128 completed, 61 unknown, 28 recruiting, 17 not yet recruiting. 100 Not applicable, 25 Phase 4, 10 Phase 2, 9 Phase 3, 2 Phase 1.
Follow Postoperative Cognitive Complications: new trials by email Literature Review of Postoperative Cognitive Complications trials Research Report on Postoperative Cognitive Complications
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment - Carotid Stenosis, Carotid Artery Diseases | Not yet recruiting | Nguyen Toan Thang | 150 | 2027-01-01 | 2026-09-11 | |
| PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery | Not yet recruiting | Ain Shams University | 185 | 2026-12-01 | 2026-09-25 | |
| Prediction and Prevention of Postoperative Mortality and Morbidity Personalized CPC Prehabilitation, Cognitive Training, Meditation - Dementia, Postoperative Delirium (POD) | Not applicable | Not yet recruiting | University of Pittsburgh | 1200 | 2026-10-01 | 2026-09-25 |
| BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine BrainProtect System, Standard perioperative management - Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction | Not applicable | Not yet recruiting | Scienceforbrain, UAB | 304 | 2026-09-30 | 2026-10-14 |
| Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy - Fraily, Abdominal Surgery | Not applicable | Not yet recruiting | Ente Ospedaliero Ospedali Galliera | 100 | 2026-09-01 | 2026-03-20 |
| Ketofol Versus Ketodex for POD Prophylaxis in Elderly Cancer Surgery Group ketofol, Group ketodex, Group Control - Postoperative Delirium (POD) | Phase 3 | Recruiting | Cairo University | 180 | 2026-07-01 | 2026-06-04 |
| Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery Postoperative Cognitive Complications, Delirium | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2026-07-01 | 2026-05-11 | |
| Effect of Ciprofol Injection on Postoperative Cognitive Function Ciprofol group, Propofol group - Postoperative Cognitive Dysfunction | Phase 4 | Active not recruiting | The Second Affiliated Hospital of Chongqing Medical University | 298 | 2026-06-01 | 2026-06-29 |
| Palmitoylethanolamide/Luteolin Supplementation in Older Adults Undergoing Cardiac Surgery co-ultramicronized Palmitoylethanolamide + Luteolin (700 mg + 70 mg in 10 ml), Standard of Care - Postoperative Cognitive Dysfunction | Not applicable | Not yet recruiting | Fondazione IRCCS San Gerardo dei Tintori | 100 | 2026-06-01 | 2026-07-02 |
| Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO) Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD) | Not yet recruiting | Heart and Brain Research Group, Germany | 500 | 2026-05-25 | 2026-06-04 | |
| Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting Off-Pump Coronary Artery Bypass Grafting - Postoperative Cognitive Dysfunction (POCD) | Not yet recruiting | Beijing Anzhen Hospital | 600 | 2026-05-24 | 2026-06-11 | |
| Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty Postoperative Cognitive Dysfunction (POCD), Cognitive Change | Recruiting | Odense University Hospital | 48 | 2026-05-18 | 2026-06-22 | |
| POCD After Major Gynecologic Surgery Postoperative Cognitive Dysfunction, Perioperative Neurocognitive Disorder | Recruiting | Fatihhan Zeytun | 72 | 2026-05-06 | 2026-06-12 | |
| Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty Ketamine - Postoperative Delirium, Postoperative Cognitive Dysfunction | Not applicable | Not yet recruiting | Istinye University | 80 | 2026-05-05 | 2025-05-09 |
| Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery Continuous intraoperative monitoring of MAP and rSO₂; observational study with no therapeutic intervention. - Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD) | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 120 | 2026-05-01 | 2026-04-03 | |
| Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients Cognitive and Delirium Assessment (MoCA and CAM) - Postoperative Delirium, Postoperative Cognitive Dysfunction | Recruiting | Muğla Sıtkı Koçman University | 150 | 2026-04-05 | 2026-07-22 | |
