11 completed, 4 recruiting, 3 unknown, 1 active not recruiting. 21 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 21 | Completed 11, Recruiting 4, Unknown 3, Active not recruiting 1, Not yet recruiting 1, Terminated 1 |
Follow Ketamine: new trials by email Literature Review of Ketamine trials Research Report on Ketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Propofol-Ketamine Versus Sevoflurane for Laryngeal Mask Anesthesia in Pediatric Cardiac Catheterization Ketamine-Propofol, Sevoflurane - Propofol, Ketamine | Phase 4 | Recruiting | Rawalpindi Institute of Cardiology | 68 | 2026-10-24 | 2026-10-30 |
| Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial Esketamine combined with dexmedetomidine, Dexmedetomidine - Dexmedetomidine, Ketamine | Phase 4 | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 356 | 2026-09-28 | 2026-09-03 |
| Biomarker-Guided Antidepressant Selection TMS, Ketamine - Depression - Major Depressive Disorder, Treatment-resistant Depression (TRD) | Phase 4 | Recruiting | Weill Medical College of Cornell University | 27 | 2026-08-10 | 2026-11-06 |
| Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE) Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU) - Suicide Prevention, Ketamine | Phase 4 | Recruiting | University of Sao Paulo | 478 | 2026-06-01 | 2026-09-16 |
| Effect of Low-dose Esketamine on Maternal Depression at 3 Years After Childbirth Esketamine, Placebo - Prenatal Depression, Ketamine | Phase 4 | Active not recruiting | Peking University First Hospital | 364 | 2023-09-09 | 2024-12-05 |
| Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy Ketamine + Levobupivacaine, Levobupivacaine - Ketamine, Levobupivacaine | Phase 4 | Completed | Tanta University | 60 | 2023-08-30 | 2024-02-13 |
| Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias Repair Dexmedetomidine, Ketamine, Magnesium sulphate - Preemptive Analgesia, Dexmedetomidine | Phase 4 | Unknown | Kafrelsheikh University | 75 | 2023-05-15 | 2023-06-13 |
| Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression VTS-K - Treatment Resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Theresa Jacob, PhD, MPH | 15 | 2022-12-06 | 2026-04-21 |
| Ketamine Versus Propofol as ICU Sedation Ketamine, Propofol - Ketamine, Propofol | Phase 4 | Completed | Menoufia University | 100 | 2022-10-01 | 2024-02-06 |
| Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients Esketamine combined with dexmedetomidine, Dexmedetomidine - Dexmedetomidine, Ketamine | Phase 4 | Unknown | The First Affiliated Hospital with Nanjing Medical University | 100 | 2022-08-11 | 2024-05-07 |
| Effects of Subanesthetic Dose of Ketamine Given on Postoperative Mood in Patients Undergoing Fractional Curettage Ketamine, Saline - Ketamine, Minor Surgical Procedure | Phase 4 | Completed | Istanbul Training and Research Hospital | 140 | 2022-04-01 | 2023-12-06 |
| Esketamine Sedation and Fentanyl Sedation in Pediatric Dental Patients Fentanyl, Esketamine, Midazolam - Ketamine, Fentanyl | Phase 4 | Completed | Peking University | 48 | 2022-01-01 | 2022-03-15 |
| The Impact of Perioperative Ketamine Infusion on Surgical Recovery Ketamine, Placebo - Opioid Use, Enhanced Recovery After Surgery | Phase 4 | Completed | Vanderbilt University Medical Center | 1570 | 2021-04-12 | 2025-02-04 |
| Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures Intravenous Ketamine, Intranasal Ketamine - Trauma, Fractures, Closed | Phase 4 | Terminated | University of Alabama at Birmingham | 40 | 2019-09-09 | 2023-04-20 |
| Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy Ketamine, Midazolam, Fentanyl - Conscious Sedation, Patient Satisfaction | Phase 4 | Completed | Brooke Army Medical Center | 66 | 2019-07-15 | 2023-12-26 |
| Comparison Between Low-dose Ketamine Infusion and Intravenous Morphine Ketamine group:, Control group - Ketamine | Phase 4 | Completed | Cairo University | 80 | 2019-02-21 | 2020-07-30 |
| Ketamine Co-induction for Patients With Major Depressive Disorder Ketamine Hydrochloride, Propofol, Fentanyl - Ketamine, Depression | Phase 4 | Unknown | University of Saskatchewan | 50 | 2018-12-01 | 2018-09-13 |
| PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery. Ketamine-Morphine, Morphine - Ketamine, Morphine | Phase 4 | Completed | National University of Malaysia | 60 | 2018-04-05 | 2023-08-24 |
| PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery Ketamine-Morphine, Morphine - Ketamine, Morphine | Phase 4 | Completed | Universiti Kebangsaan Malaysia Medical Centre | 60 | 2018-04-05 | 2023-09-01 |
| Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression Ketamine, Placebo - Perinatal Depression, Ketamine | Phase 4 | Completed | Peking University First Hospital | 64 | 2017-11-23 | 2021-12-13 |
Showing 20 of 21. Sign in to see all of them.
