732 completed, 309 unknown, 187 recruiting, 140 not yet recruiting. 591 Not applicable, 176 Phase 4, 100 Phase 3, 84 Phase 2, 25 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-surgical Delirium in Patients Undergoing Radical Cystectomy. Radical cystectomy. - Delirium, Radical Cystectomy | Not yet recruiting | University of Alexandria | 100 | 2028-11-25 | 2025-04-03 | |
| Post-surgical Delirium in Patients Undergoing Open Heart Surgery. Open heart surgery - Delirium, Open Heart Surgery | Not yet recruiting | University of Alexandria | 300 | 2028-10-01 | 2025-04-03 | |
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| Concurrent Trials on Nature-Based Therapy for Inpatients in Dementia and Rehabilitation Medicine Wards Nature Immersion Therapy - Dementia, Acquired Brain Injury Including Stroke | Not applicable | Not yet recruiting | Changi General Hospital | 1600 | 2027-05-01 | 2026-03-23 |
| Lorazepam for Delirium Prevention in Critically Ill Patients With High Anttila-Index Lorazepam 1 mg, Placebo - Delirium Confusional State | Phase 4 | Not yet recruiting | University Hospital, Basel, Switzerland | 260 | 2027-03-01 | 2026-02-27 |
| Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment - Carotid Stenosis, Carotid Artery Diseases | Not yet recruiting | Nguyen Toan Thang | 150 | 2027-01-01 | 2026-09-11 | |
| Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle Dexmedetomidine, Control (placebo) group - Sleep, Delirium | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-12-01 | 2026-10-13 |
| The Impact of Left Stellate Ganglion Block on Systemic Inflammation and Neuromodulation in CABG Surgery. Stellate Ganglion Block - Delirium - Postoperative, Inflammation Biomarkers | Not applicable | Not yet recruiting | OMAR ABDELAZIZ ABOELFADL | 81 | 2026-12-01 | 2026-08-20 |
| reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit Sleep chronobundle, Control - Sleep, Circadian Dysregulation | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-11-30 | 2026-10-21 |
| Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive Care Dexmedetomidine, Midazolam - Delirium in the Intensive Care Unit | Phase 3 | Not yet recruiting | University Hospital, Tours | 266 | 2026-11-15 | 2026-09-28 |
| Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy Lidocaine, 0.9% Normal Saline - Emergence Agitation, Emergence Delirium | Phase 3 | Not yet recruiting | Assiut University | 60 | 2026-11-01 | 2026-10-13 |
| Post-Stroke Enhancement of Delirium Outcomes With Reduction in Neuro-checks Decreased Neuro Checks overnight - Stroke, Acute, Stroke, Ischemic | Not applicable | Suspended | Medical University of South Carolina | 538 | 2026-11-01 | 2026-04-09 |
| Effects of PNB Timing on Postoperative Delirium for Hip Fracture Peripheral Nerve Block for Hip Fracture - Delirium - Postoperative | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 120 | 2026-11-01 | 2026-10-02 | |
| 40 Hz Gamma Auditory Stimulation for Delirium Prevention in Critically Ill ICU Patients 40 Hz Gamma Auditory Stimulation, Silent Audio Control - Delirium | Not applicable | Not yet recruiting | Peking Union Medical College Hospital | 142 | 2026-10-31 | 2026-10-15 |
| KetAmine and Recovery After Mechanical VentilAtion ( KARMA ) Intervention Group, Placebo - Critical Illness | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 640 | 2026-10-19 | 2026-05-15 |
| Patients With Long-stay at ICU: Factors and Evaluation - Feasibility Study Frailty, Delirium Confusional State | Not yet recruiting | Uppsala University | 300 | 2026-10-01 | 2026-10-01 | |
| Transcranial Doppler and Artificial Intelligence Prediction of Postoperative Delirium in Heart Valve Surgery Postoperative Delirium, Heart Valve Diseases | Not yet recruiting | Osman Sila Aydin | 120 | 2026-10-01 | 2026-10-05 | |
| Postoperative Delirium and Analgesia in Elderly Patients adductor canal block and biFes block including bupivacain, Periarticular infiltration - Postoperative Delirium, Postoperative Pain, Acute | Not applicable | Not yet recruiting | Ankara City Hospital Bilkent | 300 | 2026-10-01 | 2026-09-30 |
| Sleep Harmonization Via Bundled Team-Based Interventions in the ICU Nighttime noise & light reduction, Clustering patient-care interactions, Non-pharmacologic sleep aids - Sleep Deprivation, Critical Illness | Not applicable | Not yet recruiting | University of California, San Diego | 62500 | 2026-10-01 | 2026-09-25 |
| Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline - Postoperative Delirium, Hip Fractures | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 130 | 2026-10-01 | 2026-09-09 |
Showing 20 of 1540. Sign in to see all of them.