| Prediction Model for Postoperative Cognitive Dysfunction in Elderly Cardiac Patients: A Special Disease Cohort Study Postoperative Cognitive Dysfunction (POCD), Cardiac Diseases Requiring Surgery | Recruiting | Shanghai Geriatric Medical Center | 634 | 2026-03-03 | 2026-03-19 | |
| Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation ibuprofen - Postoperative Delirium, Cerebral Oxygen Saturation | Not applicable | Not yet recruiting | Ondokuz Mayıs University | 54 | 2026-02-15 | 2026-02-10 |
| Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone Postoperative Cognitive Dysfunction | Not yet recruiting | Minia University | 50 | 2026-02-01 | 2026-02-10 |
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Emergence Delirium (74) · Cognitive Dysfunction (36) · Delirium (28) · Postoperative Complications (15) · Pain, Postoperative (13) · Neuroinflammatory Diseases (10) · Neurocognitive Disorders (9) · Cognition Disorders (8) · Depression (6) · Alzheimer Disease (5) · Coronary Artery Disease (5) · Frailty (5) · Stroke (4) · Brain Injuries (3)
Mental Disorders (255) · Pathologic Processes (255) · Pathological Conditions, Signs and Symptoms (255) · Cognition Disorders (248) · Neurocognitive Disorders (247) · Postoperative Complications (241) · Cognitive Dysfunction (220) · Nervous System Diseases (114) · Signs and Symptoms (111) · Neurologic Manifestations (106) · Neurobehavioral Manifestations (95) · Confusion (91) · Delirium (63) · Brain Diseases (25) · Central Nervous System Diseases (25)
Propofol (13) · Dexmedetomidine (12) · Sevoflurane (12) · Saline Solution (9) · Blood Specimen Collection (6) · Ketamine (6) · Desflurane (5) · Mental Status and Dementia Tests (5) · Midazolam (5) · Anesthesia, General (4) · Control Groups (4) · Sodium Chloride (4) · Spectroscopy, Near-Infrared (4) · Anesthesia, Spinal (3) · Cognitive Training (3)
RenJi Hospital (8) · General Hospital of Ningxia Medical University (6) · University Hospital, Basel, Switzerland (6) · Icahn School of Medicine at Mount Sinai (5) · Heart and Brain Research Group, Germany (4) · Osijek University Hospital (4) · Beni-Suef University (3) · Bursa Yuksek Ihtisas Training and Research Hospital (3) · Karolinska Institutet (3) · TC Erciyes University (3) · University of Michigan (3) · University of Zagreb (3) · Universitätsklinikum Hamburg-Eppendorf (3) · Xuzhou Medical University (3) · Ankara City Hospital Bilkent (2)
China (55) · United States (34) · Turkey (Türkiye) (32) · Germany (9) · Egypt (8) · Croatia (7) · Italy (7) · Russia (7) · Switzerland (7) · Belgium (6) · Canada (6) · Sweden (6) · United Kingdom (5) · Brazil (4) · Indonesia (4)
Nicolai Goettel, MD (4) · Claudia Spies, MD, Prof. (2) · Jeff Silverstein, MD (2) · Luzius A Steiner, MD, PhD (2) · Marius Butz, Dipl.-Psych. (2) · Maura Marcucci, MD (2) · Miles Berger, MD, PhD (2) · Stephen Choi, MD,FRCPC,MSc (2) · Susana Vacas, M.D., Ph.D. (2) · Tibo Gerriets, Prof.Dr.med. (2) · Valery Likhvantsev (2) · Vlasta Dostalova, MD, PhD (2)
PMID 9525362, PMID 11065205, PMID 18156878, PMID 22321085, PMID 22762316, PMID 28593326, PMID 40820307, PMID 10439740, PMID 10686270, PMID 10881154, PMID 11032280, PMID 11126507, PMID 11425500, PMID 11772567, PMID 12088953, PMID 12648190, PMID 12707126, PMID 12817919, PMID 12960545, PMID 13243706, PMID 13688369, PMID 14616316, PMID 15010086, PMID 15374380, PMID 15728054, PMID 15781453, PMID 16571963, PMID 16616662, PMID 16901646, PMID 16934234, PMID 17297830, PMID 17325517, PMID 1742815, PMID 17934180, PMID 18345523, PMID 18577850, PMID 18662642, PMID 18820789, PMID 19128879, PMID 19194152, PMID 19224088, PMID 19379886, PMID 19421703, PMID 19422355, PMID 19573267, PMID 19820242, PMID 20042477, PMID 20397979, PMID 20585847, PMID 20601860
2014 (1), 2016 (1), 2019 (1), 2023 (1), K23AG048332 (1), K23GM152933 (1), P30AG028716 (1), R01AG029656 (1), R01AG046634 (1), R01AG075005 (1), R01HL130443 (1), R21HD098754 (1)