144 completed, 28 unknown, 20 terminated, 17 recruiting. 79 Phase 2, 58 Phase 4, 57 Phase 3, 24 Not applicable, 24 Phase 1.
Follow Memantine: new trials by email Literature Review of Memantine trials Research Report on Memantine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury | Phase 2 | Not yet recruiting | Nova Scotia Health Authority | 45 | 2027-06-01 | 2026-10-09 |
| Escalating Doses of Memantine in Down Syndrome (MEDS-123) Memantine - Down Syndrome, Intellectual Disability | Phase 1 | Not yet recruiting | University Hospitals Cleveland Medical Center | 25 | 2026-10-14 | 2026-10-05 |
| Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial) MA-WBRT (Memory Avoidance Whole Brain Radiation Therapy (MA-WBRT)), HA-WBRT (Hippocampal Avoidance Whole Brain Radiation Therapy (HA-WBRT)), Memantine - Brain Metastases | Phase 2 | Recruiting | Case Comprehensive Cancer Center | 90 | 2026-07-09 | 2026-09-22 |
| Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain Memantine, Raloxifene - Brain Tumor | Phase 2 | Recruiting | The University of Texas Health Science Center at San Antonio | 108 | 2026-07-06 | 2026-09-22 |
| Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression D-Cycloserine (DCS), Continuous theta-burst stimulation (cTBS), Transcranial Magnetic Stimulation Sham - Major Depression | Early Phase 1 | Recruiting | Mclean Hospital | 80 | 2026-03-11 | 2026-05-13 |
| Neuroprotection of Memantine and Rosuvastatin Starch Placebo, Memantine, Rosuvastatin 20 Mg Oral Tablet - Peripheral Nerve Disease | Phase 2 / Phase 3 | Not yet recruiting | Tanta University | 46 | 2026-03-01 | 2026-03-31 |
| Efficacy and Safety of DMB-I (INN: Latrepirdine) in Patients With Alzheimer Type Dementia DMB-I (INN: Latrepirdine), Memantine Hydrochloride 20 MG, Placebo - Alzheimer Type Dementia | Phase 3 | Recruiting | Bigespas LTD | 450 | 2025-11-20 | 2025-12-10 |
| Memantine Hydrochloride in Prostate Cancer Patients Memantine Hydrochloride - Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostate Cancer | Phase 2 | Not yet recruiting | Bin Xu | 15 | 2025-11-01 | 2025-11-19 |
| Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer Memantine, Placebo medication, Exercise Intervention - Breast Cancer, Locally Advanced Breast Cancer | Phase 2 | Recruiting | UNC Lineberger Comprehensive Cancer Center | 90 | 2025-08-19 | 2026-05-06 |
| Memantine as an Additive Therapy in Patients With Traumatic Brain Injury Memantine, Mannitol - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI) | Phase 2 / Phase 3 | Not yet recruiting | Mansoura University | 80 | 2025-03-25 | 2025-04-06 |
| The Study of Atezolizumab, Bevacizumab and Memantine in Patients With Hepatocellular Carcinoma (HCC) Memantine Hydrochloride, Bevacizumab, Atezolizumab - Hepatocellular Carcinoma | Phase 2 | Recruiting | Inova Health Care Services | 19 | 2025-02-25 | 2026-10-16 |
| Effect of Acetylcholinesterase Inhibitors on Bone Metabolism Donepezil, Memantine - Osteoporosis | Phase 2 | Recruiting | Duke University | 45 | 2025-02-03 | 2026-09-21 |
| Ultrasound-Guided Stellate Ganglion Block for Alzheimer's Disease Ultrasound-Guided Stellate Ganglion Block, Memantine hydrochloride, Donepezil hydrochloride - Alzheimer's Disease(AD), Cognitive Dysfunction | Not applicable | Completed | Taizhou Second People's Hospital | 40 | 2025-01-26 | 2026-01-21 |
| "The Effect of Memantine on the Prevention and Amelioration of Paclitaxel-induced Toxicity in Breast Cancer Patients" Memantine-HCl, Placebo Oral Tablet - Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Phase 2 | Recruiting | Ain Shams University | 80 | 2024-10-30 | 2024-11-07 |
| Satisfaction With Orodispersible vs Conventional Memantine in Moderate to Severe Alzheimer's Disease Memantine, Memantine Oral Tablet - Alzheimer Disease | Phase 4 | Completed | Carnot Laboratories | 105 | 2024-10-04 | 2026-02-18 |
