3127 completed, 824 recruiting, 757 unknown, 375 terminated. 2376 Not applicable, 954 Phase 2, 690 Phase 1, 436 Phase 3, 199 Phase 4.
Follow Dementia: new trials by email Literature Review of Dementia trials Research Report on Dementia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| Smartphone App for Adolescents With Idiopathic Scoliosis DinSkoliose smartphone application - Adolescence Idiopathic Scoliosis, AIS | Not applicable | Not yet recruiting | Oslo Metropolitan University | 30 | 2028-04-01 | 2026-07-07 |
| Transcranial Magnetic Stimulation for Alzheimer's Disease Treatment Active Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation - Alzheimer Disease | Not applicable | Not yet recruiting | Universitat Oberta de Catalunya | 45 | 2027-11-01 | 2026-07-21 |
| Terazosin for Dementia With Lewy Bodies Terazosin Hydrochloride, Placebo - Dementia With Lewy Bodies | Phase 1 / Phase 2 | Not yet recruiting | Qiang Zhang | 40 | 2027-10-01 | 2026-03-12 |
| AV-1959R Vaccine in Individuals With Preclinical Alzheimer's Disease AV-1959R, Placebo - Preclinical Alzheimer's Disease, Alzheimer Disease | Phase 2 | Not yet recruiting | Institute for Molecular Medicine | 160 | 2027-10-01 | 2026-10-21 |
| Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau Neuronavigation-guided single-element focused ultrasound transducer, Lumason, Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents - Alzheimer Disease, Early Onset | Phase 1 | Not yet recruiting | Columbia University | 6 | 2027-08-01 | 2026-05-13 |
| Terazosin And Metabolic Engagement in Alzheimer's Disease Terazosin (Hytrin), Placebo - Alzheimer s Disease | Phase 2 | Not yet recruiting | Qiang Zhang | 100 | 2027-08-01 | 2026-09-01 |
| Feasibility of a Dyadic Music-based Intervention for Persons Living With Dementia and Their Care Partners Dyadic Music-based Intervention (MBI), Reminiscence Activity - Dementia | Not applicable | Not yet recruiting | Duke University | 60 | 2027-08-01 | 2026-10-05 |
| Hearing Loss and Brain Health Study Over-The-Counter (OTC) hearing aid - Hearing Loss, Adult-Onset, Dementia | Not applicable | Not yet recruiting | University of Southern California | 40 | 2027-07-01 | 2026-05-08 |
| GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD) GV1001 Placebo, GV1001 1.12mg - Moderate to Severe Alzheimer's Disease | Phase 3 | Not yet recruiting | Samsung Pharmaceutical Co., Ltd. | 750 | 2027-07-01 | 2026-06-10 |
| Concurrent Trials on Nature-Based Therapy for Inpatients in Dementia and Rehabilitation Medicine Wards Nature Immersion Therapy - Dementia, Acquired Brain Injury Including Stroke | Not applicable | Not yet recruiting | Changi General Hospital | 1600 | 2027-05-01 | 2026-03-23 |
| Advancing Ethical Goals In Society Trial ACP Counselor Video Program - Advance Care Planning, Dementia | Not applicable | Not yet recruiting | Tufts Medical Center | 12174 | 2027-03-01 | 2026-09-17 |
| ED PLWD/Care Partner Text Messaging CAPTURE Text Message Care Transition Support - Dementia, Caregiver | Not applicable | Not yet recruiting | Yale University | 80 | 2027-03-01 | 2026-02-23 |
| Vagus Nerve Stimulation to Enhance Memory in Aging Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) - Alzheimer Disease, Aging | Not applicable | Not yet recruiting | Stanford University | 150 | 2027-02-01 | 2025-10-09 |
| Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease Huntington Disease | Not yet recruiting | BioSensics | 75 | 2027-01-31 | 2026-10-13 | |
| Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB) | Not yet recruiting | BioSensics | 60 | 2027-01-15 | 2026-10-13 | |
| HomeCare Medication Management for People With Dementia HomeCare - Dementia, Alzheimer's Disease and Related Dementias | Not applicable | Not yet recruiting | HiDO Technologies | 120 | 2027-01-01 | 2026-10-13 |
