Critical Illness: Clinical Trials

920 completed, 309 unknown, 225 recruiting, 132 not yet recruiting. 636 Not applicable, 120 Phase 2, 106 Phase 3, 94 Phase 4, 32 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	636	Completed 344, Unknown 90, Recruiting 82, Not yet recruiting 47, Terminated 31, Active not recruiting 18, Withdrawn 11, Enrolling by invitation 10, Suspended 3
Phase 2	120	Completed 60, Unknown 21, Terminated 17, Recruiting 13, Not yet recruiting 5, Withdrawn 4
Phase 3	106	Completed 49, Unknown 16, Terminated 15, Recruiting 8, Withdrawn 8, Active not recruiting 5, Not yet recruiting 5
Phase 4	94	Completed 51, Terminated 14, Recruiting 11, Unknown 10, Not yet recruiting 3, Withdrawn 3, Active not recruiting 2
Phase 1	32	Completed 18, Unknown 4, Recruiting 3, Terminated 3, Not yet recruiting 2, Withdrawn 2
Early Phase 1	7	Completed 3, Not yet recruiting 2, Recruiting 1, Unknown 1

Follow Critical Illness: new trials by email Literature Review of Critical Illness trials Research Report on Critical Illness

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment - Dysphagia, Critical Illness	Not applicable	Not yet recruiting	Vanderbilt University Medical Center	120	2027-07-01	2026-10-14
Collaborative Risk-stratified Investigation in Thrombosis-prone Inpatients With Critical Illness: Anticoagulation With LMWH in Teens for ThromboProphylaxis (CRITICAL-Teens-TP). Enoxaparin - Venous Thromboembolism (VTE)	Phase 3	Not yet recruiting	Johns Hopkins All Children's Hospital	802	2027-04-15	2026-05-26
Prehospital mSOFA-Kit Decision Support for the Detection of Multiple Organ Failure mSOFA-Kit, Standard XABCDE assessment - Multiple Organ Failure, Critical Illness	Not applicable	Not yet recruiting	University of Valladolid	3780	2027-04-01	2026-11-10
Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients continuous renal replacement therapy - Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury		Not yet recruiting	University of Alberta	100000	2027-03-31	2026-09-09
Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients Extubation Failure, Mechanical Ventilation		Not yet recruiting	Universidade Federal de Pernambuco	800	2027-03-30	2026-06-22
INTUPROS 2-3: Improving First-Pass Intubation Success and Reducing Complications in ICU Patients Critical Illness, Airway Management Assessment		Not yet recruiting	Spanish Society of Critical Care Medicine and Coronary Units	1300	2027-03-01	2026-09-08
Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES) - Critical Illness, Sarcopenia	Early Phase 1	Not yet recruiting	University of Maryland, Baltimore	78	2027-03-01	2026-05-06
The Extended Study of Prevalence of Infection in Intensive Care IV Sepsis, Infection		Not yet recruiting	Universidad de la Sabana	10000	2027-02-01	2026-06-29
Family-partnered Delirium Prevention, Detection, and Management in the ICU Standard of Care, Delirium Education, Prevention, and Management - Delirium, Intensive Care Unit Delirium	Not applicable	Not yet recruiting	University of Calgary	1344	2027-02-01	2026-10-27
REFRAME: an Emotion Regulation Intervention to Improve Psychological Outcomes in Surrogate Decision-Makers of the Critically Ill REFRAME, Informational Support - Critical Illness	Not applicable	Not yet recruiting	Case Western Reserve University	387	2027-01-04	2026-06-25
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress Lift mobile mindfulness, Enlighten Recovery education program - Critical Illness, Heart Failure	Not applicable	Not yet recruiting	Duke University	450	2027-01-01	2026-07-08
SWedish Intensive Care Biobank Any Condition Underlying Critical Illness		Not yet recruiting	Uppsala University	25000	2027-01-01	2026-05-13
Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical Illness Synbiotic, Standard of Care (SOC) - Critical Illness	Phase 1 / Phase 2	Not yet recruiting	University of Calgary	64	2027-01-01	2026-09-10
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport Advanced Respiratory Support During Patient Transport - Acute Respiratory Failure, Respiratory Insufficiency		Not yet recruiting	Medipol University	565	2026-12-31	2026-09-04
Beyond Voluntary Effort: Reliability and Validity of Magnetic Femoral Nerve Stimulation for Assessing Quadriceps Strength in Critically Ill Patient Magnetic Femoral Nerve Stimulation - Critical Illness, ICU-acquired Weakness	Not applicable	Not yet recruiting	Daniel Langer	33	2026-12-01	2026-10-23
Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle Dexmedetomidine, Control (placebo) group - Sleep, Delirium	Early Phase 1	Not yet recruiting	University of Alberta	50	2026-12-01	2026-10-13
Geriatrics in the Intensive Care Unit Age group - Geriatrics		Not yet recruiting	Hospital Departamental de Villavicencio	1000	2026-12-01	2026-02-09
Acute Kidney Injury and Intermittent Dialysis Dose Intermittent hemodialysis (no study-assigned intervention) - Acute Kidney Injury, Renal Dialysis		Not yet recruiting	Assistance Publique - Hôpitaux de Paris	200	2026-12-01	2026-11-09
Core Competencies in General Intensive Care Ultrasound (GenIUS): a Delphi Study Delphi procedure - Critical Illness, Ultrasound		Not yet recruiting	Hospital General Universitario de Castellón	60	2026-11-16	2026-11-05
Diastolic Shock Index for Predicting Hemodynamic Instability During Continuous Renal Replacement Therapy Diastolic Shock Index Assessment - Acute Kidney Injury, Hypotension (MeSH: D007022)		Not yet recruiting	Istanbul University - Cerrahpasa	70	2026-11-15	2026-11-05

Showing 20 of 1780. Sign in to see all of them.

