126 completed, 29 unknown, 24 terminated, 16 withdrawn. 68 Phase 4, 49 Phase 2, 38 Not applicable, 37 Phase 3, 28 Phase 1.
Follow Clonidine: new trials by email Literature Review of Clonidine trials Research Report on Clonidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty Liposomal Bupivacaine, Bupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination - Knee Arthroplasty, Total | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 90 | 2027-02-01 | 2026-08-25 |
| Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study Psilocybin, Saline Placebo, Clonidine - Well-Being, Psychological, Psychedelic Experiences | Phase 1 | Not yet recruiting | University of Wisconsin, Madison | 120 | 2027-02-01 | 2026-10-30 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery Clonidine, Dexmedetomidine - Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids | Phase 4 | Recruiting | Columbia University | 150 | 2026-05-14 | 2026-10-29 |
| Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty Ropivacain 5 mg/ml + Clonidine - Osteo Arthritis of the Knee | Phase 4 | Recruiting | Region Skane | 200 | 2026-03-05 | 2026-05-08 |
| Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder clonidine, clonazepam 0,25 mg - Cocaine Use Disorder, Crack Abuse or Dependence | Phase 4 | Recruiting | University of Sao Paulo General Hospital | 36 | 2026-01-28 | 2026-02-24 |
| Effect of Clonidine Additive to suprascapular_ Costoclavicular Versus Standard Interscalene Block in Arthroscopic Shoulder Surgeries Bupivacaine 0.5% (hyperbaric), US-guided costoclavicular block, Interscalene brachial plexus block - Arthroscopic Shoulder Surgeries | Phase 4 | Not yet recruiting | Assiut University | 60 | 2025-12-01 | 2025-12-01 |
| R.E.C.K vs Exparel in Robotic Nephrectomy Ropivacaine HCL, Exparel, Epinephrine - Renal Carcinoma, Nephrectomy / Methods | Phase 3 | Recruiting | Wake Forest University Health Sciences | 170 | 2025-11-14 | 2026-07-13 |
| Effect of RECK in Posterior Spinal Fusion Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo - Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease | Phase 1 / Phase 2 | Withdrawn | University of Maryland, Baltimore | 2025-10-01 | 2025-07-31 | |
| Ropiclobet for Regional Anesthesia and Post-Operative Pain Control in Upper Extremity Surgery Ropivacaine + Clonidine + Betamethasone - Nerve Block, Upper Extremity Surgery | Phase 2 | Completed | PHARMAFINA | 40 | 2025-09-02 | 2026-01-12 |
| Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery. Oral Clonidine (OC) - Pediatric Sedation, Clonidine Sedation | Not applicable | Recruiting | Cairo University | 84 | 2025-04-15 | 2026-03-10 |
| Protecting Renal Function in Chronic Kidney Disease Patients with Isolated Nighttime Hypertension Antihypertensive treatment with Arotinolol or Amlodipine or Clonidine, Placebo-controlled group - Chronic Kidney Disease(CKD), Nocturnal Hypertension | Not applicable | Not yet recruiting | Shanghai Institute of Hypertension | 200 | 2025-01-30 | 2025-01-17 |
| Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty Rectus Sheath Block, Rectus Sheath Block with Clonidine - Hernia, Umbilical, Clonidine | Phase 2 / Phase 3 | Recruiting | Universidade Federal do Rio de Janeiro | 62 | 2025-01-07 | 2025-07-14 |
| Phase I Study of Ropivacaine, Clonidine, and Betamethasone Combination for Sciatic Nerve Block in the Popliteal Region ropivacaine - Healthy, Nerve Block | Phase 1 | Completed | PHARMAFINA | 12 | 2024-11-13 | 2025-05-18 |
| Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy Propofol, Propofol combined with clonidine - Clonidine, Propofol | Not applicable | Unknown | Tanta University | 62 | 2024-07-20 | 2024-07-23 |
