Signs and Symptoms, Digestive: Clinical Trials

3145 completed, 681 unknown, 393 recruiting, 309 terminated. 2171 Not applicable, 654 Phase 2, 647 Phase 3, 556 Phase 4, 271 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	2171	Completed 1311, Unknown 306, Recruiting 203, Not yet recruiting 118, Terminated 90, Active not recruiting 58, Withdrawn 58, Enrolling by invitation 21, Suspended 6
Phase 2	654	Completed 421, Unknown 73, Terminated 65, Recruiting 46, Not yet recruiting 19, Withdrawn 16, Active not recruiting 10, Enrolling by invitation 2, Suspended 2
Phase 3	647	Completed 442, Unknown 73, Terminated 64, Recruiting 33, Withdrawn 18, Not yet recruiting 8, Active not recruiting 6, Suspended 3
Phase 4	556	Completed 373, Unknown 70, Terminated 48, Recruiting 22, Withdrawn 19, Not yet recruiting 16, Active not recruiting 6, Enrolling by invitation 2
Phase 1	271	Completed 196, Unknown 20, Terminated 16, Recruiting 14, Not yet recruiting 10, Withdrawn 10, Active not recruiting 5
Early Phase 1	33	Completed 19, Not yet recruiting 4, Terminated 3, Active not recruiting 2, Unknown 2, Withdrawn 2, Recruiting 1

Follow Signs and Symptoms, Digestive: new trials by email Literature Review of Signs and Symptoms, Digestive trials Research Report on Signs and Symptoms, Digestive

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Vagal Auricular Stimulation for Motion Sickness UROStim - Chronic Nausea	Not applicable	Not yet recruiting	Spaulding Rehabilitation Hospital	115	2027-09-24	2026-10-16
OLE Study Subsequent to Parent Study of Rilogrotug for the Treatment of Weight Loss and Anorexia in Patients With Cancer Cachexia and mCRC or mNSCLC Rilogrotug - Cachexia; Cancer, Cachexia	Phase 2 / Phase 3	Not yet recruiting	AVEO Pharmaceuticals, Inc.	400	2027-02-01	2026-10-22
Biobehavioral Mechanisms of Activity and Loss of Control Eating in Children Go/No-go task, Visual food task, Emotion regulation task - Binge Eating Behaviour, Eating Disorders	Not applicable	Not yet recruiting	The University of Texas at Dallas	200	2027-01-15	2026-09-16
3-Dimensional Optical Scanning to Assess and Monitor Malnutrition in Eating Disorders (3D-ED) Study Anorexia in Adolescence, Anorexia Nervosa		Not yet recruiting	University of California, San Francisco	90	2027-01-01	2026-07-24
Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents A 10-week multicomponent camp intervention for children, A BED intervention for parents - Binge Eating Disorder, Binge Eating	Not applicable	Not yet recruiting	University of Aarhus	200	2027-01-01	2026-04-13
Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation Regulating Together group therapy - Prader-Willi Syndrome	Not applicable	Recruiting	Children's Mercy Hospital Kansas City	10	2027-01-01	2026-09-02
Binaural Beats and Postoperative Nausea and Vomiting in Laparoscopic Cholecystectomy Binaural Beats Application, Placebo - Laparoscopic Cholecystectomy	Not applicable	Not yet recruiting	Bitlis Eren University	76	2027-01-01	2026-10-21
An Open Trial of a Novel Pharmacotherapy for Habit Modification in Anorexia Nervosa Donepezil - Anorexia Nervosa	Phase 2	Not yet recruiting	New York State Psychiatric Institute	10	2027-01-01	2026-10-23
Determine if Human Infant Weight Gain Can be Modulated to Prevent Obesity Calibration of infant breast milk and formula milk intake - Obesity, Infant	Not applicable	Withdrawn	Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center		2026-12-20	2025-11-21
Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide Fosaprepitant for Injection, Metoclopramide Injection - Nausea and Vomiting, Nausea	Phase 4	Not yet recruiting	Montefiore Medical Center	212	2026-12-01	2026-06-29
The Use of a Comfort Tote to Improve Recovery in Pediatric and Adolescent Patients After Surgery The Therapeutic Comfort Tote, The Modified Comfort Tote - Adolescent Idiopathic Scoliosis, Postoperative Pain, Acute	Not applicable	Recruiting	Columbia University	50	2026-12-01	2026-10-09
Testing an Intervention for College Students With Food Insecurity and Binge Eating novel binge eating intervention for college students experiencing food insecurity. - Binge Eating	Early Phase 1	Not yet recruiting	Virginia Polytechnic Institute and State University	10	2026-12-01	2026-04-09
Fecal Microbiota Transplantation in Females With Anorexia Nervosa Fecal Microbiota Transplantation Capsule, Placebo Capsule(s) - Anorexia Nervosa	Not applicable	Not yet recruiting	Andreas Munk Petersen	60	2026-11-16	2026-10-16
Amisulpride Injection for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery Amisulpride, Ondansetron - PONV	Not applicable	Not yet recruiting	Qianfoshan Hospital	718	2026-11-15	2026-10-23
ADAPTing CBT for Pediatric Functional Abdominal Pain in Spain Aim to Decrease Anxiety and Pain Treatment (ADAPT) - Abdominal Pain	Not applicable	Not yet recruiting	Michigan State University	20	2026-11-01	2026-10-15
Final Examination Stress and Bowel Symptoms Observational Assessment During the Final Examination Period - Bowel Symptoms, Constipation		Not yet recruiting	Lokman Hekim University	100	2026-11-01	2026-09-24
Cognitive and Behavioral Approaches to Reduce Binge Eating and Excess Weight in Adolescents (Online) Cognitive-Behavioral Therapy for Adolescent Binge Eating, Lifestyle Behavioral Obesity Intervention, Active Control - Binge Eating, Overweight and Obesity	Not applicable	Not yet recruiting	Indiana University	159	2026-11-01	2026-10-05
The Interactive Media and Gender-related Stressors and Strengths Study digital web based toolkit - Eating Disorders, Substance Use	Not applicable	Not yet recruiting	Boston University	120	2026-11-01	2026-09-23
Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus Surgery Ketamine and Propofol, Sevoflurane - Postoperative Vomiting, Postoperative Nausea and Vomiting	Phase 4	Not yet recruiting	Assiut University	50	2026-11-01	2026-10-13
Diagnostic and Psychometric Validation of the FRENCH HELP Scale in Hyperemesis Gravidarum HELP score - Hyperemesis Gravidarum, Nausea and Vomiting of Pregnancy		Not yet recruiting	Centre Hospitalier Universitaire de Nīmes	300	2026-11-01	2026-10-20

