1883 completed, 419 recruiting, 258 terminated, 209 unknown. 1513 Not applicable, 617 Phase 2, 284 Phase 1, 252 Phase 4, 138 Phase 3.
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis Site specific standard of care comparison - Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis | Withdrawn | Massachusetts General Hospital | 2030-01-01 | 2026-01-16 | ||
| Screening Cardiometabolic Opportunities Using Transformative Echocardiography Artificial Intelligence (SCOUT Echo-AI) AI-Enabled Identification (EchoNet-Liver) - MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis | Not applicable | Not yet recruiting | Kaiser Permanente | 2000 | 2028-01-01 | 2026-08-13 |
| Cognitive-behavioral Therapy vs. Nutrition Counseling for Avoidant/Restrictive Food Intake Disorder Part II Cognitive-Behavioral Therapy for Avoidance Restrictive Food Intake Disorder (CBT-AR), Nutrition Counseling for Avoidant/Restrictive Food Intake Disorder - Avoidant/Restrictive Food Intake Disorder (ARFID) | Not applicable | Not yet recruiting | Massachusetts General Hospital | 70 | 2027-11-01 | 2026-10-07 |
| Mindfulness-based Neurofeedback to Reduce Negative Thinking in CHARMS Adolescents Mindfulness Training, Active mindfulness-based neurofeedback (Active mbNF), Sham mindfulness-based neurofeedback - Repetitive Negative Thinking, Serious Mental Illness Symptoms | Not applicable | Not yet recruiting | Massachusetts General Hospital | 90 | 2027-09-01 | 2026-02-12 |
| Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep Ocular light exposure from portable light box - Circadian Rhythm, Pupillometry | Not applicable | Not yet recruiting | Elizabeth B Klerman MD PhD | 100 | 2027-09-01 | 2026-09-08 |
| Intervention to Reduce Implicit Bias in Pharmacies The adapted PHBI, The NIH Implicit Bias course - Bias, Implicit, HIV | Not applicable | Not yet recruiting | Massachusetts General Hospital | 70 | 2027-07-01 | 2025-11-12 |
| A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults Large language model-based chatbot brief alcohol intervention session - Alcohol Use Disorder | Not applicable | Not yet recruiting | Massachusetts General Hospital | 20 | 2027-06-01 | 2025-10-22 |
| Clinician Notification to Increase Aspirin Prophylaxis for Preeclampsia Prevention Clinician notification of elevated preeclampsia risk - Preeclampsia, Hypertensive Disorders of Pregnancy (HDP) | Not applicable | Not yet recruiting | Massachusetts General Hospital | 1000 | 2027-05-01 | 2026-05-29 |
| Early Intervention Juzo Compression Sleeve and Glove, Compression Sleeve Sensor - Breast Cancer, Breast Cancer Treatment Related Lymphedema | Not applicable | Not yet recruiting | Massachusetts General Hospital | 40 | 2027-05-01 | 2026-07-13 |
| Quantification of Change in MG Disease Activity in Individuals With Generalized Myasthenia Gravis (gMG) After Administration of VYVGART® or VYVGART Hytrulo® Using BioDigit MG Myasthenia Gravis Generalized | Not yet recruiting | BioSensics | 25 | 2027-03-15 | 2026-10-13 | |
| Symptom Monitoring and Management Intervention After CAR-T WAYPOINT - Chimeric Antigen Receptor T-cell Therapy, Hematologic Malignancy | Not applicable | Not yet recruiting | Massachusetts General Hospital | 65 | 2027-03-01 | 2026-10-21 |
| Teclistamab In Waldenstrom's Macroglobulinemia Teclistamab - Waldenstrom's Macroglobulinemia | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 24 | 2027-02-19 | 2026-09-01 |
| A Study to Test New Investigational Drugs (LCFA-01and LC103) for Bacterial Vaginosis (BV) Treatment metronidazole (MTZ)+ LCFA-01 placebo + LC103 placebo, metronidazole (MTZ)+ LCFA-01 + LC103 placebo, metronidazole (MTZ)+ LC103 + LCFA-01 placebo - Bacterial Vaginosis | Phase 1 | Not yet recruiting | Massachusetts General Hospital | 280 | 2027-02-03 | 2026-10-15 |
