914 completed, 311 unknown, 216 recruiting, 127 not yet recruiting. 628 Not applicable, 120 Phase 2, 106 Phase 3, 94 Phase 4, 32 Phase 1.
Follow Critical Illness: new trials by email Literature Review of Critical Illness trials Research Report on Critical Illness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment - Dysphagia, Critical Illness | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 120 | 2027-07-01 | 2026-10-14 |
| Collaborative Risk-stratified Investigation in Thrombosis-prone Inpatients With Critical Illness: Anticoagulation With LMWH in Teens for ThromboProphylaxis (CRITICAL-Teens-TP). Enoxaparin - Venous Thromboembolism (VTE) | Phase 3 | Not yet recruiting | Johns Hopkins All Children's Hospital | 802 | 2027-04-15 | 2026-05-26 |
| Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients continuous renal replacement therapy - Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury | Not yet recruiting | University of Alberta | 100000 | 2027-03-31 | 2026-09-09 | |
| Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients Extubation Failure, Mechanical Ventilation | Not yet recruiting | Universidade Federal de Pernambuco | 800 | 2027-03-30 | 2026-06-22 | |
| INTUPROS 2-3: Improving First-Pass Intubation Success and Reducing Complications in ICU Patients Critical Illness, Airway Management Assessment | Not yet recruiting | Spanish Society of Critical Care Medicine and Coronary Units | 1300 | 2027-03-01 | 2026-09-08 | |
| Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES) - Critical Illness, Sarcopenia | Early Phase 1 | Not yet recruiting | University of Maryland, Baltimore | 78 | 2027-03-01 | 2026-05-06 |
| The Extended Study of Prevalence of Infection in Intensive Care IV Sepsis, Infection | Not yet recruiting | Universidad de la Sabana | 10000 | 2027-02-01 | 2026-06-29 | |
| REFRAME: an Emotion Regulation Intervention to Improve Psychological Outcomes in Surrogate Decision-Makers of the Critically Ill REFRAME, Informational Support - Critical Illness | Not applicable | Not yet recruiting | Case Western Reserve University | 387 | 2027-01-04 | 2026-06-25 |
| Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress Lift mobile mindfulness, Enlighten Recovery education program - Critical Illness, Heart Failure | Not applicable | Not yet recruiting | Duke University | 450 | 2027-01-01 | 2026-07-08 |
| SWedish Intensive Care Biobank Any Condition Underlying Critical Illness | Not yet recruiting | Uppsala University | 25000 | 2027-01-01 | 2026-05-13 | |
| Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical Illness Synbiotic, Standard of Care (SOC) - Critical Illness | Phase 1 / Phase 2 | Not yet recruiting | University of Calgary | 64 | 2027-01-01 | 2026-09-10 |
| HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport Advanced Respiratory Support During Patient Transport - Acute Respiratory Failure, Respiratory Insufficiency | Not yet recruiting | Medipol University | 565 | 2026-12-31 | 2026-09-04 | |
| Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle Dexmedetomidine, Control (placebo) group - Sleep, Delirium | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-12-01 | 2026-10-13 |
| Geriatrics in the Intensive Care Unit Age group - Geriatrics | Not yet recruiting | Hospital Departamental de Villavicencio | 1000 | 2026-12-01 | 2026-02-09 | |
| Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit 13C6-Glucose - Glucose, Metabolism | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 25 | 2026-11-01 | 2026-09-09 |
| Effect of PEEP on Indirect Calorimetry in Critically Ill Patients Protocolized PEEP Adjustment - Indirect Calorimetry, Mechanical Ventilation | Not applicable | Not yet recruiting | Vastra Gotaland Region | 20 | 2026-11-01 | 2026-09-01 |
| Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay continuous renal replacement therapy - AKI - Acute Kidney Injury, Critical Illness | Not yet recruiting | Karolinska Institutet | 500000 | 2026-11-01 | 2026-09-18 | |
