170 terminated. 170 Phase 3, 18 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 170 | Terminated 170 |
| Phase 2 | 18 | Terminated 18 |
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Erector Spinae Plane Block With Bupivacaine for Medical Thoracoscopy Bupivacaine injection, Placebo, Monitored Anesthesia Care - Pleural Disease, Postoperative Pain | Phase 3 | Terminated | Icahn School of Medicine at Mount Sinai | 33 | 2024-03-28 | 2025-05-01 |
| Cannabidiol for the Treatment of Pelvic Pain in Endometriosis (DREAMLAND) Cannabis Derivatives, Placebo, Hormonal Contraceptive Agents - Endometriosis, Pelvic Pain | Phase 2 / Phase 3 | Terminated | University of Sao Paulo | 50 | 2023-01-03 | 2025-04-02 |
| Cannabidiol 133mg + Cannabigerol 66mg + Tetrahydrocannabinol 4mg Vs Placebo As Adjuvant Treatment in Chronic Migraine - Placebo oral drops, Cannabidiol + Cannabigerol + Tetrahydrocannabinol 133/66/4mg - Chronic Migraine, Headache, Overuse Headache Medication | Phase 2 / Phase 3 | Terminated | Hospital Israelita Albert Einstein | 110 | 2022-10-18 | 2025-02-24 |
| Recurrent Abdominal Pain and Exocrine Pancreatic Insufficiency synthetic human secretin - Abdominal Pain, Irritable Bowel Syndrome | Phase 3 | Terminated | Orlando Health, Inc. | 27 | 2022-01-28 | 2024-04-03 |
| Analgesic Ear Drops for Children With Acute Otitis Media lidocaine hydrochloride 5mg/g - Acute Otitis Media, Pain | Phase 3 | Terminated | UMC Utrecht | 29 | 2021-10-06 | 2026-07-16 |
| Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity Dexamethasone, Ibuprofen, Acetaminophen - Adenotonsillectomy, Analgesia | Phase 3 | Terminated | David Chi, MD | 222 | 2021-08-05 | 2024-09-05 |
| Efficacy of CLORazepate for the Treatment of MIGraine Attack in the Emergency Room Clorazepate Dipotassium, Placebo, Ketoprofen - Migraine, Migraine Without Aura | Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 323 | 2021-07-08 | 2025-09-08 |
| Rofecoxib Efficacy and Safety Evaluation Trial in Hemophilic Arthropathy TRM-201 (Rofecoxib), Placebo - Hemophilic Arthropathy | Phase 3 | Terminated | Tremeau Pharmceuticals, Inc. | 2 | 2021-06-02 | 2022-10-27 |
| Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy Gabapentin - Thoracotomy, Pain, Postoperative | Phase 3 | Terminated | Indiana University | 20 | 2021-04-06 | 2024-03-21 |
| Buprenorphine Plus Baclofen to Increase Analgesia in Healthy Volunteers Placebos, Baclofen 5 mg, Baclofen 10mg - Acute Pain, Analgesia | Phase 2 / Phase 3 | Terminated | University of Alabama at Birmingham | 19 | 2021-01-21 | 2026-01-07 |
| The Effect of Ganglion Sphenopalatine Block Versus Placebo on Persistent Headache Following COVID-19 Infection Sphenopalatine Ganglion Block with Local Anesthetic, Sphenopalatine Ganglion Block with Placebo (Isotone NaCl), "Sham"-block with Placebo (Isotone NaCl) - Headache, Covid19 | Phase 3 | Terminated | University Hospital Bispebjerg and Frederiksberg | 18 | 2021-01-12 | 2022-06-10 |
| Cannabidiol and Management of Endometriosis Pain Cannabidiol (CBD) Extract, Norethindrone Acetate, Placebo - Endometriosis, CBD | Phase 3 | Terminated | Milton S. Hershey Medical Center | 12 | 2020-12-04 | 2025-04-04 |
| Comparison of Quadratus Lumborum Block Types Ropivacaine injection Location 1, Ropivacaine injection Location 2, Multimodal Pharmacological Management - Pain, Opioid Use | Phase 3 | Terminated | University of Massachusetts, Worcester | 9 | 2020-12-01 | 2025-07-28 |
| Intraoperative Methadone in Children Undergoing Surgery Methadone Hydrochloride, Placebo - Pain, Acute, Pain, Postoperative | Phase 3 | Terminated | University of Aarhus | 60 | 2020-11-16 | 2024-02-28 |
| Phase III Efficacy and Tolerability Trial of the Fixed Dose Combination of Etodolac 400 mg and Cyclobenzaprine 10 mg Versus Isolated Active Substances in Pain Control After Impacted Third Molar Extraction Fixed Dose Combination, Etodolac, Cyclobenzaprine - Pain, Acute | Phase 3 | Terminated | Apsen Farmaceutica S.A. | 140 | 2020-10-05 | 2026-09-09 |
| Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain Lidocaine, Esmolol, Placebo - Injection Site Irritation, Pain | Phase 2 / Phase 3 | Terminated | Wake Forest University Health Sciences | 33 | 2020-09-09 | 2024-09-19 |
| Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain 75 mg linzagolix tablet, 200 mg linzagolix tablet, Add-back capsule (E2 1 mg / NETA 0.5 mg) - Endometriosis | Phase 3 | Terminated | Kissei Pharmaceutical Co., Ltd. | 30 | 2020-03-23 | 2025-04-02 |
| Low-Dose Naltrexone in Combination With Standard Treatment in Women With Endometriosis Naltrexone, Norethindrone Acetate, Placebo - Endometriosis | Phase 3 | Terminated | Milton S. Hershey Medical Center | 9 | 2020-01-16 | 2022-11-03 |
| Management Of Pain After Cesarean Trial Acetaminophen, Placebo, Ibuprofen - Pain, Postoperative, Opioid Use | Phase 3 | Terminated | Milton S. Hershey Medical Center | 49 | 2019-08-05 | 2024-09-04 |
| A Phase 3 Study to Confirm the Efficacy and Safety of Linzagolix to Treat Endometriosis-associated Pain 75 mg linzagolix tablet, 200 mg linzagolix tablet, Add-back capsule (E2 1 mg / NETA 0.5 mg) - Endometriosis | Phase 3 | Terminated | Kissei Pharmaceutical Co., Ltd. | 85 | 2019-05-23 | 2025-04-02 |
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Pain, Postoperative (24) · Chronic Pain (15) · Agnosia (14) · Headache (10) · Acute Pain (9) · Neoplasms (9) · Cancer Pain (7) · Constipation (7) · Neuralgia (7) · Osteoarthritis (7) · Endometriosis (6) · Low Back Pain (6) · Bronchiolitis Obliterans Syndrome (5) · Opioid-Induced Constipation (5)
Neurologic Manifestations (170) · Pathological Conditions, Signs and Symptoms (170) · Signs and Symptoms (170) · Nervous System Diseases (40) · Pathologic Processes (38) · Postoperative Complications (25) · Musculoskeletal Diseases (23) · Neuromuscular Diseases (18) · Neurobehavioral Manifestations (14) · Perceptual Disorders (14) · Signs and Symptoms, Digestive (14) · Joint Diseases (13) · Neoplasms (12) · Peripheral Nervous System Diseases (12)
Morphine (9) · Ropivacaine (9) · Sodium Chloride (9) · Bupivacaine (8) · Ibuprofen (8) · Saline Solution (7) · Acetaminophen (5) · Tapentadol (5) · Gabapentin (4) · Ketamine (4) · Lidocaine (4) · Pregabalin (4) · Radiotherapy (4) · Buprenorphine (3) · Dexamethasone (3)
Mayo Clinic (5) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (4) · Grünenthal GmbH (4) · Pfizer (4) · Endo USA Inc., a Keenova Therapeutics Company (3) · M.D. Anderson Cancer Center (3) · Milton S. Hershey Medical Center (3) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (3) · Purdue Pharma LP (3) · University Hospital, Bordeaux (3) · ZARS Pharma Inc. (3) · Assistance Publique - Hôpitaux de Paris (2) · Hoffmann-La Roche (2) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (2) · Kissei Pharmaceutical Co., Ltd. (2)
United States (100) · Canada (20) · France (20) · Germany (15) · United Kingdom (12) · Poland (11) · Puerto Rico (9) · Spain (9) · Australia (8) · Belgium (8) · Brazil (6) · Chile (6) · Denmark (6) · Hungary (6) · Italy (6)
Eduardo Bruera, MD (2) · Pierfrancesco Fusco, MD (2) · Richard Rauck, MD (2) · Alexander Chan, MD (1) · Alexander Ehlgen, MD, PhD (1) · Alexandre O Kaup, MD, PhD (1) · Amy Monroe (1)
PMID 24907403, PMID 30936738, PMID 37460782, PMID 10853874, PMID 18438931, PMID 21806387, PMID 21807566, PMID 21902692, PMID 21957829, PMID 22494013, PMID 22791906, PMID 22900785, PMID 23386053, PMID 23475406, PMID 23594025, PMID 23707270, PMID 23957658, PMID 25018648, PMID 25115871, PMID 25236346, PMID 25621213, PMID 25828692, PMID 27788026, PMID 27906937, PMID 29033296, PMID 29089172, PMID 29238824, PMID 29605036, PMID 29716637, PMID 30365202, PMID 30787078, PMID 30821824, PMID 31145798, PMID 31556911, PMID 31750899, PMID 32104059, PMID 32797734, PMID 33258687, PMID 33973384, PMID 34404270, PMID 34420143, PMID 34626502, PMID 34865085, PMID 35339694, PMID 35779938, PMID 36813504, PMID 38285446, PMID 40099426, PMID 42490074
2009 (6), 2005 (1), 2014 (1), 2015 (1), P30CA015083 (1), R01CA124481 (1), U01NS076788 (1), U10CA037429 (1), U10EY025990 (1)