Delirium (880) · Emergence Delirium (730) · Cognitive Dysfunction (124) · Postoperative Cognitive Complications (91) · Critical Illness (78) · Dementia (61) · Pain (51) · Pain, Postoperative (49) · Postoperative Complications (45) · Psychomotor Agitation (42) · Hip Fractures (38) · Anxiety Disorders (36) · Depression (30) · Neurocognitive Disorders (28)
Pathological Conditions, Signs and Symptoms (1540) · Signs and Symptoms (1532) · Neurobehavioral Manifestations (1530) · Neurologic Manifestations (1529) · Nervous System Diseases (1523) · Mental Disorders (1490) · Neurocognitive Disorders (1484) · Pathologic Processes (924) · Postoperative Complications (732) · Delirium (625) · Cognition Disorders (192) · Central Nervous System Diseases (131) · Brain Diseases (120) · Behavior (112)
Dexmedetomidine (159) · Propofol (77) · Saline Solution (74) · Sevoflurane (48) · Sodium Chloride (45) · Midazolam (33) · Ketamine (31) · Haloperidol (27) · Melatonin (23) · Fentanyl (20) · Standard of Care (14) · Electroencephalography (13) · remimazolam (12) · Desflurane (11) · Ear Protective Devices (11)
Charite University, Berlin, Germany (26) · Peking University First Hospital (21) · Chinese PLA General Hospital (18) · Assiut University (17) · Assistance Publique - Hôpitaux de Paris (15) · Vanderbilt University Medical Center (15) · Ain Shams University (14) · Beijing Tiantan Hospital (14) · RenJi Hospital (14) · Yonsei University (14) · Tanta University (13) · University Hospital, Basel, Switzerland (13) · Seoul National University Hospital (12) · Beth Israel Deaconess Medical Center (11) · University Health Network, Toronto (11)
United States (311) · China (251) · Turkey (Türkiye) (122) · Canada (89) · Germany (70) · Egypt (67) · South Korea (62) · France (54) · Netherlands (36) · Italy (33) · Denmark (31) · United Kingdom (24) · Spain (22) · Switzerland (19) · Taiwan (18)
Claudia Spies, MD, Prof. (18) · Dong-Xin Wang, MD, PhD (15) · Nicolai Goettel, MD (7) · Charles Brown, MD (4) · Dong-Xin Wang, MD,PhD (4) · E Wesley Ely, MD, MPH (4) · Liwei Wang, Doctor (4) · Yangzi Zhu, Doctor (4) · Azra Bihorac, MD (3) · Balachundhar Subramaniam, MD, MPH (3) · Hina Faisal, MD (3) · Jian-Xin Zhou, MD (3) · Jin H Han, MD, MSc (3) · Lian Kah Ti (3) · Malaz Boustani, MD, MPH (3)
PMID 23992774, PMID 15114210, PMID 15082703, PMID 22323509, PMID 28576285, PMID 19745202, PMID 22762316, PMID 25535538, PMID 28973626, PMID 33238043, PMID 37535937, PMID 10053175, PMID 11129764, PMID 11797025, PMID 12760985, PMID 14980921, PMID 15562048, PMID 16540616, PMID 17179249, PMID 18577850, PMID 18686756, PMID 19347026, PMID 19687169, PMID 19865006, PMID 20047899, PMID 20497353, PMID 20526708, PMID 21926597, PMID 22091567, PMID 22301509, PMID 23182527, PMID 23506796, PMID 24088092, PMID 24287327, PMID 24441670, PMID 25348864, PMID 26077062, PMID 26118922, PMID 26275092, PMID 26418126, PMID 26601849, PMID 27660922, PMID 27798810, PMID 27922747, PMID 28263192, PMID 28593326, PMID 28601132, PMID 29728150, PMID 30113379, PMID 30721296
2014 (3), 2016 (3), 2025 (3), R01NS120924 (3), 2009 (2), 2017 (2), 2019 (2), R01AG053582 (2), R21AG075230 (2), R21EB027344 (2), U54AG063546 (2), 1RF1AG077557-01 (1), 1UG3HL165740-01A1 (1), 1UH2AG050312-01 (1), 2015 (1)