338 completed, 148 unknown, 116 recruiting, 97 not yet recruiting. 292 Not applicable, 94 Phase 4, 41 Phase 3, 33 Phase 2, 13 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery Postoperative Cognitive Complications, Delirium | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2027-07-01 | 2026-10-23 | |
| Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment - Carotid Stenosis, Carotid Artery Diseases | Not yet recruiting | Nguyen Toan Thang | 150 | 2027-01-01 | 2026-09-11 | |
| The Impact of Left Stellate Ganglion Block on Systemic Inflammation and Neuromodulation in CABG Surgery. Stellate Ganglion Block - Delirium - Postoperative, Inflammation Biomarkers | Not applicable | Not yet recruiting | OMAR ABDELAZIZ ABOELFADL | 81 | 2026-12-01 | 2026-08-20 |
| Comparison of IV Dexmedetomidine Versus Clonidine Versus no Alpha 2 Agonist on Emergency Delirium, PACU Length of Stay and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: a Prospective Observational Study Intravenous dexmedetomidine, Intravenous clonidine, Standard Anesthetic Care Without Alpha-2 Agonist - Emergency Delirium, Postoperative Delirium (POD) | Not yet recruiting | Universitair Ziekenhuis Brussel | 150 | 2026-12-01 | 2026-11-04 | |
| Sugammadex Timing and Recovery Profile in Pediatric Adenotonsillectomy Neuromuscular Blockade, Delayed Emergence From Anesthesia | Not yet recruiting | Namik Kemal University | 140 | 2026-12-01 | 2026-10-28 | |
| Lactium Premedication to Prevent Emergence Agitation Lactium - Lactium, Premedication | Phase 3 | Recruiting | Tanta University | 40 | 2026-11-04 | 2026-11-05 |
| Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy Lidocaine, 0.9% Normal Saline - Emergence Agitation, Emergence Delirium | Phase 3 | Not yet recruiting | Assiut University | 60 | 2026-11-01 | 2026-10-13 |
| Effects of PNB Timing on Postoperative Delirium for Hip Fracture Peripheral Nerve Block for Hip Fracture - Delirium - Postoperative | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 120 | 2026-11-01 | 2026-10-02 | |
| Intracuff Dexmedetomidine Versus Alkalinized Lidocaine for Peri-Extubation Cough and Hemodynamic Responses in Elderly Patients Dexmedetomidine, Alkalinized Lidocaine - Airway Complication of Anesthesia, Hemodynamic Instability | Not applicable | Not yet recruiting | Beni-Suef University | 184 | 2026-11-01 | 2026-11-04 |
| Prediction and Prevention of Postoperative Mortality and Morbidity Personalized CPC Prehabilitation, Cognitive Training, Meditation - Dementia, Postoperative Delirium (POD) | Not applicable | Not yet recruiting | University of Pittsburgh | 1200 | 2026-11-01 | 2026-11-05 |
| Creatine and Perioperative Brain Health Creatine monohydrate, Placebo - Neurocognitive Disorders, Postoperative Delirium | Not applicable | Not yet recruiting | Massachusetts General Hospital | 120 | 2026-11-01 | 2026-10-27 |
| Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery Remimazolam Besylate, propofol - Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch | Phase 4 | Not yet recruiting | Seoul National University Hospital | 80 | 2026-11-01 | 2026-10-29 |
| Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Sphenopalatine Ganglion Block for Functional Endoscopic Sinus Surgery Bupivacaine & normal saline, Dexmedetomidine & Bupivacaine., Dexamethasone & Bupivacaine. - Post Operative Pain, Emergence Agitation | Phase 4 | Not yet recruiting | Sohag University | 60 | 2026-11-01 | 2026-11-10 |
| Low Pneumoperitoneum Pressure for Delirium Prevention in Elderly Laparoscopy Low Intraabdominal Pressure Pneumoperitoneum, Standard Intraabdominal Pressure Pneumoperitoneum - Postoperative Delirium (POD), Intracranial Hypertension | Not applicable | Recruiting | Benha University | 110 | 2026-10-26 | 2026-10-30 |
| Transcranial Doppler and Artificial Intelligence Prediction of Postoperative Delirium in Heart Valve Surgery Postoperative Delirium, Heart Valve Diseases | Not yet recruiting | Osman Sila Aydin | 120 | 2026-10-01 | 2026-10-05 | |
| Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline - Postoperative Delirium, Hip Fractures | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 130 | 2026-10-01 | 2026-09-09 |
| Immunonutrition and Neuromonitoring for Postoperative Delirium in Gynecologic Oncology Preoperative Immunonutritional Scoring and Intraoperative Neuromonitoring - Postoperative Delirium (POD), Gynecologic Cancers | Recruiting | Elazıg Fethi Sekin Sehir Hastanesi | 80 | 2026-10-01 | 2026-10-16 | |
| Evaluation of a Hospital Program to Prevent Postoperative Delirium in Older Patients Multicomponent delirium prevention program - Postoperative Delirium, Delirium Prevention | Not applicable | Not yet recruiting | Universitätsklinikum Hamburg-Eppendorf | 720 | 2026-10-01 | 2026-08-26 |
| BIS in ICU Interventional Study Device-guided sedation, standard sedation practice - Cardiac Surgical Procedures (Postoperative Population), Critical Illness | Not applicable | Not yet recruiting | Medical University of Graz | 144 | 2026-10-01 | 2026-10-07 |
| Postoperative GI Dysfunction and Nutrition in Malnourished Cancer Surgery Patients Serotonin (e.g., serotonin adipinate), Standard Prokinetic Therapy (excluding serotonin) - Gastrointestinal Dysfunction, Malnutrition | Not yet recruiting | Arma Ltd. | 120 | 2026-10-01 | 2026-06-03 |
Showing 20 of 743. Sign in to see all of them.
