2100 completed, 546 recruiting, 448 unknown, 292 terminated. 1388 Not applicable, 713 Phase 2, 557 Phase 1, 346 Phase 3, 136 Phase 4.
Follow Alzheimer Disease: new trials by email Literature Review of Alzheimer Disease trials Research Report on Alzheimer Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| Smartphone App for Adolescents With Idiopathic Scoliosis DinSkoliose smartphone application - Adolescence Idiopathic Scoliosis, AIS | Not applicable | Not yet recruiting | Oslo Metropolitan University | 30 | 2028-04-01 | 2026-07-07 |
| Transcranial Magnetic Stimulation for Alzheimer's Disease Treatment Active Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation - Alzheimer Disease | Not applicable | Not yet recruiting | Universitat Oberta de Catalunya | 45 | 2027-11-01 | 2026-07-21 |
| AV-1959R Vaccine in Individuals With Preclinical Alzheimer's Disease AV-1959R, Placebo - Preclinical Alzheimer's Disease, Alzheimer Disease | Phase 2 | Not yet recruiting | Institute for Molecular Medicine | 160 | 2027-10-01 | 2026-10-21 |
| Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau Neuronavigation-guided single-element focused ultrasound transducer, Lumason, Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents - Alzheimer Disease, Early Onset | Phase 1 | Not yet recruiting | Columbia University | 6 | 2027-08-01 | 2026-05-13 |
| Terazosin And Metabolic Engagement in Alzheimer's Disease Terazosin (Hytrin), Placebo - Alzheimer s Disease | Phase 2 | Not yet recruiting | Qiang Zhang | 100 | 2027-08-01 | 2026-09-01 |
| GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD) GV1001 Placebo, GV1001 1.12mg - Moderate to Severe Alzheimer's Disease | Phase 3 | Not yet recruiting | Samsung Pharmaceutical Co., Ltd. | 750 | 2027-07-01 | 2026-06-10 |
| Advancing Ethical Goals In Society Trial ACP Counselor Video Program - Advance Care Planning, Dementia | Not applicable | Not yet recruiting | Tufts Medical Center | 12174 | 2027-03-01 | 2026-09-17 |
| Vagus Nerve Stimulation to Enhance Memory in Aging Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) - Alzheimer Disease, Aging | Not applicable | Not yet recruiting | Stanford University | 150 | 2027-02-01 | 2025-10-09 |
| HomeCare Medication Management for People With Dementia HomeCare - Dementia, Alzheimer's Disease and Related Dementias | Not applicable | Not yet recruiting | HiDO Technologies | 120 | 2027-01-01 | 2026-10-13 |
| Acupressure as Long-term Intervention to Slow the Progression of Early/Mild Alzheimer's Disease Comfy Acupressure for the Elderly, Least acupressure control - Alzheimer's Disease | Not applicable | Not yet recruiting | The University of Hong Kong | 188 | 2027-01-01 | 2026-08-24 |
| Repurposing a Combination Antiretroviral Drug Therapy to Target Retrotransposons and Treat Early Alzheimer's Disease Emtricitabine and tenofovir disoproxil fumarate combination, Placebo - Alzheimer's Disease | Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 20 | 2026-12-01 | 2026-08-31 |
| Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease Brain Stimulation - Alzheimer&Amp;#39;s Disease-related Dementia, Alzheimer Disease | Not applicable | Not yet recruiting | Baylor College of Medicine | 20 | 2026-12-01 | 2026-10-05 |
| Improv Music Therapy for Older Adults Clinical Improvisation - Alzheimer's Disease (AD), Older Adults (65 Years and Older) | Not applicable | Not yet recruiting | University of California, San Francisco | 40 | 2026-12-01 | 2026-02-23 |
| Aging and Exercise Impacts on Glymphatic Function Acute Aerobic exercise - Aging and Exercise Impacts on Glymphatic Function | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 240 | 2026-12-01 | 2026-10-05 |
| High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults High-Velocity Resistance Training - At Risk for AD-dementia, With Subjective Cognitive Decline, At Risk for Cognitive Decline | Not applicable | Not yet recruiting | University of Illinois at Chicago | 60 | 2026-12-01 | 2026-10-14 |
