Dementia: Clinical Trials

3144 completed, 835 recruiting, 752 unknown, 380 terminated. 2388 Not applicable, 954 Phase 2, 690 Phase 1, 436 Phase 3, 200 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	2388	Completed 1271, Recruiting 355, Unknown 343, Not yet recruiting 141, Terminated 89, Active not recruiting 88, Withdrawn 57, Enrolling by invitation 36, Suspended 8
Phase 2	954	Completed 546, Terminated 109, Recruiting 95, Unknown 86, Active not recruiting 49, Not yet recruiting 34, Withdrawn 23, Enrolling by invitation 11, Suspended 1
Phase 1	690	Completed 454, Terminated 60, Recruiting 59, Unknown 51, Not yet recruiting 27, Active not recruiting 26, Withdrawn 12, Suspended 1
Phase 3	436	Completed 243, Terminated 80, Recruiting 44, Unknown 28, Active not recruiting 23, Not yet recruiting 9, Withdrawn 6, Enrolling by invitation 2, Suspended 1
Phase 4	200	Completed 126, Unknown 23, Recruiting 16, Terminated 11, Active not recruiting 8, Withdrawn 6, Enrolling by invitation 5, Not yet recruiting 5
Early Phase 1	80	Completed 47, Recruiting 13, Terminated 9, Active not recruiting 4, Unknown 3, Not yet recruiting 2, Enrolling by invitation 1, Withdrawn 1

Follow Dementia: new trials by email Literature Review of Dementia trials Research Report on Dementia

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease		Recruiting	Uppsala University Hospital	30	2029-04-01	2026-10-15
Smartphone App for Adolescents With Idiopathic Scoliosis DinSkoliose smartphone application - Adolescence Idiopathic Scoliosis, AIS	Not applicable	Not yet recruiting	Oslo Metropolitan University	30	2028-04-01	2026-07-07
Transcranial Magnetic Stimulation for Alzheimer's Disease Treatment Active Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation - Alzheimer Disease	Not applicable	Not yet recruiting	Universitat Oberta de Catalunya	45	2027-11-01	2026-07-21
Terazosin for Dementia With Lewy Bodies Terazosin Hydrochloride, Placebo - Dementia With Lewy Bodies	Phase 1 / Phase 2	Not yet recruiting	Qiang Zhang	40	2027-10-01	2026-03-12
AV-1959R Vaccine in Individuals With Preclinical Alzheimer's Disease AV-1959R, Placebo - Preclinical Alzheimer's Disease, Alzheimer Disease	Phase 2	Not yet recruiting	Institute for Molecular Medicine	160	2027-10-01	2026-10-21
Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau Neuronavigation-guided single-element focused ultrasound transducer, Lumason, Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents - Alzheimer Disease, Early Onset	Phase 1	Not yet recruiting	Columbia University	6	2027-08-01	2026-05-13
Terazosin And Metabolic Engagement in Alzheimer's Disease Terazosin (Hytrin), Placebo - Alzheimer s Disease	Phase 2	Not yet recruiting	Qiang Zhang	100	2027-08-01	2026-09-01
Feasibility of a Dyadic Music-based Intervention for Persons Living With Dementia and Their Care Partners Dyadic Music-based Intervention (MBI), Reminiscence Activity - Dementia	Not applicable	Not yet recruiting	Duke University	60	2027-08-01	2026-10-05
Hearing Loss and Brain Health Study Over-The-Counter (OTC) hearing aid - Hearing Loss, Adult-Onset, Dementia	Not applicable	Not yet recruiting	University of Southern California	40	2027-07-01	2026-05-08
GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD) GV1001 Placebo, GV1001 1.12mg - Moderate to Severe Alzheimer's Disease	Phase 3	Not yet recruiting	Samsung Pharmaceutical Co., Ltd.	750	2027-07-01	2026-06-10
Tricaprilin Phase 3 ALTER-AD (Alternative-Alzheimer Disease) Study Tricaprilin, Placebo - Alzheimer Disease	Phase 3	Not yet recruiting	Cerecin	535	2027-07-01	2026-10-30
The Effectiveness of a Caregiver-Based Multicomponent Intervention to Prevent Pressure Ulcers in Home-Cared-For Individuals With Dementia Pressure Injury Prevention Education - Dementia, Home Care for Elderly or Disabled Individuals	Not applicable	Not yet recruiting	Manisa Celal Bayar University	120	2027-05-10	2026-11-02
Concurrent Trials on Nature-Based Therapy for Inpatients in Dementia and Rehabilitation Medicine Wards Nature Immersion Therapy - Dementia, Acquired Brain Injury Including Stroke	Not applicable	Not yet recruiting	Changi General Hospital	1600	2027-05-01	2026-03-23
Music Listening for Chronic Pain in Adults With Early-Stage Dementia MUSIC CARE® Standardized Music Listening, Neutral Spoken-Word Audiobook Control - Chronic Pain, Alzheimer Disease	Not applicable	Not yet recruiting	Florida State University	40	2027-03-30	2026-11-05
Advancing Ethical Goals In Society Trial ACP Counselor Video Program - Advance Care Planning, Dementia	Not applicable	Not yet recruiting	Tufts Medical Center	12174	2027-03-01	2026-09-17
ED PLWD/Care Partner Text Messaging CAPTURE Text Message Care Transition Support - Dementia, Caregiver	Not applicable	Not yet recruiting	Yale University	80	2027-03-01	2026-02-23
Primary Care Screening and Intervention for Patients With Dementia and Caregivers SIRENS application, SIRENS screening - Dementia, Elder Abuse	Not applicable	Not yet recruiting	Weill Medical College of Cornell University	774	2027-03-01	2026-11-12
Tailored Education for Aging and Cognitive Health: A Health Behavior Change Intervention for Midlife Adults at Risk for Alzheimer's Disease and Related Dementias TEACH, Basic health education - ADRD, Alzheimer's Disease	Not applicable	Not yet recruiting	Rhode Island Hospital	280	2027-02-15	2026-11-12
Vagus Nerve Stimulation to Enhance Memory in Aging Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) - Alzheimer Disease, Aging	Not applicable	Not yet recruiting	Stanford University	150	2027-02-01	2025-10-09
ALDH2 Genetic Testing in East Asian Community Genetic Test Results Return, Alcohol Flushing Education - Healthy Adult, Flushing	Not applicable	Not yet recruiting	Northwestern University	100	2027-02-01	2026-10-28

