2228 completed, 790 unknown, 716 recruiting, 266 not yet recruiting. 2355 Not applicable, 479 Phase 2, 223 Phase 1, 189 Phase 3, 178 Phase 4.
Follow Cognition Disorders: new trials by email Literature Review of Cognition Disorders trials Research Report on Cognition Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| MRI Technical Development and Applications in Kidney Disease Chronic Kidney Diseases, Kidney Transplantation | Not yet recruiting | University of Minnesota | 180 | 2028-06-30 | 2026-04-13 | |
| cMIND AI Web Tool Usability Study (Hong Kong) Web-Based AI Dietary Assessment System - Mild Cognitive Impairment (MCI), Healthy Aging | Not yet recruiting | Hong Kong Metropolitan University | 20 | 2027-09-01 | 2026-07-29 | |
| Fall Prevention in Mild Cognitive Impairment Virtual Neurophysiological Rehabilitation - Cognitive Impairment, High Fall Risk | Not applicable | Not yet recruiting | VA Office of Research and Development | 28 | 2027-06-01 | 2026-04-09 |
| Dyadic Cognitive Intervention for Older Adults With Cognitive Impairment and Their Spouses Dyadic Cognitive Intervention Program for Older Couples, Standard Community Health Education on Cognitive Impairment - Cognitive Impairment | Not applicable | Not yet recruiting | Gansu University of Chinese Medicine | 136 | 2027-06-01 | 2026-10-13 |
| Prucalopride for Cognitive Functioning in Schizophrenia Prucalopride 1 MG - Schizophrenia | Not applicable | Not yet recruiting | University of Pittsburgh | 34 | 2027-05-31 | 2026-09-17 |
| Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries | Phase 2 | Not yet recruiting | VA Office of Research and Development | 46 | 2027-05-24 | 2026-02-17 |
| Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog Assessments, Neuroimaging volumetric measures, Biofluid samples - Mild Cognitive Impairment, Subjective Cognitive Decline | Enrolling by invitation | Ohio State University | 100 | 2027-03-01 | 2026-10-16 | |
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Auditory-Cognitive Optimization Care Program for Older Adults With Hearing Loss and Cognitive Impairment Auditory-Cognitive Optimization Care Program (A-COP), Hearing Management and Newspaper-Reading Activities - Hearing Loss, Cognitive Impairment | Not applicable | Not yet recruiting | Taipei Medical University | 76 | 2027-02-01 | 2026-10-13 |
| Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns Bedroom Environment Tailoring, Sleep Health Education - Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) | Not applicable | Not yet recruiting | Johns Hopkins University | 40 | 2027-02-01 | 2026-10-09 |
| Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease Huntington Disease | Not yet recruiting | BioSensics | 75 | 2027-01-31 | 2026-10-13 | |
| Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder | Not applicable | Not yet recruiting | Central South University | 400 | 2027-01-01 | 2026-03-04 |
| Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment - Carotid Stenosis, Carotid Artery Diseases | Not yet recruiting | Nguyen Toan Thang | 150 | 2027-01-01 | 2026-09-11 | |
| The CDAC Study - Cerebral Dysfunction After Coronary Revascularization Neurocognitive testing - CABG, PCI | Not yet recruiting | The Scripps Research Institute | 600 | 2027-01-01 | 2026-03-24 | |
| Gaze and Gait Training With rTMS Repetitive Transcranial Magnetic Stimulation (rTMS), Gait training, Gaze training - Mild Cognitive Impairment | Not applicable | Not yet recruiting | University of Florida | 30 | 2027-01-01 | 2026-05-06 |
| A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia Xanomeline/trospium - Schizophrenia; Psychosis, Cognitive Impairment | Phase 3 | Not yet recruiting | European Group for Research In Schizophrenia | 171 | 2027-01-01 | 2026-05-13 |
| Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment Mild Cognitive Impairment (MCI), Opioid Use | Not yet recruiting | Miklos Kertai | 552 | 2027-01-01 | 2026-10-21 | |
| Synbiotic LA-5 and Agave Inulin for Mild Cognitive Impairment Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin) Intervention Type: - Cognitive Impairment | Not applicable | Recruiting | Anahuac University | 20 | 2026-12-31 | 2026-09-14 |
| Wearable Sensor for Early Detection and Monitoring of Cognitive Decline Mild Cognitive Impairment (MCI), Older Adults With Cognitive Decline | Not yet recruiting | BioSensics | 100 | 2026-12-15 | 2026-09-02 |
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Cognitive Dysfunction (3773) · Alzheimer Disease (885) · Dementia (649) · Huntington Disease (291) · Postoperative Cognitive Complications (256) · Depression (194) · Motor Activity (178) · Memory Disorders (158) · Parkinson Disease (157) · Stroke (150) · Delirium (133) · Schizophrenia (123) · Emergence Delirium (104) · Neurocognitive Disorders (94)
Mental Disorders (4565) · Neurocognitive Disorders (4532) · Nervous System Diseases (2463) · Central Nervous System Diseases (1958) · Brain Diseases (1925) · Pathological Conditions, Signs and Symptoms (1351) · Neurodegenerative Diseases (1214) · Signs and Symptoms (875) · Tauopathies (865) · Dementia (863) · Neurologic Manifestations (729) · Pathologic Processes (709) · Behavior (558) · Neurobehavioral Manifestations (477)
Cognitive Training (101) · Exercise (100) · Transcranial Direct Current Stimulation (82) · Transcranial Magnetic Stimulation (47) · Donepezil (43) · Neuropsychological Tests (38) · Control Groups (35) · Propofol (32) · Blood Specimen Collection (29) · Magnetic Resonance Spectroscopy (29) · Mental Status and Dementia Tests (29) · Dexmedetomidine (25) · Memantine (23) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (20) · Sevoflurane (20)
Massachusetts General Hospital (41) · VA Office of Research and Development (41) · Johns Hopkins University (38) · University of California, San Francisco (36) · Assistance Publique - Hôpitaux de Paris (33) · Wake Forest University Health Sciences (30) · Vanderbilt University Medical Center (29) · Emory University (27) · University of California, Los Angeles (27) · University of Pennsylvania (27) · Chang Gung Memorial Hospital (25) · Duke University (24) · Icahn School of Medicine at Mount Sinai (24) · Indiana University (23) · Riphah International University (23)
United States (1674) · China (374) · Canada (280) · France (278) · Italy (211) · Spain (198) · United Kingdom (197) · Germany (170) · Taiwan (121) · Turkey (Türkiye) (116) · Netherlands (106) · Australia (88) · Denmark (88) · South Korea (78) · Sweden (77)
Suzanne Craft, PhD (16) · Mariana Figueiro, PhD (8) · Paul Aisen, MD (8) · Tammie Benzinger, MD, PhD (8) · Emil Fristed, MSc (7) · Malaz Boustani, MD, MPH (6) · Cay Anderson-Hanley, PhD (5) · Claudia Spies, MD, Prof. (5)
PMID 36463457, PMID 38489195, PMID 15817019, PMID 29480210, PMID 32250312, PMID 39324520, PMID 29780318, PMID 30200183, PMID 30233154, PMID 31221697, PMID 31381524, PMID 32905623, PMID 33189083, PMID 36398903, PMID 36811812, PMID 39498781, PMID 39800465, PMID 41804324, PMID 9525362, PMID 10881154, PMID 11065205, PMID 1202204, PMID 12648190, PMID 13688369, PMID 15010086, PMID 15324367, PMID 16300724, PMID 17179457, PMID 18156878, PMID 18686756, PMID 19379886, PMID 19422355, PMID 19617584, PMID 19812460, PMID 21514249, PMID 21514250, PMID 21951520, PMID 22261206, PMID 22321085, PMID 22762316, PMID 23337978, PMID 24303859, PMID 25407304, PMID 25459243, PMID 25568297, PMID 25580839, PMID 26285025, PMID 26714284, PMID 26762403, PMID 27337738
2016 (13), 2025 (12), 2018 (10), 2023 (10), 2014 (8), 2015 (8), U54AG063546 (7), 2017 (5), 2019 (5), P30AG022849 (5), U01AG024904 (4), 2009 (3), 2SB1AG059458-04A1 (3), K23AG052633 (3), K76AG064394 (3)