Complications (557) · Depressive Disorder (555) · Mental Disorders (555) · Mood Disorders (553) · Puerperal Disorders (553) · Behavior (186) · Behavioral Symptoms (106) · Pathological Conditions, Signs and Symptoms (56) · Signs and Symptoms (41) · Feeding Behavior (37) · Obstetric Labor Complications (30) · Personal Satisfaction (26) · Neurologic Manifestations (22)
Therapeutics (13) · Cognitive Behavioral Therapy (11) · brexanolone (11) · Ketamine (9) · Esketamine (7) · Saline Solution (7) · Exercise (6) · Standard of Care (6) · Estradiol (5) · Interpersonal Psychotherapy (5) · Psychiatric Status Rating Scales (5) · Sertraline (5) · Transcranial Magnetic Stimulation (5) · Quetiapine Fumarate (4) · Sodium Chloride (4)
McMaster University (16) · Northwestern University (11) · Supernus Pharmaceuticals, Inc. (7) · University of North Carolina, Chapel Hill (7) · Women and Infants Hospital of Rhode Island (7) · Columbia University (6) · Istanbul University - Cerrahpasa (6) · Massachusetts General Hospital (6) · Peking University First Hospital (6) · University of California, San Francisco (6) · Washington University School of Medicine (6) · Women's College Hospital (6) · Assistance Publique - Hôpitaux de Paris (5) · Children's Hospital of Philadelphia (5) · Johns Hopkins University (5)
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Ryan Van Lieshout, MD, PhD (6) · Darius Tandon, PhD (4) · Dong-Xin Wang, MD, PhD (4) · Martha G Welch, MD (4) · Sona Dimidjian, PhD (4) · Caron Zlotnick, PhD (3) · Nadia G Diamond-Smith, PhD (3) · Peter J Schmidt, M.D. (3) · Rhonda Boyd, PhD (3) · Scott Stuart, MD (3) · Aaron Williamon, PhD (2) · Alison M El Ayadi, ScD (2) · Antonin Sebela, Ph.D. (2) · Aparna Chaudhari (2) · Beth A Lewis, PhD (2)
PMID 42383885, PMID 34286512, PMID 33181049, PMID 22581378, PMID 25374288, PMID 27227751, PMID 30119704, PMID 30177236, PMID 33078388, PMID 34232578, PMID 39010232, PMID 12171026, PMID 16390366, PMID 17431740, PMID 17993363, PMID 18806079, PMID 19427131, PMID 19819416, PMID 20056720, PMID 20071021, PMID 20654860, PMID 20869936, PMID 20884642, PMID 21381158, PMID 21615968, PMID 21782020, PMID 21984467, PMID 22064874, PMID 22283499, PMID 22314029, PMID 22401479, PMID 22488220, PMID 22629341, PMID 22840621, PMID 22888979, PMID 23215909, PMID 23394227, PMID 23409290, PMID 23460682, PMID 23487258, PMID 23562990, PMID 23977257, PMID 24015137, PMID 24019052, PMID 24063360, PMID 24187119, PMID 24191345, PMID 24262719, PMID 24407163, PMID 24835540
2023 (2), R01MH134538 (2), R21HD101786 (2), R21MD011320 (2), R34MH083866 (2), R61MH118405 (2), 2008 (1), 2017 (1), 2025 (1), 5KL2TR001455 (1), F32MH077371 (1), K23HD065872 (1), K23MD018092 (1), K23MH066265 (1), K23MH090245 (1)