Depression, Postpartum: Clinical Trials

324 completed, 72 unknown, 70 recruiting, 32 not yet recruiting. 380 Not applicable, 34 Phase 2, 21 Phase 3, 14 Phase 4, 10 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	380	Completed 216, Recruiting 53, Unknown 45, Not yet recruiting 26, Active not recruiting 17, Terminated 11, Withdrawn 9, Enrolling by invitation 3
Phase 2	34	Completed 22, Terminated 5, Unknown 3, Active not recruiting 2, Recruiting 1, Withdrawn 1
Phase 3	21	Completed 12, Active not recruiting 3, Recruiting 2, Terminated 2, Unknown 1, Withdrawn 1
Phase 4	14	Completed 7, Unknown 2, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Terminated 1, Withdrawn 1
Phase 1	10	Completed 6, Recruiting 2, Active not recruiting 1, Withdrawn 1
Early Phase 1	4	Completed 2, Unknown 2

Follow Depression, Postpartum: new trials by email Literature Review of Depression, Postpartum trials Research Report on Depression, Postpartum

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Whole-Body Hyperthermia for Mood and Anxiety Disorders Whole-Body Hyperthermia, fMRI - Postpartum Depression, Mood Disorders	Not applicable	Not yet recruiting	Weill Medical College of Cornell University	240	2028-06-01	2026-06-23
Postpartum Care in the NICU Multi-Site Postpartum Doula Support in the NICU - Postpartum, Postpartum Depression (PPD)	Not applicable	Not yet recruiting	Children's Hospital of Philadelphia	756	2027-01-01	2026-10-14
AI-Enabled Wearable Monitoring for Detection of Postpartum Depression and Anxiety Postpartum Depression (PPD), Postpartum Anxiety		Not yet recruiting	University of Hawaii	100	2026-12-01	2026-10-21
Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms Contingency Management & Problem Solving Therapy, Usual Care - Postpartum Depression (PPD), Alcohol Use	Not applicable	Recruiting	University of Illinois at Chicago	30	2026-10-01	2026-10-13
Effect of Peripartum 40 Hz Audiovisual Stimulation on Postpartum Depression in Women Undergoing Elective Cesarean Section: A Randomized Clinical Trial 40 Hz Audiovisual Stimulation, Placebo Audiovisual Stimulation - Depression, Postpartum	Not applicable	Not yet recruiting	The First People's Hospital of Lianyungang	204	2026-10-01	2026-09-08
LLM-Generated Medical Summaries During Hospitalization to Improve Patient Activation in High-Risk Pregnancies LLM-Generated Medical Summaries - High-risk Pregnancy, Hospitalization	Not applicable	Not yet recruiting	Sheba Medical Center	200	2026-10-01	2026-09-16
Deconstructing Maternal Burdens: Doulas and the Community Unite for Health Doula, Standard (non-enhanced) Medicaid doula support - Pregnancy, Post Partum	Not applicable	Recruiting	University of Florida	516	2026-09-15	2026-09-28
The Effects of a Caregiver-initiated Reading Intervention to Their Infant in the Neonatal Intensive Care Unit Reading Intervention - Infant Admitted to Neonatal Intensive Care Unit (NICU)	Not applicable	Not yet recruiting	University of Texas Southwestern Medical Center	120	2026-09-14	2026-08-27
