21174 completed, 6671 unknown, 5718 recruiting, 2574 terminated. 17280 Not applicable, 5739 Phase 2, 3598 Phase 1, 3384 Phase 3, 1800 Phase 4.
Follow this condition Literature Review of Central Nervous System Diseases trials Research Report on Central Nervous System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patient-centered Assessment of the Effects of Powered Exoskeleton Use in People With Spinal Cord Injury Rehabilitation - Spinal Cord Injuries | Not applicable | Suspended | Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro | 18 | 2030-01-01 | 2026-03-27 |
| Observational Study to Assess Migraine Prediction Tool Daily questionnaire - Migraine | Suspended | Theranica | 200 | 2030-01-01 | 2024-11-22 | |
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of TBN Tetramethylpyrazine nitrone (TBN) tablet / Placebo - Healthy | Phase 1 | Not yet recruiting | Guangzhou Magpie Pharmaceuticals Co., Ltd. | 16 | 2028-09-01 | 2026-09-11 |
| A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas RNS System Implantation - Glioma, Glioma Intracranial | Not applicable | Not yet recruiting | Medical College of Wisconsin | 3 | 2028-08-01 | 2026-10-13 |
| The Effect of Sympathetic Modulation on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage Vectris trial leads and stimulation, Sham - Vasospasm, Cerebral, Aneurysmal Subarachnoid Hemorrhage | Not applicable | Suspended | University of Alabama at Birmingham | 25 | 2028-07-31 | 2026-09-24 |
| Terazosin And Metabolic Energetics in Parkinson's Disease Terazosin 5 MG, Placebo - Parkinson's Disease (PD) | Phase 2 | Suspended | Ergun Y. Uc | 120 | 2028-07-01 | 2026-10-09 |
| Device for Bladder Control for Men With SCI Noninvasive electrical stimulation device to improve bladder control - Neurogenic Bladder | Phase 1 / Phase 2 | Not yet recruiting | VA Office of Research and Development | 12 | 2028-06-01 | 2026-06-25 |
| Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial Allogeneic Human Induced Pluripotent Stem Cell (iPSC)-Derived Motor Neuron Progenitor Cells, Placebo - Spinal Cord Injury, Safety | Phase 2 | Not yet recruiting | XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. | 60 | 2028-05-25 | 2025-11-25 |
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| Smartphone App for Adolescents With Idiopathic Scoliosis DinSkoliose smartphone application - Adolescence Idiopathic Scoliosis, AIS | Not applicable | Not yet recruiting | Oslo Metropolitan University | 30 | 2028-04-01 | 2026-07-07 |
| EMBRACE Study: Enduring Migraine Benefit From Responsive Artery Coil Embolization TEMMA Endovascular Treatment - Migraine Disorders, Refractory Migraine | Not applicable | Not yet recruiting | Cortex Neurovascular | 25 | 2028-03-01 | 2026-10-20 |
| Using Power Mobility Training to Promote Arm & Hand Function in Children With Cerebral Palsy Arm- and hand-use focused power mobility training - Cerebral Palsy, Hemiplegia, Infantile | Not applicable | Not yet recruiting | Grand Valley State University | 10 | 2028-01-19 | 2026-09-11 |
| Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury | Phase 2 | Not yet recruiting | University of California, Los Angeles | 264 | 2028-01-10 | 2026-01-16 |
| Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury MUSE Stem Cell Therapy - Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients | Not yet recruiting | Healing Hope International | 10 | 2028-01-01 | 2026-03-10 | |
| Double-Blind Clinical Trial of Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease active subthalamic nucleus deep brain stimulation plus optimal drug therapy, inactive subthalamic nucleus deep brain stimulation plus optimal drug therapy - Parkinson Disease | Not applicable | Not yet recruiting | Mallory Hacker | 40 | 2028-01-01 | 2026-02-20 |
| To Evaluate the Safety and Efficacy of GS1168 Injection in Adult Phenylketonuria GS1168 injection - Phenylketonuria (PKU) | Early Phase 1 | Not yet recruiting | Gritgen Therapeutics Co., Ltd. | 9 | 2027-12-31 | 2026-09-10 |
| Essential Acute Stroke Care in Low Resource Settings: a Pilot studY Acute stroke care Intervention arm - Acute Stroke | Not applicable | Not yet recruiting | The George Institute | 300 | 2027-12-30 | 2026-06-11 |
| Study to Evaluate the Safety, Tolerability, Efficacy, and PK of FHL-301 in Parkinson's Disease Patients. Gemfibrozil, Placebo - Parkinson Disease | Phase 2 | Withdrawn | Forest Hills Lab | 2027-11-01 | 2026-08-19 | |
| Transcranial Magnetic Stimulation for Alzheimer's Disease Treatment Active Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation - Alzheimer Disease | Not applicable | Not yet recruiting | Universitat Oberta de Catalunya | 45 | 2027-11-01 | 2026-07-21 |
Showing 20 of 41585. Sign in to see all of them.