Narrower conditions

Sepsis (164)  ·  Acute Kidney Injury (93)  ·  Respiratory Insufficiency (78)  ·  Delirium (77)  ·  COVID-19 (70)  ·  Shock, Septic (62)  ·  Shock (50)  ·  Wounds and Injuries (42)  ·  Respiratory Distress Syndrome (40)  ·  Hyperglycemia (37)  ·  Infections (36)  ·  Multiple Organ Failure (34)  ·  Muscle Weakness (34)  ·  Muscular Atrophy (34)

Broader conditions

Pathological Conditions, Signs and Symptoms (1780)  ·  Disease Attributes (1776)  ·  Pathologic Processes (1776)  ·  Infections (327)  ·  Signs and Symptoms (295)  ·  Respiratory Tract Diseases (271)  ·  Nervous System Diseases (232)  ·  Neurologic Manifestations (214)  ·  Inflammation (191)  ·  Systemic Inflammatory Response Syndrome (181)  ·  Lung Diseases (170)  ·  Mental Disorders (156)  ·  Nutritional and Metabolic Diseases (156)  ·  Respiration Disorders (136)  ·  Respiratory Tract Infections (120)

Interventions

Standard of Care (26)  ·  Saline Solution (20)  ·  Dexmedetomidine (17)  ·  Blood Specimen Collection (13)  ·  Sodium Chloride (13)  ·  Midazolam (12)  ·  Propofol (11)  ·  Cholecalciferol (10)  ·  Enteral Nutrition (10)  ·  Observation (9)  ·  Echocardiography (8)  ·  Meropenem (8)  ·  Ringer's Lactate (8)  ·  Calorimetry, Indirect (7)  ·  Ketamine (7)

Sponsors

Vanderbilt University Medical Center (24)  ·  Australian and New Zealand Intensive Care Research Centre (23)  ·  Assiut University (21)  ·  Duke University (20)  ·  Mayo Clinic (18)  ·  University Medical Center Groningen (17)  ·  Medical University of Vienna (16)  ·  National Taiwan University Hospital (15)  ·  Assistance Publique - Hôpitaux de Paris (14)  ·  Massachusetts General Hospital (14)  ·  University Hospital, Lille (13)  ·  Charite University, Berlin, Germany (12)  ·  Karolinska University Hospital (12)  ·  Shanghai Zhongshan Hospital (12)  ·  University of Liege (12)

Countries

United States (364)  ·  France (130)  ·  China (110)  ·  Canada (101)  ·  United Kingdom (79)  ·  Germany (73)  ·  Netherlands (69)  ·  Belgium (65)  ·  Turkey (Türkiye) (64)  ·  Australia (61)  ·  Italy (59)  ·  Brazil (47)  ·  Spain (44)  ·  Switzerland (44)  ·  Sweden (43)

Top investigators

Stefan J Schaller, MD (12)  ·  Daren K Heyland, MD (7)  ·  Mohan Gurjar, MD, PDCC (7)  ·  Olav Rooyackers, PhD (7)  ·  Ulrike Holzinger, MD (6)  ·  Alexander Zarbock, MD (4)  ·  Christopher E Cox, MD (4)  ·  Gianluca Villa, MD (4)  ·  Karen Choong, MB, BCh, MSc (4)  ·  Manfred Weiss, MD (4)  ·  Matthew W Semler, MD, MSc (4)  ·  Matthias Eikermann, MD, PhD (4)  ·  Max Bell, MD, PhD (4)

Results publications

PMID 28374096, PMID 33755076, PMID 34519356, PMID 36416787, PMID 10776874, PMID 18511703, PMID 19446324, PMID 23417207, PMID 23506003, PMID 24088092, PMID 24108501, PMID 26903338, PMID 26986466, PMID 27922747, PMID 28302179, PMID 28866754, PMID 28936712, PMID 29181557, PMID 29485925, PMID 29980655, PMID 30448193, PMID 30920411, PMID 32669140, PMID 33196806, PMID 33929361, PMID 35169170, PMID 35443809, PMID 36066025, PMID 37029295, PMID 37326325, PMID 38063184, PMID 38127779, PMID 38461657, PMID 38990335, PMID 3928249, PMID 39382222, PMID 39878152, PMID 40920961, PMID 9559604, PMID 10446815, PMID 10470711, PMID 10525595, PMID 10642782, PMID 10660851, PMID 10722036, PMID 10781452, PMID 10816184, PMID 10861149, PMID 10887767, PMID 10966293

NIH funding

2017 (4), 2005 (3), 2014 (3), 2016 (3), 2018 (3), 2025 (3), 2019 (2), K23HL088020 (2), R21NR018693 (2), U01AT009974 (2), 1UG3AT013109-01 (1), 1UG3HL165740-01A1 (1), 1UG3HL166785 (1), 2004 (1), 2008 (1)