210 completed, 100 unknown, 35 recruiting, 32 terminated. 138 Not applicable, 132 Phase 2, 86 Phase 3, 52 Phase 4, 43 Phase 1.
Follow Melatonin: new trials by email Literature Review of Melatonin trials Research Report on Melatonin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy Melatonin 10 MG, Selenium, Placebo - Ppm, Cardiomyopathy | Not applicable | Not yet recruiting | Tanta University | 25 | 2026-12-20 | 2026-01-12 |
| Oral Melatonin as Adjunctive Therapy in Adults With Atopic Dermatitis Melatonin, Standard Treatment for Atopic Dermatitis - Atopic Dermatitis | Not applicable | Not yet recruiting | Can Tho University of Medicine and Pharmacy | 130 | 2026-10-10 | 2026-09-25 |
| Melatonin and Immunonutrition for Pain Relief in Fibromyalgia Melatonin 1mg and intravenous B-complex vitamin drip, Placebo - Fibromyalgia | Not applicable | Recruiting | University of Thessaly | 60 | 2026-10-01 | 2026-10-07 |
| Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICU Melatonin - Critical Illness, ICU | Phase 4 | Not yet recruiting | Rutgers, The State University of New Jersey | 30 | 2026-09-01 | 2026-07-13 |
| Comparison Between the Effect of Two Different Doses of Oral Melatonin on Sleep Quality After Total Hip Arthroplasty Melatonin 5 MG, Melatonin 10 MG, Placebo - Sleep Disturbance | Early Phase 1 | Not yet recruiting | Benha University | 150 | 2026-08-04 | 2026-07-29 |
| Efficacy of CBT-I With Adjuvant Melatonin in Older Adults Chronic Insomnia Cognitive behavioural therapy for insomnia, Melatonin 3 mg immediate-release, Psychoeducation - Insomnia, Aging | Not applicable | Recruiting | The University of Hong Kong | 183 | 2026-08-01 | 2026-08-21 |
| Effect of Melatonin Administration on Systemic Lupus Erythematosus Patients Melatonin - Therapy, Treatment | Phase 2 / Phase 3 | Not yet recruiting | Ain Shams University | 64 | 2026-07-21 | 2026-07-23 |
| Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery melatonin (Circadin ®) 0.2 mg/kg, melatonin (Circadin ®) 0.4 mg/kg, placebo group - Preoperative Anxiety | Not applicable | Recruiting | Al-Azhar University | 120 | 2026-07-12 | 2026-01-06 |
| Melatonin for the Treatment of DEE-SWAS Melatonin - CSWS, Developmental and/or Epileptic Encephalopathies | Phase 2 | Not yet recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 3 | 2026-07-01 | 2025-10-30 |
| COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHLOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE MgSO4 (seizure prevention), Melatonin , Mgso4 - HIE - Hypoxic - Ischemic Encephalopathy | Phase 3 | Not yet recruiting | University of Child Health Sciences and Children's Hospital, Lahore | 80 | 2026-07-01 | 2026-06-17 |
| Preventive Role of Melatonin and Propranolol Administration in Pediatric Migraine Melatonin, Propranolol - Migraine Disorders | Not applicable | Enrolling by invitation | Nishtar Medical University | 60 | 2026-06-10 | 2026-08-03 |
| Sleep Quality and the Efficacy of a Multimodal Sleep Pathway in Hospitalized Orthopedic Trauma Patients Standard Postoperative Care, Zolpidem, Melatonin - Orthopedic Trauma, Sleep Quality | Phase 3 | Recruiting | Emory University | 30 | 2026-06-02 | 2026-07-30 |
| Melatonin Versus Placebo for Bipolar Disorder Melatonin, Placebo - Bipolar Affective Disorder | Phase 2 | Recruiting | Lars Vedel Kessing | 200 | 2026-05-08 | 2026-05-12 |
| Melatonin and Solifenacin for Double-J Ureteral Stent Symptoms Solifenacin, Melatonin - Ureteral Stent-Related Symptoms, Ureteral Calculi | Phase 2 | Recruiting | Beni-Suef University | 189 | 2026-05-07 | 2026-06-02 |
| Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic Cholecystectomy Melatonin (N-acetyl-5-methoxytryptamine), Placebo - Laparoscopic Cholecystectomy, Postoperative Quality of Recovery | Not applicable | Recruiting | Armed Forces Medical Institute Bangladesh | 84 | 2026-05-01 | 2026-09-30 |