Delirium (105) · Postoperative Cognitive Complications (74) · Pain, Postoperative (41) · Cognitive Dysfunction (39) · Postoperative Complications (29) · Hip Fractures (17) · Pain (17) · Anxiety Disorders (15) · Frailty (14) · Postoperative Nausea and Vomiting (14) · Psychomotor Agitation (14) · Neurocognitive Disorders (12) · Depression (9) · Parasomnias (9)
Pathologic Processes (743) · Pathological Conditions, Signs and Symptoms (743) · Neurobehavioral Manifestations (742) · Signs and Symptoms (742) · Nervous System Diseases (741) · Neurologic Manifestations (741) · Confusion (739) · Mental Disorders (738) · Neurocognitive Disorders (731) · Postoperative Complications (714) · Delirium (638) · Cognition Disorders (98) · Cognitive Dysfunction (63) · Pain (37) · Behavior (36)
Dexmedetomidine (94) · Saline Solution (56) · Propofol (51) · Sevoflurane (38) · Sodium Chloride (23) · Ketamine (20) · Midazolam (18) · Fentanyl (12) · remimazolam (11) · Desflurane (8) · Magnesium Sulfate (8) · Bupivacaine (7) · Esketamine (7) · Lidocaine (7) · Mental Status and Dementia Tests (7)
Assiut University (14) · Chinese PLA General Hospital (14) · Charite University, Berlin, Germany (12) · RenJi Hospital (12) · Peking University First Hospital (11) · Beijing Tiantan Hospital (10) · Tanta University (10) · Yonsei University (10) · Ain Shams University (9) · University Hospital, Basel, Switzerland (8) · Cairo University (7) · Universitätsklinikum Hamburg-Eppendorf (7) · Seoul National University Hospital (6) · Universitas Indonesia (6) · Ankara City Hospital Bilkent (5)
China (182) · Turkey (Türkiye) (92) · United States (79) · Egypt (56) · South Korea (40) · Germany (28) · Canada (16) · Italy (13) · Switzerland (11) · Singapore (10) · Denmark (9) · Russia (9) · Thailand (9) · Chile (8) · France (8)
Dong-Xin Wang, MD, PhD (9) · Claudia Spies, MD, Prof. (7) · Nicolai Goettel, MD (7) · Liwei Wang, Doctor (4) · Yangzi Zhu, Doctor (4) · Lian Kah Ti (3) · Qin Zhang, phd (3) · Ting Li, MD. PhD (3) · Chao-Chao Zhong (2) · Cheol Lee, M.D.,Ph.D (2) · Eugene Kim, MD (2) · Fuxia Yan (2) · Hina Faisal, MD (2) · Jeff Silverstein, MD (2)
PMID 15114210, PMID 23992774, PMID 25535538, PMID 28576285, PMID 12760985, PMID 14980921, PMID 15562048, PMID 17179249, PMID 18577850, PMID 18686756, PMID 20047899, PMID 20497353, PMID 20526708, PMID 22762316, PMID 24287327, PMID 26275092, PMID 26601849, PMID 27798810, PMID 28593326, PMID 28601132, PMID 28973626, PMID 32798069, PMID 32976205, PMID 33189147, PMID 34322079, PMID 34591807, PMID 34928310, PMID 37290122, PMID 37599617, PMID 37819663, PMID 40090678, PMID 9416712, PMID 10335730, PMID 10839257, PMID 10976589, PMID 11161124, PMID 11797025, PMID 12145033, PMID 13889092, PMID 1394752, PMID 14524640, PMID 15071384, PMID 15344424, PMID 15765453, PMID 15851892, PMID 15992223, PMID 16231283, PMID 16324031, PMID 16677266, PMID 16879517
2014 (2), 2019 (2), 2025 (2), 2016 (1), K23AG065443 (1), K76AG088424 (1), R01AG029656 (1), R01AG046634 (1), R01AG053582 (1), R01AG075005 (1), R03AG040673 (1), R03AG078857 (1), R21AG050850 (1), U54AG063546 (1)