| Digital Coach to Support Exposure Therapy Homework for Anxious Youth BraveBot, Self-Guided Exposure Therapy Homework - Anxiety Disorders, OCD | Not applicable | Not yet recruiting | Massachusetts General Hospital | 50 | 2027-02-01 | 2026-10-07 |
| Telehealth Intervention for Symptom Management and Adherence to Adjuvant Endocrine Therapy STRIDE, Usual Care - Hormone Receptor Positive Breast Cancer | Not applicable | Not yet recruiting | Massachusetts General Hospital | 400 | 2027-02-01 | 2026-10-07 |
| Losartan and Paclitaxel in Platinum Resistant Ovarian Cancer losartan, Paclitaxel - Platinum Resistant Ovarian Cancer | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 27 | 2027-02-01 | 2026-09-22 |
| A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior Smartphone-delivered Therapeutic Evaluative Conditioning for Suicide (TEC-S), Smartphone-delivered inactive Therapeutic Evaluative Conditioning - Suicidal Ideation, Suicide Attempt | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2027-01-30 | 2026-07-13 |
| Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB) | Not yet recruiting | BioSensics | 60 | 2027-01-15 | 2026-10-13 | |
| Semaglutide for the Treatment of Cannabis Use Disorder semaglutide - Cannabis Use Disorder, Cue-reactivity | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2027-01-10 | 2026-10-19 |
| Clinician Practice Companion to Address Youth Substance Use Practice Companion - Substance Use, Substance-Related Disorders | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2027-01-01 | 2026-10-07 |
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Depression (179) · Depressive Disorder, Major (98) · Breast Neoplasms (97) · Obesity (82) · Anxiety Disorders (75) · Bipolar Disorder (73) · Attention Deficit Disorder with Hyperactivity (67) · Lung Neoplasms (58) · Insulin Resistance (49) · Acquired Immunodeficiency Syndrome (47) · Pain (47) · Schizophrenia (46) · Diabetes Mellitus (45) · Heart Failure (44) · Neoplasms (44)
Cognitive Behavioral Therapy (42) · Bevacizumab (41) · Radiotherapy (26) · Rituximab (26) · Carboplatin (23) · Methylphenidate (23) · Cisplatin (22) · Sodium Chloride (22) · Fluorouracil (21) · Cyclophosphamide (19) · Doxorubicin (19) · Paclitaxel (19) · Escitalopram (18) · Proton Therapy (18) · Surveys and Questionnaires (18)
United States (2980) · Canada (47) · Uganda (43) · South Africa (32) · Italy (21) · Germany (20) · Australia (18) · United Kingdom (17) · China (16) · India (14) · Netherlands (14) · Kenya (13) · Puerto Rico (12) · Belgium (11) · Spain (10)
Joseph Biederman, MD (24) · Ana-Maria Vranceanu, PhD (23) · Areej El-Jawahri, MD (21) · Lorenzo Berra, MD (18) · Maurizio Fava, MD (16) · Jeff C Huffman, MD (15) · Steven J Russell, MD, PhD (15) · Thomas Spencer, MD (13) · Gagan Joshi, MD (12) · Sabine Wilhelm, PhD (12) · Guillermo Tearney, MD, PhD (11) · Janet Wozniak, MD (11) · Karen Sepucha, PhD (11) · Matthias Eikermann, MD, PhD (11) · Neal Chen, MD (11)
PMID 37811711, PMID 38767196, PMID 21262884, PMID 30118397, PMID 31132118, PMID 34817851, PMID 35141873, PMID 35397575, PMID 37722196, PMID 38429079, PMID 41589067, PMID 16636217, PMID 18375483, PMID 18591942, PMID 19139178, PMID 20802500, PMID 21209029, PMID 22035648, PMID 22110166, PMID 23308216, PMID 23401516, PMID 23809203, PMID 24137663, PMID 24291224, PMID 24891325, PMID 24931572, PMID 25272149, PMID 25593740, PMID 28433500, PMID 28616847, PMID 28923845, PMID 29669934, PMID 31650412, PMID 31838154, PMID 31952842, PMID 32034419, PMID 32645158, PMID 32870266, PMID 32876469, PMID 33394722, PMID 33484847, PMID 33549871, PMID 33575971, PMID 33763296, PMID 33766254, PMID 33782093, PMID 34569250, PMID 34930421, PMID 35588200, PMID 35652353
P01CA021239 (7), U01DK112193 (6), P50GM021700 (5), U19CA021239 (5), U24DK074008 (5), R01AG013241 (4), R01CA103769 (4), R01CA184102 (4), R01DK049302 (4), U01DK073974 (4), U01DK073975 (4), U01DK073983 (4), U01DK074007 (4), U01DK074035 (4), K23HL123607 (3)