| Frailty and Outcomes in Critically Ill Patients Receiving CRRT Acute Kidney Injury | Not yet recruiting | Karolinska Institutet | 22000 | 2026-11-01 | 2026-09-28 | |
| Healthcare and Community Service Utilisation in Older Survivors of Critical Illness Critical Illness | Not yet recruiting | Monash University | 30 | 2026-11-01 | 2026-10-13 | |
| Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled Trial Resistance-Optimised Precision Dosing, Standard Care Dosing - Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP) | Not applicable | Not yet recruiting | The University of Queensland | 610 | 2026-11-01 | 2026-09-15 |
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Sepsis (162) · Acute Kidney Injury (91) · Respiratory Insufficiency (77) · Delirium (76) · COVID-19 (70) · Shock, Septic (61) · Shock (50) · Wounds and Injuries (42) · Respiratory Distress Syndrome (40) · Hyperglycemia (36) · Infections (36) · Muscle Weakness (34) · Muscular Atrophy (34) · Multiple Organ Failure (33)
Pathological Conditions, Signs and Symptoms (1760) · Disease Attributes (1756) · Pathologic Processes (1756) · Infections (323) · Signs and Symptoms (291) · Respiratory Tract Diseases (268) · Nervous System Diseases (229) · Neurologic Manifestations (210) · Inflammation (189) · Systemic Inflammatory Response Syndrome (179) · Lung Diseases (168) · Mental Disorders (155) · Nutritional and Metabolic Diseases (155) · Respiration Disorders (135) · Respiratory Tract Infections (118)
Standard of Care (25) · Saline Solution (20) · Dexmedetomidine (17) · Blood Specimen Collection (13) · Sodium Chloride (13) · Midazolam (12) · Propofol (11) · Cholecalciferol (10) · Enteral Nutrition (10) · Observation (9) · Echocardiography (8) · Meropenem (8) · Ringer's Lactate (8) · Calorimetry, Indirect (7) · Ketamine (7)
Vanderbilt University Medical Center (24) · Australian and New Zealand Intensive Care Research Centre (23) · Assiut University (20) · Duke University (20) · Mayo Clinic (18) · University Medical Center Groningen (17) · Medical University of Vienna (16) · National Taiwan University Hospital (15) · Massachusetts General Hospital (14) · Assistance Publique - Hôpitaux de Paris (13) · University Hospital, Lille (13) · Charite University, Berlin, Germany (12) · Karolinska University Hospital (12) · University of Liege (12) · Helsinki University Central Hospital (11)
United States (363) · France (130) · China (109) · Canada (100) · United Kingdom (79) · Germany (73) · Netherlands (69) · Belgium (63) · Australia (61) · Turkey (Türkiye) (60) · Italy (59) · Brazil (47) · Switzerland (44) · Spain (43) · Sweden (43)
Stefan J Schaller, MD (12) · Daren K Heyland, MD (7) · Mohan Gurjar, MD, PDCC (7) · Olav Rooyackers, PhD (7) · Ulrike Holzinger, MD (6) · Alexander Zarbock, MD (4) · Christopher E Cox, MD (4) · Gianluca Villa, MD (4) · Karen Choong, MB, BCh, MSc (4) · Manfred Weiss, MD (4) · Matthew W Semler, MD, MSc (4) · Matthias Eikermann, MD, PhD (4) · Max Bell, MD, PhD (4)
PMID 28374096, PMID 33755076, PMID 34519356, PMID 36416787, PMID 10776874, PMID 18511703, PMID 19446324, PMID 23417207, PMID 23506003, PMID 24088092, PMID 24108501, PMID 26903338, PMID 26986466, PMID 27922747, PMID 28302179, PMID 28866754, PMID 28936712, PMID 29181557, PMID 29485925, PMID 29980655, PMID 30448193, PMID 30920411, PMID 32669140, PMID 33196806, PMID 33929361, PMID 35169170, PMID 35443809, PMID 36066025, PMID 37029295, PMID 37326325, PMID 38063184, PMID 38127779, PMID 38461657, PMID 38990335, PMID 3928249, PMID 39382222, PMID 39878152, PMID 40920961, PMID 9559604, PMID 10446815, PMID 10470711, PMID 10525595, PMID 10642782, PMID 10660851, PMID 10722036, PMID 10781452, PMID 10816184, PMID 10861149, PMID 10887767, PMID 10966293
2017 (4), 2005 (3), 2014 (3), 2016 (3), 2018 (3), 2025 (3), 2019 (2), K23HL088020 (2), R21NR018693 (2), U01AT009974 (2), 1UG3AT013109-01 (1), 1UG3HL165740-01A1 (1), 1UG3HL166785 (1), 2004 (1), 2008 (1)