| The Effect of Adjunctive Melatonin With Colistin in Patients With Multidrug-Resistant Gram-Negative Bacterial Infections Melatonin, Placebo - Multidrug-Resistant Gram-Negative Bacterial Infections, Antimicrobial Resistance | Phase 3 | Not yet recruiting | Ain Shams University | 70 | 2026-03-26 | 2026-03-31 |
| Effect of Melatonin on Oxidative Stress Parameters in Levodopa-Treated Parkinson's Disease Patients MELATONIN (MELATL07959) - Parkinson Disease | Phase 2 | Enrolling by invitation | Bangladesh Medical University | 70 | 2026-02-17 | 2026-01-29 |
| Melatonin for Glycemic Control in Gestational Diabetes Mellitus Melatonin, Placebo - Gestational Diabetes | Phase 2 | Not yet recruiting | Obstetrics & Gynecology Hospital of Fudan University | 150 | 2026-02-01 | 2026-01-27 |
| Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery Placebo capsule, Melatonin capsule, Pregabalin capsule - Oral, Melatonin | Not applicable | Recruiting | Tanta University | 105 | 2026-01-17 | 2026-01-21 |
| Somato® (Phytomelatonin) Versus Synthetic Melatonin and Placebo on Sleep Quality Plant-based melatonin, Melatonin, Placebo - Sleep | Not applicable | Completed | Nutraland USA, Inc. | 244 | 2026-01-13 | 2026-06-30 |
Showing 20 of 427. Sign in to see all of them.
Sleep Initiation and Maintenance Disorders (31) · Parasomnias (22) · Anxiety Disorders (19) · Delirium (19) · Sleep Wake Disorders (19) · Pain (15) · Pain, Postoperative (13) · Sleep Disorders, Circadian Rhythm (13) · Breast Neoplasms (12) · Depression (9) · COVID-19 (8) · Hypertension (8) · Agnosia (7) · Autism Spectrum Disorder (7) · Fatigue (7)
Ain Shams University (19) · Tanta University (10) · Neurim Pharmaceuticals Ltd. (9) · Brigham and Women's Hospital (8) · Cairo University (7) · Oregon Health and Science University (7) · Benha University (5) · Emory University (5) · M.D. Anderson Cancer Center (5) · University of Aarhus (5) · Duquesne University (4) · Herlev Hospital (4) · Hospital de Clinicas de Porto Alegre (4) · Khon Kaen University (4) · Mansoura University (4)
United States (119) · Egypt (58) · Denmark (27) · Canada (19) · Italy (14) · Spain (13) · China (11) · France (10) · Brazil (9) · Iran (9) · Israel (9) · Mexico (8) · Turkey (Türkiye) (8) · United Kingdom (8) · Netherlands (6)
Alfred J Lewy, MD, PhD (3) · Amy A Gelfand, MD (3) · Changwei Liu, MD (3) · Alfred Lewy, MD, PhD (2) · Arlene Chapman, M.D. (2) · Christina Barkauskas, MD (2) · Dennis B Zetner, MD (2) · Donald Bliwise, Ph.D. (2) · Hui Xin Ong, PhD (2) · Naomi L Deacon, Ph.D. (2) · Paula A Witt-Enderby, PhD (2) · Phyllis Zee, MD, PhD (2) · Ron Grunstein, MBBS MD PhD FRACP (2)
PMID 33319916, PMID 33189083, PMID 17123867, PMID 10208286, PMID 10488881, PMID 10924859, PMID 11117539, PMID 11390919, PMID 11587154, PMID 11703564, PMID 11976067, PMID 12648190, PMID 12748199, PMID 14525940, PMID 14605526, PMID 15069466, PMID 15145300, PMID 15318468, PMID 15364185, PMID 15521903, PMID 15541431, PMID 15794175, PMID 15911704, PMID 16393710, PMID 16406488, PMID 16524783, PMID 16920470, PMID 16953900, PMID 17122221, PMID 17198534, PMID 17418968, PMID 17496462, PMID 17826314, PMID 17916225, PMID 17920917, PMID 18292756, PMID 18972769, PMID 18993042, PMID 19076157, PMID 19171788, PMID 19225527, PMID 1947597, PMID 19573038, PMID 19606092, PMID 19682955, PMID 19687359, PMID 19720932, PMID 20050989, PMID 20082715, PMID 20207600
2015 (2), 2018 (2), 2023 (2), R01DK102696 (2), R01HD042125 (2), R21AT004509 (2), 2004 (1), 2005 (1), 2014 (1), 2017 (1), 2019 (1), K01NR017465 (1), K23HL150229 (1), K23MH120503 (1), M01RR000051 (1)