Cognition Disorders: Clinical Trials

2242 completed, 785 unknown, 718 recruiting, 267 not yet recruiting. 2361 Not applicable, 479 Phase 2, 223 Phase 1, 189 Phase 3, 179 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	2361	Completed 1146, Recruiting 387, Unknown 385, Not yet recruiting 155, Active not recruiting 109, Terminated 81, Withdrawn 52, Enrolling by invitation 39, Suspended 7
Phase 2	479	Completed 258, Recruiting 67, Unknown 51, Terminated 37, Active not recruiting 30, Not yet recruiting 14, Withdrawn 14, Enrolling by invitation 5, Suspended 3
Phase 1	223	Completed 119, Unknown 32, Recruiting 26, Terminated 19, Active not recruiting 11, Not yet recruiting 10, Withdrawn 6
Phase 3	189	Completed 100, Terminated 24, Unknown 24, Recruiting 17, Active not recruiting 14, Withdrawn 4, Enrolling by invitation 3, Suspended 2, Not yet recruiting 1
Phase 4	179	Completed 98, Unknown 38, Terminated 13, Recruiting 9, Not yet recruiting 8, Active not recruiting 7, Enrolling by invitation 4, Withdrawn 2
Early Phase 1	49	Completed 27, Recruiting 5, Active not recruiting 4, Unknown 4, Not yet recruiting 3, Terminated 3, Withdrawn 3

Follow Cognition Disorders: new trials by email Literature Review of Cognition Disorders trials Research Report on Cognition Disorders

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease		Recruiting	Uppsala University Hospital	30	2029-04-01	2026-10-15
MRI Technical Development and Applications in Kidney Disease Chronic Kidney Diseases, Kidney Transplantation		Not yet recruiting	University of Minnesota	180	2028-06-30	2026-04-13
cMIND AI Web Tool Usability Study (Hong Kong) Web-Based AI Dietary Assessment System - Mild Cognitive Impairment (MCI), Healthy Aging		Not yet recruiting	Hong Kong Metropolitan University	20	2027-09-01	2026-07-29
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery Postoperative Cognitive Complications, Delirium		Not yet recruiting	University of Texas Southwestern Medical Center	300	2027-07-01	2026-10-23
Fall Prevention in Mild Cognitive Impairment Virtual Neurophysiological Rehabilitation - Cognitive Impairment, High Fall Risk	Not applicable	Not yet recruiting	VA Office of Research and Development	28	2027-06-01	2026-04-09
Dyadic Cognitive Intervention for Older Adults With Cognitive Impairment and Their Spouses Dyadic Cognitive Intervention Program for Older Couples, Standard Community Health Education on Cognitive Impairment - Cognitive Impairment	Not applicable	Not yet recruiting	Gansu University of Chinese Medicine	136	2027-06-01	2026-10-13
Prucalopride for Cognitive Functioning in Schizophrenia Prucalopride 1 MG - Schizophrenia	Not applicable	Not yet recruiting	University of Pittsburgh	34	2027-05-31	2026-09-17
Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries	Phase 2	Not yet recruiting	VA Office of Research and Development	46	2027-05-24	2026-02-17
Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog Assessments, Neuroimaging volumetric measures, Biofluid samples - Mild Cognitive Impairment, Subjective Cognitive Decline		Enrolling by invitation	Ohio State University	100	2027-03-01	2026-10-16
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)	Phase 1 / Phase 2	Not yet recruiting	George Washington University	24	2027-03-01	2026-10-05
Auditory-Cognitive Optimization Care Program for Older Adults With Hearing Loss and Cognitive Impairment Auditory-Cognitive Optimization Care Program (A-COP), Hearing Management and Newspaper-Reading Activities - Hearing Loss, Cognitive Impairment	Not applicable	Not yet recruiting	Taipei Medical University	76	2027-02-01	2026-10-13
Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns Bedroom Environment Tailoring, Sleep Health Education - Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)	Not applicable	Not yet recruiting	Johns Hopkins University	40	2027-02-01	2026-10-09
Robot-Assisted Meditation for Older Adults With Cognitive Concerns Robot-Guided Meditation, Audio-Only Robot - Cognitive Impairment, Perceived Stress	Not applicable	Not yet recruiting	Johns Hopkins University	100	2027-02-01	2026-10-30
Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease Huntington Disease		Not yet recruiting	BioSensics	75	2027-01-31	2026-10-13
Prospective Research on Identification of Dementia in Early Stages (P.R.I.D.E) Mild Cognitive Impairment, Memory Disorders		Not yet recruiting	Don Mottola Medical Center	1000	2027-01-20	2026-11-05
A Mobile Informatics Solution to Assist Caregivers in Care Coordination and Monitoring Social Engagement Social Reminder System - Memory Disorders, Mild Cognitive Impairment	Not applicable	Not yet recruiting	University of Minnesota	200	2027-01-16	2026-11-04
SleepSMART for Veterans With Insomnia and Mild Cognitive Impairment Cognitive BehavioralTherapy for Insomnia (CBT-I), SleepSMART - Insomnia, Mild Cognitive Impairment	Not applicable	Not yet recruiting	VA Office of Research and Development	150	2027-01-05	2026-11-09
Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder	Not applicable	Not yet recruiting	Central South University	400	2027-01-01	2026-03-04
Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment - Carotid Stenosis, Carotid Artery Diseases		Not yet recruiting	Nguyen Toan Thang	150	2027-01-01	2026-09-11
The CDAC Study - Cerebral Dysfunction After Coronary Revascularization Neurocognitive testing - CABG, PCI		Not yet recruiting	The Scripps Research Institute	600	2027-01-01	2026-03-24

Showing 20 of 4643. Sign in to see all of them.

