60 completed, 10 terminated, 8 unknown, 4 recruiting. 28 Phase 3, 24 Phase 2, 10 Phase 4, 6 Phase 1, 4 Not applicable.
Follow Opioid-Induced Constipation: new trials by email Literature Review of Opioid-Induced Constipation trials Research Report on Opioid-Induced Constipation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Naldemedine in Clinical Practice in Cancer Patients With Opioid Induced CONstipation: Clinical Outcomes and Patient Experience Naldemedine, an peripherally acting opioid antagonist - Cancer, Opioid Induced Constipation (OIC) | Recruiting | Professor Monique A. H. Steegers | 100 | 2026-01-02 | 2026-01-02 | |
| Real World Study of Oxycodone/Naloxone Sustained-Release Tablets (Mimeixin) for Patients With Severe Cancer Pain Oxycodone Hydrochloride and Naloxone Hydrochloride Sustained-release Tablets - Opioid-Induced Constipation, Pain Cancer | Phase 4 | Not yet recruiting | Henan Cancer Hospital | 203 | 2025-04-01 | 2025-03-27 |
| Fiber-Enriched Enteral Nutrition and Opioid-Induced Constipation in the ICU Constipation, Opioid-Induced | Completed | Sisli Hamidiye Etfal Training and Research Hospital | 80 | 2024-12-20 | 2025-10-01 | |
| The Effect of Naldemedine on Opioid-induced Bowel Dysfunction Naldemedine, Placebo, Tramadol - Opioid-Induced Bowel Dysfunction, Constipation | Phase 2 | Unknown | Asbjørn Mohr Drewes | 20 | 2024-03-12 | 2024-03-28 |
| Electroacupuncture for Opioid-Induced Constipation in Cancer Patients: A Randomized Clinical Trial Electroacupuncture - Constipation, Opioid-Induced, Cancer | Not applicable | Completed | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine | 92 | 2024-01-10 | 2025-11-21 |
| Safety and Pharmacokinetics Study of Naldemedine in Paediatric Participants Receiving Opioids Naldemedine - Opioid-Induced Constipation (OIC) | Phase 1 / Phase 2 | Recruiting | Shionogi | 24 | 2023-01-04 | 2026-07-28 |
| Prevention of Opioid-induced Constipation in Patients With Advanced Cancer Macrogol Only Product in Oral Dose Form, Magnesium hydroxide 724mg - Constipation, Opioid-Induced | Phase 4 | Recruiting | Amsterdam UMC, location VUmc | 258 | 2022-12-02 | 2026-10-05 |
| The Influence of Tramadol on Opioid-induced Bowel Dysfunction Tramadol, Placebo - Opioid-Induced Bowel Dysfunction, Constipation | Phase 2 | Completed | Asbjørn Mohr Drewes | 20 | 2022-08-11 | 2024-04-26 |
| Safety and Preliminary Efficacy of BGP345A in Constipation Due to Opioid-based Medications Lactobacillus gasseri BGP345A, Placebo - Opioid-Induced Constipation | Phase 2 | Completed | BioGaia Pharma AB | 14 | 2022-01-20 | 2025-06-26 |
| European Study of Opioid Induced Constipation Opioid-Induced Constipation | Completed | University of Dublin, Trinity College | 1200 | 2021-09-16 | 2025-04-03 | |
| Reflexology Socks and Opioid-induced Constipation Reflexology socks+walking, Just walking - Opioid Use, Constipation | Not applicable | Completed | Muğla Sıtkı Koçman University | 101 | 2020-10-30 | 2023-04-12 |
| Effect of Naloxegol on Postoperative Ileus in Patients Undergoing Cardiac Surgery Naloxegol, inert tablet - Postoperative Ileus (Post Cardiac Surgery Constipation) | Phase 3 | Completed | CMC Ambroise Paré | 305 | 2020-10-14 | 2026-05-20 |
| The Efficacy of Acupressure in Managing Opioid-induced Constipation Accupressure - Opioid-induced Bowel Dysfunction, Constipation Drug Induced | Not applicable | Unknown | Istanbul Aydın University | 120 | 2020-08-01 | 2021-05-06 |
| Targin® for Chronic Pain Management in Patients With Spinal Cord Injury Oxycodone Naloxone Combination - Chronic Pain | Phase 4 | Completed | University of British Columbia | 1 | 2019-09-05 | 2021-12-10 |
| Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation Naldemedine, Lubiprostone, Naloxegol - Opioid-induced Constipation | Recruiting | BioDelivery Sciences International | 34532 | 2019-01-04 | 2026-09-30 | |
| Study on Quality of Life in Advanced Cancer Patients With Opioid-induced Constipation Treated With Naloxegol Naloxegol - Opioid Use, Constipation Drug Induced | Completed | Fondazione ANT Franco Pannuti ETS | 250 | 2018-09-01 | 2022-02-28 | |
| Real World Observational Study of Naloxegol for Patients With Cancer Pain Diagnosed With OIC. Naloxegol - Opioid Induced Constipation | Completed | Kyowa Kirin Pharmaceutical Development Ltd | 183 | 2018-08-16 | 2024-06-17 | |
| Colonic Motor Patterns in Healthy Volunteers Naloxegol, codeine phosphate, Placebo - Opioid-Induced Constipation | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 15 | 2018-06-27 | 2023-03-16 |
| Naloxegol and Opioid-induced Constipation Naloxegol 25 MG, Placebo pill - Constipation, Constipation Drug Induced | Phase 2 / Phase 3 | Unknown | TriHealth Inc. | 280 | 2017-11-06 | 2022-05-05 |
| Evaluation of the Quality of Life of Patients With Opioid-induced Constipation Under Treatment With Naloxegol Naloxegol - Opioid-induced Constipation | Completed | Kyowa Kirin Farmacéutica S.L.U. | 126 | 2017-09-21 | 2019-11-22 |
Showing 20 of 84. Sign in to see all of them.