| Tricaprilin Phase 3 ALTER-AD (Alternative-Alzheimer Disease) Study Tricaprilin, Placebo - Alzheimer Disease | Phase 3 | Not yet recruiting | Cerecin | 535 | 2026-12-01 | 2026-07-01 |
| Electroconvulsive Therapy for Treatment of Alzheimer´s Disease Thymatron IV device (Somatics) - Alzheimer's Disease | Not applicable | Not yet recruiting | Central Institute of Mental Health, Mannheim | 15 | 2026-12-01 | 2026-09-08 |
| SmartEnLite for Nursing Home Residents With Dementia Smart Environmental Light (SmartEnLite) - Alzheimer's Disease and Related Dementias, Alzheimer Disease and Related Dementias | Not applicable | Not yet recruiting | Penn State University | 300 | 2026-12-01 | 2026-10-20 |
| A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease Trontinemab, Placebo - Alzheimer's Disease | Phase 3 | Recruiting | Hoffmann-La Roche | 1600 | 2026-11-30 | 2026-10-13 |
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Dementia (940) · Cognitive Dysfunction (837) · Neurodegenerative Diseases (128) · Parkinson Disease (126) · Memory Disorders (121) · Dementia, Vascular (116) · Lewy Body Disease (108) · Frontotemporal Dementia (91) · Depression (88) · Brain Diseases (82) · Caregiver Burden (80) · Motor Activity (72) · Neurocognitive Disorders (72) · Plaque, Amyloid (72)
Tauopathies (3820) · Central Nervous System Diseases (3811) · Nervous System Diseases (3811) · Mental Disorders (3803) · Neurocognitive Disorders (3802) · Brain Diseases (3792) · Neurodegenerative Diseases (3746) · Dementia (2934) · Cognition Disorders (837) · Pathological Conditions, Signs and Symptoms (662) · Signs and Symptoms (439) · Neurologic Manifestations (421) · Behavior (383) · Neurobehavioral Manifestations (311) · Nutritional and Metabolic Diseases (248)
Donepezil (123) · florbetapir (53) · Memantine (47) · Transcranial Direct Current Stimulation (44) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (41) · Galantamine (38) · Exercise (35) · Magnetic Resonance Spectroscopy (33) · Blood Specimen Collection (32) · Transcranial Magnetic Stimulation (29) · Rivastigmine (28) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (26) · Cognitive Training (23) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (20) · latrepirdine (20)
Pfizer (62) · Eli Lilly and Company (57) · Avid Radiopharmaceuticals (42) · National Institute on Aging (NIA) (42) · Indiana University (32) · Wyeth is now a wholly owned subsidiary of Pfizer (32) · GlaxoSmithKline (31) · Merck Sharp & Dohme LLC (31) · Assistance Publique - Hôpitaux de Paris (28) · Johns Hopkins University (28) · Massachusetts General Hospital (28) · Chang Gung Memorial Hospital (27) · Emory University (27) · Hoffmann-La Roche (27) · Centre Hospitalier Universitaire de Nice (26)
United States (1902) · France (429) · Canada (307) · Spain (267) · United Kingdom (246) · China (238) · Germany (202) · Italy (199) · Australia (169) · South Korea (168) · Japan (132) · Netherlands (132) · Sweden (127) · Poland (106) · Taiwan (103)
Danna Jennings, MD (16) · Paul Aisen, MD (12)
PMID 39498781, PMID 33189083, PMID 40603145, PMID 39800465, PMID 34815790, PMID 40049590, PMID 25918556, PMID 26120369, PMID 26402769, PMID 33417236, PMID 33974419, PMID 39324520, PMID 40667684, PMID 40681915, PMID 41533472, PMID 41804324, PMID 41961243, PMID 27807285, PMID 27871675, PMID 29318278, PMID 30474567, PMID 31193334, PMID 31969177, PMID 33773598, PMID 34532852, PMID 36627206, PMID 36641609, PMID 36934371, PMID 36946603, PMID 37996817, PMID 39108660, PMID 39350369, PMID 39513754, PMID 39556389, PMID 41220869, PMID 41537338, PMID 41591746, PMID 42552749, PMID 42841310, PMID 15817019, PMID 18854539, PMID 20921879, PMID 21371747, PMID 22749065, PMID 22784036, PMID 24345389, PMID 24450890, PMID 24450891, PMID 25022541, PMID 25125457
2023 (18), 2009 (17), 2016 (15), 2015 (14), 2017 (14), 2025 (14), 2014 (12), 2018 (11), U54AG063546 (8), 2019 (6), U01AG010483 (6), P30AG024978 (5), U01AG059798 (5), 1RC2AG036535 (4), R01AG046179 (4)