Showing 20 of 5039. Sign in to see all of them.

Narrower conditions

Constipation (803)  ·  Vomiting (768)  ·  Diarrhea (699)  ·  Feeding and Eating Disorders (641)  ·  Postoperative Nausea and Vomiting (632)  ·  Nausea (627)  ·  Abdominal Pain (363)  ·  Hyperphagia (281)  ·  Dyspepsia (256)  ·  Pain, Postoperative (194)  ·  Anorexia Nervosa (191)  ·  Bulimia (173)  ·  Irritable Bowel Syndrome (166)  ·  Obesity (159)  ·  Anorexia (155)

Broader conditions

Pathological Conditions, Signs and Symptoms (5039)  ·  Signs and Symptoms (5035)  ·  Mental Disorders (1046)  ·  Pathologic Processes (1021)  ·  Digestive System Diseases (938)  ·  Neurologic Manifestations (917)  ·  Gastrointestinal Diseases (797)  ·  Postoperative Complications (675)  ·  Pain (623)  ·  Vomiting (583)  ·  Nausea (569)  ·  Intestinal Diseases (528)  ·  Nutritional and Metabolic Diseases (439)  ·  Behavior (425)

Interventions

Dexamethasone (204)  ·  Ondansetron (185)  ·  Aprepitant (119)  ·  Palonosetron (87)  ·  Sodium Chloride (67)  ·  Saline Solution (62)  ·  Granisetron (58)  ·  Probiotics (58)  ·  Olanzapine (45)  ·  Esomeprazole (44)  ·  Acupuncture Therapy (38)  ·  Metoclopramide (38)  ·  Calcium Dobesilate (36)  ·  Surveys and Questionnaires (33)  ·  Cognitive Behavioral Therapy (32)

Sponsors

Mayo Clinic (43)  ·  Stanford University (38)  ·  AstraZeneca (36)  ·  Bausch Health Americas, Inc. (33)  ·  GlaxoSmithKline (33)  ·  Merck Sharp & Dohme LLC (31)  ·  Assiut University (30)  ·  Massachusetts General Hospital (30)  ·  M.D. Anderson Cancer Center (27)  ·  University of North Carolina, Chapel Hill (26)  ·  Duke University (25)  ·  Cairo University (24)  ·  New York State Psychiatric Institute (24)  ·  Novartis (21)  ·  Medical University of Warsaw (20)

Countries

United States (1650)  ·  China (326)  ·  Turkey (Türkiye) (303)  ·  Canada (257)  ·  France (243)  ·  United Kingdom (202)  ·  Italy (159)  ·  Spain (145)  ·  Germany (139)  ·  Denmark (122)  ·  Brazil (114)  ·  South Korea (113)  ·  Egypt (107)  ·  Poland (99)  ·  Belgium (92)

Top investigators

Eric Stice, PhD (11)  ·  John McGowan (8)  ·  Michael Camilleri, MD (8)  ·  Aminah Jatoi, MD (7)  ·  Faming Zhang, PhD (7)  ·  Kerri Boutelle, Ph.D. (7)

Results publications

PMID 34002866, PMID 34585675, PMID 36994923, PMID 39664231, PMID 42286373, PMID 41245385, PMID 10485781, PMID 23471754, PMID 24012235, PMID 24535604, PMID 25032676, PMID 28705783, PMID 32467512, PMID 33006765, PMID 11756886, PMID 16036506, PMID 21382575, PMID 24106924, PMID 24732867, PMID 24896818, PMID 24917940, PMID 25581251, PMID 26210388, PMID 26582720, PMID 27342744, PMID 32086791, PMID 32280263, PMID 32378735, PMID 33788162, PMID 34295186, PMID 36922331, PMID 10422602, PMID 10486687, PMID 10522604, PMID 10794256, PMID 10910795, PMID 10964347, PMID 11952185, PMID 12145595, PMID 12150647, PMID 12355695, PMID 12567343, PMID 14504060, PMID 15459950, PMID 16013747, PMID 16314401, PMID 16679671, PMID 16703549, PMID 16766588, PMID 16846542

NIH funding

2008 (12), 2009 (12), 2025 (10), 2019 (8), 2014 (7), UL1RR024150 (7), 2015 (6), 2018 (6), 2017 (5), 2023 (4), P01DK068055 (4), P50GM021700 (4), 2005 (3), P30CA033572 (3), P30CA069533 (3)