Agnosia (3) · Depressive Disorder, Treatment-Resistant (3) · Depression (2) · Depression, Postpartum (2) · Acute Pain (1) · Chronic Pain (1) · Depressive Disorder, Major (1) · Emergencies (1) · Fractures, Bone (1) · Fractures, Closed (1) · Hypospadias (1) · Pain, Postoperative (1) · Patient Satisfaction (1) · Psychomotor Agitation (1) · Suicide Prevention (1)
Pathological Conditions, Signs and Symptoms (6) · Behavior (5) · Depressive Disorder (5) · Mental Disorders (5) · Mood Disorders (5) · Neurologic Manifestations (5) · Signs and Symptoms (5) · Behavioral Symptoms (4) · Female Urogenital Diseases and Pregnancy Complications (3) · Nervous System Diseases (3) · Neurobehavioral Manifestations (3) · Perceptual Disorders (3) · Urogenital Diseases (3) · Pain (2) · Pathologic Processes (2)
Ketamine (11) · Dexmedetomidine (3) · Fentanyl (3) · Sodium Chloride (3) · Esketamine (2) · Midazolam (2) · Morphine (2) · Propofol (2) · Saline Solution (2) · Aspirin (1) · Control Groups (1) · Fumigant 93 (1) · Levobupivacaine (1) · Magnesium Sulfate (1) · Sevoflurane (1)
Peking University First Hospital (2) · The First Affiliated Hospital with Nanjing Medical University (2) · University of Saskatchewan (2) · Brooke Army Medical Center (1) · Cairo University (1) · Istanbul Training and Research Hospital (1) · Kafrelsheikh University (1) · Menoufia University (1) · National University of Malaysia (1) · Peking University (1) · Rawalpindi Institute of Cardiology (1) · Tanta University (1) · Theresa Jacob, PhD, MPH (1) · Universiti Kebangsaan Malaysia Medical Centre (1) · University of Alabama at Birmingham (1)
China (5) · United States (5) · Egypt (4) · Malaysia (2) · Brazil (1) · Canada (1) · Pakistan (1) · Turkey (Türkiye) (1)
Jonathan Gamble, MD (2) · Britany L Raymond, MD (1) · Chian Yong Liu, MMed (Anaes) (1) · Conor Liston, MD, PhD (1) · Dong-Xin Wang, MD, PhD (1) · Dong-Xin Wang, MD,PhD (1) · James Statler, MD (1) · Jess Anderson, DO (1) · Judson Barber, MD (1) · Mostafa Saieed Mansour, MD (1) · Theresa Jacob, PhD, MPH (1) · Xudong Yang, MD (1) · Yong C Liu, MMed (Anaes) (1)
PMID 29850262, PMID 36570810, PMID 36993617, PMID 37391729, PMID 38956664, PMID 40739637, PMID 40903379, PMID 42372120, PMID 42548425
UG3MH137656 (1)