187 completed, 35 unknown, 30 terminated, 8 recruiting. 70 Phase 2, 67 Phase 1, 56 Phase 4, 40 Phase 3, 27 Not applicable.
Follow Donepezil: new trials by email Literature Review of Donepezil trials Research Report on Donepezil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open Trial of a Novel Pharmacotherapy for Habit Modification in Anorexia Nervosa Donepezil - Anorexia Nervosa | Phase 2 | Not yet recruiting | New York State Psychiatric Institute | 10 | 2027-01-01 | 2026-10-23 |
| A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2511 in Participants With Early Alzheimer's Disease (AD) E2511, Donepezil - Alzheimers Disease | Phase 1 | Not yet recruiting | Eisai Inc. | 32 | 2026-10-15 | 2026-08-17 |
| Efficacy of Lymphatic-Venous Anastomosis Plus Donepezil Versus Donepezil Alone for Alzheimer's Disease Cervical lymph vessel/node-venous anastomosis surgery combined with oral donepezil, Oral treatment with donepezil - Alzheimer s Disease | Not applicable | Not yet recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 216 | 2026-07-15 | 2026-07-22 |
| Clinical Study to Evaluate the Efficacy and Safety of Huperzine A Controlled-Release Tablets in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type Huperzine A Controlled-Release Tablets, Donepezil hydrochloride tablets, Huperzine A controlled-release tablets placebo; Donepezil hydrochloride tablets placebo - Alzheimer Dementia | Phase 2 / Phase 3 | Recruiting | Wanbangde Pharmaceutical Group Co., LTD | 720 | 2025-08-29 | 2026-08-17 |
| Pharmacokinetic Study of GB-5001A 280 mg Long Acting Injection, in Comparison With the Comparator Drug Aricept® 5 mg and Aricept® 10 mg Film-coated Tablet in Healthy Subjects GB-5001A 280 mg long acting Injection, Aricept® 5 mg film-coated tablet, Aricept® 10 mg film-coated tablet - Bioavailability Study on Healthy Volunteers | Phase 1 | Completed | G2GBio, Inc. | 28 | 2025-08-12 | 2026-09-02 |
| Rivastigmine Mini-Tablet for Alzheimer's Disease Rivastigmine Mini-Tablet, Donepezil Hydrochloride - Alzheimer's Disease | Not yet recruiting | Peking University First Hospital | 1000 | 2025-02-28 | 2025-02-20 | |
| Effect of Acetylcholinesterase Inhibitors on Bone Metabolism Donepezil, Memantine - Osteoporosis | Phase 2 | Recruiting | Duke University | 45 | 2025-02-03 | 2026-09-21 |
| Phenserine on the Alzheimer's Treatment Horizon, Study 1 Phenserine, Donepezil (Aricept®) - Alzheimer Disease, Mild Cognitive Impairment | Phase 1 | Completed | Helse Stavanger HF | 16 | 2025-02-01 | 2026-05-04 |
| Ultrasound-Guided Stellate Ganglion Block for Alzheimer's Disease Ultrasound-Guided Stellate Ganglion Block, Memantine hydrochloride, Donepezil hydrochloride - Alzheimer's Disease(AD), Cognitive Dysfunction | Not applicable | Completed | Taizhou Second People's Hospital | 40 | 2025-01-26 | 2026-01-21 |
| Acetylcholinesterase Inhibitor in Anorexia Nervosa: Multicenter, Double-Blind, Placebo-Controlled Trial Donepezil 2.5 mg, Donepezil 5 mg, Placebo Comparator - Anorexia Nervosa Restricting Type | Phase 2 | Not yet recruiting | Centre Hospitalier St Anne | 147 | 2024-11-01 | 2024-11-14 |
| Investigating the Cholinergic Contribution to Gait Dysfunction in Parkinson's Disease Donepezil (Aricept) - Parkinson Disease | Phase 2 | Completed | University of Virginia | 6 | 2024-11-01 | 2026-03-09 |
| δ in Dementia Clinical Trials Donepezil - Alzheimer's Disease (AD), Dementia | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 200 | 2024-08-05 | 2026-05-05 |
| Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers Acupuncture, Sham Acupuncture, Donepezil - Alzheimer Disease, Cognitive Impairment | Not applicable | Recruiting | ZhanYJ | 176 | 2024-06-01 | 2025-05-21 |
| Comparison of Therapeutic Strategies With Cholinesterase Inhibitors (SOS TRIAL) cholinesterase inhibitors (CI) (donepezil, galantamine or rivastigmine) - Alzheimer Disease, Cholinesterase Inhibitors | Phase 4 | Not yet recruiting | University Hospital, Bordeaux | 1205 | 2024-06-01 | 2023-10-06 |
| Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia Taking Stable Donepezil Treatment (MK-1167-007) MK-1167, Donepezil, Placebo - Alzheimer's Disease | Phase 1 | Completed | Merck Sharp & Dohme LLC | 28 | 2024-03-28 | 2025-10-14 |
| Randomized Clinical Trial of Donepezil for the Treatment of Mild Cognitive Impairment in Parkinson's Disease Donepezil Hydrochloride, Placebo - Parkinson Disease, Mild Cognitive Impairment | Phase 2 | Unknown | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 120 | 2023-10-01 | 2023-09-28 |
| A Clinical Trial to Access Pharmacokinetic Profiles and Safety of IVL3003. Aricept Tablet, IVL3003 - Alzheimer Disease | Phase 1 / Phase 2 | Active not recruiting | Inventage Lab., Inc. | 62 | 2023-04-01 | 2024-12-19 |
| Effect of Donepezil on Speech Recognition in Cochlear Implant Users Donepezil, Placebo - Bilateral Sensorineural Hearing Loss | Early Phase 1 | Completed | Vanderbilt University Medical Center | 50 | 2023-03-10 | 2026-10-14 |
| To Explore the Therapeutic Potential of Jiedu Yizhi Formula for Alzheimer 's Disease Jiedu Yizhi Formula, Donepezil Hydrochloride Tablets - Ensure the Legality and Compliance of the Testing Process | Early Phase 1 | Completed | Changchun University of Chinese Medicine | 62 | 2022-12-01 | 2024-05-02 |
| Donepezil and Cognitive Training for Alcohol Use Disorder (AUD) Donepezil + Cognitive remediation therapy (CRT), Donepezil + Placebo CRT, Placebo medication + Cognitive remediation therapy (CRT) - Alcohol Use Disorder | Phase 2 | Recruiting | VA Connecticut Healthcare System | 160 | 2022-08-08 | 2026-06-23 |
Showing 20 of 274. Sign in to see all of them.
Alzheimer Disease (123) · Cognitive Dysfunction (38) · Dementia (33) · Parkinson Disease (12) · Memory Disorders (10) · Lewy Body Disease (9) · Delirium (8) · Stroke (8) · Cognition Disorders (7) · Central Nervous System Diseases (6) · Depression (6) · Dementia, Vascular (5) · Pain (5) · Radiation Injuries (5) · Brain Diseases (4)
Eisai Inc. (20) · Eisai Co., Ltd. (15) · Pfizer (11) · Merck Sharp & Dohme LLC (9) · AstraZeneca (7) · Eisai Korea Inc. (5) · GlaxoSmithKline (5) · Wake Forest University Health Sciences (5) · AbbVie (prior sponsor, Abbott) (4) · Dr. Reddy's Laboratories Limited (4) · Eisai Limited (4) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (4) · New York State Psychiatric Institute (4) · Oregon Health and Science University (4) · Samsung Medical Center (4)
United States (118) · South Korea (29) · China (24) · Canada (23) · France (19) · United Kingdom (19) · Japan (18) · Germany (14) · Australia (11) · Spain (11) · Poland (8) · Russia (8) · Czechia (7) · South Africa (7) · Austria (6)
Malaz Boustani, MD, MPH (3) · Naoki Kubota (3) · Allan L Reiss (2) · Anita Murthy (2) · Benoit J Deschamps, M.D. (2) · Danielle Armas, MD (2) · Davangere Devanand, M.D. (2) · Doh Kwan Kim, PhD, M.D. (2) · Dr. L Krishna Murthy (2) · Eric Sicard, MD (2)
PMID 29854923, PMID 33189083, PMID 14732621, PMID 15480814, PMID 16494088, PMID 16549835, PMID 17210817, PMID 17914039, PMID 18198262, PMID 18251622, PMID 18296124, PMID 18667813, PMID 18971479, PMID 19210951, PMID 19674471, PMID 19836169, PMID 19874395, PMID 19917989, PMID 20678673, PMID 20872778, PMID 21295494, PMID 21612646, PMID 21644059, PMID 21679156, PMID 21689411, PMID 21723605, PMID 22091574, PMID 22281004, PMID 22572767, PMID 22930699, PMID 23408503, PMID 23763450, PMID 23782591, PMID 24073978, PMID 24078735, PMID 24144505, PMID 24290367, PMID 24299497, PMID 24315979, PMID 24418055, PMID 25079803, PMID 25218827, PMID 25713599, PMID 25713600, PMID 26482056, PMID 26697847, PMID 26795874, PMID 27442715, PMID 27662321, PMID 27756421
2009 (3), U10CA081851 (3), R01MH035182 (2), R01NS057594 (2), 2004 (1), 2015 (1), 2017 (1), 2018 (1), 3UG1CA189824-04S1 (1), K23MH064196 (1), P01HD024448 (1), P30CA012197 (1), R01AA029075 (1), R01AG018487 (1), R01AG040093 (1)