Constipation (29) · Pain (9) · Neoplasms (7) · Chronic Pain (6) · Cancer Pain (5) · Bronchiolitis Obliterans Syndrome (4) · Intestinal Diseases (2) · Pain, Postoperative (1) · Spinal Cord Injuries (1)
Chemically-Induced Disorders (84) · Mental Disorders (84) · Narcotic-Related Disorders (84) · Pathological Conditions, Signs and Symptoms (84) · Signs and Symptoms (84) · Signs and Symptoms, Digestive (84) · Substance-Related Disorders (84) · Constipation (55) · Neurologic Manifestations (17) · Pain (8) · Bronchial Diseases (4) · Bronchiolitis (4) · Bronchiolitis Obliterans (4) · Bronchitis (4) · Graft vs Host Disease (4)
naloxegol (19) · methylnaltrexone (10) · naldemedine (9) · 3-(8-(2-(cyclohexylmethyl(2,3-dihydroxypropionyl)amino)ethyl)-8-azabicyclo(3.2.1)oct-3-yl)benzamide (5) · Lubiprostone (5) · Naloxone (4) · Oxycodone (4) · oxycodone naloxone combination (4) · tegaserod (3) · Tramadol (2) · Carbon-14 (1) · Codeine (1) · Dosage Forms (1) · Electroacupuncture (1) · Electrolytes (1)
AstraZeneca (9) · Bausch Health Americas, Inc. (9) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (7) · Glycyx Therapeutics (6) · Shionogi (6) · Kyowa Kirin Pharmaceutical Development Ltd (4) · Sucampo Pharma Americas, LLC (4) · Mundipharma CVA (3) · Novartis (3) · Alkermes, Inc. (2) · Asbjørn Mohr Drewes (2) · Royal Surrey County Hospital NHS Foundation Trust (2) · Amsterdam UMC, location VUmc (1) · BioDelivery Sciences International (1) · BioGaia Pharma AB (1)
United States (41) · United Kingdom (17) · Germany (12) · Belgium (11) · Spain (11) · Canada (10) · France (9) · Sweden (8) · Australia (6) · Czechia (6) · Italy (6) · Poland (6) · Denmark (5) · China (4) · Netherlands (4)
Mark Sostek (5) · Andrew Davies, MD (3) · Enoch Bortey (3) · Lindsey Mathew (3) · Jeff Cohn (2) · Mark Sostek, MD (2) · Andrei Krassioukov, MD,PhD,FRCPC (1) · Andrew N Davies, MD (1) · Andriy V Samokhvalov, MD, PhD (1) · Arpeat Kaviya, MBCHB, MRCP (1)
PMID 24896818, PMID 26582720, PMID 27342744, PMID 32086791, PMID 32280263, PMID 33788162, PMID 34295186, PMID 10964347, PMID 16036506, PMID 19912069, PMID 25164154, PMID 26535126, PMID 28576452, PMID 31145214, PMID 33965574, PMID 34377150, PMID 14739871, PMID 17955081, PMID 18721170, PMID 18838491, PMID 18924451, PMID 21672306, PMID 21810165, PMID 21998076, PMID 24716835, PMID 24883055, PMID 24904217, PMID 25112584, PMID 25757607, PMID 25802051, PMID 27144627, PMID 27486340, PMID 27573565, PMID 28059433, PMID 28371937, PMID 31058652, PMID 31396746, PMID 32310620, PMID 34348942, PMID 34830889, PMID 35257230, PMID 36915062, PMID 39988233, PMID 40071858
2009 (2), 2019 (1), 2023 (1)