265 completed, 94 unknown, 39 terminated, 38 recruiting. 504 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 504 | Completed 265, Unknown 94, Terminated 39, Recruiting 38, Not yet recruiting 26, Withdrawn 21, Active not recruiting 13, Enrolling by invitation 7, Suspended 1 |
Follow Neurocognitive Disorders: new trials by email Literature Review of Neurocognitive Disorders trials Research Report on Neurocognitive Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease Donanemab - Alzheimer Disease | Phase 4 | Not yet recruiting | Eli Lilly and Company | 50 | 2026-11-01 | 2026-10-15 |
| Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery Remimazolam Besylate, propofol - Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch | Phase 4 | Not yet recruiting | Seoul National University Hospital | 80 | 2026-10-01 | 2026-09-17 |
| Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial Rosuvastatin, Ezetimibe, Recaticimab - Intracranial Arteriosclerosis, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 440 | 2026-09-17 | 2026-09-15 |
| Remifentanil vs Fentanyl in Children 7-12 After Urologic Surgery: Emergence Delirium and Recovery Quality Opioids - Emergence Delirium, Emergence Agitation | Phase 4 | Not yet recruiting | Konya City Hospital | 88 | 2026-09-05 | 2026-10-06 |
| Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart Failure Low dose ketamine infusion, Dexmedetomidine infusion - Delirium in Intensive Care Unit, Acute Heart Failure (AHF) | Phase 4 | Not yet recruiting | Alexandria University | 150 | 2026-09-01 | 2026-08-24 |
| Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients Lemborexant, Placebo - Sleep Disturbance, Delirium | Phase 4 | Recruiting | Mahidol University | 100 | 2026-09-01 | 2026-10-08 |
| Comparing the Efficacy of Propofol and Dexmedetomidine in Prevention of Emergence Agitation After Sevoflurane Anesthesia in Children propofol 1mg/kg, Dexmedetomidine - Emergence Delirium, Anesthesia | Phase 4 | Recruiting | Pakistan Institute of Medical Sciences | 114 | 2026-08-28 | 2026-09-02 |
| Amyloid Lowering for Alzheimer's in Down's With Donanemab Investigation Donanemab, Placebo - Down Syndrome (DS), Down Syndrome (Trisomy 21) | Phase 4 | Not yet recruiting | Michael Rafii, MD, PhD | 60 | 2026-08-01 | 2026-05-15 |
| Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery Remimazolam - Emergence Agitation, General Anesthesia | Phase 4 | Not yet recruiting | Jeju National University School of Medicine | 138 | 2026-07-24 | 2026-07-31 |
| Evaluation System for Lecanemab Efficacy Using Gold Electrode ECL to Monitor Alzheimer's Biomarkers Lecanemab - Alzheimer Disease | Phase 4 | Recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 100 | 2026-07-10 | 2026-07-07 |
| Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis Acoramidis (AG10) oral tablet - Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM), Amyloidosis | Phase 4 | Recruiting | Eidos Therapeutics, a BridgeBio company | 150 | 2026-07-01 | 2026-07-29 |
| Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging Dexmedetomidine (IV) 0.5 mcg/kg, Propofol (IV) 2-4 mg/kg, Dexmedetomidine (IV) 1 mcg/kg - MRI Sedation, Pediatric Sedation | Phase 4 | Recruiting | Boston Children's Hospital | 105 | 2026-06-30 | 2026-09-21 |
| Effects of Ginkgo Biloba on Blood Biomarkers in Mild Cognitive Impairment Ginkgo Biloba Extract 240 mg, Placebo - Mild Cognitive Impairment, Alzheimer's Disease | Phase 4 | Not yet recruiting | Hanyang University | 120 | 2026-06-01 | 2026-06-26 |
| Light and Sleep Fragmentation Light therapy - Sleep, Mild Cognitive Impairment | Phase 4 | Not yet recruiting | Stanford University | 120 | 2026-06-01 | 2023-08-25 |
| Effect of Ciprofol Injection on Postoperative Cognitive Function Ciprofol group, Propofol group - Postoperative Cognitive Dysfunction | Phase 4 | Active not recruiting | The Second Affiliated Hospital of Chongqing Medical University | 298 | 2026-06-01 | 2026-06-29 |