| Comparison Between Blocks or Not in Joint Arthroplasty Ropivacain 5 mg/ml + Clonidine - Osteoarthritis of the Knee or Hip | Not applicable | Active not recruiting | Region Skane | 400 | 2024-02-01 | 2026-04-28 |
| The Effect of Clonidine-enhanced Sedation on Delirium in Ventilated Critically Ill Patients Clonidine, SodiumChloride - Delirium | Phase 3 | Unknown | Deventer Ziekenhuis | 115 | 2024-01-01 | 2023-02-15 |
| Intraoperative Autonomic Neural Blockade Local anesthetic injection Bupivacaine plus dexamethasone, Local anesthetic injection bupivacainde plus dexamethasone plus a colloid, Local anesthetic injection bupivacaine plus clonidine - Pain, Postoperative, Nausea, Postoperative | Phase 3 | Unknown | Universidad Simón Bolívar | 150 | 2023-12-02 | 2023-11-18 |
| Efficacy of Intrathecal Clonidine Versus Neostigmine as Adjuvants to Bupivacaine on Postoperative Maternal and Fetal Outcomes After Elective Cesarean Section Clonidine - Postoperative Pain | Phase 1 | Unknown | Assiut University | 111 | 2023-12-01 | 2023-07-13 |
| Adjuvants for Bupivacaine in Brachial Plexus Block in Pediatrics magnesium sulfate., clonidine. - Upper Limb Injury | Not applicable | Unknown | Assiut University | 70 | 2023-12-01 | 2023-12-26 |
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Pain, Postoperative (27) · Agnosia (19) · Pain (17) · Hypertension (13) · Neonatal Abstinence Syndrome (8) · Delirium (6) · Opioid-Related Disorders (5) · Osteoarthritis, Knee (5) · Substance-Related Disorders (5) · Anxiety Disorders (4) · Attention Deficit Disorder with Hyperactivity (4) · Chronic Pain (4) · Critical Illness (4) · Labor Pain (4) · Breast Neoplasms (3)
Wake Forest University Health Sciences (7) · Assiut University (5) · Oslo University Hospital (5) · Johns Hopkins University (4) · Region Skane (4) · Charite University, Berlin, Germany (3) · Columbia University (3) · Federal University of Minas Gerais (3) · Federal University of São Paulo (3) · Hospices Civils de Lyon (3) · Mayo Clinic (3) · National Institute on Drug Abuse (NIDA) (3) · Salem Anaesthesia Pain Clinic (3) · The George Institute (3) · The University of Texas Health Science Center, Houston (3)
United States (100) · Brazil (15) · France (13) · Canada (10) · Egypt (9) · Germany (9) · Belgium (8) · Italy (8) · Denmark (7) · United Kingdom (6) · Australia (5) · Norway (5) · Sweden (5) · Switzerland (5) · Austria (4)
Charles Raison, MD (2) · Craig Anderson, PhD (2) · Elisabeth Norman, MD (2) · Estelle B Gauda, MD (2) · James C. Eisenach, M.D. (2) · Kenzie Preston, Ph.D. (2) · P. David Mozley, MD (2) · Richard Rauck, M.D. (2) · Ruth Landau, MD (2) · Vegard Bruun Wyller, MD, PhD (2) · Zoher Naja, MD (2) · Adam P Bress, PharmD, MS (1) · Adil Bharucha, MBBS, MD (1) · Adil E Bharucha, M.D. (1) · Afua Gyamfi, MD (1)
PMID 32640944, PMID 22871021, PMID 25503550, PMID 25589782, PMID 25657175, PMID 25712944, PMID 25823544, PMID 26746184, PMID 27165954, PMID 27178897, PMID 27919055, PMID 30890109, PMID 31085948, PMID 33598552, PMID 34231914, PMID 38018833, PMID 40541207, PMID 41855454, PMID 42848972, PMID 10851208, PMID 11133600, PMID 11473855, PMID 11927799, PMID 12119802, PMID 12923400, PMID 15738343, PMID 15911704, PMID 16391172, PMID 16533484, PMID 16677266, PMID 17006921, PMID 1718720, PMID 17312203, PMID 17416907, PMID 17959952, PMID 18396107, PMID 18426998, PMID 18553032, PMID 19047577, PMID 19398463, PMID 19687359, PMID 19738158, PMID 19877975, PMID 19884426, PMID 20299988, PMID 20823381, PMID 21192304, PMID 21422302, PMID 21707560, PMID 22129475
2015 (3), 2018 (3), 2014 (2), 2017 (2), P01NS041386 (2), R01DK078924 (2), UL1RR024150 (2), 1UL1RR024150-01 (1), 2009 (1), 2019 (1), 2025 (1), P50DA009250 (1), R01DA018125 (1), R01DA039088 (1), R01DA043519 (1)