100 completed, 51 unknown, 32 recruiting, 21 not yet recruiting. 79 Not applicable, 65 Phase 4, 25 Phase 1, 23 Phase 3, 20 Phase 2.
Follow Esketamine: new trials by email Literature Review of Esketamine trials Research Report on Esketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial. Esketamine, Placebo - Endometriosis | Phase 4 | Not yet recruiting | Region Skane | 1000 | 2028-01-01 | 2026-10-19 |
| Intravenous Ketamine for Acute Suicidal Crisis and Psychiatric Hospital Length of Stay Esketamine, Midazolam (Intravenous) - Suicidal Ideation, Suicidal Behavior | Phase 2 | Not yet recruiting | University of Sao Paulo | 106 | 2027-04-30 | 2026-10-22 |
| Propofol or Esketamine: Tracheal Intubation Comparison Esketamine, Propofol - Critically Ill Adults Requiring Emergency Tracheal Intubation in the Intensive Care Unit | Phase 4 | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 130 | 2026-10-08 | 2026-09-29 |
| Intranasal Dexmedetomidine Combined With Esketamine for Emergence Quality After Suspension Laryngoscopy Dexmedetomidin, Esketamine - Emergence Agitation, Vocal Cord Polyps | Not applicable | Not yet recruiting | The First Hospital of Jilin University | 134 | 2026-09-01 | 2026-10-19 |
| The Effect of Intraoperative Infusion of Esketamine on Cholestatic Pruritus in Patients Undergoing Hepatobiliary Surgery Esketamine, normal Saline - Cholestatic Pruritus | Not applicable | Not yet recruiting | Tianjin Medical University General Hospital | 100 | 2026-08-15 | 2026-08-12 |
| Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy Fentanyl and Propofol, Esketamine and remimazolam - Adverse Respiratory Events, Hypoxemia | Phase 4 | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 120 | 2026-08-01 | 2026-08-06 |
| Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants. Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine - Knee Osteoarthritis, Replacement, Knee | Not applicable | Recruiting | China-Japan Friendship Hospital | 100 | 2026-07-30 | 2026-10-28 |
| A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression Esketamine 56 mg, Esketamine 84 mg, Placebo - Depressive Disorder, Treatment-Resistant | Phase 3 | Recruiting | Janssen Research & Development, LLC | 348 | 2026-07-23 | 2026-09-25 |
| The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline Anesthesia Midazolam, Dexmedetomidine, Esketamine - Depth of Anesthesia Monitoring, BIS-EEG | Not applicable | Recruiting | China-Japan Friendship Hospital | 120 | 2026-07-14 | 2026-10-28 |
| Esketamine Versus Sufentanil for Sedation in Patients Undergoing ERCP Esketamine, Sufentanil - Biliary Tract Diseases, Procedural Sedation and Analgesia | Not applicable | Not yet recruiting | Ren Da | 530 | 2026-07-10 | 2026-07-14 |
| The Effect of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Oral and Maxillofacial Surgery esketamine, Normal Saline - Perioperative Neurocognitive Disorders | Not applicable | Not yet recruiting | Xijing Hospital | 98 | 2026-07-01 | 2026-06-24 |
| The Effects of Different Anesthetics on the Brain's Neural Networks propofol, Dexmeditomidine, Esketamine - Electroencephalogram (EEG), Anesthesia | Phase 4 | Not yet recruiting | Fudan University | 120 | 2026-06-09 | 2026-06-12 |
| The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Open Thyroid Surgery Esketamine, Normal Saline - Thyroidectomy, Coughing Reflex | Not applicable | Not yet recruiting | The Second Hospital of Anhui Medical University | 136 | 2026-06-01 | 2026-06-04 |
| Intranasal Dexmedetomidine or Esketamine for Negative Postoperative Behavioral Changes in Children Dexmedetomidine, Esketamine, Normal Saline - Behavior Problem | Phase 4 | Not yet recruiting | Nanjing Children's Hospital | 342 | 2026-06-01 | 2026-05-06 |