Narrower conditions

Cognitive Dysfunction (3788)  ·  Alzheimer Disease (888)  ·  Dementia (652)  ·  Huntington Disease (292)  ·  Postoperative Cognitive Complications (257)  ·  Depression (194)  ·  Motor Activity (179)  ·  Memory Disorders (159)  ·  Parkinson Disease (157)  ·  Stroke (152)  ·  Delirium (133)  ·  Schizophrenia (124)  ·  Emergence Delirium (104)  ·  Neurocognitive Disorders (94)

Broader conditions

Mental Disorders (4582)  ·  Neurocognitive Disorders (4549)  ·  Nervous System Diseases (2473)  ·  Central Nervous System Diseases (1966)  ·  Brain Diseases (1933)  ·  Pathological Conditions, Signs and Symptoms (1359)  ·  Neurodegenerative Diseases (1219)  ·  Signs and Symptoms (879)  ·  Tauopathies (868)  ·  Dementia (865)  ·  Neurologic Manifestations (733)  ·  Pathologic Processes (714)  ·  Behavior (559)  ·  Neurobehavioral Manifestations (479)

Interventions

Cognitive Training (101)  ·  Exercise (100)  ·  Transcranial Direct Current Stimulation (83)  ·  Transcranial Magnetic Stimulation (47)  ·  Donepezil (43)  ·  Neuropsychological Tests (38)  ·  Control Groups (35)  ·  Propofol (34)  ·  Blood Specimen Collection (30)  ·  Magnetic Resonance Spectroscopy (29)  ·  Mental Status and Dementia Tests (29)  ·  Dexmedetomidine (25)  ·  Memantine (23)  ·  7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (20)  ·  Sevoflurane (20)

Sponsors

Massachusetts General Hospital (41)  ·  VA Office of Research and Development (41)  ·  Johns Hopkins University (38)  ·  University of California, San Francisco (36)  ·  Assistance Publique - Hôpitaux de Paris (33)  ·  Wake Forest University Health Sciences (30)  ·  Vanderbilt University Medical Center (29)  ·  Emory University (27)  ·  University of California, Los Angeles (27)  ·  University of Pennsylvania (27)  ·  Chang Gung Memorial Hospital (25)  ·  Duke University (24)  ·  Icahn School of Medicine at Mount Sinai (24)  ·  Chinese University of Hong Kong (23)  ·  Indiana University (23)

Countries

United States (1676)  ·  China (380)  ·  Canada (281)  ·  France (278)  ·  Italy (211)  ·  Spain (200)  ·  United Kingdom (197)  ·  Germany (170)  ·  Taiwan (122)  ·  Turkey (Türkiye) (116)  ·  Netherlands (105)  ·  Denmark (89)  ·  Australia (88)  ·  South Korea (78)  ·  Sweden (77)

Top investigators

Suzanne Craft, PhD (16)  ·  Mariana Figueiro, PhD (8)  ·  Paul Aisen, MD (8)  ·  Tammie Benzinger, MD, PhD (8)  ·  Emil Fristed, MSc (7)  ·  Malaz Boustani, MD, MPH (6)  ·  Cay Anderson-Hanley, PhD (5)  ·  Claudia Spies, MD, Prof. (5)

Results publications

PMID 36463457, PMID 38489195, PMID 15817019, PMID 29480210, PMID 32250312, PMID 39324520, PMID 29780318, PMID 30200183, PMID 30233154, PMID 31221697, PMID 31381524, PMID 32905623, PMID 33189083, PMID 36398903, PMID 36811812, PMID 39498781, PMID 39800465, PMID 41804324, PMID 9525362, PMID 10881154, PMID 11065205, PMID 1202204, PMID 12648190, PMID 13688369, PMID 15010086, PMID 15324367, PMID 16300724, PMID 17179457, PMID 18156878, PMID 18686756, PMID 19379886, PMID 19422355, PMID 19617584, PMID 19812460, PMID 21514249, PMID 21514250, PMID 21951520, PMID 22261206, PMID 22321085, PMID 22762316, PMID 23337978, PMID 24303859, PMID 25407304, PMID 25459243, PMID 25568297, PMID 25580839, PMID 26285025, PMID 26714284, PMID 26762403, PMID 27337738

NIH funding

2016 (13), 2025 (12), 2018 (10), 2023 (10), 2014 (8), 2015 (8), U54AG063546 (7), 2017 (5), 2019 (5), P30AG022849 (5), U01AG024904 (4), 2009 (3), 2SB1AG059458-04A1 (3), K23AG052633 (3), K76AG064394 (3)