5406 completed, 1676 unknown, 1478 recruiting, 614 not yet recruiting. 4827 Not applicable, 1279 Phase 2, 823 Phase 1, 635 Phase 3, 504 Phase 4.
Follow Neurocognitive Disorders: new trials by email Literature Review of Neurocognitive Disorders trials Research Report on Neurocognitive Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| Post-surgical Delirium in Patients Undergoing Radical Cystectomy. Radical cystectomy. - Delirium, Radical Cystectomy | Not yet recruiting | University of Alexandria | 100 | 2028-11-25 | 2025-04-03 | |
| Post-surgical Delirium in Patients Undergoing Open Heart Surgery. Open heart surgery - Delirium, Open Heart Surgery | Not yet recruiting | University of Alexandria | 300 | 2028-10-01 | 2025-04-03 | |
| MRI Technical Development and Applications in Kidney Disease Chronic Kidney Diseases, Kidney Transplantation | Not yet recruiting | University of Minnesota | 180 | 2028-06-30 | 2026-04-13 | |
| Smartphone App for Adolescents With Idiopathic Scoliosis DinSkoliose smartphone application - Adolescence Idiopathic Scoliosis, AIS | Not applicable | Not yet recruiting | Oslo Metropolitan University | 30 | 2028-04-01 | 2026-07-07 |
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| Transcranial Magnetic Stimulation for Alzheimer's Disease Treatment Active Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation - Alzheimer Disease | Not applicable | Not yet recruiting | Universitat Oberta de Catalunya | 45 | 2027-11-01 | 2026-07-21 |
| Terazosin for Dementia With Lewy Bodies Terazosin Hydrochloride, Placebo - Dementia With Lewy Bodies | Phase 1 / Phase 2 | Not yet recruiting | Qiang Zhang | 40 | 2027-10-01 | 2026-03-12 |
| AV-1959R Vaccine in Individuals With Preclinical Alzheimer's Disease AV-1959R, Placebo - Preclinical Alzheimer's Disease, Alzheimer Disease | Phase 2 | Not yet recruiting | Institute for Molecular Medicine | 160 | 2027-10-01 | 2026-10-21 |
| cMIND AI Web Tool Usability Study (Hong Kong) Web-Based AI Dietary Assessment System - Mild Cognitive Impairment (MCI), Healthy Aging | Not yet recruiting | Hong Kong Metropolitan University | 20 | 2027-09-01 | 2026-07-29 | |
| Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau Neuronavigation-guided single-element focused ultrasound transducer, Lumason, Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents - Alzheimer Disease, Early Onset | Phase 1 | Not yet recruiting | Columbia University | 6 | 2027-08-01 | 2026-05-13 |
| Terazosin And Metabolic Engagement in Alzheimer's Disease Terazosin (Hytrin), Placebo - Alzheimer s Disease | Phase 2 | Not yet recruiting | Qiang Zhang | 100 | 2027-08-01 | 2026-09-01 |
| Feasibility of a Dyadic Music-based Intervention for Persons Living With Dementia and Their Care Partners Dyadic Music-based Intervention (MBI), Reminiscence Activity - Dementia | Not applicable | Not yet recruiting | Duke University | 60 | 2027-08-01 | 2026-10-05 |
| Hearing Loss and Brain Health Study Over-The-Counter (OTC) hearing aid - Hearing Loss, Adult-Onset, Dementia | Not applicable | Not yet recruiting | University of Southern California | 40 | 2027-07-01 | 2026-05-08 |
| GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD) GV1001 Placebo, GV1001 1.12mg - Moderate to Severe Alzheimer's Disease | Phase 3 | Not yet recruiting | Samsung Pharmaceutical Co., Ltd. | 750 | 2027-07-01 | 2026-06-10 |
| Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery Postoperative Cognitive Complications, Delirium | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2027-07-01 | 2026-10-23 | |
| Fall Prevention in Mild Cognitive Impairment Virtual Neurophysiological Rehabilitation - Cognitive Impairment, High Fall Risk | Not applicable | Not yet recruiting | VA Office of Research and Development | 28 | 2027-06-01 | 2026-04-09 |
| Dyadic Cognitive Intervention for Older Adults With Cognitive Impairment and Their Spouses Dyadic Cognitive Intervention Program for Older Couples, Standard Community Health Education on Cognitive Impairment - Cognitive Impairment | Not applicable | Not yet recruiting | Gansu University of Chinese Medicine | 136 | 2027-06-01 | 2026-10-13 |
| Prucalopride for Cognitive Functioning in Schizophrenia Prucalopride 1 MG - Schizophrenia | Not applicable | Not yet recruiting | University of Pittsburgh | 34 | 2027-05-31 | 2026-09-17 |
| Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries | Phase 2 | Not yet recruiting | VA Office of Research and Development | 46 | 2027-05-24 | 2026-02-17 |
Showing 20 of 10594. Sign in to see all of them.
