42 completed, 10 unknown, 9 recruiting, 6 not yet recruiting. 80 Phase 2, 20 Phase 3, 12 Phase 1.
Follow Delirium: new trials by email Literature Review of Delirium trials Research Report on Delirium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline - Postoperative Delirium, Hip Fractures | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 130 | 2026-10-01 | 2026-09-09 |
| Lemborexant Use for Cognition Improvement in Postoperative Delirium in Elderly Patients: A Randomized Controlled Trial Lemborexant Pill, Placebo tablet - Postoperative Delirium | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 992 | 2026-09-01 | 2026-07-14 |
| Oral Versus Intravenous Magnesium on Emergence Delirium Magnesium glycinate, Magnesium sulfate injection, Oral juice and intravenous saline - Magnesium, Emergence Delirium | Phase 2 / Phase 3 | Recruiting | Tanta University | 360 | 2026-07-01 | 2026-07-06 |
| CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium Citicoline - Cognitive Decline, Delirium | Phase 2 | Recruiting | University of Milano Bicocca | 122 | 2026-06-03 | 2026-09-09 |
| MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES) Dexmedetomidine, Placebo - Major Abdominal Surgery, Postoperative Delirium (POD) | Phase 2 / Phase 3 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 400 | 2026-05-01 | 2026-04-20 |
| Intranasal Insulin to Prevent Intensive Care Unit Delirium Intranasal insulin-40U, Intranasal sodium chloride 0.9% - Delirium - Postoperative | Phase 2 / Phase 3 | Completed | Radboud University Medical Center | 30 | 2026-04-30 | 2026-08-03 |
| Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG) - Total Knee Arthroplasty (TKA) | Phase 1 / Phase 2 | Recruiting | University of Chicago | 150 | 2026-03-11 | 2026-06-26 |
| The Effect of Omega 3 Supplementation on Postoperative Delirium in Elderly Patients Undergoing Major Cardiac Surgery Omega-3 Ethyl Esters 4 g, Omega-3 Ethyl Esters 2 g - Postoperative Delirium | Phase 2 | Terminated | University of Missouri-Columbia | 1 | 2026-03-03 | 2026-05-11 |
| Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery Dexmedetomidine (Low dose), Dexmedetomidine (High dose), Fentanyl - Delirium - Postoperative | Phase 2 | Completed | Benha University | 75 | 2026-02-26 | 2026-08-25 |
| Daridorexant to Prevent Post-cardiotomy Delirium Daridorexant 50 mg, Placebo - Postoperative Cognitive Decline, Postoperative Delirium | Phase 2 | Recruiting | University of Rochester | 80 | 2025-10-14 | 2026-01-07 |
| Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery Acetaminophen, Saline - Delirium in Old Age | Phase 2 / Phase 3 | Not yet recruiting | RenJi Hospital | 1930 | 2025-06-01 | 2025-04-04 |
| The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery oxytocin nasal spray - Cervical Spinal Stenosis, Thoracic Spinal Stenosis | Phase 2 | Completed | Zhejiang University | 227 | 2025-06-01 | 2026-08-20 |
| Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients Lemborexant 5 mg, Control (placebo) group - Delirium - Postoperative, Cardiac Surgery | Phase 2 | Not yet recruiting | University of British Columbia | 60 | 2025-05-01 | 2025-04-23 |
| Intravenous Dexmedetomidine as an Adjuvant to Locoregional Anesthesia in Pediatric Surgery Dexmedetomidine, Placebo administration, Face Legs Activity Cry Consolability scale - Anesthesia, Pediatric Surgery | Phase 2 | Recruiting | University Hospital, Montpellier | 200 | 2025-02-03 | 2026-10-13 |
| Daridorexant to Prevent Delirium After Heart Surgery Daridorexant 50 mg, Placebo - POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE | Phase 2 | Completed | University of Rochester | 11 | 2024-11-11 | 2025-07-11 |
| The Use of Melatonin for Delirium Prevention in Medically Hospitalized Patients Intervention 1, Intervention 2, Control - Delirium | Phase 2 / Phase 3 | Recruiting | Sultan Qaboos University | 240 | 2024-09-30 | 2025-01-14 |
| Ketofol Versus Dexmedetomidine for Prevention of Emergence Delirium in Pediatric Patients Undergoing Squint Surgeries Ketamine, Dexmedetomidine - Emergence Delirium | Phase 1 / Phase 2 | Unknown | Cairo University | 46 | 2024-08-10 | 2024-08-20 |
| Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery Erector Spinae Block, Local infiltration with local anesthetic - Postoperative Delirium, Pain, Postoperative | Phase 2 | Completed | Rashmi Mueller | 29 | 2024-05-15 | 2026-02-13 |
| Emergence Agitation of Sevoflurane in Pediatric we will give the patient 0.1 mg nalbuphine 15 min before the end of the procedure, we will give the patient 0.5 mg dexmedetomidine 15 min before the end of the procedure - Emergence Delirium | Phase 2 / Phase 3 | Completed | Ain Shams University | 126 | 2024-05-01 | 2025-02-17 |
| Remimazolam for Emergence Delirium Prevention in Patients Undergoing Rhinoseptoplasty, FESS or Septoplasty Remimazolam 20 MG Injection [Byfavo], NaCl 0.9% - Remimazolam, Emergence Delirium | Phase 2 | Unknown | University Hospital of Split | 80 | 2024-03-06 | 2024-05-03 |
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Emergence Delirium (33) · Cognitive Dysfunction (12) · Psychomotor Agitation (6) · Alzheimer Disease (5) · Critical Illness (5) · Dementia (4) · Hip Fractures (4) · Postoperative Cognitive Complications (4) · Mental Disorders (3) · Pain, Postoperative (3) · Brain Diseases (2) · Central Nervous System Diseases (2) · Cognition Disorders (2) · Death (2)
Confusion (80) · Neurobehavioral Manifestations (80) · Neurologic Manifestations (80) · Pathological Conditions, Signs and Symptoms (80) · Signs and Symptoms (80) · Nervous System Diseases (78) · Neurocognitive Disorders (78) · Mental Disorders (77) · Pathologic Processes (46) · Postoperative Complications (34) · Cognition Disorders (11) · Behavior (7) · Disease Attributes (7) · Aberrant Motor Behavior in Dementia (6)
Dexmedetomidine (21) · Saline Solution (10) · Sodium Chloride (7) · Haloperidol (6) · Melatonin (6) · Ketamine (4) · Lorazepam (3) · Quetiapine Fumarate (3) · Chlorpromazine (2) · Clonidine (2) · Donepezil (2) · Fentanyl (2) · Nalbuphine (2) · Propofol (2) · daridorexant (2)
Ain Shams University (4) · M.D. Anderson Cancer Center (4) · Assiut University (3) · Vanderbilt University (3) · Austin Health (2) · Bruyère Health Research Institute. (2) · Cairo University (2) · Massachusetts General Hospital (2) · University of Colorado, Denver (2) · University of Rochester (2) · Air Liquide Santé International (1) · Albert Einstein College of Medicine (1) · Amira Hassan Ahmed Ali (1) · Antonia New (1) · Assistance Publique - Hôpitaux de Paris (1)
United States (37) · Egypt (11) · Canada (7) · France (3) · Italy (3) · Australia (2) · Brazil (2) · Belgium (1) · China (1) · Croatia (1) · Denmark (1) · Germany (1) · Greece (1) · Japan (1) · Jordan (1)
David Hui (2) · David Hui, MD (2) · E Wesley Ely, MD, MPH (2) · Alessandro Santini, MD (1) · Ali M. Abu Dalo, MD (1) · Amany Saleh, MD (1) · Amira Hassan Ahmed, resident (1) · Andrew Davis, MBBS (1) · Ann M Kolanowski, PhD, RN (1) · Anthony Delaney, MBBS (1) · Antonia S. New, MD (1) · Antonio Pesenti, MD (1) · Arash Afshari, PhD (1) · Ben Cheung, MBBS (1) · BioXcel MM, MD (1)
PMID 10976589, PMID 16231283, PMID 18073360, PMID 19219713, PMID 19454032, PMID 20047458, PMID 20095068, PMID 20233428, PMID 20664045, PMID 21309472, PMID 21429671, PMID 21802441, PMID 21859765, PMID 22091574, PMID 22215593, PMID 22922544, PMID 23016882, PMID 23575742, PMID 23992774, PMID 24635006, PMID 24856271, PMID 25887557, PMID 26767820, PMID 26975647, PMID 27107209, PMID 27138855, PMID 27228512, PMID 27515515, PMID 28087128, PMID 28289281, PMID 28363933, PMID 28467893, PMID 28586471, PMID 28629540, PMID 28651648, PMID 28663651, PMID 28930284, PMID 28965836, PMID 28975307, PMID 29048602, PMID 29363356, PMID 29397119, PMID 29497187, PMID 29678977, PMID 29729237, PMID 29884231, PMID 30243062, PMID 30501612, PMID 30643009, PMID 31233803
2025 (2), R01AG053582 (2), R01AG075005 (1), R01GM112871 (1), R01MH097799 (1), R01NS102190 (1), R03AG040673 (1), R21AG027549 (1), R21AG050850 (1), R21AT003302 (1), R21CA186000 (1), R21NR016736 (1)