131 completed, 30 unknown, 25 recruiting, 13 not yet recruiting. 199 Not applicable, 4 Phase 1, 4 Phase 2, 3 Early Phase 1, 2 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ACT for Veterans With IBD and Mental Health Challenges Acceptance and Commitment Therapy - Inflammatory Bowel Diseases, Crohn's Disease | Not applicable | Not yet recruiting | VA Office of Research and Development | 50 | 2028-01-01 | 2026-02-09 |
| Substance Use Prevention for Recently Displaced Adults - SUPRA (R33) RCT Acceptance and Commitment Therapy, Attention Control - Prevention, Substance Use | Not applicable | Not yet recruiting | Boston Medical Center | 144 | 2027-04-01 | 2026-06-29 |
| Comparative Effects of Acceptance and Commitment Therapy, Cognitive Behavioral Therapy, and Treatment-as-Usual on Depression Among People With Marital Crisis Acceptance and Commitment Therapy, Cognitive Behavioral Therapy - Depression - Major Depressive Disorder, Anxiety | Not applicable | Not yet recruiting | Universiti Sains Malaysia | 120 | 2027-01-01 | 2026-09-08 |
| Psychotherapy in Patients With Endometriosis: Cognitive Behavioral Therapy Versus Acceptance and Commitment Therapy Cognitive Behavioral Therapy (CBT), Acceptance and Commitment Therapy (ACT) - Endometriosis, Adenomyosis | Not applicable | Not yet recruiting | Fiammetta Cosci | 128 | 2027-01-01 | 2026-10-30 |
| Acceptance and Commitment Therapy Plus Physiotherapy for Chronic Low Back Pain Acceptance and Commitment Therapy (ACT), Standard Physiotherapy Program - Low Back Pain | Not applicable | Not yet recruiting | Al-Azhar University | 64 | 2026-10-28 | 2026-10-28 |
| Impact of Play Interventions on Stress and Anxiety Using EEG and AI. playful intervention - Anxiety, Stress | Not applicable | Not yet recruiting | Universidad Autonoma de Baja California | 60 | 2026-08-30 | 2026-04-29 |
| Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic Cough Acceptance and Commitment Therapy (ACT) - Chronic Cough | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 30 | 2026-08-01 | 2026-05-06 |
| Effectiveness of Acceptance and Commitment Therapy for Chronic Non-Malignant Pain: A Randomized Controlled Trial Acceptance and Commitment Therapy (ACT), Cognitive Behavioral Therapy (CBT) - Chronic Non-Malignant Pain (Chronic Musculoskeletal Pain, Chronic Widespread Pain) | Not applicable | Active not recruiting | GIFT University | 60 | 2026-05-13 | 2026-07-16 |
| An Integrated Intervention of Spinal Cord Stimulation and Multidisciplinary Rehabilitation for Chronic Neuropathic Leg Pain: A Single-case Experimental Design Protocol Treatment bundle - Neuropathic Pain, Multidisciplinary Approach | Not applicable | Recruiting | Oslo University Hospital | 10 | 2026-05-04 | 2026-10-16 |
| An ACT-Based Family Psychosocial Intervention for Women With Perinatal Loss and Their Spouses: A Pilot Randomised Controlled Trial Acceptance and Commitment Therapy - ACT, Perinatal Loss | Not applicable | Completed | Second Xiangya Hospital of Central South University | 88 | 2026-04-10 | 2026-10-02 |
| ACT for Individuals With MNCD and Their Care Partners Acceptance Commitment Therapy - Depression in Adults, Anxiety Disorder Generalized | Phase 1 | Recruiting | Texas Tech University | 100 | 2026-04-01 | 2026-05-15 |
| Group-Based Acceptance and Commitment Therapy Versus Active Control in University Students With Emotional Symptoms Acceptance and Commitment Therapy (ACT), Non-Directive Group Therapy (NDT) - Depression, Anxiety | Not applicable | Recruiting | Mónica Larrosa Signorelli | 48 | 2026-03-20 | 2026-04-01 |
