7229 completed, 1665 unknown, 1368 recruiting, 661 not yet recruiting. 8006 Not applicable, 875 Phase 2, 596 Phase 3, 551 Phase 4, 387 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module - Severe Mental Illness, Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ludwig-Maximilians - University of Munich | 140 | 2028-10-01 | 2026-05-14 |
| INNOV5-MH-MAROC: Integrated Mental Health Care for Adolescents and Adults in Primary Care Centers and Schools in Morocco INNOV5 Integrated Mental Health Program, Enhanced Treatment as Usual (TAU+) - Depression in Adolescence, Depression in Adults | Not applicable | Not yet recruiting | Swiss Medical Academy Maroc | 146 | 2028-03-01 | 2025-12-02 |
| Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE Stepped collaborative care intervention, Enhanced Usual Care - Cancer, Depression | Not applicable | Not yet recruiting | University of Pittsburgh | 40 | 2028-01-14 | 2026-04-09 |
| Pilot Randomized Trial of BA-GSH in VA PC-MHI Behavioral Activation-Guided Self-Help - Depression | Not applicable | Not yet recruiting | VA Office of Research and Development | 30 | 2027-10-15 | 2026-04-21 |
| Regulating Together for Intellectual Disability and Autism: A Group Behavioral Therapy for for Emotion Dysregulation Regulating Together group therapy - Autism, Intellectual Disabilities With Other Behavioral Symptoms | Not applicable | Recruiting | Children's Mercy Hospital Kansas City | 10 | 2027-10-01 | 2026-09-03 |
| Improving Affordability in Cancer Care Through Economic Screening and Support (I-ACCESS) Financial counseling and navigation - Cancer, Financial Burden | Not applicable | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 220 | 2027-09-01 | 2026-06-24 |
| AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN YOUTH Peer-mentoring behavioral intervention, Health Education - Anxiety Depression | Not applicable | Not yet recruiting | University of Patras | 1680 | 2027-09-01 | 2026-04-14 |
| Prevalence of Depression Among Patients With Alopecia Areata Observation only - Alopecia Areata Depression, Depression | Not yet recruiting | Sohag University | 100 | 2027-09-01 | 2026-07-17 | |
| Whole Selves User Testing and Feasibility Study Whole Selves - Alcohol Use, Unspecified, Relationship, Social | Not applicable | Not yet recruiting | Boston University | 107 | 2027-09-01 | 2026-07-28 |
| Mitigating Burnout in Nursing and Associated Healthcare Staff Zen Den Experience, Music Therapy Experience - Burn Out, Nurses | Not applicable | Not yet recruiting | Milton S. Hershey Medical Center | 300 | 2027-09-01 | 2026-06-05 |
| Mental Health INtervention With Digital APPlications (MIND-APP): Randomized Controlled Researcher Blinded Trial Evaluating the Effectiveness of the Tankevirus and Grubl Mental Health Apps Tankevirus, Grubl, Placebo Application - Anxiety, Depression | Not applicable | Not yet recruiting | University Hospital, Akershus | 1000 | 2027-08-15 | 2026-06-04 |
| Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania IDEAS-AUD - Alcohol Use Disorder, Suicide Prevention | Not applicable | Not yet recruiting | Duke University | 30 | 2027-08-01 | 2026-03-17 |
| Apple Watch Evaluation of Endodontics Occupational Stress Occupational Stress | Not yet recruiting | University of Illinois at Chicago | 12 | 2027-08-01 | 2026-10-06 | |
| Monitoring Occupational Dental Stress Using Apple Watch Occupational Stress | Not yet recruiting | University of Illinois at Chicago | 10 | 2027-08-01 | 2026-10-06 | |
| Developing and Piloting an Implementation Strategy for a Brief, Motivational Interviewing-based Lethal Means Safety Counseling Intervention in Primary Care Settings RAMP, Active control - Suicide Prevention | Not applicable | Not yet recruiting | VA Office of Research and Development | 50 | 2027-07-01 | 2025-11-25 |
| Improving Quality of Informal Care for People With Schizophrenia Dyadic Multicomponent Intervention (DMI), Dyadic Benefit-Finding Intervention (DBFI) - Schizophrenia | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 228 | 2027-07-01 | 2026-08-25 |
