570 completed, 99 unknown, 61 recruiting, 48 terminated. 359 Not applicable, 135 Phase 2, 121 Phase 3, 98 Phase 4, 43 Phase 1.
Follow this condition Literature Review of Constipation trials Research Report on Constipation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Final Examination Stress and Bowel Symptoms Observational Assessment During the Final Examination Period - Bowel Symptoms, Constipation | Not yet recruiting | Lokman Hekim University | 100 | 2026-11-01 | 2026-09-24 | |
| Xingqi Daozhi Decoction for Antipsychotic-Induced Constipation Xingqi Daozhi Decoction, Placebo Group - Schizophrenia, Antipsychotic Drug | Phase 1 / Phase 2 | Not yet recruiting | Shanghai Mental Health Center | 46 | 2026-10-01 | 2026-08-17 |
| Relationship Between Interoception and Postural Control in Constipation-Predominant Irritable Bowel Syndrome Constipation, Irritable Bowel Disease | Recruiting | Saglik Bilimleri Universitesi | 128 | 2026-10-01 | 2026-10-21 | |
| Study of Transanal Irrigation vs Standard Care for Constipation, Gut Microbiota, and Motor Disorders in Parkinson's Disease Transanal Irrigation System, Standard Bowel Care - Parkinson Disease, Constipation | Not applicable | Not yet recruiting | University Hospital of Ferrara | 200 | 2026-09-30 | 2026-07-30 |
| EFFECT OF ABDOMINAL MASSAGE TRAINING PROVIDED TO CAREGIVERS ON CONSTIPATION MANAGEMENT Caregiver Training in Abdominal Massage - Constipation | Not applicable | Recruiting | HAMİYET KIZIL | 62 | 2026-09-09 | 2026-10-21 |
| Segmental Laser Acupuncture for Constipation and Sleep in Patients With Parkinson's Disease TI-816-3E3 Portable Laser Phototherapy Device, TI-816-3E3 Portable Laser Phototherapy Device - Sham (0 J/cm²) - Parkinson's Disease | Not applicable | Not yet recruiting | China Medical University Hospital | 60 | 2026-09-01 | 2026-08-27 |
| Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder Features Fluoxetine, Placebo - Refractory Constipation, Somatic Symptom Disorder (DSM-5) | Phase 2 | Not yet recruiting | Zhifeng Zhao, PhD | 194 | 2026-09-01 | 2026-09-02 |
| Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer Surgery Water-based transanal irrigation system - Low Anterior Resection Syndrome (LARS) | Not applicable | Not yet recruiting | Simona Ascanelli | 250 | 2026-09-01 | 2026-07-10 |
| Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children Body Surface Colonic Mapping - Bowel Dysfunction, Dysmotility | Not applicable | Not yet recruiting | Murdoch Childrens Research Institute | 50 | 2026-09-01 | 2026-09-02 |
| This is a Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Efficacy and Safety of 2 Weight-based Treatment Groups of Plecanatide Versus Placebo in Children and Adolescent Participants 6 to Less Than 18 Years of Age With FC plecanatide, Placebo - Functional Constipation (FC) | Phase 2 | Recruiting | Bausch Health Americas, Inc. | 180 | 2026-08-18 | 2026-10-07 |
| Probiotics Improve Constipation Probitics, Placebo - Constipation | Not applicable | Recruiting | Wecare Probiotics Co., Ltd. | 76 | 2026-08-07 | 2026-08-17 |
| Butyrate Yogurt for Cancer Constipation butyrate-containing short-chain fatty acid yogurt - Constipation, Gastrointestinal Cancer | Phase 2 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 30 | 2026-08-01 | 2026-07-23 |
| GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity GLP-1 receptor agonist therapy - Morbid Obesity, Anorectal Diseases | Not yet recruiting | Gazi University | 100 | 2026-08-01 | 2026-06-25 | |
| Research on the Efficacy and Mechanism of Shouhui Tongbian Capsules in Treating Postoperative Constipation of Benign Anal and Rectal Diseases Based on Gut Microbiota Analysis Shouhui Tongbian Capsules, Lactulose Oral Solution Control Group - Intestinal Flora, Anorectal Diseases | Phase 1 / Phase 2 | Not yet recruiting | China-Japan Friendship Hospital | 120 | 2026-08-01 | 2026-07-22 |
| Radicle GI HealthTM VNB: A Study Assessing the Impact of Health and Wellness Products on Constipation and Related Health Outcomes Placebo GI Health Control, Active GI Health Product - Constipation | Not applicable | Recruiting | Radicle Science | 550 | 2026-07-30 | 2026-08-20 |
| Kinesio Taping for Neurogenic Bowel Dysfunction in Spinal Cord Injury Kinesio Taping, Routine Bowel Management Program - Neurogenic Bowel Dysfunction, Spinal Cord Injury | Not applicable | Not yet recruiting | Pamukkale University | 30 | 2026-07-30 | 2026-07-15 |
| Adults With Constipation Probiotics, Placebo - Constipation | Not applicable | Recruiting | Wecare Probiotics Co., Ltd. | 70 | 2026-07-24 | 2026-08-28 |
| Probiotic Improve Constipation Probiotic, Placebo, High-activity probiotic probiotic - Constipation | Not applicable | Recruiting | Wecare Probiotics Co., Ltd. | 105 | 2026-06-10 | 2026-06-09 |
| A Clinical Trial to Evaluate the Effects of a Fibre Supplement on Microbiome and Gut Health Essential Fibre+ - Gut Health, Microbiome | Not applicable | Active not recruiting | Artah Nutrition Limited | 50 | 2026-06-01 | 2026-08-24 |
| Balloon Inflation in Biofeedback Inflating anorectal catheter balloon to defecatory desired volume during push manoeuvres in biofeedback therapy., No intervention - Constipation, Chronic Constipation | Not applicable | Completed | Hull University Teaching Hospitals NHS Trust | 8 | 2026-05-13 | 2026-09-22 |
Showing 20 of 857. Sign in to see all of them.
