2627 completed, 548 unknown, 534 recruiting, 249 terminated. 2004 Not applicable, 651 Phase 2, 532 Phase 3, 433 Phase 4, 292 Phase 1.
Follow Depressive Disorder: new trials by email Literature Review of Depressive Disorder trials Research Report on Depressive Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module - Severe Mental Illness, Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ludwig-Maximilians - University of Munich | 140 | 2028-10-01 | 2026-05-14 |
| Whole-Body Hyperthermia for Mood and Anxiety Disorders Whole-Body Hyperthermia, fMRI - Postpartum Depression, Mood Disorders | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 240 | 2028-06-01 | 2026-06-23 |
| ACT for Veterans With IBD and Mental Health Challenges Acceptance and Commitment Therapy - Inflammatory Bowel Diseases, Crohn's Disease | Not applicable | Not yet recruiting | VA Office of Research and Development | 50 | 2028-01-01 | 2026-02-09 |
| iMORE+ Study: A Multi-Omics Cohort Study of Major Depressive Disorder Major Depressive Disorder (MDD) | Not yet recruiting | Shanghai Mental Health Center | 150 | 2027-09-01 | 2026-08-03 | |
| Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder bupropion hydrobromide, Placebo - Major Depressive Disorder | Phase 4 | Not yet recruiting | Bausch Health Americas, Inc. | 246 | 2027-07-01 | 2026-09-29 |
| Evaluation of the Acceptability, Feasibility and Exploration of the Efficacy of an Integrated Care Pathway CARIBOU CARIBOU Integrated Care Pathway, Treatment as Usual (TAU) - Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | Universidad de los Andes, Chile | 72 | 2027-07-01 | 2026-10-20 |
| Stony Brook Medicine Anti-Inflammatory Trial Celecoxib, Minocycline - Major Depressive Disorder | Phase 4 | Not yet recruiting | Stony Brook University | 42 | 2027-06-01 | 2026-04-23 |
| Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Randomized Controlled Trial UJI Online Transdiagnostic Protocol, UJI On Line Transdiagnostic Hibrid Protocol - Emotional Disorders, Anxiety | Not applicable | Not yet recruiting | Universitat Jaume I | 366 | 2027-05-01 | 2026-05-27 |
| A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression Symptoms Self-Guided STAIR Coach with Real-Time Assessment, Real-Time Assessment - Psychosocial Functioning, Stress Disorders, Post-Traumatic | Not applicable | Not yet recruiting | VA Office of Research and Development | 40 | 2027-04-01 | 2026-10-06 |
| Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation. Major Depressive Disorder (MDD) | Not yet recruiting | Sohag University | 90 | 2027-03-14 | 2026-08-20 | |
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder Psilocybin - Treatment Resistant Depression, Substance Use Disorders | Phase 1 / Phase 2 | Not yet recruiting | Indiana University | 50 | 2027-02-01 | 2026-10-23 |
| A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients PDC-1421 Capsule - Major Depressive Disorder | Phase 1 / Phase 2 | Not yet recruiting | BioLite, Inc. | 12 | 2027-01-15 | 2026-04-20 |
| Qualitative Study of Student Financial Insecurity and Psychiatry Semi-structured interviews - Depressive Disorder, Generalized Anxiety Disorder | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 30 | 2027-01-01 | 2026-08-05 | |
| Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder | Not applicable | Not yet recruiting | Central South University | 400 | 2027-01-01 | 2026-03-04 |
| The SPARK-PMDD Study Premenstrual Dysphoric Disorder, PMDD | Not yet recruiting | King's College London | 120 | 2027-01-01 | 2026-08-18 | |
| Postpartum Care in the NICU Multi-Site Postpartum Doula Support in the NICU - Postpartum, Postpartum Depression (PPD) | Not applicable | Not yet recruiting | Children's Hospital of Philadelphia | 756 | 2027-01-01 | 2026-10-14 |
| Augmented Depression Therapy (ADepT) Case Series Augmented Depression Therapy (ADepT) - Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ohio State University | 40 | 2027-01-01 | 2026-10-15 |