Stroke (7794) · Parkinson Disease (4473) · Alzheimer Disease (3874) · Ischemic Stroke (2540) · Brain Neoplasms (2363) · Dementia (2249) · Spinal Cord Injuries (1930) · Cerebral Palsy (1829) · Epilepsy (1806) · Brain Injuries, Traumatic (1677) · Cognitive Dysfunction (1576) · Migraine Disorders (1484) · Amyotrophic Lateral Sclerosis (972) · Brain Injuries (918) · Motor Activity (739)
Nervous System Diseases (41157) · Brain Diseases (36754) · Vascular Diseases (13057) · Cardiovascular Diseases (12970) · Cerebrovascular Disorders (12365) · Pathological Conditions, Signs and Symptoms (10924) · Neurodegenerative Diseases (10569) · Mental Disorders (7674) · Signs and Symptoms (6934) · Neurocognitive Disorders (6352) · Neurologic Manifestations (6144) · Movement Disorders (5680) · Basal Ganglia Diseases (5448) · Wounds and Injuries (5055)
Transcranial Direct Current Stimulation (460) · Exercise (358) · Transcranial Magnetic Stimulation (281) · Blood Specimen Collection (245) · Sodium Chloride (243) · Standard of Care (213) · Aspirin (203) · Magnetic Resonance Spectroscopy (203) · Saline Solution (202) · Temozolomide (198) · Control Groups (189) · Physical Therapy Modalities (177) · Surveys and Questionnaires (175) · Donepezil (172) · Botulinum Toxins, Type A (160)
National Institute of Neurological Disorders and Stroke (NINDS) (374) · Riphah International University (362) · VA Office of Research and Development (336) · Assistance Publique - Hôpitaux de Paris (330) · Beijing Tiantan Hospital (242) · Pfizer (237) · National Taiwan University Hospital (230) · Mayo Clinic (224) · GlaxoSmithKline (216) · Duke University (193) · Chang Gung Memorial Hospital (191) · Johns Hopkins University (191) · Hospices Civils de Lyon (186) · Xuanwu Hospital, Beijing (184) · Cairo University (183)
United States (15152) · France (3507) · China (3395) · Canada (2608) · United Kingdom (2221) · Italy (2159) · Germany (2150) · Spain (1904) · Turkey (Türkiye) (1568) · Belgium (1084) · Taiwan (1077) · Netherlands (1047) · South Korea (1025) · Australia (985) · Denmark (936)
PMID 36602886, PMID 38588457, PMID 33175411, PMID 34813082, PMID 37870112, PMID 31867054, PMID 39498781, PMID 33189083, PMID 34184251, PMID 34196963, PMID 40603145, PMID 12807523, PMID 35857365, PMID 36700520, PMID 18190818, PMID 37467180, PMID 11914403, PMID 20451898, PMID 34022170, PMID 34487721, PMID 40680102, PMID 16731270, PMID 21899409, PMID 34081125, PMID 34515113, PMID 36398903, PMID 39800465, PMID 15817019, PMID 22108357, PMID 2375765, PMID 25671797, PMID 26898852, PMID 26899665, PMID 31356217, PMID 31420846, PMID 32905623, PMID 33825230, PMID 34695300, PMID 35305920, PMID 37565307, PMID 40049590, PMID 8984084, PMID 24144944, PMID 24524452, PMID 27657681, PMID 31662037, PMID 32640944, PMID 33417236, PMID 33461041, PMID 34218211
2023 (144), 2018 (118), 2019 (112), 2014 (111), 2017 (103), 2025 (99), 2016 (92), 2015 (89), 2009 (68), 2008 (53), 2004 (27), 2005 (27), U10EY011751 (23), U54AG063546 (22), U01CA081457 (14)