| Exergames-acceptance and Commitment Therapy(e-ACT) for Breast Cancer Depression and Anxiety: A Randomized Controlled Trial exergames-acceptance and commitment therapy (e-ACT), Acceptance and commitment therapy (ACT) - Breast Cancer Survivors, Depression Anxiety Disorder | Not applicable | Recruiting | Universiti Sains Malaysia | 120 | 2026-03-01 | 2026-07-23 |
| ACT-Based Intervention for Problem Gambling Acceptance and Commitment Therapy (ACT) - Problem Gambling | Not applicable | Not yet recruiting | Universidad Europea de Madrid | 72 | 2026-03-01 | 2025-07-18 |
| Acceptance and Commitment Therapy for Parents of Children With ASD: Effects on Cognitive Fusion, Stigma, and Mindfulness Acceptance and Commitment Therapy (ACT) - Autism Spectrum Disorder (ASD) | Not applicable | Completed | University of Jazan | 30 | 2026-01-25 | 2026-05-13 |
| Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain Yoga, Acceptance and Commitment Therapy (ACT) - Chronic Pain, Musculoskeletal Pain | Not applicable | Recruiting | Palo Alto Veterans Institute for Research | 274 | 2026-01-07 | 2026-01-29 |
| Effectiveness of Acceptance and Commitment Therapy in Promoting Mental Health of Emerging Adults With Internet Addiction Acceptance and Commitment Therapy (ACT) - Internet Addiction | Not applicable | Completed | National University of Modern Languages | 54 | 2025-12-01 | 2026-08-13 |
| Impact of Therapeutic Exercise Integrated With Psychotherapy and Education in Patients With Depression Psychotherapy, Graded activity combined with exercise and education - Depression Disorder | Not applicable | Not yet recruiting | MarcoMateoRiera | 112 | 2025-12-01 | 2025-11-28 |
| Digital Intervention for Adults With Misophonia Acceptance and commitment therapy - Misophonia | Not applicable | Completed | Utah State University | 102 | 2025-10-16 | 2026-10-20 |
| A Pilot Study on an ACT-Based Program for Individuals With Special Needs and Their Caregivers Acceptance and Commitment Therapy - Parenting Stress, Psychological Flexibility | Not applicable | Recruiting | The University of Hong Kong | 62 | 2025-10-14 | 2026-01-16 |
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Anxiety Disorders (36) · Depression (36) · Chronic Pain (23) · Psychological Well-Being (11) · Neoplasms (9) · Fatigue (7) · Psychotic Disorders (7) · Schizophrenia (7) · Smoking Cessation (7) · Caregiver Burden (6) · Mental Disorders (6) · Breast Neoplasms (5) · Dementia (5) · Motor Activity (5) · Obesity (5)
University of Alabama at Birmingham (9) · VA Office of Research and Development (6) · Duke University (5) · Indiana University (5) · The Hong Kong Polytechnic University (5) · Universidad Europea de Madrid (5) · Universiti Sains Malaysia (5) · Fred Hutchinson Cancer Center (4) · Karolinska Institutet (4) · Utah State University (4) · Alexandria University (3) · The Miriam Hospital (3) · The University of Hong Kong (3) · University of Aarhus (3) · University of California, San Diego (3)
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Areum Han, PhD (7) · Francisco Montesinos, Ph.D. (5) · Catherine E Mosher, Ph.D. (3) · Rhonda Merwin, PhD (3) · AY Loke, PhD (2) · Charlotte U Rask, MD, PhD (2) · David Lobato, Ph.D. (2) · Jonathan Bricker (2) · Juan V. Luciano, PhD (2) · Karsten Lunze, MD DrPH MPH (2) · Maria Karekla, Ph.D. (2) · Niloofar Afari, PhD (2) · Rikard Wicksell, PhD (2) · Shelley A Johns, PsyD (2) · YW Mak, PhD (2)
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