11 completed, 6 unknown, 2 recruiting, 2 withdrawn. 7 Phase 3, 5 Phase 1, 5 Phase 2, 4 Phase 4, 3 Not applicable.
Follow Chlorpromazine: new trials by email Literature Review of Chlorpromazine trials Research Report on Chlorpromazine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Preliminary Efficacy of Hibernation-Like Therapy (Chlorpromazine and Promethazine) in Patients With Acute Ischemic Stroke (AIS) Eligible for Reperfusion Therapy. Hibernation-like Therapy (Chlorpromazine and Promethazine, C+P) - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Ji Xunming,MD,PhD | 57 | 2026-01-01 | 2026-01-23 |
| Study on Hibernation-like Therapy Based on Mechanical Thrombectomy chlorpromazine and promethazine, Placebo group, endovascular thrombectomy - Acute Ischemic Stroke | Phase 1 | Recruiting | Capital Medical University | 32 | 2024-11-09 | 2024-12-20 |
| Correlation of Genetic Variations With Clinical Response in Substance Use Disorder Quetiapine, olanzapine, mirtazapine, carbamazepine, sertraline, amitriptyline, chlorpromazine and risperidone - Substance Use Disorders, Substance Dependence | Unknown | Alexandria University | 200 | 2022-11-28 | 2023-04-27 | |
| Repurposing the Antipsychotic Drug Chlorpromazine as Adjuvant Therapeutic Agent for Resected Stage III Colon Cancer ChlorproMAZINE 50 MG, Control - Colon Cancer Stage III | Phase 1 / Phase 2 | Withdrawn | Sadat City University | 2022-07-20 | 2022-10-27 | |
| Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy Haloperidol, Chlorpromazine, Valproate - Delirium, Epileptics | Phase 2 / Phase 3 | Recruiting | M.D. Anderson Cancer Center | 42 | 2022-07-19 | 2025-11-18 |
| Chlorpromazine and Standard of Care in Glioblastoma Chlorpromazine, Temozolomide, Radiation Therapy - Glioblastoma Multiforme | Phase 1 | Completed | Mohammed Milhem | 10 | 2022-01-28 | 2025-09-02 |
| Administration of Chlorpromazine as a Treatment for COVID-19 Chlorpromazine - COVID-19 | Phase 2 / Phase 3 | Unknown | Cairo University | 100 | 2020-08-01 | 2020-07-08 |
| Comparison of Chlorpromazine or Pentobarbital Premedications for Pediatric Imaging Procedures Chlorpromazine or Pentobarbital - Children Sedation | Unknown | University Hospital, Brest | 254 | 2020-04-30 | 2020-04-17 | |
| Repurposing of Chlorpromazine in Covid-19 Treatment CHLORPROMAZINE (CPZ), Standard of Care (SOC) - COVID-19 | Phase 3 | Withdrawn | Centre Hospitalier St Anne | 2020-04-29 | 2024-07-10 | |
| Repurposing Chlorpromazine in the Treatment of Glioblastoma Chlorpromazine Pill - Glioblastoma Multiforme, MGMT-Unmethylated Glioblastoma | Phase 2 | Unknown | Marco G Paggi, MD, PhD | 41 | 2019-12-15 | 2020-01-13 |
| Bioequivalence Study in Healthy Subjects by Using of Chlorpromazine HCl 100mg Tablets Chlorpromazine HCl 100mg Tablets - Healthy Subject | Phase 1 | Completed | Whanin Pharmaceutical Company | 70 | 2018-12-06 | 2023-12-08 |
| TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting Haloperidol + Promethazine + Chlorpromazine, Haloperidol + Promethazine - Psychiatric Emergency, Aggression | Phase 4 | Completed | Joseph Dib | 100 | 2018-08-28 | 2022-06-14 |
| The Effect of Chlorpromazine on Esophageal Sensitivity in Healthy Volunteers. Chlorpromazine, Multimodal stimulation probe, Placebo - Concentrate - Esophageal Reflux | Not applicable | Unknown | Universitaire Ziekenhuizen KU Leuven | 14 | 2017-07-01 | 2017-06-12 |
| Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer Chlorpromazine, Haloperidol, Quality-of-Life Assessment - Advanced Malignant Neoplasm, Delirium | Phase 2 / Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 70 | 2017-06-05 | 2026-09-14 |
| Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride Chlorpromazine Hydrochloride - Anti-Psychotic, Management of Manifestations of Psychotic Disorders | Phase 1 | Completed | Cycle Pharmaceuticals Ltd. | 20 | 2016-11-01 | 2017-11-14 |
| Family Intervention in Recent Onset Schizophrenia Treatment (FIRST) Caregiver psycho-education and skills training, Caregiver support available at the study site, Paliperidone palmitate - Schizophrenia | Completed | Janssen Scientific Affairs, LLC | 296 | 2015-07-24 | 2019-01-23 | |
| Clinical Trial to Evaluate the Efficacy of Treatment vs Discontinuation in a First Episode of Non-affective Psychosis Discontinuation antipsychotic treatment, Antipsychotic treatment - Psychosis Nos/Other | Phase 3 | Unknown | Fundación Pública Andaluza Progreso y Salud | 104 | 2012-11-01 | 2014-12-05 |
| Antipsychotics and Risk of Hyperglycemic Emergencies Olanzapine, Risperidone, atypical antipsychotics (other) - Psychotic Disorders, Schizophrenia | Completed | Canadian Network for Observational Drug Effect Studies, CNODES | 725489 | 2012-04-01 | 2015-10-21 | |
| Use of Intravitreal Triamcinolone and Retrobulbar Chlorpromazine as Alternatives to the Management of Painful Blind Eye Triamcinolone, Chlorpromazine - Blind Painful Eye, Refractory Glaucoma | Not applicable | Completed | Hospital Governador Celso Ramos | 36 | 2010-01-01 | 2011-07-28 |
| Efficacy and Safety of Quetiapine Fumarate in the Treatment of Schizophrenic Patients Quetiapine Fumarate (SEROQUEL) Extended-Release (XR), Chlorpromazine - Schizophrenia | Phase 3 | Completed | AstraZeneca | 388 | 2009-04-01 | 2012-05-15 |
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Schizophrenia (5) · Bipolar Disorder (2) · COVID-19 (2) · Delirium (2) · Glioblastoma (2) · Ischemic Stroke (2) · Psychotic Disorders (2) · Aggression (1) · Colonic Neoplasms (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Drug-Related Side Effects and Adverse Reactions (1) · Epilepsy (1) · Gastroesophageal Reflux (1) · Glaucoma (1)
M.D. Anderson Cancer Center (2) · Alexandria University (1) · AstraZeneca (1) · Cairo University (1) · Canadian Network for Observational Drug Effect Studies, CNODES (1) · Capital Medical University (1) · Central South University (1) · Centre Hospitalier St Anne (1) · Cycle Pharmaceuticals Ltd. (1) · Fundación Pública Andaluza Progreso y Salud (1) · Harvard Medical School (HMS and HSDM) (1) · Hospital Governador Celso Ramos (1) · Janssen Scientific Affairs, LLC (1) · Ji Xunming,MD,PhD (1) · Joseph Dib (1)
United States (5) · China (3) · Egypt (3) · France (2) · Australia (1) · Belgium (1) · Brazil (1) · Canada (1) · Italy (1) · Lebanon (1) · South Africa (1) · South Korea (1) · Spain (1)
Ahmed F El-Yazbi, PhD (1) · Ahmed Rezk (1) · Alan I Green, MD (1) · Aymen H Hamouri, MSc (1) · David Hui (1) · David Hui, MD (1) · Deborah C Ribas, MD (1) · Dr. Yolandi Swart, FCPHM(SA) (1) · Hans U Bucher, Prof (1) · Jan Tack, MD, PhD (1) · Juliette Ropars, MD (1) · Lorraine Lipscombe, MD, MSc (1) · Marco G Paggi, MD, PhD (1)
PMID 1881539, PMID 20819983, PMID 21369751, PMID 24581419, PMID 25064681, PMID 26067128, PMID 2689885, PMID 27462117, PMID 28919116, PMID 28973661, PMID 29129157, PMID 29674752, PMID 31691849, PMID 32479786, PMID 32528650, PMID 33718225, PMID 35436231, PMID 38162492, PMID 747719, PMID 9400355
2019 (1), R01MH049891 (1), R21NR016736 (1)