728 completed, 300 unknown, 187 recruiting, 134 not yet recruiting. 587 Not applicable, 174 Phase 4, 99 Phase 3, 80 Phase 2, 23 Phase 1.
Follow Delirium: new trials by email Literature Review of Delirium trials Research Report on Delirium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-surgical Delirium in Patients Undergoing Radical Cystectomy. Radical cystectomy. - Delirium, Radical Cystectomy | Not yet recruiting | University of Alexandria | 100 | 2028-11-25 | 2025-04-03 | |
| Post-surgical Delirium in Patients Undergoing Open Heart Surgery. Open heart surgery - Delirium, Open Heart Surgery | Not yet recruiting | University of Alexandria | 300 | 2028-10-01 | 2025-04-03 | |
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery Postoperative Cognitive Complications, Delirium | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2027-07-01 | 2026-10-23 | |
| Concurrent Trials on Nature-Based Therapy for Inpatients in Dementia and Rehabilitation Medicine Wards Nature Immersion Therapy - Dementia, Acquired Brain Injury Including Stroke | Not applicable | Not yet recruiting | Changi General Hospital | 1600 | 2027-05-01 | 2026-03-23 |
| Family-partnered Delirium Prevention, Detection, and Management in the ICU Standard of Care, Delirium Education, Prevention, and Management - Delirium, Intensive Care Unit Delirium | Not applicable | Not yet recruiting | University of Calgary | 1344 | 2027-02-01 | 2026-10-27 |
| DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) Dexmedetomidine, Normal Saline (0.9% NaCl) - Neurosurgery, Brain Cancer | Not applicable | Not yet recruiting | University of Malaya | 60 | 2027-01-01 | 2026-11-05 |
| Prehab-COG: Does Preoperative Exercise Improve Postoperative Cognitive Outcomes? Tailored exercise program - Cognition, Postoperative Delirium | Not applicable | Not yet recruiting | Stanford University | 15 | 2027-01-01 | 2026-11-12 |
| Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Postoperative neurological and cognitive assessment - Carotid Stenosis, Carotid Artery Diseases | Not yet recruiting | Nguyen Toan Thang | 150 | 2027-01-01 | 2026-11-12 | |
| Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle Dexmedetomidine, Control (placebo) group - Sleep, Delirium | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-12-01 | 2026-10-13 |
| The Impact of Left Stellate Ganglion Block on Systemic Inflammation and Neuromodulation in CABG Surgery. Stellate Ganglion Block - Delirium - Postoperative, Inflammation Biomarkers | Not applicable | Not yet recruiting | OMAR ABDELAZIZ ABOELFADL | 81 | 2026-12-01 | 2026-08-20 |
| Comparison of IV Dexmedetomidine Versus Clonidine Versus no Alpha 2 Agonist on Emergency Delirium, PACU Length of Stay and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: a Prospective Observational Study Intravenous dexmedetomidine, Intravenous clonidine, Standard Anesthetic Care Without Alpha-2 Agonist - Emergency Delirium, Postoperative Delirium (POD) | Not yet recruiting | Universitair Ziekenhuis Brussel | 150 | 2026-12-01 | 2026-11-04 | |
| Sugammadex Timing and Recovery Profile in Pediatric Adenotonsillectomy Neuromuscular Blockade, Delayed Emergence From Anesthesia | Not yet recruiting | Namik Kemal University | 140 | 2026-12-01 | 2026-10-28 | |
| reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit Sleep chronobundle, Control - Sleep, Circadian Dysregulation | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-11-30 | 2026-10-21 |
| Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive Care Dexmedetomidine, Midazolam - Delirium in the Intensive Care Unit | Phase 3 | Not yet recruiting | University Hospital, Tours | 266 | 2026-11-15 | 2026-09-28 |
| Lactium Premedication to Prevent Emergence Agitation Lactium - Lactium, Premedication | Phase 3 | Recruiting | Tanta University | 40 | 2026-11-04 | 2026-11-05 |
| Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy Lidocaine, 0.9% Normal Saline - Emergence Agitation, Emergence Delirium | Phase 3 | Not yet recruiting | Assiut University | 60 | 2026-11-01 | 2026-10-13 |