| Adapting Changing Talk: Online (CHATO) to CHATO-Inclusive CHATO-I - Dementia | Not applicable | Not yet recruiting | University of Kansas Medical Center | 1200 | 2027-01-01 | 2026-06-02 |
| Acupressure as Long-term Intervention to Slow the Progression of Early/Mild Alzheimer's Disease Comfy Acupressure for the Elderly, Least acupressure control - Alzheimer's Disease | Not applicable | Not yet recruiting | The University of Hong Kong | 188 | 2027-01-01 | 2026-08-24 |
| The Dose Finding Study of DAOIB Added to tDCS for AD DAOIB - Transcranial Direct Current Stimulation, Dementia | Phase 2 | Suspended | Chang Gung Memorial Hospital | 140 | 2027-01-01 | 2026-03-20 |
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Alzheimer Disease (3875) · Cognitive Dysfunction (1187) · Huntington Disease (291) · Lewy Body Disease (236) · Parkinson Disease (231) · Frontotemporal Dementia (205) · Dementia, Vascular (181) · Depression (179) · Neurodegenerative Diseases (166) · Memory Disorders (151) · Caregiver Burden (136) · Motor Activity (112) · Neurocognitive Disorders (111) · Stroke (109)
Central Nervous System Diseases (5761) · Nervous System Diseases (5757) · Brain Diseases (5742) · Mental Disorders (5711) · Neurocognitive Disorders (5701) · Neurodegenerative Diseases (4309) · Tauopathies (3861) · Cognition Disorders (1440) · Pathological Conditions, Signs and Symptoms (1186) · Signs and Symptoms (804) · Neurologic Manifestations (762) · Basal Ganglia Diseases (689) · Movement Disorders (676) · Behavior (670)
Donepezil (143) · Transcranial Direct Current Stimulation (70) · Memantine (63) · florbetapir (56) · Exercise (55) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (47) · Galantamine (46) · Blood Specimen Collection (41) · Magnetic Resonance Spectroscopy (41) · Cognitive Training (40) · Rivastigmine (35) · Transcranial Magnetic Stimulation (34) · Neuropsychological Tests (28) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (26) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (24)
Pfizer (67) · Johns Hopkins University (63) · Eli Lilly and Company (58) · Assistance Publique - Hôpitaux de Paris (55) · Massachusetts General Hospital (46) · National Institute on Aging (NIA) (46) · Chang Gung Memorial Hospital (45) · Avid Radiopharmaceuticals (43) · Mayo Clinic (41) · Indiana University (38) · Emory University (37) · VA Office of Research and Development (36) · University of California, San Francisco (35) · University of Pennsylvania (35) · GlaxoSmithKline (34)
United States (2663) · France (575) · Canada (486) · United Kingdom (420) · Spain (342) · China (310) · Germany (307) · Italy (287) · Australia (229) · South Korea (193) · Netherlands (189) · Taiwan (189) · Sweden (158) · Japan (145) · Poland (131)
Danna Jennings, MD (16) · Paul Aisen, MD (12)
PMID 39498781, PMID 33189083, PMID 40603145, PMID 39800465, PMID 40049590, PMID 33417236, PMID 36463457, PMID 33974419, PMID 34815790, PMID 38489195, PMID 25918556, PMID 26120369, PMID 26402769, PMID 29480210, PMID 32250312, PMID 34532852, PMID 39324520, PMID 40667684, PMID 40681915, PMID 41533472, PMID 41804324, PMID 41961243, PMID 15817019, PMID 27807285, PMID 27871675, PMID 29318278, PMID 30474567, PMID 31193334, PMID 31381524, PMID 31969177, PMID 3337862, PMID 33773598, PMID 35790423, PMID 35833913, PMID 36627206, PMID 36641609, PMID 36811812, PMID 36934371, PMID 36946603, PMID 37996817, PMID 38706271, PMID 39108660, PMID 39350369, PMID 39513754, PMID 39556389, PMID 40368603, PMID 41220869, PMID 41537338, PMID 41591746, PMID 42552749
2023 (26), U54AG063546 (22), 2009 (20), 2016 (20), 2025 (19), 2014 (18), 2015 (18), 2017 (17), 2018 (13), 2019 (7), P30AG064200 (7), U01AG010483 (6), 2008 (5), P30AG024978 (5), U01AG059798 (5)