Early Detection of Perinatal Depression With Wearable Technology Oura Ring (Photoplethysmography-based wearable ring), EmbracePlus Watch (Electrodermal activity wristband sensor) - Perinatal Depression	Not applicable	Not yet recruiting	Women's College Hospital	10	2026-09-01	2026-08-25
Treatment With Repetitive Transcranial Magnetic Stimulation in Peripartal Depression Repetitive transcranial magnetic stimulation, Sham repetitive transcranial magnetic stimulation - Depression During Pregnancy, Postpartum Depression (PPD)	Not applicable	Not yet recruiting	Psychiatric University Hospital, Zurich	60	2026-09-01	2026-08-19
Multimodal Biomarkers and Precision TMS for Postpartum Depression Repetitive Transcranial Magnetic Stimulation (rTMS) - Depression, Postpartum	Not applicable	Not yet recruiting	University of Macau	290	2026-09-01	2026-08-11
Routine vs. Early Postpartum Depression Screening: A Pragmatic Clinical Trial Early PPD Screening - Postpartum Depression (PPD)	Not applicable	Not yet recruiting	Massachusetts General Hospital	428	2026-09-01	2026-08-12
Mental and Reproductive Health Integration and Access MARIA Integrated Maternal Mental Health and Family Planning Package - Family Planning Services, Post Partum Depression	Not applicable	Not yet recruiting	Eastern Mediterranean Public Health Network	920	2026-09-01	2026-06-22
POSH-Ex: Physiotherapist-Led Telerehabilitation Exercise Programme for Postpartum Sexual Health POSH-Ex (Postpartum Sexual Health Exercise) - Postpartum Sexual Dysfunction, Postpartum Depression	Not applicable	Not yet recruiting	University Medical Centre Ljubljana	84	2026-09-01	2026-08-05
Brexanolone Lifting Outcomes Of Moms LPCN 1154A, Placebo - Depression, Postpartum, Postpartum Depression (PPD)	Phase 3	Recruiting	Lipocine Inc.	120	2026-09-01	2026-09-16
The Goal is to Examine the Impact of Doula-coordinated, Midwife-delivered Postpartum Care Among Individuals With Preterm Births <34 Weeks' Gestation Requiring NICU Admission. Doula-coordinated, Midwife-delivered postpartum care - Doula Support, Postpartum	Not applicable	Not yet recruiting	University of South Carolina	350	2026-09-01	2026-08-26
Parents and Babies Pilot Parents and Babies Virtual Group Intervention, Parents and Babies Hybrid Group Intervention - Perinatal Depression, Postpartum Depression (PPD)	Not applicable	Recruiting	Northwestern University	16	2026-08-03	2026-08-06
Informing Implementation of a Circadian-Focused Intervention for Postpartum Depression Light therapy - Postpartum Depression (PPD)	Not applicable	Recruiting	University of Michigan	30	2026-07-29	2026-08-14
A Study of MI078 for Postpartum Depression MI078 capsule, Placebo of MI078 capsules - Postpartum Depression (PPD)	Phase 3	Recruiting	Nanjing Minova Pharmaceutical Co., Ltd.	200	2026-07-10	2026-07-23
Women's Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime Ukraine Psychological Assessment, Routine Clinical Data Collection - Perinatal Mental Health, Reproductive Behavior		Recruiting	Taras Shevchenko National University of Kyiv	328	2026-07-07	2026-08-11