Alzheimer Disease (3878) · Cognitive Dysfunction (3778) · Dementia (2255) · Delirium (881) · Emergence Delirium (735) · Cognition Disorders (398) · Depression (385) · Parkinson Disease (328) · Huntington Disease (292) · Consciousness Disorders (281) · Stroke (266) · Postoperative Cognitive Complications (257) · Motor Activity (256) · Lewy Body Disease (236)
Mental Disorders (10452) · Nervous System Diseases (8303) · Central Nervous System Diseases (6408) · Brain Diseases (6356) · Neurodegenerative Diseases (4423) · Cognition Disorders (4236) · Tauopathies (3866) · Pathological Conditions, Signs and Symptoms (3724) · Dementia (3562) · Signs and Symptoms (2997) · Neurologic Manifestations (2819) · Neurobehavioral Manifestations (2411) · Pathologic Processes (1746) · Confusion (1464)
Dexmedetomidine (183) · Donepezil (167) · Transcranial Direct Current Stimulation (154) · Exercise (135) · Cognitive Training (122) · Saline Solution (101) · Propofol (98) · Transcranial Magnetic Stimulation (80) · Memantine (79) · Sodium Chloride (67) · Sevoflurane (62) · Control Groups (61) · Blood Specimen Collection (59) · Magnetic Resonance Spectroscopy (58) · Neuropsychological Tests (57)
Johns Hopkins University (89) · Assistance Publique - Hôpitaux de Paris (88) · Massachusetts General Hospital (83) · University of California, San Francisco (69) · Pfizer (68) · VA Office of Research and Development (68) · Chang Gung Memorial Hospital (66) · Eli Lilly and Company (63) · University of Pennsylvania (59) · Indiana University (57) · Mayo Clinic (57) · Charite University, Berlin, Germany (55) · Emory University (53) · National Institute on Aging (NIA) (52) · The Hong Kong Polytechnic University (51)
United States (3924) · China (910) · France (802) · Canada (727) · United Kingdom (550) · Spain (479) · Germany (464) · Italy (462) · Turkey (Türkiye) (309) · Taiwan (291) · South Korea (290) · Netherlands (287) · Australia (254) · Sweden (203) · Belgium (198)
Claudia Spies, MD, Prof. (22) · Dong-Xin Wang, MD, PhD (18) · Danna Jennings, MD (16)
PMID 33189083, PMID 39498781, PMID 40603145, PMID 39800465, PMID 15817019, PMID 40049590, PMID 23992774, PMID 33417236, PMID 36463457, PMID 15114210, PMID 33238043, PMID 33974419, PMID 34815790, PMID 38489195, PMID 1202204, PMID 15082703, PMID 22323509, PMID 22762316, PMID 25918556, PMID 26120369, PMID 26402769, PMID 28576285, PMID 29480210, PMID 32250312, PMID 32905623, PMID 34532852, PMID 36398903, PMID 39324520, PMID 40667684, PMID 40681915, PMID 41533472, PMID 41537338, PMID 41804324, PMID 41961243, PMID 42063312, PMID 11001602, PMID 18156878, PMID 18577850, PMID 19745202, PMID 19954851, PMID 24574549, PMID 25022459, PMID 25535538, PMID 25671576, PMID 27472878, PMID 27660922, PMID 27807285, PMID 27871675, PMID 28973626, PMID 29318278
2023 (33), 2016 (31), 2025 (28), 2009 (23), 2015 (23), U54AG063546 (23), 2014 (22), 2017 (20), 2018 (16), 2019 (14), P30AG064200 (8), U01AG010483 (7), P30AG022849 (6), P30AG024978 (6), 2008 (5)