| Early Application of Memantine and Pioglitazone to Protect Cognitive Function After Radiotherapy Memantine Oral Tablet, Pioglitazone 15mg, Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) - Radiation Disease, Cognitive Impairment | Phase 2 | Not yet recruiting | Affiliated Cancer Hospital & Institute of Guangzhou Medical University | 67 | 2024-09-10 | 2024-09-19 |
| Efficacy and Safety of memanTine in the Treatment Of Frequently symPtomatic Atrial Premature Beats Memantine Hydrochloride 10 MG, Placebo - Atrial Premature Beats, Contractions, or Systoles | Phase 2 | Completed | Shanghai East Hospital | 256 | 2024-08-29 | 2025-11-25 |
| Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI Memantine Oral Tablet - Neurocognitive Dysfunction | Phase 3 | Recruiting | Tata Memorial Centre | 101 | 2024-02-22 | 2025-04-09 |
| Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury Memantine Hydrochloride - Treatment of Cognitive Deficits After Traumatic Brain Injury | Phase 3 | Completed | Assiut University | 60 | 2024-01-01 | 2024-08-07 |
| Behavioral Treatment and Memantine in Body Focused Repetitive Behaviors Memantine, ComB Behavioral Therapy - Skin-Picking, Trichotillomania (Hair-Pulling Disorder) | Phase 2 / Phase 3 | Active not recruiting | University of Chicago | 26 | 2023-08-02 | 2026-07-07 |
Showing 20 of 228. Sign in to see all of them.
Alzheimer Disease (47) · Cognitive Dysfunction (18) · Dementia (15) · Brain Neoplasms (11) · Schizophrenia (11) · Depression (10) · Autism Spectrum Disorder (9) · Depressive Disorder, Major (9) · Autistic Disorder (7) · Bipolar Disorder (7) · Brain Injuries, Traumatic (6) · Parkinson Disease (6) · Amyotrophic Lateral Sclerosis (5) · Multiple Sclerosis (5) · Obsessive-Compulsive Disorder (5)
Forest Laboratories (10) · Massachusetts General Hospital (8) · New York State Psychiatric Institute (7) · H. Lundbeck A/S (6) · National Cheng-Kung University Hospital (6) · Mclean Hospital (4) · Merz Pharmaceuticals GmbH (4) · Stanford University (4) · University of California, San Diego (4) · Allergan (3) · Johns Hopkins University (3) · NRG Oncology (3) · National Taiwan University Hospital (3) · University Hospital, Clermont-Ferrand (3) · University of Chicago (3)
United States (118) · France (18) · Canada (16) · Germany (11) · Taiwan (11) · China (9) · Spain (9) · United Kingdom (9) · South Korea (8) · Egypt (7) · Italy (5) · Denmark (4) · New Zealand (4) · Poland (4) · South Africa (4)
Ru-Band Lu, MD (4) · Adam Bisaga, M.D. (3) · Gagan Joshi, MD (3) · Jordan Lateiner, MS, MBA (3) · Tzu-Yun Wang (3) · Alberto C Costa, MD, PhD (2) · Arthur Winer, MD (2) · James I Hudson, M.D., Sc.D. (2) · Jon E Grant, MD, JD, MPH (2) · Marcelo L. Berthier, M.D., Ph.D (2) · Martin Schaefer, MD (2) · Stephen L Ruedrich, MD (2)
PMID 36006807, PMID 37811711, PMID 31169568, PMID 31390660, PMID 10465680, PMID 15911704, PMID 16009352, PMID 16490414, PMID 17721095, PMID 18348597, PMID 18582848, PMID 18834506, PMID 19092106, PMID 19142108, PMID 19204653, PMID 19687359, PMID 19812461, PMID 19874395, PMID 19906345, PMID 20028712, PMID 20303474, PMID 20400412, PMID 20483885, PMID 20721537, PMID 20729148, PMID 21157021, PMID 21274364, PMID 21471647, PMID 21476613, PMID 21561398, PMID 21715107, PMID 21792308, PMID 21914212, PMID 22014101, PMID 22173933, PMID 22233455, PMID 22269160, PMID 22492589, PMID 22567095, PMID 22674572, PMID 22806212, PMID 22922703, PMID 23063327, PMID 23077087, PMID 23290598, PMID 23472619, PMID 23525525, PMID 23826157, PMID 23870798, PMID 23956241
2004 (2), 2005 (2), 2017 (2), R01DA017572 (2), UG1CA189867 (2), 1RL1AG032115-01 (1), 2008 (1), 2014 (1), 2016 (1), 2019 (1), K12HD001441 (1), K23AG086604 (1), K23DA000429 (1), K23MH064196 (1), P50AA012870 (1)