1372 completed, 432 unknown, 389 recruiting, 316 terminated. 1554 Phase 2, 639 Phase 1, 589 Phase 3, 303 Not applicable, 33 Early Phase 1.
Follow Radiotherapy: new trials by email Literature Review of Radiotherapy trials Research Report on Radiotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adding Surgery and Radiation to the Usual Treatment for HER2-Positive Breast Cancer That Had Already Spread at Diagnosis Biopsy Procedure, Biospecimen Collection, Breast Conservation Treatment - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Positive Breast Carcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 562 | 2027-03-09 | 2026-10-13 |
| MINTER Trial: Metal Intervention aNd ThErapy With Radiotherapy In Thoracic Cancer Using Copper Donor Therapy: A Phase 2, Open-Label Study Disulfiram 250 mg, Copper Gluconate 2 mg, Radiation Therapy - Thoracic Cancer | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 30 | 2027-03-01 | 2026-09-28 |
| SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Not yet recruiting | Northwestern University | 125 | 2027-02-03 | 2026-08-06 |
| Assessment of Biosignature Classification of DCIS for RadioTherapy Benefit Post Lumpectomy (ABCD RT) Radiation Therapy, Standard of Care Radiation Therapy, No Intervention - Breast Cancer | Phase 3 | Not yet recruiting | NRG Oncology | 5270 | 2027-01-30 | 2026-09-30 |
| NG101m Adjuvant Therapy in Glioblastoma Patients Intensity-modulated radiation therapy, Temozolomide, NG101m - Glioblastoma Multiforme | Phase 1 / Phase 2 | Not yet recruiting | NeuGATE Theranostics | 52 | 2027-01-01 | 2025-10-21 |
| Glutaminase Inhibition and Chemoradiation in Advanced Cervical Cancer Telaglenastat, Radiation treatment, Cisplatin - Advanced Cervical Carcinoma, Cervical Cancer | Phase 2 | Not yet recruiting | Washington University School of Medicine | 42 | 2026-12-31 | 2026-09-03 |
| Testing Repeat Radiation Therapy for Recurrent Non-small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Immunotherapy - Locally Recurrent Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 2 | Not yet recruiting | NRG Oncology | 138 | 2026-12-18 | 2026-09-23 |
| Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of Ependymoma Biospecimen Collection, Echocardiography Test, Fluorouracil - Childhood Posterior Fossa Ependymoma | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 70 | 2026-12-11 | 2026-09-30 |
| Radiotherapy in Combination With Glofitamab in Relapsed/Refractory Diffuse Large B Cell Lymphoma Glofitamab, Radiotherapy, Obinutuzumab - Relapsed /Refractory DLBCL | Phase 2 | Not yet recruiting | Olivia Newton-John Cancer Research Institute | 40 | 2026-12-01 | 2026-06-08 |
| PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Contrast-enhanced Magnetic Resonance Imaging, Magnetic Resonance Imaging - Glioblastoma | Phase 3 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 60 | 2026-12-01 | 2026-07-07 |
| Becotatug Vedotin + Pucotenlimab+Platinum Induction and Sequential CCRT for Unresectable LA NSCLC Becotatug Vedotin (MRG003)+pucotenlimab+platinum, radiotherapy - Non-Small Cell Carcinoma of Lung, Locally Advanced | Phase 2 | Not yet recruiting | Sun Yat-sen University | 24 | 2026-11-15 | 2026-10-20 |
| DEPART Study at Yale Radiation Therapy - Dupuytren's Contracture | Phase 3 | Not yet recruiting | Yale University | 158 | 2026-11-01 | 2026-10-13 |
| Best Salvage Treatment for High-risk Relapsing Prostate Cancer (PEACE-9 - ESCALATE-RT) Radiotherapy for MDT ± WPRT, Androgen Deprivation Therapy (ADT), Enzalutamide - Prostatic Neoplasms, Biochemical Recurrence | Phase 3 | Not yet recruiting | Ente Ospedaliero Cantonale, Bellinzona | 140 | 2026-11-01 | 2026-08-24 |
| Exploratory Study of Low-Dose Whole-Brain Radiation Therapy With HeLaXON 1X in Patients With Mild Alzheimer's Disease Dementia HeLaXON 1X Low-Dose Radiation Therapy, Sham HeLaXON 1X Procedure - Alzheimer Disease | Not applicable | Recruiting | ReadyCure Inc. | 30 | 2026-10-26 | 2026-10-07 |
| Tris-CAR-T Cell Therapy Targeting CD44 and CD133 in Newly Diagnosed Glioblastoma Tris-CAR-T cell injection, Ommaya reservoir implantation, Temozolomide (TMZ) - Newly Diagnosed Glioblastoma, IDH-wildtype | Phase 2 / Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 60 | 2026-10-15 | 2026-10-14 |
