178 completed, 35 unknown, 22 terminated, 17 recruiting. 95 Not applicable, 54 Phase 3, 48 Phase 4, 46 Phase 2, 8 Phase 1.
Follow Psychomotor Agitation: new trials by email Literature Review of Psychomotor Agitation trials Research Report on Psychomotor Agitation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep Ferrous Sulfate, Placebo - ADHD, Sleep Problems | Phase 1 / Phase 2 | Not yet recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 70 | 2027-03-01 | 2026-05-04 |
| Virtual Reality to Advance Dementia Care and Quality of Life Supervised Virtual Reality Sessions - Dementia, Agitation | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 10 | 2026-12-01 | 2026-10-26 |
| Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial Esketamine combined with dexmedetomidine, Dexmedetomidine - Dexmedetomidine, Ketamine | Phase 4 | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 356 | 2026-09-28 | 2026-09-03 |
| A Computer-Assisted Tool for Objective Assessment of Extrapyramidal Symptoms Computer-Assisted Objective Assessment of Extrapyramidal Symptoms - Extrapyramidal Symptoms, Drug-induced Parkinsonism | Not yet recruiting | Shanghai Mental Health Center | 180 | 2026-07-01 | 2026-07-21 | |
| Clinical Trial of Peer Support in the ED (PCORI) Peer-Support Enhanced Agitation Code Team (PACT) - Psychomotor Agitation, Behavioral Disorder | Not applicable | Not yet recruiting | Yale University | 57870 | 2026-07-01 | 2026-05-18 |
| Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients Virtual reality (VR) therapy - Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients | Not applicable | Completed | Milton S. Hershey Medical Center | 20 | 2026-06-02 | 2026-10-23 |
| Effect of Daily Screen Time on Postoperative Emergence Delirium in Children Aged 2-11 Years Daily Screen Exposure Duration - Agitation, Postoperative Agitation | Recruiting | Kanuni Sultan Suleyman Training and Research Hospital | 288 | 2026-05-01 | 2026-08-05 | |
| Activation-Socialization Intervention Program for Seniors Activation and Socialization Intervention Program - Healthy | Not applicable | Enrolling by invitation | Diana Ďuricová | 200 | 2026-04-20 | 2026-04-09 |
| ED-TREAT (Early Detection and Treatment to Reduce Events With Agitation Tool) Compared to Usual Care ED-TREAT - Psychomotor Agitation, Behavioral Disorder | Not applicable | Suspended | Yale University | 26 | 2026-04-01 | 2026-03-12 |
| Inhibition of Aggressive Behavior in Participants With Fragile X Syndrome SRX246, Placebo - Aggressive Behavior in Fragile X Syndome | Phase 2 | Not yet recruiting | Azevan Pharmaceuticals | 80 | 2026-03-01 | 2026-01-09 |
| Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit Personalized Music, Relaxing Music, Standard of Care - Critical Illness, Delirium | Not applicable | Recruiting | HOSPITAL BRITANICO DE BUENOS AIRES | 330 | 2026-02-02 | 2026-02-04 |
| The Effect of Therapeutic Touch on Agitation, Pain, and Cortisol Levels in Intensive Care Patients Therapeutic Touch - Therapeutic Touch | Not applicable | Not yet recruiting | Firat University | 60 | 2025-12-31 | 2025-11-17 |
| PARO-agitation-study PARO - Agitation, POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE | Not applicable | Recruiting | Hannover Medical School | 300 | 2025-12-15 | 2026-05-05 |
| Melatonin for Post Tonsillectomy Emergence Agitation in Pediatric Melatonin, Placebo - Post Tonsillectomy Emergence Agitation | Not applicable | Recruiting | Benha University | 120 | 2025-12-10 | 2026-07-17 |
| Therapeutic Cuddling in Critically Ill Children Therapeutic cuddling, Standard of care - Pain, Delirium in the Intensive Care Unit | Not applicable | Recruiting | University of Calgary | 112 | 2025-12-08 | 2026-05-01 |
| A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3) KarXT, KarX-EC - Alzheimer Disease, Agitation | Phase 3 | Recruiting | Bristol-Myers Squibb | 650 | 2025-12-02 | 2026-10-16 |
