46 completed, 14 recruiting, 13 terminated, 10 unknown. 99 Phase 3, 20 Phase 2.
Follow Delirium: new trials by email Literature Review of Delirium trials Research Report on Delirium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive Care Dexmedetomidine, Midazolam - Delirium in the Intensive Care Unit | Phase 3 | Not yet recruiting | University Hospital, Tours | 266 | 2026-11-15 | 2026-09-28 |
| Lactium Premedication to Prevent Emergence Agitation Lactium - Lactium, Premedication | Phase 3 | Recruiting | Tanta University | 40 | 2026-11-04 | 2026-11-05 |
| Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy Lidocaine, 0.9% Normal Saline - Emergence Agitation, Emergence Delirium | Phase 3 | Not yet recruiting | Assiut University | 60 | 2026-11-01 | 2026-10-13 |
| KetAmine and Recovery After Mechanical VentilAtion ( KARMA ) Intervention Group, Placebo - Critical Illness | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 640 | 2026-10-19 | 2026-05-15 |
| Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline - Postoperative Delirium, Hip Fractures | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 130 | 2026-10-01 | 2026-09-09 |
| Ketofol Versus Ketodex for POD Prophylaxis in Elderly Cancer Surgery Group ketofol, Group ketodex, Group Control - Postoperative Delirium (POD) | Phase 3 | Recruiting | Cairo University | 180 | 2026-07-01 | 2026-06-04 |
| Oral Versus Intravenous Magnesium on Emergence Delirium Magnesium glycinate, Magnesium sulfate injection, Oral juice and intravenous saline - Magnesium, Emergence Delirium | Phase 2 / Phase 3 | Recruiting | Tanta University | 360 | 2026-07-01 | 2026-07-06 |
| MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES) Dexmedetomidine, Placebo - Major Abdominal Surgery, Postoperative Delirium (POD) | Phase 2 / Phase 3 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 400 | 2026-05-01 | 2026-04-20 |
| Intranasal Insulin to Prevent Intensive Care Unit Delirium Intranasal insulin-40U, Intranasal sodium chloride 0.9% - Delirium - Postoperative | Phase 2 / Phase 3 | Completed | Radboud University Medical Center | 30 | 2026-04-30 | 2026-08-03 |
| Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery Fluvoxamine, Placebo - Delirium, Surgery-Complications | Phase 3 | Recruiting | Washington University School of Medicine | 46 | 2026-04-06 | 2026-04-29 |
| Melatonin vs Midazolam in Children Undergoing Tonsillectomy Melatonin group, Midazolam group, Control group - Emergence Delirium, Anesthesia, Child | Phase 3 | Not yet recruiting | Ain Shams University | 195 | 2026-03-01 | 2026-01-13 |
| Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery Аrgon-oxygen breathing mixture, Nitrogen-oxygen breathing mixture - Carotid Artery Disease, Carotid Artery Stenoses | Phase 3 | Recruiting | Negovsky Reanimatology Research Institute | 100 | 2025-09-22 | 2026-06-18 |
| The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium Sleep Hygiene, Brain Game, and IV Acetaminophen Intervention, Control - Delirium, Postoperative, Delirium in Old Age | Phase 3 | Recruiting | Beth Israel Deaconess Medical Center | 406 | 2025-06-06 | 2026-04-15 |
| Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery Acetaminophen, Saline - Delirium in Old Age | Phase 2 / Phase 3 | Not yet recruiting | RenJi Hospital | 1930 | 2025-06-01 | 2025-04-04 |
| Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients Dexmedetomidine nasal spray - Postoperative Delirium, Preoperative Sleep Disorder | Phase 3 | Completed | Xijing Hospital | 686 | 2025-03-03 | 2026-11-13 |
| The Effect of Oral Gabapentin on Emergence Agitation and Delirium in Adult Patients After Nasal Surgery. Gabapentin 600 mg capsules, Gabapentin 400 mg capsules, Placebo - Emergence Agitation | Phase 3 | Not yet recruiting | Cairo University | 63 | 2025-03-01 | 2025-03-21 |
| MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children Melatonin, Isotonic sodium chloride solution - Emergence Delirium | Phase 3 | Recruiting | Arash Afshari | 676 | 2025-01-21 | 2026-08-18 |
| Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II) Intravenous Dexmedetomidine, Sublingual Dexmedetomidine, Intravenous Placebo - Delirium | Phase 3 | Recruiting | Massachusetts General Hospital | 1800 | 2025-01-06 | 2026-09-14 |
| Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium Sevoflurane, Isoflurane - Delirium on Emergence | Phase 3 | Recruiting | Mayo Clinic | 400 | 2024-12-20 | 2025-12-16 |
| Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery Liraglutide injection, Placebo injection - Delirium, Postoperative | Phase 3 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 260 | 2024-11-19 | 2024-12-20 |
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Emergence Delirium (41) · Critical Illness (9) · Nervous System Diseases (7) · Cognitive Dysfunction (6) · Pain, Postoperative (6) · Mental Disorders (5) · Postoperative Cognitive Complications (5) · Psychomotor Agitation (5) · Alzheimer Disease (4) · Central Nervous System Diseases (4) · Dementia (4) · Brain Diseases (3) · Cognition Disorders (3) · Depression (3)
Neurobehavioral Manifestations (99) · Neurologic Manifestations (99) · Pathological Conditions, Signs and Symptoms (99) · Signs and Symptoms (99) · Confusion (98) · Neurocognitive Disorders (97) · Mental Disorders (94) · Nervous System Diseases (92) · Pathologic Processes (59) · Postoperative Complications (42) · Disease Attributes (12) · Cognition Disorders (11) · Behavior (10) · Behavioral Symptoms (8)
Dexmedetomidine (23) · Haloperidol (11) · Saline Solution (11) · Sodium Chloride (9) · Melatonin (6) · Midazolam (5) · Donepezil (4) · Quetiapine Fumarate (4) · Acetaminophen (3) · Clonidine (3) · Ketamine (3) · Chlorpromazine (2) · Control Groups (2) · Gabapentin (2) · Lidocaine (2)
Assistance Publique - Hôpitaux de Paris (7) · Assiut University (5) · Cairo University (3) · M.D. Anderson Cancer Center (3) · RenJi Hospital (3) · Vanderbilt University Medical Center (3) · Washington University School of Medicine (3) · Ain Shams University (2) · Beth Israel Deaconess Medical Center (2) · Chiang Mai University (2) · Deventer Ziekenhuis (2) · Hospira, now a wholly owned subsidiary of Pfizer (2) · Massachusetts General Hospital (2) · Negovsky Reanimatology Research Institute (2) · Tanta University (2)
United States (32) · France (12) · Egypt (8) · Canada (7) · China (7) · Netherlands (7) · Denmark (4) · Australia (3) · Italy (3) · Japan (3) · Russia (3) · Saudi Arabia (3) · Brazil (2) · Germany (2) · Spain (2)
David Hui (2) · Naoki Kubota (2) · Alan J Chaput, MD, MSc (1) · Alessandro Santini, MD (1) · Aminah Jatoi, MD (1) · Andrew Barker, MD (1) · Andrew Davis, MBBS (1) · Anthony Delaney, MBBS (1) · Antonio Pesenti, MD (1) · Anwar Huda, FRCA (1) · Arash Afshari, PhD (1) · Arash L Afshari, MD, PhD (1) · Balachundhar Subramaniam, MD, MPH (1) · Barbara Power, MD (1)
PMID 12534838, PMID 15480814, PMID 15935018, PMID 16181185, PMID 16914695, PMID 16979083, PMID 18041437, PMID 20487083, PMID 23926422, PMID 26171895, PMID 26975647, PMID 27767991, PMID 28576285, PMID 28651648, PMID 28935558, PMID 29678977, PMID 29866205, PMID 29926288, PMID 30243062, PMID 30336852, PMID 30346242, PMID 30768457, PMID 31112380, PMID 31764959, PMID 32102644, PMID 32197636, PMID 32479786, PMID 32678054, PMID 32967873, PMID 33528922, PMID 33692183, PMID 34462007, PMID 34952881, PMID 35396310, PMID 35667730, PMID 36215171, PMID 36590787, PMID 37029295, PMID 37068889, PMID 37535937, PMID 37904241, PMID 38252439, PMID 38419119, PMID 38701817, PMID 38710325, PMID 38883767, PMID 39110454, PMID 39150711, PMID 39446661, PMID 39921932
2016 (3), 2009 (1), 2015 (1), 2017 (1), 2025 (1), K23HL078760 (1), R01AG053582 (1), R01AG065554 (1), R01GM112871 (1), R21AG086855 (1), R21NR016736 (1), R61HL151951 (1)