613 completed, 244 unknown, 189 recruiting, 71 terminated. 1078 Not applicable, 115 Phase 2, 54 Phase 1, 41 Phase 3, 9 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries | Phase 2 | Not yet recruiting | VA Office of Research and Development | 46 | 2027-05-24 | 2026-02-17 |
| Multiparameter Optimized tES for Memory in Aging Transcranial electrical stimulation - Healthy Aging | Not applicable | Withdrawn | Medical University of South Carolina | 2026-12-31 | 2026-02-25 | |
| Improving Awareness for Spatial Neglect With tDCS transcranial direct current stimulation (tDCS) - Stroke, Anosognosia | Not applicable | Not yet recruiting | University of Geneva, Switzerland | 12 | 2026-12-01 | 2025-05-30 |
| Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) Depression Cognitive Training, Non-Specific Cognitive Training, tDCS (active stimulation) - Aging, Depression | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 69 | 2026-12-01 | 2026-10-21 |
| A Novel Multimodal Approach to Promote Motor Recovery and Plasticity After Stroke tRNS (Transcranial Random Noise Stimulation), FES (Functional Electrical Stimulation)-assisted task-specific practice, Sham-tRNS (Transcranial Random Noise Stimulation) - Stroke | Not applicable | Not yet recruiting | University of Utah | 78 | 2026-11-02 | 2026-10-22 |
| Transcranial Electrical Stimulation for Comorbid Depression and Chronic Pain tDCS, alpha-tACS, Sham - Depression Disorder, Chronic Pain | Not applicable | Recruiting | Shanghai Mental Health Center | 160 | 2026-11-01 | 2026-09-04 |
| Effects of Anodal Transcranial Direct Current Stimulation on Muscle Inhibition After ACL Reconstruction Anodal Transcranial Direct Current Stimulation (tDCS), Standard Physical Therapy - ACL Reconstruction | Not applicable | Not yet recruiting | University of Lahore | 64 | 2026-11-01 | 2026-10-09 |
| Combined Functional Electrical and Transcranial Direct Current Stimulation for Foot Drop Standard protocol for combo of FES and tDCS - Falls, Foot Drop | Not applicable | Recruiting | Saint Joseph's University, Philadelphia | 30 | 2026-11-01 | 2026-10-22 |
| Mechanistic Validation of Human Multipolar TES-TI: Amplitude Modulation, Frequency, and Benchmarking TES-TI with hdEEG - Transcranial Electric Stimulation | Not applicable | Recruiting | University of Wisconsin, Madison | 24 | 2026-10-09 | 2026-10-23 |
| tDCS for Late-Life Depression High-intensity (6 mA) transcranial direct current stimulation (tDCS) - Late Life Depression (LLD), Depression - Major Depressive Disorder | Phase 1 / Phase 2 | Recruiting | Andre Russowsky Brunoni | 20 | 2026-10-01 | 2026-09-25 |
| Lily's Grace Temporal Interference TES-TI, Sham Stimulation, Structural and Functional MRI - Epilepsy | Not applicable | Not yet recruiting | University of Wisconsin, Madison | 24 | 2026-10-01 | 2026-09-29 |
| Effects of Non-invasive Brain Stimulation on Pain Avoidance Behavior in Chronic Pain Patients transcranial alternating current stimulation (tACS) - Complex Regional Pain Syndrome (CRPS) | Not applicable | Recruiting | The Cleveland Clinic | 30 | 2026-10-01 | 2026-08-28 |
| Overnight Thalamic TES-TI to Modulate Sleep Spindles in Individuals With Schizophrenia Spectrum Disorders and Matched Healthy Controls TES-TI, Sham TES-TI - Schizophrenia | Not applicable | Recruiting | University of Wisconsin, Madison | 20 | 2026-10-01 | 2026-10-01 |
| Noninvasive Brain Stimulation Combined With Written Exposure Therapy for PTSD in Military Personnel With TBI Transcranial Direct Current Stimulator, Written Exposure Therapy - Post Traumatic Stress Disorder | Not applicable | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 150 | 2026-09-30 | 2026-07-20 |
| Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring Temporal Interference Stimulation, Direct Electrical Stimulation - Drug-Resistant Focal Epilepsy | Not applicable | Recruiting | Duke University | 30 | 2026-09-16 | 2026-10-15 |