| Protocolized Receptive Music Intervention to Reduce Care Refusal in Nursing Home Residents With Major Neurocognitive Disorders Receptive music therapy, Standard Nursing Home Care - Dementia, Cognitive Dysfunction | Not applicable | Recruiting | LNA SANTE | 60 | 2025-10-30 | 2026-07-28 |
| Impact of Harp Therapy on Behavioral Disorders in Nursing Home Residents With Neurodegenerative Disease (ARPE) Harp therapy (receptive music therapy) - Neurodegenerative Diseases, Behavioral Symptoms | Completed | LNA SANTE | 25 | 2025-10-01 | 2026-08-07 | |
| Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type 12 cm2 - 2 Active DMTS Patches, 6 cm2 - 1 Active and 1 Placebo DMTS Patches, Placebo - 2 Placebo DMTS Patches - Agitation | Phase 2 | Active not recruiting | Teikoku Pharma USA, Inc. | 150 | 2025-09-16 | 2026-10-27 |
| Effect of Virtual Reality on Agitation in Acute Stroke Virtual Reality Application, Standard Care (in control arm) - Acute Stroke, Psychomotor Agitation | Not applicable | Completed | Ankara Etlik City Hospital | 68 | 2025-09-08 | 2026-08-26 |
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Dementia (71) · Alzheimer Disease (69) · Delirium (30) · Pain (23) · Aggression (20) · Anxiety Disorders (20) · Schizophrenia (20) · Psychotic Disorders (19) · Emergence Delirium (14) · Mental Disorders (13) · Behavior (12) · Depression (12) · Cognitive Dysfunction (9) · Bipolar Disorder (8)
Dyskinesias (284) · Neurologic Manifestations (284) · Pathological Conditions, Signs and Symptoms (284) · Signs and Symptoms (284) · Nervous System Diseases (281) · Neurobehavioral Manifestations (281) · Psychomotor Disorders (281) · Aberrant Motor Behavior in Dementia (278) · Behavioral Symptoms (275) · Behavior (269) · Mental Disorders (189) · Neurocognitive Disorders (144) · Central Nervous System Diseases (117) · Brain Diseases (114) · Neurodegenerative Diseases (71)
Dexmedetomidine (37) · Haloperidol (18) · Loxapine (10) · Midazolam (10) · Saline Solution (10) · Olanzapine (9) · Sodium Chloride (9) · Risperidone (8) · Standard of Care (8) · Ketamine (6) · Quetiapine Fumarate (6) · ziprasidone (6) · Lorazepam (5) · Music Therapy (5) · Valproic Acid (5)
BioXcel Therapeutics Inc (12) · Otsuka Pharmaceutical Development & Commercialization, Inc. (10) · Assistance Publique - Hôpitaux de Paris (5) · Axsome Therapeutics, Inc. (5) · Hennepin Healthcare Research Institute (5) · Alexza Pharmaceuticals, Inc. (4) · University Hospital, Clermont-Ferrand (4) · Ain Shams University (3) · Johns Hopkins University (3) · National Institute on Aging (NIA) (3) · New York State Psychiatric Institute (3) · Seoul National University Hospital (3) · Sunnybrook Health Sciences Centre (3) · ACADIA Pharmaceuticals Inc. (2) · Alexandria University (2)
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PMID 40681915, PMID 41533472, PMID 41961243, PMID 39108660, PMID 41591746, PMID 23245705, PMID 23422376, PMID 24035670, PMID 29163985, PMID 31708380, PMID 34532852, PMID 35703367, PMID 36002761, PMID 40847656, PMID 41439450, PMID 41689409, PMID 42052145, PMID 42502037, PMID 10692189, PMID 11001602, PMID 11087767, PMID 11133600, PMID 11442853, PMID 11473855, PMID 11604980, PMID 12040306, PMID 15114210, PMID 15840076, PMID 16247923, PMID 16677266, PMID 16879517, PMID 17035647, PMID 17416907, PMID 17984395, PMID 18519523, PMID 19369318, PMID 19454032, PMID 19700947, PMID 19709377, PMID 20214847, PMID 20418301, PMID 20492042, PMID 20492047, PMID 20497353, PMID 20528148, PMID 20621273, PMID 20705788, PMID 21294997, PMID 21323778, PMID 21476613
2023 (3), 2005 (2), 2016 (2), 2017 (2), 1RC2AG036535 (1), 2008 (1), 2009 (1), 2025 (1), K23MH126366 (1), N01MH090001 (1), N01MH90001 (1), P30AG073105 (1), P50AG005136 (1), R01AG010172 (1), R01AG018644 (1)