Opioid-Induced Constipation (84) · Diarrhea (58) · Irritable Bowel Syndrome (49) · Fecal Incontinence (32) · Abdominal Pain (31) · Pain (31) · Parkinson Disease (26) · Neoplasms (21) · Gastroesophageal Reflux (16) · Encopresis (14) · Gastrointestinal Diseases (14) · Intestinal Diseases (14) · Digestive System Diseases (12) · Nausea (12)
Pathological Conditions, Signs and Symptoms (857) · Signs and Symptoms (856) · Signs and Symptoms, Digestive (854) · Digestive System Diseases (156) · Gastrointestinal Diseases (144) · Mental Disorders (137) · Intestinal Diseases (118) · Neurologic Manifestations (109) · Chemically-Induced Disorders (90) · Substance-Related Disorders (87) · Narcotic-Related Disorders (86) · Nervous System Diseases (82) · Colonic Diseases (72) · Pain (60)
prucalopride (28) · polyethylene glycol 3350 (26) · naloxegol (25) · Lubiprostone (22) · Probiotics (21) · Polyethylene Glycols (18) · methylnaltrexone (18) · Oxycodone (14) · Lactulose (12) · maltodextrin (12) · Bisacodyl (11) · Sennosides (11) · Biofeedback, Psychology (10) · naldemedine (10) · Psyllium (9)
Bausch Health Americas, Inc. (22) · Movetis (17) · Braintree Laboratories (15) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (12) · Mayo Clinic (12) · AstraZeneca (9) · Augusta University (9) · Medical University of Warsaw (8) · Kissei Pharmaceutical Co., Ltd. (7) · Massachusetts General Hospital (7) · Novartis (7) · Vibrant Ltd. (7) · Wecare Probiotics Co., Ltd. (7) · Bayer (6) · Cairo University (6)
United States (281) · China (73) · Turkey (Türkiye) (62) · United Kingdom (61) · Canada (44) · France (40) · Spain (30) · Poland (28) · Taiwan (27) · Italy (26) · Denmark (25) · Germany (25) · Belgium (22) · Netherlands (22) · Brazil (20)
John McGowan (7) · Jeff Cohn (6) · Mark Sostek (5) · Jorge Herrera, MD (4) · Lindsey Mathew (4) · Michael Camilleri, MD (4) · Andrew Davies, MD (3) · Christopher P Cardozo, MD (3) · Enoch Bortey (3)
PMID 34585675, PMID 39664231, PMID 21382575, PMID 24106924, PMID 24732867, PMID 24896818, PMID 24917940, PMID 25581251, PMID 26582720, PMID 27342744, PMID 32086791, PMID 32280263, PMID 33788162, PMID 34295186, PMID 10522604, PMID 10964347, PMID 16036506, PMID 19912069, PMID 21045817, PMID 21998076, PMID 22959620, PMID 23535761, PMID 25164154, PMID 25473191, PMID 26348685, PMID 26535126, PMID 27486340, PMID 27618593, PMID 28576452, PMID 30788281, PMID 31145214, PMID 31780015, PMID 32660770, PMID 33965574, PMID 34377150, PMID 35086735, PMID 37332239, PMID 39470206, PMID 39679695, PMID 10636972, PMID 10733120, PMID 11314289, PMID 11475180, PMID 11721760, PMID 11755892, PMID 11986017, PMID 12144586, PMID 12172223, PMID 12201887, PMID 12738468
2009 (4), UL1RR024150 (3), K23DK134752 (2), R01DK078924 (2), 1RC1DK086182 (1), 1UG3NS115108-01A1 (1), 1UL1RR024150 (1), 2008 (1), 2015 (1), 2018 (1), 2019 (1), 2023 (1), 2025 (1), 5UH3NS115108-04 (1), K23DK098235 (1)