Showing 20 of 5861. Sign in to see all of them.

Narrower conditions

Alzheimer Disease (3889)  ·  Cognitive Dysfunction (1192)  ·  Huntington Disease (292)  ·  Lewy Body Disease (237)  ·  Parkinson Disease (232)  ·  Frontotemporal Dementia (207)  ·  Dementia, Vascular (182)  ·  Depression (178)  ·  Neurodegenerative Diseases (167)  ·  Memory Disorders (152)  ·  Caregiver Burden (137)  ·  Motor Activity (113)  ·  Neurocognitive Disorders (111)  ·  Stroke (109)

Broader conditions

Central Nervous System Diseases (5783)  ·  Nervous System Diseases (5779)  ·  Brain Diseases (5764)  ·  Mental Disorders (5733)  ·  Neurocognitive Disorders (5723)  ·  Neurodegenerative Diseases (4323)  ·  Tauopathies (3874)  ·  Cognition Disorders (1446)  ·  Pathological Conditions, Signs and Symptoms (1193)  ·  Signs and Symptoms (810)  ·  Neurologic Manifestations (768)  ·  Basal Ganglia Diseases (692)  ·  Movement Disorders (679)  ·  Behavior (672)

Interventions

Donepezil (143)  ·  Transcranial Direct Current Stimulation (71)  ·  Memantine (63)  ·  florbetapir (56)  ·  Exercise (55)  ·  7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (47)  ·  Galantamine (46)  ·  Blood Specimen Collection (42)  ·  Magnetic Resonance Spectroscopy (41)  ·  Cognitive Training (40)  ·  Rivastigmine (35)  ·  Transcranial Magnetic Stimulation (34)  ·  Neuropsychological Tests (28)  ·  4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (26)  ·  2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (24)

Sponsors

Pfizer (68)  ·  Johns Hopkins University (63)  ·  Eli Lilly and Company (58)  ·  Assistance Publique - Hôpitaux de Paris (55)  ·  Massachusetts General Hospital (46)  ·  National Institute on Aging (NIA) (46)  ·  Chang Gung Memorial Hospital (45)  ·  Avid Radiopharmaceuticals (43)  ·  Mayo Clinic (41)  ·  Indiana University (38)  ·  Emory University (37)  ·  VA Office of Research and Development (36)  ·  University of California, San Francisco (35)  ·  University of Pennsylvania (35)  ·  GlaxoSmithKline (34)

Countries

United States (2666)  ·  France (576)  ·  Canada (491)  ·  United Kingdom (421)  ·  Spain (347)  ·  China (316)  ·  Germany (308)  ·  Italy (289)  ·  Australia (229)  ·  South Korea (193)  ·  Netherlands (189)  ·  Taiwan (189)  ·  Sweden (158)  ·  Japan (145)  ·  Belgium (131)

Top investigators

Danna Jennings, MD (16)  ·  Paul Aisen, MD (12)

Results publications

PMID 39498781, PMID 33189083, PMID 40603145, PMID 39800465, PMID 40049590, PMID 33417236, PMID 36463457, PMID 33974419, PMID 34815790, PMID 38489195, PMID 25918556, PMID 26120369, PMID 26402769, PMID 29480210, PMID 32250312, PMID 34532852, PMID 39324520, PMID 40667684, PMID 40681915, PMID 41533472, PMID 41804324, PMID 41961243, PMID 15817019, PMID 27807285, PMID 27871675, PMID 29318278, PMID 30474567, PMID 31193334, PMID 31381524, PMID 31969177, PMID 3337862, PMID 33773598, PMID 35790423, PMID 35833913, PMID 36627206, PMID 36641609, PMID 36811812, PMID 36934371, PMID 36946603, PMID 37996817, PMID 38706271, PMID 39108660, PMID 39350369, PMID 39513754, PMID 39556389, PMID 40368603, PMID 41220869, PMID 41537338, PMID 41591746, PMID 42552749

NIH funding

2023 (26), U54AG063546 (22), 2009 (20), 2016 (20), 2025 (19), 2014 (18), 2015 (18), 2017 (17), 2018 (13), 2019 (7), P30AG064200 (7), U01AG010483 (6), 2008 (5), P30AG024978 (5), U01AG059798 (5)