| Low-Dose Radiotherapy for Painful Knee Osteoarthritis Low-Dose Radiotherapy (LDRT) - Knee Osteoarthritis | Not applicable | Not yet recruiting | Universidad Rey Juan Carlos | 283 | 2026-10-15 | 2026-10-21 |
| Prospective Phase II Study of Concurrent Radiotherapy Combined With Full-Course Immunotherapy or Consolidation Immunotherapy for Locally Advanced NSCLC Induction chemoimmunotherapy, radiotherapy, Concurrent Chemotherapy - Lung Cancer (NSCLC) | Phase 2 | Not yet recruiting | Sun Yat-sen University | 256 | 2026-10-12 | 2026-10-14 |
| Local Consolidative Therapy Versus Maintenance Immunotherapy After First-Line Chemoimmunotherapy in Metastatic NSCLC Immediate Local Consolidative Therapy (LCT) - NSCLC (Non-small Cell Lung Carcinoma) | Phase 2 | Not yet recruiting | Guangdong Provincial People's Hospital | 117 | 2026-10-08 | 2026-09-25 |
| Immunotherapy and Nodal-Sparing Irradiation for T-Cell Induction and Unmasking of Tumor Antigenicity in the Microenvironment for Head and Neck Cancer Pembrolizumab, Radiotherapy, ENI - Head and Neck Cancer Squamous Cell Carcinoma | Phase 2 | Recruiting | Medical College of Wisconsin | 20 | 2026-10-08 | 2026-10-19 |
| FAPI-Guided Radiotherapy With Cadonilimab and Standard Chemotherapy for Colorectal Peritoneal Metastasis: A Phase III Randomized Controlled Trial (TORHC-PM02) Second-Line Chemotherapy, Radiation Therapy, Cadonilimab (AK104) - Colon Rectal Cancer Adenocarcinoma, Peritoneal (Metastatic) Cancer | Phase 3 | Recruiting | Fudan University | 198 | 2026-10-01 | 2026-10-13 |
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Carcinoma, Non-Small-Cell Lung (262) · Breast Neoplasms (219) · Lung Neoplasms (209) · Glioblastoma (205) · Head and Neck Neoplasms (195) · Prostatic Neoplasms (181) · Squamous Cell Carcinoma of Head and Neck (174) · Lymphoma (152) · Rectal Neoplasms (141) · Esophageal Neoplasms (126) · Central Nervous System Neoplasms (122) · Leukemia (111) · Brain Neoplasms (107) · Pancreatic Neoplasms (97) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (93)
National Cancer Institute (NCI) (120) · M.D. Anderson Cancer Center (114) · Radiation Therapy Oncology Group (81) · European Organisation for Research and Treatment of Cancer - EORTC (68) · Children's Oncology Group (63) · Memorial Sloan Kettering Cancer Center (59) · Alliance for Clinical Trials in Oncology (57) · Sun Yat-sen University (49) · Fudan University (42) · SWOG Cancer Research Network (37) · Case Comprehensive Cancer Center (28) · Mayo Clinic (28) · Northwestern University (27) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (26) · Dana-Farber Cancer Institute (25)
United States (1506) · China (427) · Canada (264) · United Kingdom (203) · France (194) · Netherlands (146) · Germany (139) · Switzerland (134) · Australia (126) · Italy (125) · Belgium (116) · Spain (96) · New Zealand (58) · Puerto Rico (52) · Sweden (50)
You Lu, MD (9) · Arthur William Blackstock, MD (7) · Amar Gajjar, MD (6) · Corey J. Langer, MD (6) · David H. Ilson, MD, PhD (6) · Roger Stupp, MD (6) · Edward G. Shaw, MD (5) · Jane N. Winter, MD (5) · John R. Yarnold, MD, FRCR (5) · Peter W. Pisters, MD (5) · Silvia Formenti, M.D. (5) · Amol J. Ghia, MD (4)
PMID 37505794, PMID 32827353, PMID 25057165, PMID 34780125, PMID 38603649, PMID 40135712, PMID 32691060, PMID 33242441, PMID 35135810, PMID 36346112, PMID 38320143, PMID 38421243, PMID 12126818, PMID 15172146, PMID 16467544, PMID 16971718, PMID 17008704, PMID 17236771, PMID 19269519, PMID 19901100, PMID 20138809, PMID 24121121, PMID 24423462, PMID 25023199, PMID 25366678, PMID 25592642, PMID 27243238, PMID 27465021, PMID 29926156, PMID 30207593, PMID 30523055, PMID 31416685, PMID 31500595, PMID 32499241, PMID 33496745, PMID 33539743, PMID 33607632, PMID 35115306, PMID 35157764, PMID 35731991, PMID 36596347, PMID 36603187, PMID 37890117, PMID 39121442, PMID 39863139, PMID 40073837, PMID 40967259, PMID 41531940, PMID 41544350, PMID 42085640
U10CA032102 (38), U10CA180886 (32), U10CA098543 (27), U10CA180868 (24), P30CA043703 (22), U10CA031946 (19), P30CA016672 (18), U10CA021115 (18), P30CA006973 (16), P30CA033572 (15), 2017 (12), P30CA138292 (12), 2023 (11), P30CA006927 (11), U01CA062475 (11)