74 completed, 13 unknown, 12 terminated, 8 recruiting. 118 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 118 | Completed 74, Unknown 13, Terminated 12, Recruiting 8, Withdrawn 5, Active not recruiting 2, Suspended 2, Enrolling by invitation 1, Not yet recruiting 1 |
Follow Chronic Pain: new trials by email Literature Review of Chronic Pain trials Research Report on Chronic Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance Duloxetine, Placebo - Knee Osteoarthritis (Knee OA), Chronic Pain | Phase 4 | Recruiting | Benedict Alter | 85 | 2026-09-15 | 2026-10-21 |
| Dex & Mastectomy Pain Dexamethasone (intravenous), Normal Saline (0.9% NaCl) - Post-Mastectomy Chronic Pain Syndrome | Phase 4 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 170 | 2026-04-13 | 2026-06-04 |
| Accelerated Neuromodulation for Concurrent Post-Traumatic Stress Disorder (PTSD) & Chronic Pain in Veterans Transcranial magnetic stimulation - Chronic Pain, Post-traumatic Stress Disorder (PTSD) | Phase 4 | Not yet recruiting | Legion Veterans Village Research Foundation | 30 | 2026-01-01 | 2025-11-18 |
| Better Options for Chronic Cancer Pain Multimodal pain care, Medication optimization, Buprenorphine rotation - Chronic Pain, Cancer Survivor | Phase 4 | Recruiting | VA Office of Research and Development | 294 | 2025-10-07 | 2026-05-11 |
| Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression Ketamine, Normal saline - Chronic Pain, Depression | Phase 4 | Active not recruiting | Stanford University | 40 | 2025-01-28 | 2025-10-02 |
| Superficial Cervical Plexus Block Versus Ketamine in the Prevention of Chronic Pain After Thyroidectomy Ketamine perfusion, Superficial cervical plexus block - Chronic Pain, Thyroidectomy | Phase 4 | Completed | University Tunis El Manar | 69 | 2024-10-14 | 2025-11-17 |
| Efficacy and Safety of Liposomal Bupivacaine Injection for Paravertebral Nerve Block in the Treatment of Acute and Chronic Pain After Thoracoscopic Pneumonectomy: A Multicenter, Randomized, Double-blind, Controlled Clinical Trial Liposomal bupivacaine, Bupivacaine Hydrochloride - Acute Pain, Chronic Pain | Phase 4 | Recruiting | The Second Affiliated Hospital of Chongqing Medical University | 284 | 2024-08-26 | 2025-06-27 |
| NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow Diclofenac, Tramadol, Acetaminophen - Elbow Pain, Chronic Pain | Phase 4 | Recruiting | The Cleveland Clinic | 92 | 2024-08-12 | 2026-08-28 |
| Haloperidol for Pain Control in Patients With Acute Musculoskeletal Back Pain in the Emergency Department Haloperidol, Ketorolac Tromethamine - Back Pain, Chronic Pain | Phase 4 | Recruiting | Western Michigan University School of Medicine | 75 | 2024-07-09 | 2024-07-10 |
| Intraoperative Sufentanil and Chronic Postsurgical Pain in Non-major Scheduled Abdominal Surgery phone interview - Chronic Postsurgical Pain, Chronic Pain | Phase 4 | Active not recruiting | Centre Hospitalier Universitaire, Amiens | 855 | 2024-06-24 | 2025-11-19 |
| Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment Patient-Oriented Dosing (POD), Pain Self-Management (PSM), Usual Care - Opioid Use Disorder, Chronic Pain | Phase 4 | Completed | Erin Winstanley | 273 | 2024-05-28 | 2026-11-05 |
| Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome Low dose naltrexone, Placebo sugar capsules - Complex Regional Pain Syndrome, Chronic Pain | Phase 4 | Enrolling by invitation | Hospital for Special Surgery, New York | 40 | 2024-01-02 | 2026-11-06 |
| Helping Osteoarthritis Patients to Walk With NSAID therapeutic program including intermittent drug intake and multimodal rehabilitation program - Osteoarthritis, Knee, Osteoarthritis, Hip | Phase 4 | Recruiting | University Hospital, Clermont-Ferrand | 55 | 2023-12-14 | 2026-02-27 |
| Comparison of Ultrasound-Guided Perimeniscal Steroid and 5% Dextrose Injections in Knee Osteoarthritis Triamcinolone Acetonide, Dextrose 5% in water - Gonarthrosis, Meniscus; Degeneration | Phase 4 | Completed | Kastamonu University | 32 | 2023-10-02 | 2026-08-20 |
| Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy Ketamine + Levobupivacaine, Levobupivacaine - Ketamine, Levobupivacaine | Phase 4 | Completed | Tanta University | 60 | 2023-08-30 | 2024-02-13 |
| Tapentadol vs Tramadol in Total Knee Arthroplasty Tapentadol, Tramadol - Total Knee Replacement, Post-operative Pain | Phase 4 | Unknown | University of Thessaly | 96 | 2023-05-01 | 2024-05-14 |
| The Effect of Subcutaneous Injection of Botulinum Toxin A on Chronic Wound Pain in Lower Extremities Botulinum Toxin A - Chronic Pain, Lower Extremity Wound | Phase 4 | Completed | Bispebjerg Hospital | 10 | 2023-02-07 | 2024-08-09 |
| Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization BUP microdose induction, TAU, Linkage to outpatient BUP treatment - Substance Use Disorders, Opioid-use Disorder | Phase 4 | Terminated | Montefiore Medical Center | 23 | 2022-09-29 | 2026-05-08 |
| Comparison of Analgesic Efficacy of Intrathecal Levobupivacaine With and Without Oral Tizanidine in Lower Limb Surgeries: A Prospective Randomized Study Tizanidine - Tizanididne, Levobupicaine | Phase 4 | Completed | All India Institute of Medical Sciences | 64 | 2022-08-20 | 2026-01-09 |
| True Functional Restoration and Analgesia in Non-Radicular Low Back Pain Buprenorphine Buccal Film [Belbuca], Urine Drug Screening, actigraph - Back Pain Lower Back Chronic, Chronic Pain | Phase 4 | Unknown | Carolinas Pain Institute | 40 | 2022-08-03 | 2023-02-08 |
Showing 20 of 118. Sign in to see all of them.
Pain, Postoperative (15) · Pain (13) · Acute Pain (12) · Back Pain (7) · Low Back Pain (6) · Opioid-Related Disorders (6) · Osteoarthritis (6) · Osteoarthritis, Knee (6) · Agnosia (5) · Neuralgia (5) · Fibromyalgia (3) · Hernia, Inguinal (3) · Hyperalgesia (3) · Joint Diseases (3)
Neurologic Manifestations (118) · Pathological Conditions, Signs and Symptoms (118) · Signs and Symptoms (118) · Pain (105) · Nervous System Diseases (23) · Pathologic Processes (20) · Musculoskeletal Diseases (18) · Rheumatic Diseases (16) · Postoperative Complications (15) · Arthritis (13) · Joint Diseases (12) · Neuromuscular Diseases (11) · Mental Disorders (10) · Chemically-Induced Disorders (8) · Peripheral Nervous System Diseases (8)
Morphine (11) · Ketamine (9) · Sodium Chloride (9) · Dexamethasone (6) · Duloxetine Hydrochloride (6) · Fentanyl (6) · Oxycodone (6) · Amitriptyline (5) · Lidocaine (5) · Acetaminophen (4) · Bupivacaine (4) · Buprenorphine (4) · Methadone (4) · Saline Solution (4) · Sugars (4)
Boston Scientific Corporation (3) · Fondazione IRCCS Policlinico San Matteo di Pavia (3) · Hospital for Special Surgery, New York (3) · Stanford University (3) · Wake Forest University Health Sciences (3) · Copenhagen University Hospital, Hvidovre (2) · Copenhagen University Hospital, Rigshospitalet (2) · Endeavor Health (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Groene Hart Ziekenhuis (2) · Insel Gruppe AG, University Hospital Bern (2) · Mahidol University (2) · Mustafa Kemal University (2) · Pfizer (2) · Tanta University (2)
United States (47) · Canada (8) · Denmark (6) · Italy (5) · Turkey (Türkiye) (5) · China (4) · France (3) · Hong Kong (3) · South Korea (3) · Thailand (3) · Austria (2) · Belgium (2) · Brazil (2) · Egypt (2) · Germany (2)
Massimo Allegri, MD (2) · Nicolai Bang Foss, Dr.med. (2) · Pascal H Vuilleumier, MD (2) · Stanley SC Wong, MBBS (2) · Thomas Yearwood, MD (2) · Ulrike Stamer, Professor (2) · Aaron Fox, MD (1) · Ajay D Wasan, MD, MSc (1) · Alexandra Sideris, PhD (1) · Allegri Massimo, MD (1) · Andrea Furlan, MD, PhD (1)
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P01HD033988 (2), 1RM1DA055437-01 (1), 1UG3NR019196-01 (1), 2014 (1), 2017 (1), I01CX002902 (1), K23NS123429 (1), R01DA036564 (1), R01DK100368 (1), RM1DA055311 (1)