| Post-Stroke Enhancement of Delirium Outcomes With Reduction in Neuro-checks Decreased Neuro Checks overnight - Stroke, Acute, Stroke, Ischemic | Not applicable | Suspended | Medical University of South Carolina | 538 | 2026-11-01 | 2026-04-09 |
| Effects of PNB Timing on Postoperative Delirium for Hip Fracture Peripheral Nerve Block for Hip Fracture - Delirium - Postoperative | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 120 | 2026-11-01 | 2026-10-02 | |
| Intracuff Dexmedetomidine Versus Alkalinized Lidocaine for Peri-Extubation Cough and Hemodynamic Responses in Elderly Patients Dexmedetomidine, Alkalinized Lidocaine - Airway Complication of Anesthesia, Hemodynamic Instability | Not applicable | Not yet recruiting | Beni-Suef University | 184 | 2026-11-01 | 2026-11-04 |
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Emergence Delirium (744) · Cognitive Dysfunction (119) · Postoperative Cognitive Complications (91) · Critical Illness (78) · Dementia (59) · Pain, Postoperative (51) · Pain (49) · Confusion (47) · Postoperative Complications (47) · Psychomotor Agitation (42) · Hip Fractures (39) · Anxiety Disorders (37) · Depression (29) · Neurocognitive Disorders (28)
Pathological Conditions, Signs and Symptoms (1520) · Signs and Symptoms (1512) · Neurobehavioral Manifestations (1510) · Neurologic Manifestations (1509) · Nervous System Diseases (1504) · Mental Disorders (1497) · Neurocognitive Disorders (1492) · Confusion (1473) · Pathologic Processes (930) · Postoperative Complications (744) · Cognition Disorders (187) · Central Nervous System Diseases (127) · Brain Diseases (117) · Behavior (106)
Dexmedetomidine (161) · Propofol (77) · Saline Solution (73) · Sevoflurane (48) · Sodium Chloride (45) · Midazolam (33) · Ketamine (29) · Haloperidol (27) · Melatonin (23) · Fentanyl (19) · Standard of Care (15) · Electroencephalography (13) · remimazolam (12) · Desflurane (11) · Ear Protective Devices (11)
Charite University, Berlin, Germany (26) · Peking University First Hospital (21) · Chinese PLA General Hospital (18) · Assiut University (17) · Assistance Publique - Hôpitaux de Paris (15) · Vanderbilt University Medical Center (15) · Ain Shams University (14) · Beijing Tiantan Hospital (14) · RenJi Hospital (14) · Tanta University (14) · Yonsei University (14) · Seoul National University Hospital (12) · University Hospital, Basel, Switzerland (12) · Beth Israel Deaconess Medical Center (11) · University Health Network, Toronto (11)
United States (305) · China (254) · Turkey (Türkiye) (124) · Canada (88) · Egypt (72) · Germany (67) · South Korea (61) · France (47) · Netherlands (35) · Denmark (32) · Italy (32) · United Kingdom (24) · Spain (21) · Switzerland (19) · Taiwan (18)
Claudia Spies, MD, Prof. (18) · Dong-Xin Wang, MD, PhD (15) · Nicolai Goettel, MD (7) · Charles Brown, MD (4) · Dong-Xin Wang, MD,PhD (4) · E Wesley Ely, MD, MPH (4) · Liwei Wang, Doctor (4) · Yangzi Zhu, Doctor (4) · Azra Bihorac, MD (3) · Balachundhar Subramaniam, MD, MPH (3) · Hina Faisal, MD (3) · Jian-Xin Zhou, MD (3) · Jin H Han, MD, MSc (3) · Lian Kah Ti (3) · Malaz Boustani, MD, MPH (3)
PMID 23992774, PMID 15114210, PMID 15082703, PMID 22323509, PMID 28576285, PMID 19745202, PMID 22762316, PMID 25535538, PMID 28973626, PMID 33238043, PMID 37535937, PMID 10053175, PMID 11129764, PMID 11797025, PMID 12760985, PMID 14980921, PMID 15562048, PMID 16540616, PMID 17179249, PMID 18577850, PMID 18686756, PMID 19347026, PMID 19687169, PMID 19865006, PMID 20047899, PMID 20497353, PMID 20526708, PMID 21926597, PMID 22091567, PMID 22301509, PMID 23182527, PMID 23506796, PMID 24088092, PMID 24287327, PMID 24441670, PMID 25348864, PMID 26077062, PMID 26118922, PMID 26275092, PMID 26418126, PMID 26601849, PMID 27660922, PMID 27798810, PMID 27922747, PMID 28593326, PMID 28601132, PMID 29728150, PMID 30113379, PMID 30721296, PMID 30794305
2014 (3), 2016 (3), 2025 (3), R01NS120924 (3), 2009 (2), 2017 (2), 2019 (2), R01AG053582 (2), R21AG075230 (2), R21EB027344 (2), U54AG063546 (2), 1RF1AG077557-01 (1), 1UG3HL165740-01A1 (1), 1UH2AG050312-01 (1), 2015 (1)