4 completed, 1 recruiting, 1 terminated, 1 unknown. 7 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 1 | Completed 1 |
Follow Ketamine: new trials by email Literature Review of Ketamine trials Research Report on Ketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression (2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg), Placebo - Suicide, Depressive Disorder, Treatment-Resistant | Phase 2 | Recruiting | National Institute of Mental Health (NIMH) | 50 | 2024-11-06 | 2026-10-05 |
| Continuous IntraVenous Infusion of Ketamine in Terminally Ill Cancer Patients Ketamine - Ketamine, Refractory Cancer Pain | Phase 2 | Terminated | Pusan National University Yangsan Hospital | 20 | 2018-06-01 | 2026-09-18 |
| Rapid Agitation Control With Ketamine in the Emergency Department Ketalar, Midazolam injection, Haloperidol - Violent Aggressive Behavior, Ketamine | Phase 2 | Completed | David Barbic | 81 | 2018-05-29 | 2020-11-30 |
| Perioperative Ketamine for Pain With Gastric Bypass Ketamine, Standard therapy - Laparoscopic Gastric Bypass Surgery, Ketamine | Phase 2 | Completed | Mayo Clinic | 34 | 2018-04-16 | 2021-04-29 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) electroconvulsive therapy (ECT), Ketamine - Treatment Resistant Depression, Electroconvulsive Therapy | Phase 2 / Phase 3 | Completed | Bo Hu | 403 | 2017-04-07 | 2023-09-28 |
| Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter (S)-ketamine (Main study), (S)-ketamine (Pilot II), (R,S)-ketamine (Pilot II) - Depression, Ketamine | Phase 2 | Unknown | Medical University of Vienna | 74 | 2016-05-01 | 2018-10-15 |
| Use of S+Ketamine During Target-Controlled Intravenous Anaesthesia After Abdominal Hysterectomy Esketamine, Saline, Remifentanil - Ketamine, Anesthesia | Phase 2 | Completed | KK Women's and Children's Hospital | 90 | 2014-03-01 | 2026-08-14 |
Depression (3) · Depressive Disorder (2) · Depressive Disorder, Major (2) · Depressive Disorder, Treatment-Resistant (2) · Mental Disorders (2) · Aggression (1) · Behavioral Symptoms (1) · Cancer Pain (1) · Emergencies (1) · Mood Disorders (1) · Suicide (1)
Behavior (4) · Behavioral Symptoms (3) · Pathological Conditions, Signs and Symptoms (2) · Aberrant Motor Behavior in Dementia (1) · Disease Attributes (1) · Mood Disorders (1) · Neurologic Manifestations (1) · Pain (1) · Pathologic Processes (1) · Self-Injurious Behavior (1) · Signs and Symptoms (1) · Social Behavior (1)
Ketamine (6) · 6-hydroxynorketamine (1) · Electroconvulsive Therapy (1) · Esketamine (1) · Haloperidol (1) · Midazolam (1) · Propofol (1) · Remifentanil (1) · Sodium Chloride (1) · Standard of Care (1)
Bo Hu (1) · David Barbic (1) · KK Women's and Children's Hospital (1) · Mayo Clinic (1) · Medical University of Vienna (1) · National Institute of Mental Health (NIMH) (1) · Pusan National University Yangsan Hospital (1)
United States (3) · Austria (1) · Canada (1) · Singapore (1) · South Korea (1)
Amit Anand, MD (1) · Andrew W Gorlin, M.D. (1) · Carlos A Zarate, M.D. (1) · David Barbic, MD MSc FRCPC, (1) · Farida Ithnin, MBBCh (1) · Kwonoh Park, MD, PhD (1) · Rupert Lanzenberger, Prof. (1)
PMID 11027905, PMID 11576800, PMID 1349061, PMID 17355955, PMID 22965960, PMID 28657160, PMID 29045739, PMID 30477544, PMID 30572160, PMID 37224232, PMID 38752431, PMID 40900112, PMID 8577492
2014 (1)