| Effect of Neurofeedback and TMS Repetitive Transcranial Magnetic Stimulation, Alpha-down EEG Neurofeedback - Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Massachusetts General Hospital | 20 | 2027-01-01 | 2026-10-23 |
| Psilocybin for Depression in Veterans Psilocybin, modafinil, zolpidem - Major Depression | Phase 2 | Not yet recruiting | VA Office of Research and Development | 150 | 2027-01-01 | 2026-10-26 |
| Feasibility, Acceptability, and Preliminary Effectiveness of Cognitive Behavioral Therapy for Depression in Autistic Youth in Clinical Settings CBT-DAY (Cognitive Behavioral Therapy for Depression in Autistic Youth), Treatment-as-Usual (TAU) - Autism Spectrum Disorder, Depressive Disorder | Not applicable | Not yet recruiting | Children's Hospital Los Angeles | 140 | 2026-12-01 | 2026-08-10 |
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Depressive Disorder, Major (2963) · Depression (1510) · Depression, Postpartum (560) · Depressive Disorder, Treatment-Resistant (447) · Anxiety Disorders (374) · Bipolar Disorder (329) · Mood Disorders (190) · Schizophrenia (145) · Mental Disorders (141) · Stress Disorders, Post-Traumatic (128) · Psychological Well-Being (96) · Psychotic Disorders (88) · Suicidal Ideation (79) · Generalized Anxiety Disorder (77)
Mental Disorders (4338) · Mood Disorders (4289) · Behavior (1757) · Behavioral Symptoms (1561) · Urogenital Diseases (588) · Female Urogenital Diseases and Pregnancy Complications (576) · Pregnancy Complications (555) · Puerperal Disorders (548) · Pathological Conditions, Signs and Symptoms (427) · Bipolar and Related Disorders (326) · Nervous System Diseases (295) · Signs and Symptoms (248) · Pathologic Processes (212) · Neurologic Manifestations (179)
Escitalopram (193) · Ketamine (153) · Transcranial Magnetic Stimulation (144) · Sertraline (108) · Therapeutics (102) · Duloxetine Hydrochloride (98) · Cognitive Behavioral Therapy (97) · Fluoxetine (77) · Transcranial Direct Current Stimulation (69) · Vortioxetine (66) · Bupropion (60) · Venlafaxine Hydrochloride (56) · Psilocybin (55) · Paroxetine (54) · Citalopram (52)
Massachusetts General Hospital (104) · National Institute of Mental Health (NIMH) (82) · New York State Psychiatric Institute (70) · GlaxoSmithKline (68) · Centre for Addiction and Mental Health (62) · Eli Lilly and Company (60) · Stanford University (59) · Janssen Research & Development, LLC (53) · Shanghai Mental Health Center (45) · VA Office of Research and Development (40) · Mclean Hospital (38) · University of California, Los Angeles (38) · Otsuka Pharmaceutical Development & Commercialization, Inc. (37) · AstraZeneca (35) · H. Lundbeck A/S (35)
United States (2039) · Canada (432) · China (271) · Germany (239) · France (200) · United Kingdom (157) · Spain (138) · Turkey (Türkiye) (104) · Poland (98) · Taiwan (87) · Australia (84) · Sweden (81) · Israel (77) · South Korea (77) · Denmark (75)
Maurizio Fava, MD (15) · Carlos A Zarate, M.D. (13) · Hesheng Liu, Ph.D. (11) · Jenna Hoogerheyde (11)
PMID 34817851, PMID 25758058, PMID 39428602, PMID 34510411, PMID 26644956, PMID 26709542, PMID 34183490, PMID 42383885, PMID 24816198, PMID 29140227, PMID 24067192, PMID 24175720, PMID 24571916, PMID 26474010, PMID 30508090, PMID 27685842, PMID 27780334, PMID 31577867, PMID 31818787, PMID 33128208, PMID 34131914, PMID 36708956, PMID 23485955, PMID 23497790, PMID 26644957, PMID 27488181, PMID 29608461, PMID 32242018, PMID 32860422, PMID 34235612, PMID 34286512, PMID 34874888, PMID 37656180, PMID 38819882, PMID 11556941, PMID 17074942, PMID 21731833, PMID 22106941, PMID 23106023, PMID 23146246, PMID 23216998, PMID 23585997, PMID 23585999, PMID 23673347, PMID 23982301, PMID 24127687, PMID 24766999, PMID 25271445, PMID 27035159, PMID 29282469
2008 (15), 2023 (13), 2025 (13), 2019 (12), 2014 (11), 2018 (11), 2016 (10), 2015 (8), 2017 (7), 2009 (3), R25DA020537 (3), 2005 (2), 271201100006I-0-27100007-1 (2), 5UH3NS103550 (2), K23MH076049 (2)