Showing 20 of 560. Sign in to see all of them.

Narrower conditions

Depression (101)  ·  Anxiety Disorders (53)  ·  Breast Feeding (37)  ·  Psychological Well-Being (27)  ·  Premature Birth (24)  ·  Depressive Disorder, Major (19)  ·  Stress Disorders, Post-Traumatic (14)  ·  Motor Activity (13)  ·  Puerperal Disorders (12)  ·  Mood Disorders (11)  ·  Depressive Disorder (10)  ·  Mental Disorders (10)  ·  COVID-19 (8)  ·  Pregnancy Complications (8)

Broader conditions

Female Urogenital Diseases and Pregnancy Complications (559)  ·  Urogenital Diseases (559)  ·  Pregnancy Complications (552)  ·  Depressive Disorder (550)  ·  Mental Disorders (550)  ·  Mood Disorders (549)  ·  Puerperal Disorders (548)  ·  Behavior (185)  ·  Behavioral Symptoms (105)  ·  Pathological Conditions, Signs and Symptoms (56)  ·  Signs and Symptoms (41)  ·  Feeding Behavior (37)  ·  Obstetric Labor Complications (30)  ·  Personal Satisfaction (26)  ·  Neurologic Manifestations (22)

Interventions

Therapeutics (13)  ·  Cognitive Behavioral Therapy (11)  ·  brexanolone (11)  ·  Ketamine (9)  ·  Esketamine (7)  ·  Saline Solution (7)  ·  Exercise (6)  ·  Standard of Care (6)  ·  Estradiol (5)  ·  Interpersonal Psychotherapy (5)  ·  Psychiatric Status Rating Scales (5)  ·  Sertraline (5)  ·  Quetiapine Fumarate (4)  ·  Sodium Chloride (4)  ·  Transcranial Magnetic Stimulation (4)

Sponsors

McMaster University (16)  ·  Northwestern University (11)  ·  Supernus Pharmaceuticals, Inc. (7)  ·  University of North Carolina, Chapel Hill (7)  ·  Women and Infants Hospital of Rhode Island (7)  ·  Columbia University (6)  ·  Istanbul University - Cerrahpasa (6)  ·  Massachusetts General Hospital (6)  ·  Peking University First Hospital (6)  ·  University of California, San Francisco (6)  ·  Washington University School of Medicine (6)  ·  Women's College Hospital (6)  ·  Assistance Publique - Hôpitaux de Paris (5)  ·  Children's Hospital of Philadelphia (5)  ·  Johns Hopkins University (5)

Countries

United States (215)  ·  Turkey (Türkiye) (55)  ·  Canada (50)  ·  France (23)  ·  China (20)  ·  United Kingdom (16)  ·  Pakistan (12)  ·  Israel (10)  ·  Hong Kong (9)  ·  Italy (8)  ·  Denmark (7)  ·  India (6)  ·  Spain (6)  ·  Taiwan (6)  ·  Australia (5)

Top investigators

Ryan Van Lieshout, MD, PhD (6)  ·  Darius Tandon, PhD (4)  ·  Dong-Xin Wang, MD, PhD (4)  ·  Martha G Welch, MD (4)  ·  Sona Dimidjian, PhD (4)  ·  Caron Zlotnick, PhD (3)  ·  Nadia G Diamond-Smith, PhD (3)  ·  Peter J Schmidt, M.D. (3)  ·  Rhonda Boyd, PhD (3)  ·  Scott Stuart, MD (3)  ·  Aaron Williamon, PhD (2)  ·  Alison M El Ayadi, ScD (2)  ·  Antonin Sebela, Ph.D. (2)  ·  Aparna Chaudhari (2)  ·  Beth A Lewis, PhD (2)

Results publications

PMID 42383885, PMID 34286512, PMID 33181049, PMID 22581378, PMID 25374288, PMID 27227751, PMID 30119704, PMID 30177236, PMID 33078388, PMID 34232578, PMID 39010232, PMID 12171026, PMID 16390366, PMID 17431740, PMID 17993363, PMID 18806079, PMID 19427131, PMID 19819416, PMID 20056720, PMID 20071021, PMID 20654860, PMID 20869936, PMID 20884642, PMID 21381158, PMID 21615968, PMID 21782020, PMID 21984467, PMID 22064874, PMID 22283499, PMID 22314029, PMID 22401479, PMID 22488220, PMID 22629341, PMID 22840621, PMID 22888979, PMID 23215909, PMID 23394227, PMID 23409290, PMID 23460682, PMID 23487258, PMID 23562990, PMID 23977257, PMID 24015137, PMID 24019052, PMID 24063360, PMID 24187119, PMID 24191345, PMID 24262719, PMID 24407163, PMID 24835540

NIH funding

2023 (2), R01MH134538 (2), R21HD101786 (2), R21MD011320 (2), R34MH083866 (2), R61MH118405 (2), 2008 (1), 2017 (1), 2025 (1), 5KL2TR001455 (1), F32MH077371 (1), K23HD065872 (1), K23MD018092 (1), K23MH066265 (1), K23MH090245 (1)