| Transcranial Alternating Current Stimulation (tACS) Combined With Cognitive Training in Alzheimer's Disease Transcranial Alternating Current Stimulation, Sham Transcranial Alternating Current Stimulation, Individualized Computerized Memory Training - Transcranial Alternating Current Stimulation, Alzheimer Disease (AD) | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 30 | 2026-09-16 | 2026-09-24 |
| Study Evaluating the Effect of Transcranial Direct Current Stimulation (tDCS) Targeting the Right Inferior Frontal Gyrus on Inhibitory Control in Patients With PSP tDCS, or transcranial direct current stimulation - PSP - Progressive Supranuclear Palsy | Not applicable | Not yet recruiting | Nantes University Hospital | 20 | 2026-09-15 | 2026-09-14 |
| Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue Transcranial Direct Current Stimulation - Long COVID, Post-COVID Conditions | Not applicable | Not yet recruiting | University of Las Palmas de Gran Canaria | 20 | 2026-09-15 | 2026-07-22 |
| Treatment of Cognitive and Sensorimotor Deficits in Parkinson's Disease With High Definition Transcranial Direct Current Stimulation transcranial direct current stimulation, Sham transcranial direct current stimulation - PARKINSON DISEASE (Disorder) | Not applicable | Recruiting | The University of Texas at Dallas | 20 | 2026-09-15 | 2026-09-16 |
| Transcranial Direct Current Stimulation for the Treatment of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors Sham Intervention, Survey Administration, Transcranial Direct Current Stimulation - Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphatic System Neoplasm | Not applicable | Recruiting | University of Michigan Rogel Cancer Center | 50 | 2026-09-10 | 2026-10-15 |
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Stroke (199) · Cognitive Dysfunction (73) · Schizophrenia (67) · Depression (66) · Depressive Disorder, Major (54) · Chronic Pain (47) · Parkinson Disease (46) · Alzheimer Disease (44) · Aphasia (34) · Pain (27) · Anxiety Disorders (26) · Brain Injuries, Traumatic (26) · Ischemic Stroke (24) · Fatigue (22) · Motor Activity (22)
Charite University, Berlin, Germany (27) · University of Minnesota (26) · Spaulding Rehabilitation Hospital (22) · Federal University of Paraíba (20) · University of Liege (18) · Hospital de Clinicas de Porto Alegre (16) · Mahidol University (16) · Medical University of South Carolina (16) · Johns Hopkins University (15) · Riphah International University (15) · Seoul National University Hospital (14) · Universidade Federal de Pernambuco (14) · University of Sao Paulo (14) · The University of New South Wales (13) · The Hong Kong Polytechnic University (12)
United States (413) · Brazil (108) · China (71) · Germany (71) · France (58) · Canada (47) · Italy (45) · Belgium (41) · Spain (37) · United Kingdom (36) · South Korea (28) · Taiwan (21) · Turkey (Türkiye) (19) · Switzerland (17) · Hong Kong (16)
Mirza Obaid Baig, MSPT (10) · Felipe Fregni, MD, PhD, MPH (8) · Wanalee Klomjai, PhD (8) · Suellen Andrade (7) · Wolnei Caumo, PhD (5) · Brad Manor, PhD (4) · Felipe Fregni, MD PhD MPH (4) · Flavio Frohlich, PhD (4) · Jazmin Camchong, PhD (4) · Joan Camprodon, MD, PhD, MPH (4) · Stephen Bornheim, Msc (4) · Wen Li, PhD (4) · Yvonne Han, PhD (4)
PMID 33175411, PMID 10990547, PMID 28709880, PMID 17452283, PMID 20633386, PMID 27866120, PMID 16427357, PMID 19348793, PMID 21320389, PMID 21631313, PMID 22031888, PMID 23370085, PMID 28440034, PMID 31617873, PMID 34196963, PMID 11723286, PMID 15753425, PMID 17086200, PMID 17591596, PMID 19064743, PMID 19109497, PMID 19833552, PMID 20395612, PMID 21167786, PMID 21441148, PMID 22032743, PMID 22037126, PMID 22215866, PMID 22581236, PMID 22695026, PMID 23122848, PMID 24345389, PMID 24574549, PMID 26848997, PMID 26890096, PMID 27056623, PMID 27173384, PMID 27199889, PMID 28566193, PMID 29066167, PMID 29213226, PMID 29550525, PMID 30083095, PMID 30902640, PMID 31672712, PMID 32147282, PMID 33022345, PMID 33045706, PMID 34062145, PMID 34785366
P2CHD086844 (3), 1RF1MH116987-01 (2), 2017 (2), K23MH111977 (2), R01MH132209 (2), 1IK2RD000464-01A2 (1), 1IK2RX002420-01A2 (1), 1UG3DA048508-01 (1), 1UG3DA061594 (1), 2014 (1), 2015 (1), 2016 (1), 2018 (1), 2023 (1), 5KL2TR001429 (1)