| Intranasal Dexmedetomidine or Esketamine for Negative Postoperative Behavioral Changes in Children Dexmedetomidine, Esketamine, Normal Saline - Behavior Problem | Phase 4 | Not yet recruiting | Nanjing Children's Hospital | 342 | 2026-06-01 | 2026-05-06 |
| Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment Dexmedetomidine-esketamine combination, Placebo - Older Adults, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking University First Hospital | 60 | 2026-06-01 | 2026-06-01 |
| Dexmedetomidine Nasal Spray on Postoperative Delirium in Elderly Thoracoscopic Lung Resection Patients Dexmedetomidine hydrochloride nasal spray, Placebo - Postoperative Delirium (POD) | Phase 4 | Not yet recruiting | Sichuan Provincial People's Hospital | 264 | 2026-06-01 | 2026-05-12 |
| A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE) Zunveyl® - Alzheimer Disease | Phase 4 | Recruiting | Alpha Cognition, Inc | 150 | 2026-05-20 | 2026-10-19 |
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Alzheimer Disease (136) · Cognitive Dysfunction (127) · Emergence Delirium (93) · Delirium (91) · Dementia (73) · Cognition Disorders (29) · Postoperative Cognitive Complications (26) · Depression (23) · Schizophrenia (16) · Psychomotor Agitation (14) · Stroke (14) · Lewy Body Disease (12) · Psychotic Disorders (12) · Parkinson Disease (10) · Depressive Disorder, Major (9)
Mental Disorders (495) · Nervous System Diseases (408) · Pathological Conditions, Signs and Symptoms (256) · Central Nervous System Diseases (225) · Brain Diseases (223) · Signs and Symptoms (222) · Neurologic Manifestations (217) · Neurobehavioral Manifestations (204) · Confusion (170) · Neurodegenerative Diseases (163) · Cognition Disorders (150) · Pathologic Processes (141) · Tauopathies (137) · Dementia (126)
Dexmedetomidine (68) · Propofol (41) · Donepezil (36) · Saline Solution (36) · Memantine (32) · Sevoflurane (21) · Sodium Chloride (21) · Midazolam (19) · Rivastigmine (18) · Ketamine (15) · Galantamine (12) · Escitalopram (11) · Risperidone (10) · Fentanyl (9) · Haloperidol (9)
Peking University First Hospital (15) · Mayo Clinic (8) · Novartis (8) · Novartis Pharmaceuticals (8) · University of California, Los Angeles (8) · Eisai Inc. (7) · NYU Langone Health (6) · New York State Psychiatric Institute (6) · VA Office of Research and Development (6) · Sunnybrook Health Sciences Centre (5) · University Hospital, Basel, Switzerland (5) · University of Pennsylvania (5) · Assiut University (4) · Avid Radiopharmaceuticals (4) · Chinese PLA General Hospital (4)
United States (168) · China (87) · South Korea (31) · Egypt (17) · Canada (15) · Germany (12) · Turkey (Türkiye) (11) · Italy (10) · France (9) · Spain (9) · Denmark (8) · Netherlands (8) · Switzerland (8) · United Kingdom (8) · Norway (6)
Dong-Xin Wang, MD, PhD (10) · Davangere Devanand, M.D. (3) · Helen Lavretsky, M.D. (3) · Alexa Hollinger, MD (2) · Anita Murthy (2) · Bradley Boeve, MD (2) · E. Sherwood Brown, MD, PhD (2) · Jeff Silverstein, MD (2) · Jian-Xin Zhou, MD (2) · Jihee Mun (2) · Jinzhou Tian, M.D,PhD (2)
PMID 33189083, PMID 12760985, PMID 15114210, PMID 19617584, PMID 35833913, PMID 36413436, PMID 37142273, PMID 39498781, PMID 10070549, PMID 10511011, PMID 10588403, PMID 10913502, PMID 11065205, PMID 11072948, PMID 1130742, PMID 11903027, PMID 12075033, PMID 12556542, PMID 12640407, PMID 12648190, PMID 1394752, PMID 14595310, PMID 15082703, PMID 15374380, PMID 15817019, PMID 1593914, PMID 16469995, PMID 16494088, PMID 16677266, PMID 17060562, PMID 17179249, PMID 17183151, PMID 17325517, PMID 17667565, PMID 17914039, PMID 17986678, PMID 18198262, PMID 18251622, PMID 18372935, PMID 18591575, PMID 18611150, PMID 18813051, PMID 19210951, PMID 19253247, PMID 19347026, PMID 19389332, PMID 19422355, PMID 19687169, PMID 19812461, PMID 19865006
2005 (2), 2014 (2), 2017 (2), 2025 (2), 2004 (1), 2008 (1), 2009 (1), 2015 (1), 2019 (1), I01RX003143 (1), I21RX002180 (1), K23AA017666 (1), P30AG028747 (1), P30AI045008 (1), P50AG016574 (1)