| Leveraging Video Vignettes and Social Media to Promote Safe Firearm Storage Among Veterans WAV videos, VA News videos, VA LMS brochure - Lethal Means Safety | Not applicable | Not yet recruiting | VA Office of Research and Development | 654 | 2027-07-01 | 2026-08-13 |
| Health Coaching and Veteran Reintegration Health Coaching, Enhanced treatment as usual - Reintegration Into Civilian Life | Phase 2 | Not yet recruiting | VA Office of Research and Development | 398 | 2027-07-01 | 2026-07-24 |
| Virtual Intervention for Behavioral Health in Emerging Adults; "VIBE in the Parks" "VIBE in the Parks", Digital Control - Anxiety, Depression | Not applicable | Not yet recruiting | University of Illinois at Chicago | 268 | 2027-07-01 | 2026-04-23 |
| Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment Sildenafil - Cancer | Phase 2 / Phase 3 | Not yet recruiting | The University of Texas Medical Branch, Galveston | 30 | 2027-06-15 | 2026-05-11 |
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Depression (8219) · Anxiety Disorders (3054) · Depressive Disorder, Major (1112) · Stress, Psychological (831) · Psychological Well-Being (610) · Suicide (603) · Suicidal Ideation (563) · Stress Disorders, Post-Traumatic (546) · Caregiver Burden (483) · Burnout, Psychological (451) · Depressive Disorder (437) · Bipolar Disorder (341) · Sleep Initiation and Maintenance Disorders (332) · Dementia (308) · Pain (308)
Behavior (12162) · Mental Disorders (6408) · Pathological Conditions, Signs and Symptoms (2645) · Nervous System Diseases (2116) · Signs and Symptoms (2108) · Mood Disorders (1663) · Neurologic Manifestations (1315) · Stress, Psychological (1249) · Depressive Disorder (1154) · Self-Injurious Behavior (1029) · Central Nervous System Diseases (958) · Brain Diseases (899) · Pathologic Processes (831) · Neurocognitive Disorders (729)
Therapeutics (325) · Cognitive Behavioral Therapy (287) · Escitalopram (164) · Ketamine (157) · Exercise (136) · Transcranial Magnetic Stimulation (123) · Sertraline (120) · Surveys and Questionnaires (98) · Fluoxetine (81) · Mindfulness (81) · Transcranial Direct Current Stimulation (81) · Methods (79) · Standard of Care (68) · Citalopram (66) · Duloxetine Hydrochloride (65)
Massachusetts General Hospital (211) · VA Office of Research and Development (173) · University of Pittsburgh (121) · University of Michigan (108) · National Institute of Mental Health (NIMH) (106) · University of Washington (99) · University of California, Los Angeles (95) · Stanford University (93) · Yale University (87) · New York State Psychiatric Institute (86) · University of California, San Francisco (85) · University of Pennsylvania (85) · Duke University (83) · Karolinska Institutet (78) · Northwestern University (71)
United States (5322) · Canada (689) · Turkey (Türkiye) (577) · France (497) · China (420) · United Kingdom (395) · Germany (354) · Spain (342) · Sweden (271) · Taiwan (207) · Denmark (196) · Italy (172) · Hong Kong (165) · Norway (156) · Netherlands (154)
Maurizio Fava, MD (16) · Gwendolyn Portzky, PhD (15) · Asle Hoffart, PhD (14) · Gerhard Andersson, PhD (14) · Carlos A Zarate, M.D. (13) · Heather Hadjistavropoulos, PhD (11) · Sverre Urnes Johnson, PhD (11) · Amit Anand, MD (10)
PMID 33884617, PMID 32368793, PMID 33677832, PMID 32627860, PMID 40243391, PMID 2748771, PMID 34817851, PMID 34510411, PMID 16717171, PMID 25080392, PMID 11556941, PMID 31577867, PMID 34131914, PMID 37811711, PMID 39428602, PMID 17074942, PMID 24067192, PMID 24816198, PMID 26474010, PMID 26644957, PMID 30508090, PMID 31969269, PMID 32364251, PMID 32378735, PMID 32476658, PMID 32608505, PMID 33417236, PMID 34689733, PMID 36375174, PMID 36708956, PMID 37656180, PMID 40681915, PMID 41130742, PMID 41533472, PMID 41961243, PMID 42393474, PMID 16390886, PMID 21348556, PMID 23485955, PMID 23497790, PMID 24175720, PMID 24571916, PMID 24960439, PMID 25677353, PMID 25758058, PMID 26644956, PMID 26709542, PMID 29140227, PMID 29523415, PMID 29747068
2023 (35), 2025 (21), 2016 (13), 2008 (12), P50MH115838 (12), 2019 (10), P50MH115837 (10), 2009 (8), 2017 (8), 2018 (8), 2014 (7), P30MH085943 (7), 2015 (6), P30CA012197 (6), P50MH113838 (6)