| The Effect of Intraoperative Esketamine Infusion on Pruritus in Elderly Surgical Patients Esketamine, Normal Saline - Senile Pruritus | Not applicable | Not yet recruiting | Tianjin Medical University General Hospital | 200 | 2026-05-15 | 2026-05-19 |
| The Effect of a Single Intravenous Injection of Esketamine During Cesarean Section on Postoperative Pruritus in Patients With Intrahepatic Cholestasis of Pregnancy Normal Saline (0.9% NaCl), Esketamine 0.3mg/kg - Intrahepatic Cholestasis of Pregnancy | Not applicable | Not yet recruiting | Tianjin Medical University General Hospital | 160 | 2026-05-05 | 2026-05-01 |
| The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoperative Depression Esketamine, Dexmedetomidine - Depressed, Bariatric Surgery | Phase 4 | Active not recruiting | The First Hospital of Jilin University | 40 | 2026-05-01 | 2026-05-08 |
| Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-16 |
| Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-14 |
| Effect of Esketamine on Postoperative Sleep in Postmenopausal Women Esketamine, Normal Saline - Circadian Rhythm, Postoperative Sleep Disturbance | Not applicable | Recruiting | Zhuan Zhang | 164 | 2026-03-01 | 2026-08-31 |
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Depression (24) · Depressive Disorder, Treatment-Resistant (21) · Depressive Disorder, Major (18) · Pain, Postoperative (18) · Pain (13) · Agnosia (12) · Anxiety Disorders (10) · Depression, Postpartum (7) · Emergence Delirium (7) · Acute Pain (4) · Breast Neoplasms (4) · Parasomnias (4) · Sleep Initiation and Maintenance Disorders (4) · Autism Spectrum Disorder (3) · Bipolar Disorder (3)
Janssen Research & Development, LLC (35) · Peking University First Hospital (17) · Beijing Tiantan Hospital (13) · Tianjin Medical University General Hospital (9) · Chinese PLA General Hospital (6) · University of Sao Paulo (5) · Eye & ENT Hospital of Fudan University (4) · Second Affiliated Hospital of Wenzhou Medical University (4) · Second Affiliated Hospital, Zhejiang University, School of Medicine (4) · The Second Affiliated Hospital of Chongqing Medical University (4) · Yangzhou University (4) · Maternal and Child Health Hospital of Hubei Province (3) · The First Hospital of Jilin University (3) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (3) · Beijing Friendship Hospital (2)
China (121) · United States (30) · Belgium (19) · Brazil (14) · Germany (9) · Poland (9) · Spain (8) · Finland (7) · France (7) · Hungary (7) · Sweden (7) · Austria (6) · Bulgaria (6) · Canada (6) · Netherlands (6)
Dong-Xin Wang, MD, PhD (10) · Dong-Xin Wang, MD,PhD (5) · Guolin Wang (5) · Fang Tan (3) · Huacheng Liu (3) · Ruquan Han, M.D., Ph D. (3) · Guolin Wang, MD (2) · Huang He, MD (2) · Jiancheng Zhang, MD, PhD (2) · Kenneth Jensen, M.D. (2) · Pierre Chue, MBBCh (2) · Samuel Wilkinson, MD (2) · Weidong Mi, MD (2)
PMID 33128208, PMID 32860422, PMID 34235612, PMID 34510411, PMID 39428602, PMID 35022754, PMID 38557430, PMID 29656663, PMID 32367114, PMID 34288609, PMID 34973081, PMID 35816217, PMID 35904046, PMID 36149841, PMID 36273682, PMID 37019044, PMID 37302963, PMID 37439961, PMID 37568081, PMID 11936706, PMID 16192522, PMID 16415311, PMID 16531445, PMID 17563882, PMID 18478130, PMID 18653496, PMID 20172253, PMID 20407257, PMID 21256625, PMID 21277735, PMID 21818162, PMID 22174469, PMID 23170921, PMID 23382625, PMID 23394227, PMID 23513321, PMID 23893490, PMID 24785989, PMID 25038833, PMID 25318000, PMID 25335575, PMID 25587641, PMID 26142712, PMID 26707087, PMID 26739975, PMID 27607187, PMID 28086004, PMID 28414899, PMID 28576285, PMID 29202655
2014 (11), 2016 (4), 2017 (2), 2015 (1), 2018 (1), 2019 (1)