1897 completed, 698 unknown, 651 recruiting, 247 not yet recruiting. 2151 Not applicable, 374 Phase 2, 156 Phase 1, 151 Phase 4, 139 Phase 3.
Follow this condition Literature Review of Cognitive Dysfunction trials Research Report on Cognitive Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| cMIND AI Web Tool Usability Study (Hong Kong) Web-Based AI Dietary Assessment System - Mild Cognitive Impairment (MCI), Healthy Aging | Not yet recruiting | Hong Kong Metropolitan University | 20 | 2027-09-01 | 2026-07-29 | |
| Fall Prevention in Mild Cognitive Impairment Virtual Neurophysiological Rehabilitation - Cognitive Impairment, High Fall Risk | Not applicable | Not yet recruiting | VA Office of Research and Development | 28 | 2027-06-01 | 2026-04-09 |
| Dyadic Cognitive Intervention for Older Adults With Cognitive Impairment and Their Spouses Dyadic Cognitive Intervention Program for Older Couples, Standard Community Health Education on Cognitive Impairment - Cognitive Impairment | Not applicable | Not yet recruiting | Gansu University of Chinese Medicine | 136 | 2027-06-01 | 2026-10-13 |
| Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries | Phase 2 | Not yet recruiting | VA Office of Research and Development | 46 | 2027-05-24 | 2026-02-17 |
| Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog Assessments, Neuroimaging volumetric measures, Biofluid samples - Mild Cognitive Impairment, Subjective Cognitive Decline | Enrolling by invitation | Ohio State University | 100 | 2027-03-01 | 2026-10-16 | |
| Auditory-Cognitive Optimization Care Program for Older Adults With Hearing Loss and Cognitive Impairment Auditory-Cognitive Optimization Care Program (A-COP), Hearing Management and Newspaper-Reading Activities - Hearing Loss, Cognitive Impairment | Not applicable | Not yet recruiting | Taipei Medical University | 76 | 2027-02-01 | 2026-10-13 |
| Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns Bedroom Environment Tailoring, Sleep Health Education - Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) | Not applicable | Not yet recruiting | Johns Hopkins University | 40 | 2027-02-01 | 2026-10-09 |
| Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder | Not applicable | Not yet recruiting | Central South University | 400 | 2027-01-01 | 2026-03-04 |
| Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment - Carotid Stenosis, Carotid Artery Diseases | Not yet recruiting | Nguyen Toan Thang | 150 | 2027-01-01 | 2026-09-11 | |
| The CDAC Study - Cerebral Dysfunction After Coronary Revascularization Neurocognitive testing - CABG, PCI | Not yet recruiting | The Scripps Research Institute | 600 | 2027-01-01 | 2026-03-24 | |
| Gaze and Gait Training With rTMS Repetitive Transcranial Magnetic Stimulation (rTMS), Gait training, Gaze training - Mild Cognitive Impairment | Not applicable | Not yet recruiting | University of Florida | 30 | 2027-01-01 | 2026-05-06 |
| A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia Xanomeline/trospium - Schizophrenia; Psychosis, Cognitive Impairment | Phase 3 | Not yet recruiting | European Group for Research In Schizophrenia | 171 | 2027-01-01 | 2026-05-13 |
| Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment Mild Cognitive Impairment (MCI), Opioid Use | Not yet recruiting | Miklos Kertai | 552 | 2027-01-01 | 2026-10-21 | |
| Synbiotic LA-5 and Agave Inulin for Mild Cognitive Impairment Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin) Intervention Type: - Cognitive Impairment | Not applicable | Recruiting | Anahuac University | 20 | 2026-12-31 | 2026-09-14 |
| Wearable Sensor for Early Detection and Monitoring of Cognitive Decline Mild Cognitive Impairment (MCI), Older Adults With Cognitive Decline | Not yet recruiting | BioSensics | 100 | 2026-12-15 | 2026-09-02 | |
| Cholinergic Enhancement of Theta COBENFY KarXT (50/20 mg), Control - Epilepsy, Seizures | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 50 | 2026-12-01 | 2026-09-29 |
| International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Left Ventricular Dysfunction Trial Guideline-directed medical therapy (GDMT), Coronary artery bypass grafting (CABG), Percutaneous coronary intervention (PCI). - Coronary Artery Disease, Cognitive Impairment | Phase 3 | Suspended | NYU Langone Health | 1200 | 2026-12-01 | 2026-06-05 |
| PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery | Not yet recruiting | Ain Shams University | 185 | 2026-12-01 | 2026-09-25 | |
| Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance Cannabis - Cannabis Use, Impaired Driving | Phase 1 | Not yet recruiting | Johns Hopkins University | 40 | 2026-12-01 | 2026-10-16 |
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Cognitive Training (95) · Exercise (91) · Transcranial Direct Current Stimulation (74) · Transcranial Magnetic Stimulation (44) · Donepezil (39) · Control Groups (35) · Neuropsychological Tests (29) · Magnetic Resonance Spectroscopy (27) · Propofol (27) · Blood Specimen Collection (25) · Mental Status and Dementia Tests (25) · Dexmedetomidine (22) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (20) · Sevoflurane (20) · Memantine (18)
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Suzanne Craft, PhD (16) · Mariana Figueiro, PhD (8) · Paul Aisen, MD (8) · Tammie Benzinger, MD, PhD (8) · Emil Fristed, MSc (7) · Malaz Boustani, MD, MPH (6) · Cay Anderson-Hanley, PhD (5) · Elaine T Kiriakopoulos, MD, MPH, MSc (5) · Nicolai Goettel, MD (5) · Reisa Sperling, MD (5) · Susana I Justo Henriques, PhD (5)
PMID 15817019, PMID 39324520, PMID 29780318, PMID 30200183, PMID 30233154, PMID 31221697, PMID 32905623, PMID 33189083, PMID 36398903, PMID 39498781, PMID 39800465, PMID 41804324, PMID 9525362, PMID 11065205, PMID 1202204, PMID 12648190, PMID 15324367, PMID 16300724, PMID 18156878, PMID 18686756, PMID 19422355, PMID 19617584, PMID 19812460, PMID 21514249, PMID 21514250, PMID 21951520, PMID 22261206, PMID 22321085, PMID 22762316, PMID 24303859, PMID 25459243, PMID 26285025, PMID 26762403, PMID 27337738, PMID 27472878, PMID 28593326, PMID 28601132, PMID 28840742, PMID 29282327, PMID 29331848, PMID 29500313, PMID 30618593, PMID 30989165, PMID 31390660, PMID 31708380, PMID 32895890, PMID 33189147, PMID 33238043, PMID 33271079, PMID 33406266
2016 (11), 2025 (10), 2018 (8), 2023 (8), U54AG063546 (7), 2017 (5), 2019 (5), P30AG022849 (5), 2015 (4), U01AG024904 (4), 2014 (3), 2SB1AG059458-04A1 (3), K23AG052633 (3), K76AG064394 (3), P01AG073090 (3)